Deborah Downs

Deborah Downs

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Deborah Downs

Deborah Downs

Publications by authors named "Deborah Downs"

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Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes.

Chem Sci 2016 May 4;7:3117-3122. Epub 2016 Feb 4.

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 (USA); Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907 (USA); Department of Biochemistry, Purdue University, West Lafayette, IN 47907 (USA).

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http://dx.doi.org/10.1039/C5SC03718BDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916918PMC
May 2016

Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism.

FASEB J 2013 Jun 19;27(6):2132-44. Epub 2013 Feb 19.

Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1096/fj.12-214353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188231PMC
June 2013

Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice.

FASEB J 2011 Feb 8;25(2):775-84. Epub 2010 Nov 8.

Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1096/fj.10-167213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023390PMC
February 2011

Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization.

FASEB J 2007 Oct 10;21(12):3184-96. Epub 2007 May 10.

Protein Studies Program, Oklahoma Medical Research Foundation, 825 N.E. 13th St., Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1096/fj.06-7993comDOI Listing
October 2007

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors.

J Neurochem 2004 Jun;89(6):1409-16

Protein Studies Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02452.xDOI Listing
June 2004

Enzymic properties of recombinant BACE2.

Eur J Biochem 2002 Nov;269(22):5668-77

Functional Proteomics Laboratory and Crystallography Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1046/j.1432-1033.2002.03277.xDOI Listing
November 2002