Publications by authors named "Deborah A Smith"

36Publications

A Randomized, Placebo- and Positive-Controlled, Single-Dose, Crossover Thorough QT/QTc Study Assessing the Effect of Daprodustat on Cardiac Repolarization in Healthy Subjects.

Clin Pharmacol Drug Dev 2017 Nov 17;6(6):627-640. Epub 2017 Apr 17.

Metabolic Pathways and Cardiovascular, GlaxoSmithKline, Collegeville, PA, USA.

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http://dx.doi.org/10.1002/cpdd.342DOI Listing
November 2017

Effect of lapatinib on oral digoxin absorption in patients.

Clin Pharmacol Drug Dev 2015 11 2;4(6):449-53. Epub 2015 Jun 2.

Seoul National University Hospital, Clinical Research Institute, Seoul, Korea.

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http://dx.doi.org/10.1002/cpdd.189DOI Listing
November 2015

Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape.

Antioxid Redox Signal 2013 Dec 9;19(18):2244-60. Epub 2013 Jul 9.

1 Faculty of Medical Sciences, Institute for Cell and Molecular Biosciences, Newcastle University , Newcastle upon Tyne, United Kingdom .

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http://dx.doi.org/10.1089/ars.2013.5199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869436PMC
December 2013

MAPKKK-independent regulation of the Hog1 stress-activated protein kinase in Candida albicans.

J Biol Chem 2011 Dec 12;286(49):42002-16. Epub 2011 Oct 12.

Institute for Cell and Molecular Biosciences, Faculty of Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1074/jbc.M111.265231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234903PMC
December 2011

An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis.

Gastroenterology 2011 Nov 9;141(5):1593-604. Epub 2011 Aug 9.

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.07.044DOI Listing
November 2011

Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin-5 monoclonal antibody.

Clin Pharmacokinet 2011 Apr;50(4):215-27

Clinical Pharmacology Modeling & Simulation, GlaxoSmithKline, Research Triangle Park, North Carolina 27709-3398, USA.

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http://link.springer.com/content/pdf/10.2165/11584340-000000
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http://dx.doi.org/10.2165/11584340-000000000-00000DOI Listing
April 2011

Two-component mediated peroxide sensing and signal transduction in fission yeast.

Antioxid Redox Signal 2011 Jul 31;15(1):153-65. Epub 2011 Mar 31.

Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1089/ars.2010.3345DOI Listing
July 2011

Thioredoxin regulates multiple hydrogen peroxide-induced signaling pathways in Candida albicans.

Mol Cell Biol 2010 Oct 2;30(19):4550-63. Epub 2010 Aug 2.

Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1128/MCB.00313-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950526PMC
October 2010

Stress signalling to fungal stress-activated protein kinase pathways.

FEMS Microbiol Lett 2010 May 24;306(1):1-8. Epub 2010 Feb 24.

Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1574-6968.2010.01937.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644883PMC
May 2010

Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects.

Br J Clin Pharmacol 2009 Apr;67(4):421-6

Clinical Pharmacology Modelling & Simulation, GlaxoSmithKline, Inc., Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1111/j.1365-2125.2009.03370.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679105PMC
April 2009

A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.

Mol Biol Cell 2007 Nov 5;18(11):4603-14. Epub 2007 Sep 5.

Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e07-06-0581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043575PMC
November 2007

Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.

Mol Biol Cell 2006 Feb 7;17(2):1018-32. Epub 2005 Dec 7.

Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e05-06-0501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356608PMC
February 2006

A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans.

Mol Biol Cell 2004 Sep 30;15(9):4179-90. Epub 2004 Jun 30.

School of Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e04-03-0181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC515350PMC
September 2004

The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast.

J Biol Chem 2002 Sep 21;277(36):33411-21. Epub 2002 Jun 21.

School of Biochemistry and Genetics, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M204593200DOI Listing
September 2002