Publications by authors named "Debora Soncini"

23Publications

The new small tyrosine kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs.

Authors:
Debora Soncini Stefania Orecchioni Samantha Ruberti Paola Minetto Claudia Martinuzzi Luca Agnelli Katia Todoerti Antonia Cagnetta Maurizio Miglino Marino Clavio Paola Contini Riccardo Varaldo Micaela Bergamaschi Fabio Guolo Mario Passalacqua Alessio Nencioni Fiammetta Monacelli Marco Gobbi Antonino Neri Giovanni Abbadessa Sudharshan Eathiraj Brian Schwartz Francesco Bertolini Roberto M Lemoli Michele Cea

Haematologica 2020 10 1;105(10):2420-2431. Epub 2020 Oct 1.

University of Genoa, DiMI; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

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October 2020

Amino acid depletion triggered by ʟ-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death.

Authors:
Debora Soncini Paola Minetto Claudia Martinuzzi Pamela Becherini Valeria Fenu Fabio Guolo Katia Todoerti Giovanni Calice Paola Contini Maurizio Miglino Giulia Rivoli Sara Aquino Alida Dominietto Antonia Cagnetta Mario Passalacqua Santina Bruzzone Alessio Nencioni Massimo Zucchetti Tommaso Ceruti Antonino Neri Roberto M Lemoli Michele Cea

Blood Adv 2020 Sep;4(18):4312-4326

Clinic of Hematology, Department of Internal Medicine, University of Genoa, Genoa, Italy.

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September 2020

Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma.

Authors:
Elisa Taiana Vanessa Favasuli Domenica Ronchetti Katia Todoerti Francesca Pelizzoni Martina Manzoni Marzia Barbieri Sonia Fabris Ilaria Silvestris Maria Eugenia Gallo Cantafio Natalia Platonova Valeria Zuccalà Lorenza Maltese Debora Soncini Samantha Ruberti Michele Cea Raffaella Chiaramonte Nicola Amodio Pierfrancesco Tassone Luca Agnelli Antonino Neri

Leukemia 2020 01 19;34(1):234-244. Epub 2019 Aug 19.

Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.

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January 2020

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents.

Authors:
Antonia Cagnetta Debora Soncini Stefania Orecchioni Giovanna Talarico Paola Minetto Fabio Guolo Veronica Retali Nicoletta Colombo Enrico Carminati Marino Clavio Maurizio Miglino Micaela Bergamaschi Aimable Nahimana Michel Duchosal Katia Todoerti Antonino Neri Mario Passalacqua Santina Bruzzone Alessio Nencioni Francesco Bertolini Marco Gobbi Roberto M Lemoli Michele Cea

Haematologica 2018 01 12;103(1):80-90. Epub 2017 Oct 12.

Chair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy

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January 2018

SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.

Authors:
Patrizia Damonte Giovanna Sociali Marco Daniele Parenti Debora Soncini Inga Bauer Silvia Boero Alessia Grozio Maria von Holtey Francesco Piacente Pamela Becherini Roberta Sanguineti Annalisa Salis Gianluca Damonte Michele Cea Maximilien Murone Alessandro Poggi Alessio Nencioni Alberto Del Rio Santina Bruzzone

Bioorg Med Chem 2017 10 19;25(20):5849-5858. Epub 2017 Sep 19.

Department of Experimental Medicine, Section of Biochemistry, University of Genoa, V.le Benedetto XV 1, 16132 Genoa, Italy; CEBR, University of Genova, V.le Benedetto XV, 7, 16132 Genoa, Italy. Electronic address:

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October 2017

Exploiting tumor vulnerabilities: NAD(+)-depleting agents combined with anti-tumor drugs as innovative strategy to treat hematological malignancies.

Authors:
Michele Cea Debora Soncini Marco Gobbi Roberto M Lemoli Antonia Cagnetta

Expert Rev Anticancer Ther 2016 09 22;16(9):897-8. Epub 2016 Jul 22.

a Chair of Hematology, Department of Medicine (DiMI) , University of Genoa, AOU, I.R.C.C.S. San Martino -IST , Genova , Italy.

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September 2016

Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status.

Authors:
Michele Cea Antonia Cagnetta Chirag Acharya Prakrati Acharya Yu-Tzu Tai Cao Yang Davide Lovera Debora Soncini Maurizio Miglino Giulio Fraternali-Orcioni Luca Mastracci Alessio Nencioni Fabrizio Montecucco Fiammetta Monacelli Alberto Ballestrero Teru Hideshima Dharminder Chauhan Marco Gobbi Roberto M Lemoli Nikhil Munshi Steven P Treon Kenneth C Anderson

Clin Cancer Res 2016 Dec 10;22(24):6099-6109. Epub 2016 Jun 10.

LeBow Institute for Myeloma Therapeutics and Jerome Lipper Center for Multiple Myeloma Research, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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December 2016

Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.

Authors:
Mauro Di Matteo Alessandra Ammazzalorso Federico Andreoli Irene Caffa Barbara De Filippis Marialuigia Fantacuzzi Letizia Giampietro Cristina Maccallini Alessio Nencioni Marco Daniele Parenti Debora Soncini Alberto Del Rio Rosa Amoroso

Bioorg Med Chem Lett 2016 07 28;26(13):3192-3194. Epub 2016 Apr 28.

Department of Pharmacy, University of Chieti 'G. d'Annunzio', via dei Vestini 31, 66100 Chieti, Italy.

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July 2016

EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition.

Authors:
Chiara Zucal Vito G D'Agostino Antonio Casini Barbara Mantelli Natthakan Thongon Debora Soncini Irene Caffa Michele Cea Alberto Ballestrero Alessandro Quattrone Stefano Indraccolo Alessio Nencioni Alessandro Provenzani

BMC Cancer 2015 Nov 5;15:855. Epub 2015 Nov 5.

Laboratory of Genomic Screening, CIBIO, University of Trento, Trento, Italy.

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November 2015

APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells.

Authors:
Antonia Cagnetta Irene Caffa Chirag Acharya Debora Soncini Prakrati Acharya Sophia Adamia Ivana Pierri Micaela Bergamaschi Anna Garuti Giulio Fraternali Luca Mastracci Alessandro Provenzani Chiara Zucal Gianluca Damonte Annalisa Salis Fabrizio Montecucco Franco Patrone Alberto Ballestrero Santina Bruzzone Marco Gobbi Alessio Nencioni Michele Cea

Clin Cancer Res 2015 Sep 11;21(17):3934-45. Epub 2015 May 11.

Department of Hematology and Oncology, IRCCS AOU S. Martino-IST, Genoa, Italy. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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September 2015

Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition.

Authors:
Irene Caffa Vito D'Agostino Patrizia Damonte Debora Soncini Michele Cea Fiammetta Monacelli Patrizio Odetti Alberto Ballestrero Alessandro Provenzani Valter D Longo Alessio Nencioni

Oncotarget 2015 May;6(14):11820-32

Department of Internal Medicine, University of Genoa, Genoa, Italy.

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May 2015

Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity.

Authors:
Debora Soncini Irene Caffa Gabriele Zoppoli Michele Cea Antonia Cagnetta Mario Passalacqua Luca Mastracci Silvia Boero Fabrizio Montecucco Giovanna Sociali Denise Lasigliè Patrizia Damonte Alessia Grozio Elena Mannino Alessandro Poggi Vito G D'Agostino Fiammetta Monacelli Alessandro Provenzani Patrizio Odetti Alberto Ballestrero Santina Bruzzone Alessio Nencioni

J Biol Chem 2014 Dec 20;289(49):34189-204. Epub 2014 Oct 20.

From the Department of Internal Medicine, the Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-Istituto Scientifico Tumori, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, Italy,

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December 2014

Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques.

Authors:
Rodrigo A Fraga-Silva Silvia Q Savergnini Fabrizio Montecucco Alessio Nencioni Irene Caffa Debora Soncini Fabiana P Costa-Fraga Frederico B De Sousa Ruben D Sinisterra Luciano A S Capettini Sébastien Lenglet Katia Galan Graziano Pelli Maria Bertolotto Aldo Pende Giovanni Spinella Bianca Pane Franco Dallegri Domenico Palombo François Mach Nikolaos Stergiopulos Robson A S Santos Rafaela F da Silva

Thromb Haemost 2014 Apr 6;111(4):736-47. Epub 2014 Feb 6.

Rafaela Fernandes da Silva, Departamento de Fisiologia e Biofísica, Federal University of Minas Gerais, Av. Antonio Carlos, 6627 - UFMG, 31270-901 - Belo Horizonte, MG, Brazil, Tel.: +55 31 3409 2956, E-mail:

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April 2014

Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice.

Authors:
Vincent Braunersreuther Fabrizio Montecucco Graziano Pelli Katia Galan Amanda E Proudfoot Alexandre Belin Nicolas Vuilleumier Fabienne Burger Sébastien Lenglet Irene Caffa Debora Soncini Alessio Nencioni Jean-Paul Vallée François Mach

Thromb Haemost 2013 Oct 8;110(4):807-25. Epub 2013 Aug 8.

Fabrizio Montecucco, MD, PhD, Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland, Tel.: +41 223827238, Fax: +41 223827245, E-mail:

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October 2013

CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells.

Authors:
Alessia Grozio Giovanna Sociali Laura Sturla Irene Caffa Debora Soncini Annalisa Salis Nadia Raffaelli Antonio De Flora Alessio Nencioni Santina Bruzzone

J Biol Chem 2013 Sep 23;288(36):25938-49. Epub 2013 Jul 23.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy.

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September 2013

Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors as therapeutics: rationales, controversies, clinical experience.

Authors:
Fabrizio Montecucco Michele Cea Inga Bauer Debora Soncini Irene Caffa Denise Lasigliè Aimable Nahimana Antonio Uccelli Santina Bruzzone Alessio Nencioni

Curr Drug Targets 2013 Jun;14(6):637-43

Department of Internal Medicine, University of Genoa, V.le Benedetto XV 6, 16132 Genoa, Italy.

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June 2013

The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.

Authors:
Inga Bauer Alessia Grozio Denise Lasigliè Giovanna Basile Laura Sturla Mirko Magnone Giovanna Sociali Debora Soncini Irene Caffa Alessandro Poggi Gabriele Zoppoli Michele Cea Georg Feldmann Raul Mostoslavsky Alberto Ballestrero Franco Patrone Santina Bruzzone Alessio Nencioni

J Biol Chem 2012 Nov 18;287(49):40924-37. Epub 2012 Oct 18.

Department of Internal Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy.

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November 2012

Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells.

Authors:
Michele Cea Debora Soncini Floriana Fruscione Lizzia Raffaghello Anna Garuti Laura Emionite Eva Moran Mirko Magnone Gabriele Zoppoli Daniele Reverberi Irene Caffa Annalisa Salis Antonia Cagnetta Micaela Bergamaschi Salvatore Casciaro Ivana Pierri Gianluca Damonte Filippo Ansaldi Marco Gobbi Vito Pistoia Alberto Ballestrero Franco Patrone Santina Bruzzone Alessio Nencioni

PLoS One 2011 27;6(7):e22739. Epub 2011 Jul 27.

Department of Internal Medicine, University of Genoa, Genoa, Italy.

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December 2011

Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.

Authors:
Gabriele Zoppoli Michele Cea Debora Soncini Floriana Fruscione Justine Rudner Eva Moran Irene Caffa Davide Bedognetti Giulia Motta Riccardo Ghio Fabio Ferrando Alberto Ballestrero Silvio Parodi Claus Belka Franco Patrone Santina Bruzzone Alessio Nencioni

Exp Hematol 2010 Nov 7;38(11):979-88. Epub 2010 Aug 7.

Department of Internal Medicine, University of Genoa, Genoa, Italy.

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November 2010

Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression.

Authors:
Alessio Nencioni Michele Cea Anna Garuti Mario Passalacqua Lizzia Raffaghello Debora Soncini Eva Moran Gabriele Zoppoli Vito Pistoia Franco Patrone Alberto Ballestrero

PLoS One 2010 Feb 2;5(2):e9024. Epub 2010 Feb 2.

Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.

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February 2010