Deborah Cunninghame Graham

Deborah Cunninghame Graham

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Deborah Cunninghame Graham

Deborah Cunninghame Graham

Publications by authors named "Deborah Cunninghame Graham"

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34Publications

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A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus.

Hum Mol Genet 2018 07;27(13):2392-2404

Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1093/hmg/ddy140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005081PMC
July 2018

Abnormal B Cell Development in Systemic Lupus Erythematosus: What the Genetics Tell Us.

Arthritis Rheumatol 2018 04 22;70(4):496-507. Epub 2018 Feb 22.

King's College London, London, UK.

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http://dx.doi.org/10.1002/art.40396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900717PMC
April 2018

Corrigendum to "Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome" [Clin. Immunol. 168 (2016) 25-29].

Clin Immunol 2018 02 7;187:137-138. Epub 2017 Dec 7.

Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.11.012DOI Listing
February 2018

B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis.

Ann Rheum Dis 2017 Dec 17;76(12):2095-2103. Epub 2017 Aug 17.

Division of Medical and Molecular Genetics and Immunology, Infection and Inflammatory Disease, King's College London, London, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2017-21149
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http://dx.doi.org/10.1136/annrheumdis-2017-211499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705841PMC
December 2017

Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease.

PLoS Genet 2017 Oct 23;13(10):e1007071. Epub 2017 Oct 23.

Department of Medical & Molecular Genetics, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1007071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695635PMC
October 2017

Transancestral mapping and genetic load in systemic lupus erythematosus.

Authors:
Carl D Langefeld Hannah C Ainsworth Deborah S Cunninghame Graham Jennifer A Kelly Mary E Comeau Miranda C Marion Timothy D Howard Paula S Ramos Jennifer A Croker David L Morris Johanna K Sandling Jonas Carlsson Almlöf Eduardo M Acevedo-Vásquez Graciela S Alarcón Alejandra M Babini Vicente Baca Anders A Bengtsson Guillermo A Berbotto Marc Bijl Elizabeth E Brown Hermine I Brunner Mario H Cardiel Luis Catoggio Ricard Cervera Jorge M Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D'Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C Edberg Emőke Endreffy Jorge A Esquivel-Valerio Paul R Fortin Barry I Freedman Johan Frostegård Mercedes A García Ignacio García de la Torre Gary S Gilkeson Dafna D Gladman Iva Gunnarsson Joel M Guthridge Jennifer L Huggins Judith A James Cees G M Kallenberg Diane L Kamen David R Karp Kenneth M Kaufman Leah C Kottyan László Kovács Helle Laustrup Bernard R Lauwerys Quan-Zhen Li Marco A Maradiaga-Ceceña Javier Martín Joseph M McCune David R McWilliams Joan T Merrill Pedro Miranda José F Moctezuma Swapan K Nath Timothy B Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A Pineau Bernardo A Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D Reveille Laurie P Russell José M Sabio Carlos A Aguilar-Salinas Hugo R Scherbarth Raffaella Scorza Michael F Seldin Christopher Sjöwall Elisabet Svenungsson Susan D Thompson Sergio M A Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M Vilá Daniel J Wallace Michael H Weisman Joan E Wither Tushar Bhangale Jorge R Oksenberg John D Rioux Peter K Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A Criswell Chaim O Jacob Kathy L Sivils Betty P Tsao Laura E Schanberg Timothy W Behrens Earl D Silverman Marta E Alarcón-Riquelme Robert P Kimberly John B Harley Edward K Wakeland Robert R Graham Patrick M Gaffney Timothy J Vyse

Nat Commun 2017 07 17;8:16021. Epub 2017 Jul 17.

Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1038/ncomms16021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520018PMC
July 2017

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.

PLoS Genet 2017 Jun 22;13(6):e1006820. Epub 2017 Jun 22.

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501660PMC
June 2017

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.

Clin Immunol 2016 07 22;168:25-29. Epub 2016 Apr 22.

Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940221PMC
July 2016

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.

Arthritis Rheumatol 2016 05;68(5):1290-1300

College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1002/art.39560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019501PMC
May 2016

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.

Hum Mol Genet 2015 Jan 8;24(2):582-96. Epub 2014 Sep 8.

Division of Rheumatology, Center for Autoimmune Genomics and Etiology and US Department of Veterans Affairs Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1093/hmg/ddu455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275071PMC
January 2015

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

Nat Genet 2013 Nov 6;45(11):1284-92. Epub 2013 Oct 6.

1] Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA. [2] Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

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http://dx.doi.org/10.1038/ng.2792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867192PMC
November 2013

The genetics of lupus: a functional perspective.

Arthritis Res Ther 2012 May 29;14(3):211. Epub 2012 May 29.

Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King's College London, Great Maze Pond, London, SE1 9RT, UK.

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http://dx.doi.org/10.1186/ar3844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446495PMC
May 2012

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

PLoS Genet 2011 Oct 27;7(10):e1002341. Epub 2011 Oct 27.

Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, School of Medicine, King's College London, London, United Kingdom.

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https://dx.plos.org/10.1371/journal.pgen.1002341
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http://dx.doi.org/10.1371/journal.pgen.1002341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203198PMC
October 2011

Dense mapping of IL18 shows no association in SLE.

Hum Mol Genet 2011 Mar 13;20(5):1026-33. Epub 2010 Dec 13.

Rheumatology Section, Imperial College, London W12 0NN, UK.

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http://dx.doi.org/10.1093/hmg/ddq536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033184PMC
March 2011

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.

Nat Genet 2008 Jan 2;40(1):83-9. Epub 2007 Dec 2.

Section of Molecular Genetics and Rheumatology, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1038/ng.2007.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705866PMC
January 2008

Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls.

J Immunol 2008 Jan;180(2):1060-70

Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, UK.

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http://dx.doi.org/10.4049/jimmunol.180.2.1060DOI Listing
January 2008

Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.

Hum Mol Genet 2007 Mar 22;16(6):579-91. Epub 2006 Dec 22.

Imperial College, Faculty of Medicine, Molecular Genetics and Rheumatology Section, Hammersmith Hospital, London, UK.

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http://academic.oup.com/hmg/article/16/6/579/610750/Associat
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http://dx.doi.org/10.1093/hmg/ddl469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706933PMC
March 2007

A functional ISRE is required for myeloid transcription of the p47(phox) gene.

Biochim Biophys Acta 2003 Nov;1630(2-3):117-22

Department of Haematology, Imperial College of Science, Technology and Medicine, St Mary's Campus, Norfolk Place, London, UK.

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http://dx.doi.org/10.1016/j.bbaexp.2003.09.005DOI Listing
November 2003

Differentiation-dependent up-regulation of p47(phox) gene transcription is associated with changes in PU.1 phosphorylation and increased binding affinity.

Biochem Biophys Res Commun 2003 May;305(1):193-202

Department of Haematology, Faculty of Medicine, Imperial College of Science Technology and Medicine, Norfolk Place, London, UK.

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http://dx.doi.org/10.1016/s0006-291x(03)00727-7DOI Listing
May 2003