Publications by authors named "Deborah N Farlow"

12Publications

Exome sequencing in suspected monogenic dyslipidemias.

Authors:
Nathan O Stitziel Gina M Peloso Marianne Abifadel Angelo B Cefalu Sigrid Fouchier M Mahdi Motazacker Hayato Tada Daniel B Larach Zuhier Awan Jorge F Haller Clive R Pullinger Mathilde Varret Jean-Pierre Rabès Davide Noto Patrizia Tarugi Masa-Aki Kawashiri Atsushi Nohara Masakazu Yamagishi Marjorie Risman Rahul Deo Isabelle Ruel Jay Shendure Deborah A Nickerson James G Wilson Stephen S Rich Namrata Gupta Deborah N Farlow Benjamin M Neale Mark J Daly John P Kane Mason W Freeman Jacques Genest Daniel J Rader Hiroshi Mabuchi John J P Kastelein G Kees Hovingh Maurizio R Averna Stacey Gabriel Catherine Boileau Sekar Kathiresan

Circ Cardiovasc Genet 2015 Apr 27;8(2):343-50. Epub 2015 Jan 27.

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April 2015

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.

Authors:
Ron Do Nathan O Stitziel Hong-Hee Won Anders Berg Jørgensen Stefano Duga Pier Angelica Merlini Adam Kiezun Martin Farrall Anuj Goel Or Zuk Illaria Guella Rosanna Asselta Leslie A Lange Gina M Peloso Paul L Auer Domenico Girelli Nicola Martinelli Deborah N Farlow Mark A DePristo Robert Roberts Alexander F R Stewart Danish Saleheen John Danesh Stephen E Epstein Suthesh Sivapalaratnam G Kees Hovingh John J Kastelein Nilesh J Samani Heribert Schunkert Jeanette Erdmann Svati H Shah William E Kraus Robert Davies Majid Nikpay Christopher T Johansen Jian Wang Robert A Hegele Eliana Hechter Winfried Marz Marcus E Kleber Jie Huang Andrew D Johnson Mingyao Li Greg L Burke Myron Gross Yongmei Liu Themistocles L Assimes Gerardo Heiss Ethan M Lange Aaron R Folsom Herman A Taylor Oliviero Olivieri Anders Hamsten Robert Clarke Dermot F Reilly Wu Yin Manuel A Rivas Peter Donnelly Jacques E Rossouw Bruce M Psaty David M Herrington James G Wilson Stephen S Rich Michael J Bamshad Russell P Tracy L Adrienne Cupples Daniel J Rader Muredach P Reilly John A Spertus Sharon Cresci Jaana Hartiala W H Wilson Tang Stanley L Hazen Hooman Allayee Alex P Reiner Christopher S Carlson Charles Kooperberg Rebecca D Jackson Eric Boerwinkle Eric S Lander Stephen M Schwartz David S Siscovick Ruth McPherson Anne Tybjaerg-Hansen Goncalo R Abecasis Hugh Watkins Deborah A Nickerson Diego Ardissino Shamil R Sunyaev Christopher J O'Donnell David Altshuler Stacey Gabriel Sekar Kathiresan

Nature 2015 Feb 10;518(7537):102-6. Epub 2014 Dec 10.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [2] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [3] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA. [4] Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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February 2015

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.

Authors:
Jacy Crosby Gina M Peloso Paul L Auer David R Crosslin Nathan O Stitziel Leslie A Lange Yingchang Lu Zheng-zheng Tang He Zhang George Hindy Nicholas Masca Kathleen Stirrups Stavroula Kanoni Ron Do Goo Jun Youna Hu Hyun Min Kang Chenyi Xue Anuj Goel Martin Farrall Stefano Duga Pier Angelica Merlini Rosanna Asselta Domenico Girelli Oliviero Olivieri Nicola Martinelli Wu Yin Dermot Reilly Elizabeth Speliotes Caroline S Fox Kristian Hveem Oddgeir L Holmen Majid Nikpay Deborah N Farlow Themistocles L Assimes Nora Franceschini Jennifer Robinson Kari E North Lisa W Martin Mark DePristo Namrata Gupta Stefan A Escher Jan-Håkan Jansson Natalie Van Zuydam Colin N A Palmer Nicholas Wareham Werner Koch Thomas Meitinger Annette Peters Wolfgang Lieb Raimund Erbel Inke R Konig Jochen Kruppa Franziska Degenhardt Omri Gottesman Erwin P Bottinger Christopher J O'Donnell Bruce M Psaty Christie M Ballantyne Goncalo Abecasis Jose M Ordovas Olle Melander Hugh Watkins Marju Orho-Melander Diego Ardissino Ruth J F Loos Ruth McPherson Cristen J Willer Jeanette Erdmann Alistair S Hall Nilesh J Samani Panos Deloukas Heribert Schunkert James G Wilson Charles Kooperberg Stephen S Rich Russell P Tracy Dan-Yu Lin David Altshuler Stacey Gabriel Deborah A Nickerson Gail P Jarvik L Adrienne Cupples Alex P Reiner Eric Boerwinkle Sekar Kathiresan

N Engl J Med 2014 Jul 18;371(1):22-31. Epub 2014 Jun 18.

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July 2014

Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans.

Authors:
Jaclyn Ellis Ethan M Lange Jin Li Josee Dupuis Jens Baumert Jeremy D Walston Brendan J Keating Peter Durda Ervin R Fox Cameron D Palmer Yan A Meng Taylor Young Deborah N Farlow Renate B Schnabel Carola S Marzi Emma Larkin Lisa W Martin Joshua C Bis Paul Auer Vasan S Ramachandran Stacey B Gabriel Monte S Willis James S Pankow George J Papanicolaou Jerome I Rotter Christie M Ballantyne Myron D Gross Guillaume Lettre James G Wilson Ulrike Peters Wolfgang Koenig Russell P Tracy Susan Redline Alex P Reiner Emelia J Benjamin Leslie A Lange

Hum Genet 2014 Aug 19;133(8):985-95. Epub 2014 Mar 19.

Department of Genetics, University of North Carolina, 5112 Genetic Medicine Bldg., Chapel Hill, NC, 27599-7264, USA.

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August 2014

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.

Authors:
Leslie A Lange Youna Hu He Zhang Chenyi Xue Ellen M Schmidt Zheng-Zheng Tang Chris Bizon Ethan M Lange Joshua D Smith Emily H Turner Goo Jun Hyun Min Kang Gina Peloso Paul Auer Kuo-Ping Li Jason Flannick Ji Zhang Christian Fuchsberger Kyle Gaulton Cecilia Lindgren Adam Locke Alisa Manning Xueling Sim Manuel A Rivas Oddgeir L Holmen Omri Gottesman Yingchang Lu Douglas Ruderfer Eli A Stahl Qing Duan Yun Li Peter Durda Shuo Jiao Aaron Isaacs Albert Hofman Joshua C Bis Adolfo Correa Michael E Griswold Johanna Jakobsdottir Albert V Smith Pamela J Schreiner Mary F Feitosa Qunyuan Zhang Jennifer E Huffman Jacy Crosby Christina L Wassel Ron Do Nora Franceschini Lisa W Martin Jennifer G Robinson Themistocles L Assimes David R Crosslin Elisabeth A Rosenthal Michael Tsai Mark J Rieder Deborah N Farlow Aaron R Folsom Thomas Lumley Ervin R Fox Christopher S Carlson Ulrike Peters Rebecca D Jackson Cornelia M van Duijn André G Uitterlinden Daniel Levy Jerome I Rotter Herman A Taylor Vilmundur Gudnason David S Siscovick Myriam Fornage Ingrid B Borecki Caroline Hayward Igor Rudan Y Eugene Chen Erwin P Bottinger Ruth J F Loos Pål Sætrom Kristian Hveem Michael Boehnke Leif Groop Mark McCarthy Thomas Meitinger Christie M Ballantyne Stacey B Gabriel Christopher J O'Donnell Wendy S Post Kari E North Alexander P Reiner Eric Boerwinkle Bruce M Psaty David Altshuler Sekar Kathiresan Dan-Yu Lin Gail P Jarvik L Adrienne Cupples Charles Kooperberg James G Wilson Deborah A Nickerson Goncalo R Abecasis Stephen S Rich Russell P Tracy Cristen J Willer

Am J Hum Genet 2014 Feb;94(2):233-45

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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February 2014

MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition.

Authors:
Nikhil Wagle Eliezer M Van Allen Daniel J Treacy Dennie T Frederick Zachary A Cooper Amaro Taylor-Weiner Mara Rosenberg Eva M Goetz Ryan J Sullivan Deborah N Farlow Dennis C Friedrich Kristin Anderka Danielle Perrin Cory M Johannessen Aaron McKenna Kristian Cibulskis Gregory Kryukov Eran Hodis Donald P Lawrence Sheila Fisher Gad Getz Stacey B Gabriel Scott L Carter Keith T Flaherty Jennifer A Wargo Levi A Garraway

Cancer Discov 2014 Jan 21;4(1):61-8. Epub 2013 Nov 21.

1Department of Medical Oncology, Dana-Farber Cancer Institute; 2Department of Medicine, Brigham and Women's Hospital; 3Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston; 4Broad Institute of Harvard and MIT; and 5Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts.

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January 2014

Genome-wide association study of cardiac structure and systolic function in African Americans: the Candidate Gene Association Resource (CARe) study.

Authors:
Ervin R Fox Solomon K Musani Maja Barbalic Honghuang Lin Bing Yu Kofo O Ogunyankin Nicholas L Smith Abdullah Kutlar Nicole L Glazer Wendy S Post Dina N Paltoo Daniel L Dries Deborah N Farlow Christine W Duarte Sharon L Kardia Kristin J Meyers Yan V Sun Donna K Arnett Amit A Patki Jin Sha Xiangqui Cui Tandaw E Samdarshi Alan D Penman Kirsten Bibbins-Domingo Petra Bůžková Emelia J Benjamin David A Bluemke Alanna C Morrison Gerardo Heiss J Jeffrey Carr Russell P Tracy Thomas H Mosley Herman A Taylor Bruce M Psaty Susan R Heckbert Thomas P Cappola Ramachandran S Vasan

Circ Cardiovasc Genet 2013 Feb 28;6(1):37-46. Epub 2012 Dec 28.

Department of Medicine, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216, USA.

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February 2013

Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project.

Authors:
Renate B Schnabel Kathleen F Kerr Steven A Lubitz Ermeg L Alkylbekova Gregory M Marcus Moritz F Sinner Jared W Magnani Philip A Wolf Rajat Deo Donald M Lloyd-Jones Kathryn L Lunetta Reena Mehra Daniel Levy Ervin R Fox Dan E Arking Thomas H Mosley Martina Müller-Nurasyid Taylor R Young H-Erich Wichmann Sudha Seshadri Deborah N Farlow Jerome I Rotter Elsayed Z Soliman Nicole L Glazer James G Wilson Monique M B Breteler Nona Sotoodehnia Christopher Newton-Cheh Stefan Kääb Patrick T Ellinor Alvaro Alonso Emelia J Benjamin Susan R Heckbert

Circ Cardiovasc Genet 2011 Oct 16;4(5):557-64. Epub 2011 Aug 16.

National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.

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October 2011

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

Authors:
Ervin R Fox J Hunter Young Yali Li Albert W Dreisbach Brendan J Keating Solomon K Musani Kiang Liu Alanna C Morrison Santhi Ganesh Abdullah Kutlar Vasan S Ramachandran Josef F Polak Richard R Fabsitz Daniel L Dries Deborah N Farlow Susan Redline Adebowale Adeyemo Joel N Hirschorn Yan V Sun Sharon B Wyatt Alan D Penman Walter Palmas Jerome I Rotter Raymond R Townsend Ayo P Doumatey Bamidele O Tayo Thomas H Mosley Helen N Lyon Sun J Kang Charles N Rotimi Richard S Cooper Nora Franceschini J David Curb Lisa W Martin Charles B Eaton Sharon L R Kardia Herman A Taylor Mark J Caulfield Georg B Ehret Toby Johnson Aravinda Chakravarti Xiaofeng Zhu Daniel Levy

Hum Mol Genet 2011 Jun 4;20(11):2273-84. Epub 2011 Mar 4.

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

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June 2011

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

Authors:
Guillaume Lettre Cameron D Palmer Taylor Young Kenechi G Ejebe Hooman Allayee Emelia J Benjamin Franklyn Bennett Donald W Bowden Aravinda Chakravarti Al Dreisbach Deborah N Farlow Aaron R Folsom Myriam Fornage Terrence Forrester Ervin Fox Christopher A Haiman Jaana Hartiala Tamara B Harris Stanley L Hazen Susan R Heckbert Brian E Henderson Joel N Hirschhorn Brendan J Keating Stephen B Kritchevsky Emma Larkin Mingyao Li Megan E Rudock Colin A McKenzie James B Meigs Yang A Meng Tom H Mosley Anne B Newman Christopher H Newton-Cheh Dina N Paltoo George J Papanicolaou Nick Patterson Wendy S Post Bruce M Psaty Atif N Qasim Liming Qu Daniel J Rader Susan Redline Muredach P Reilly Alexander P Reiner Stephen S Rich Jerome I Rotter Yongmei Liu Peter Shrader David S Siscovick W H Wilson Tang Herman A Taylor Russell P Tracy Ramachandran S Vasan Kevin M Waters Rainford Wilks James G Wilson Richard R Fabsitz Stacey B Gabriel Sekar Kathiresan Eric Boerwinkle

PLoS Genet 2011 Feb 10;7(2):e1001300. Epub 2011 Feb 10.

Montreal Heart Institute, Montréal, Canada.

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February 2011

Candidate gene association resource (CARe): design, methods, and proof of concept.

Authors:
Kiran Musunuru Guillaume Lettre Taylor Young Deborah N Farlow James P Pirruccello Kenechi G Ejebe Brendan J Keating Qiong Yang Ming-Huei Chen Nina Lapchyk Andrew Crenshaw Liuda Ziaugra Anthony Rachupka Emelia J Benjamin L Adrienne Cupples Myriam Fornage Ervin R Fox Susan R Heckbert Joel N Hirschhorn Christopher Newton-Cheh Marcia M Nizzari Dina N Paltoo George J Papanicolaou Sanjay R Patel Bruce M Psaty Daniel J Rader Susan Redline Stephen S Rich Jerome I Rotter Herman A Taylor Russell P Tracy Ramachandran S Vasan James G Wilson Sekar Kathiresan Richard R Fabsitz Eric Boerwinkle Stacey B Gabriel

Circ Cardiovasc Genet 2010 Jun 17;3(3):267-75. Epub 2010 Apr 17.

Broad Institute, Cambridge, MA 02142, USA.

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June 2010

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.

Authors:
Brendan J Keating Sam Tischfield Sarah S Murray Tushar Bhangale Thomas S Price Joseph T Glessner Luana Galver Jeffrey C Barrett Struan F A Grant Deborah N Farlow Hareesh R Chandrupatla Mark Hansen Saad Ajmal George J Papanicolaou Yiran Guo Mingyao Li Stephanie Derohannessian Paul I W de Bakker Swneke D Bailey Alexandre Montpetit Andrew C Edmondson Kent Taylor Xiaowu Gai Susanna S Wang Myriam Fornage Tamim Shaikh Leif Groop Michael Boehnke Alistair S Hall Andrew T Hattersley Edward Frackelton Nick Patterson Charleston W K Chiang Cecelia E Kim Richard R Fabsitz Willem Ouwehand Alkes L Price Patricia Munroe Mark Caulfield Thomas Drake Eric Boerwinkle David Reich A Stephen Whitehead Thomas P Cappola Nilesh J Samani A Jake Lusis Eric Schadt James G Wilson Wolfgang Koenig Mark I McCarthy Sekar Kathiresan Stacey B Gabriel Hakon Hakonarson Sonia S Anand Muredach Reilly James C Engert Deborah A Nickerson Daniel J Rader Joel N Hirschhorn Garret A Fitzgerald

PLoS One 2008 31;3(10):e3583. Epub 2008 Oct 31.

The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, USA.

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February 2009