Publications by authors named "Deborah J Clegg"

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Diet-induced glucose homeostasis dysregulation is enhanced by taurine supplementation in ovariectomized mice.
Amino Acids 2018 Apr 27;50(3-4):469-477. Epub 2017 Dec 27.
Obesity and Comorbidities Research Center (OCRC), Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.



The ERα-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice.
Endocrinology 2015 Dec 16;156(12):4474-91. Epub 2015 Sep 16.
Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medicine, and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China; Medical College of Qingdao University (C.Y.), Qingdao 266020, People's Republic of China; Department of Cancer Biology (S.A.K.), Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267; Department of Pathology (J.Z.), Harvard Medical School, and Department of Cancer Biology Dana-Farber Cancer Institute, Boston, Massachusetts 02115; and Department of Biomedical Research (D.J.C.), Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
PLoS Genet 2015 Oct 1;11(10):e1005378. Epub 2015 Oct 1.
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Maternal high-fat diet is associated with impaired fetal lung development.
Am J Physiol Lung Cell Mol Physiol 2015 Aug 19;309(4):L360-8. Epub 2015 Jun 19.
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and


Activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass is associated with gonadal adipose tissues browning.
Mol Metab 2015 May 3;4(5):427-36. Epub 2015 Mar 3.
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA ; Biomedical Research Division, Diabetes and Obesity Research Institute, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

G-protein-coupled estrogen receptor 1 is anatomically positioned to modulate synaptic plasticity in the mouse hippocampus.
J Neurosci 2015 Feb;35(6):2384-97
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York 10065.

Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα.
Cell Rep 2014 Oct 16;9(2):633-45. Epub 2014 Oct 16.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8857, USA; Department of Biomedical Research, Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address:

ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue.
Mol Metab 2014 Sep 7;3(6):642-51. Epub 2014 Jun 7.
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

Obesity and cancer--mechanisms underlying tumour progression and recurrence.
Nat Rev Endocrinol 2014 Aug 17;10(8):455-465. Epub 2014 Jun 17.
Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, 50 UNIST Street, Ulsan 689-798, South Korea (J.P.). Touchstone Diabetes Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA (T.S.M., M.K., D.J.C., P.E.S.).

Hippocampal lipoprotein lipase regulates energy balance in rodents.
Mol Metab 2014 Apr 20;3(2):167-76. Epub 2013 Nov 20.
Université Paris Diderot, Sorbonne Paris Cité, BFA, EAC 4413 CNRS, Case courrier 7126, 4, rue Marie Andrée Lagroua Weill-Hallé, F-75205 Paris Cedex 13, France.

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
PLoS Genet 2013 Jun 6;9(6):e1003500. Epub 2013 Jun 6.
Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.


Implication of the melanocortin-3 receptor in the regulation of food intake.
Eur J Pharmacol 2011 Jun 1;660(1):80-7. Epub 2011 Jan 1.
Department of Pharmacodynamics, University of Florida, PO Box 100487, Gainesville, FL-32610, United States.

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
Nat Genet 2011 Jun 26;43(8):753-60. Epub 2011 Jun 26.
Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.


Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival.
Diabetes 2009 Oct 8;58(10):2292-302. Epub 2009 Jul 8.
Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University School of Medicine, Chicago, Illinois, USA.





The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis.
Mol Metab 2013 4;2(3):227-42. Epub 2013 Jun 4.
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., K5.252, Dallas, TX 75390-8854, USA.

Leptin Signaling Is Not Required for Anorexigenic Estradiol Effects in Female Mice.
Endocrinology 2016 05 3;157(5):1991-2001. Epub 2016 Mar 3.
Centre for Neuroendocrinology and Department of Anatomy (J.S.K, M.Z.R, G.M.A.), University of Otago School of Medical Sciences, Dunedin 9054, New Zealand; and Cedars-Sinai Diabetes and Obesity Research Institute, Department of Biomedical Research (D.J.C.), Los Angeles, California 90048.

Estrogen Receptor-α in the Medial Amygdala Prevents Stress-Induced Elevations in Blood Pressure in Females.
Hypertension 2016 06 18;67(6):1321-30. Epub 2016 Apr 18.
From the Department of Pediatrics, Children's Nutrition Research Center (A.O.H., Y.H., Y.X., P.X., Y.Y., K.S., C.W., X.Y., G.S., A.H., Q.W., Y.X.), Advanced Technology/Core Laboratory (C.R.), and Department of Molecular and Cellular Biology (Y.X.), Baylor College of Medicine, One Baylor Plaza, Houston, TX; Department of Biomedical Research, Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA (D.J.C.); Department of Cell and Cancer Biology, Vontz Center for Molecular Studies, University of Cincinnati, College of Medicine, OH (S.A.K.); and Center for Metabolic and Degenerative Diseases, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (Q.T.).

Lacking of estradiol reduces insulin exocytosis from pancreatic β-cells and increases hepatic insulin degradation.
Steroids 2016 10 15;114:16-24. Epub 2016 May 15.
Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, e Centro de Pesquisa em Obesidade e Comorbidades, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
PLoS Genet 2016 06 29;12(6):e1006166. Epub 2016 Jun 29.

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