Publications by authors named "Debdulal Chakraborty"

20 Publications

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Response to comment on: Anatomical and functional outcomes one year after vitrectomy and retinal massage for large macular holes.

Indian J Ophthalmol 2021 Oct;69(10):2912

Department of Vitreoretina Services, Disha Eye Hospitals, Kolkata, West Bengal, India.

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http://dx.doi.org/10.4103/ijo.IJO_1558_21DOI Listing
October 2021

Response to comment on: Anatomical and functional outcomes one year after vitrectomy and retinal massage for large macular holes.

Indian J Ophthalmol 2021 Oct;69(10):2910-2911

Department of Vitreoretina Services, Disha Eye Hospitals, 88 Ghosh Para Road, Barrackpore, Kolkata, West Bengal, India.

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http://dx.doi.org/10.4103/ijo.IJO_1559_21DOI Listing
October 2021

Brolucizumab in Neovascular Age-Related Macular Degeneration - Indian Real-World Experience: The BRAILLE Study.

Clin Ophthalmol 2021 7;15:3787-3795. Epub 2021 Sep 7.

Department of Vitreoretinal Services, Disha Eye Hospitals, Kolkata, West Bengal, India.

Purpose: To assess the short-term efficacy and safety profile of intravitreal brolucizumab injection in Indian eyes with neovascular age-related macular degeneration (nAMD) under real-world conditions.

Patients And Methods: This was a multicenter, retrospective chart review of 94 eyes of 94 patients with nAMD (treatment-naïve and switch-therapy) undergoing brolucizumab therapy. Re-treatment as per pro-re-nata protocol was performed based on fixed visual and tomographic criteria. The main outcome measures were changes in the best-corrected visual acuity (BCVA), intraretinal fluid (IRF), subretinal fluid (SRF), central subfield thickness (CST), and pigment epithelial detachment (PED) along with safety analysis.

Results: Of the 94 eyes, 20 eyes (21.3%) were treatment-naïve, whereas the rest 74 eyes (78.7%) underwent switch therapy. One hundred and twenty-six injections were given over a mean follow-up of 7.3 ± 2.2 (range 5-30) weeks. The BCVA improved significantly from 0.82 ± 0.5 LogMAR at baseline to 0.66 ± 0.5 LogMAR at the final visit (p < 0.0001). Significant reduction in CST was simultaneously noted (Baseline: 408.45 ± 65.63 µm; Final: 281.14 ± 37.74 µm; p < 0.0001). On qualitative analysis, resolution of subretinal fluid (SRF), intraretinal fluid (IRF), and pigment epithelial detachment (PED) was observed in 15.5%, 39.29%, and 23.81% of the eyes, respectively. The mean interval of repeat injection was 10.2 ± 2.1 weeks. Three episodes of ocular adverse drug reaction were reported, including two patients developing subretinal hemorrhage while one having a retinal pigment epithelial (RPE) tear. Notably, no intraocular inflammation (IOI) was seen in any of the eyes, and no systemic side effects were identified.

Conclusion: In a real-world scenario, brolucizumab therapy is efficacious and safe in the management of nAMD over the short term. Further long-term studies are warranted to validate these findings. Additionally, lack of ocular inflammation after 126 brolucizumab injections in our Indian data is peculiar and underlines the necessity to explore the role of race and genetics in predisposing to/safeguarding against brolucizumab-related IOIs.
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http://dx.doi.org/10.2147/OPTH.S328160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434835PMC
September 2021

Off-label intravitreal brolucizumab for recalcitrant diabetic macular edema: A real-world case series.

Am J Ophthalmol Case Rep 2021 Dec 1;24:101197. Epub 2021 Sep 1.

Department of Vitreoretinal Services, Disha Eye Hospitals, Kolkata, India.

Purpose: To report the efficacy of intravitreal injection (IVI) of brolucizumab for recalcitrant diabetic macular edema (DME) in a real-world setting.

Observations: This was a single-center, prospective uncontrolled non-randomized case series. Three eyes with recalcitrant DME, who have received a minimum of ten intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections, underwent IVI brolucizumab and were followed-up for minimum of 16 weeks. Patients underwent best-corrected visual acuity (BCVA) testing, ophthalmic examination, and optical coherence tomography at baseline and all the scheduled follow-up visits (Weeks 4, 8, 12, and 16). All three patients demonstrated notable improvement in BCVA and reduction in the fluid on SD-OCT lasting up to week 12. At week 16, all three eyes maintained the visual acuity gains. However, early increase in fluid was noted in all the three cases, for which second dose of IVI brolucizumab was planned. No ocular or systemic adverse events were noted in any of the cases.

Conclusions And Importance: In this real-world case series, treatment with IVI brolucizumab exhibited excellent visual acuity outcomes lasting up to 16 weeks for the treatment of recalcitrant DME. Single dose IVI brolucizumab achieves good anatomical improvement based on SD-OCT persisting up to 12 weeks, followed by early recurrence of fluid at week 16. The results did not show any ocular or systemic safety concerns for IVI brolucizumab.
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http://dx.doi.org/10.1016/j.ajoc.2021.101197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414050PMC
December 2021

Real-World Safety Outcomes of Intravitreal Ranibizumab Biosimilar (Razumab) Therapy for Chorioretinal Diseases.

Ophthalmol Ther 2021 Jun 17;10(2):337-348. Epub 2021 Apr 17.

Department of Vitreoretinal Services, Disha Eye Hospitals, Kolkata, 700120, India.

Introduction: To assess the safety profile of the intravitreal ranibizumab biosimilar molecule, Razumab (Intas Pharmaceuticals, Ahmedabad, India) in chorioretinal disorders under real-world conditions.

Methods: This was a multicenter, retrospective chart review which included patients from 15 centers receiving intravitreal Razumab (IVRz) injections from 2016 to 2020. Patient demographics, ocular examination data, and detailed safety information regarding serious adverse events (SAE) or serious adverse drug reactions (sADR), and non-serious AEs (nsAE) or non-serious ADRs (nsADR) occurring within 1 month of IVRz injections were compiled.

Results: A total of 6404 eyes of 6404 patients received 9406 IVRz injections [mean (± SD) = 1.49 (± 0.63)] during 4.25 years. Adverse events were reported after 1978 injections (21.03%): 64.16% nsAE, 32.96% nsADR, 2.37% sADR, and 0.51% SAE. The most frequent adverse events were subconjunctival hemorrhage (8.2% of total injections), transient blurring of vision (6.5% of total injections), and mild ocular pain (5.27% of total injections). Serious ocular (31 cases with retinal pigment epithelial tears [0.33%], two cases of non-infectious vitritis [0.02%], and one case of endophthalmitis [0.01%]) and systemic (seven patients with non-fatal myocardial infarction [0.12%] and six patients with non-fatal cerebrovascular accident [0.09%]) adverse events were infrequent.

Conclusion: The study reports the largest pooled safety data on IVRz use in a real-world scenario. The results did not raise any new ocular or systemic safety concerns for the biosimilar agent, with the incidence and spectrum of adverse reactions similar to those reported with other anti-vascular endothelial growth factor (anti-VEGF) drugs. The real-world evidence suggests that IVRz is a safe anti-VEGF agent in the management of chorioretinal disorders.
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http://dx.doi.org/10.1007/s40123-021-00345-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079600PMC
June 2021

Anatomical and functional outcomes one year after vitrectomy and retinal massage for large macular holes.

Indian J Ophthalmol 2021 04;69(4):895-899

Vitreoretina Services, Disha Eye Hospitals, Kolkata, West Bengal, India.

Purpose: The aim of this study was to report results of macular hole closure, visual benefit and longitudinal changes in foveal architecture over 1 year following macular hole surgery with retinal massage.

Methods: Records of patients with full thickness macular hole (FTMH) with minimum basal diameter of 550 μ who underwent vitrectomy, internal limiting membrane (ILM) peeling and retinal massage were drawn up. Retinal massage was performed after dye assisted ILM peeling, using a 27G flute needle with a long and soft silicone tip under air in a centripetal direction around the FTMH. At the end, 10% CF gas was used as tamponade. The foveal contour at 1 year follow up was recorded based on its cross sectional appearance on OCT and was classified into U, V and irregular types of closure as previously described.

Results: Forty-one eyes of 41 patients with a mean age of 70.4 ± 6.9 years were included. The mean preoperative vision was 0.99 ± 0.07 logMAR and mean maximum basal diameter of the FTMH was 835 ± 208 μ. Macular hole closure was seen in all patients at 1-month follow up. The BCVA improved to 0.5 ± 0.1 log MAR at 6 months (P < 0.001) and then stabilized. The U shaped closure was the commonest pattern (n = 22, 54%), followed by V-shaped closure (n = 16, 39%) while irregular closure was seen in 3 eyes (7%).

Conclusion: Retinal massage after ILM peeling is a very simple, and as yet under-utilized manoeuvre that may improve hole closure rates and lead to potentially greater improvement in vision compared to existing techniques for large holes.
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http://dx.doi.org/10.4103/ijo.IJO_1680_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012922PMC
April 2021

A novel video overlay guided enlargement of area of ILM peeled versus inverted flap technique: A long-term study in large macular holes.

Eur J Ophthalmol 2020 Dec 14:1120672120979904. Epub 2020 Dec 14.

Department of Vitreoretina, Disha Eye Hospitals Pvt Ltd, Kolkata, West Bengal, India.

Background/aim: To compare the intra-operative video overlay guided enlargement of Area of ILM peeled (AIP) more than three Disc Diameter (DD) versus the inverted flap technique in large (>400 µm ) Full Thickness Macular Holes (FTMH).

Methods: Retrospectively, 127 cases of large FTMHs divided into two groups (i) Group A ( = 62)-intra-operative video-overlay guided enlargement of AIP > 3DD performed and (ii) Group B ( = 65)-Inverted flap technique was done. Mean Best Corrected Visual Acuity (BCVA), hole closure rate and postoperative foveal anatomy were noted on Optical Coherence Tomography (OCT).

Results: Mean Minimal Diameter of Macular Hole (MDMH) were 632.05 ± 146.62 µm (A) and 677.24 ± 152.08 µm (B). Hole closure rate were 93.55% (A) and 96.92% (B). Mean preoperative BCVA was 1.07 ± 0.37 Log MAR (A) and 0.94 ± 0.23 Log MAR (B). Mean postoperative BCVA at 3 months were 0.73 ± 0.22 Log MAR (A) and 0.83 ± 0.24 Log MAR (B). One-way ANOVA test showed statistically better visual improvement in Group A at 3 months ( = 0.02), 6 months ( = 0.045), 12 months ( = 0.002), and 24 months ( = 0.011). Chi square test revealed Type I pattern of hole closure was statistically more in Group B ( < 0.001). Delayed Recovery of Outer Retinal Layers was more in group B (Pearson Chi square test,  = 0.039).

Conclusion: Anatomically, macular hole closure rate as well as closure pattern was better in Group B. But functional improvement was better in Group A.
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http://dx.doi.org/10.1177/1120672120979904DOI Listing
December 2020

Ultra-widefield noncontact imaging of bilateral congenital retinal fold.

Indian J Ophthalmol 2020 Aug;68(8):1668

Department of Ocular Pathology, Uveitis and Neuro-Ophthalmology Services, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

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http://dx.doi.org/10.4103/ijo.IJO_2305_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640850PMC
August 2020

B-HEX pupil expander in vitreoretinal surgery - A case series.

Indian J Ophthalmol 2020 06;68(6):1188-1191

Disha Eye Hospitals, Kolkata, West Bengal, India.

We describe the successful use of the B-HEX pupil expansion device in four cases of combined phacovitrectomy with significant cataract, non-dilating pupil, and surgical vitreoretinal pathologies including vitreous hemorrhage, inferior retinal detachment (RD) with proliferative vitreoretinopathy in an oil filled eye, recurrent rhegmatogenous RD, and macular hole with RD localized to the posterior pole in an eye with uveitic sequelae. The B-HEX remained well engaged and maintained excellent mydriasis throughout the surgery despite wide fluctuations in intraocular pressure and anterior chamber fluidics. This is the first series describing use of B-HEX for combined phacovitrectomy due to myriad causes.
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http://dx.doi.org/10.4103/ijo.IJO_1675_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508112PMC
June 2020

Aborted bridge coloboma with scleral fistula.

Indian J Ophthalmol 2020 03;68(3):516-517

Department of Ocular Pathology, Uveitis and Neuro-Ophthalmology Services, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

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http://dx.doi.org/10.4103/ijo.IJO_1503_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043170PMC
March 2020

Ultra-widefield image of a toxocara granuloma with an adjacent retinal break and retinal detachment.

Indian J Ophthalmol 2019 11;67(11):1884

Department of Vitreoretina Services, Disha Eye Hospitals, Kolkata, West Bengal, India.

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http://dx.doi.org/10.4103/ijo.IJO_1294_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836581PMC
November 2019

New Innovative Approaches for Difficult Retained Intraocular Foreign Bodies.

Ophthalmologica 2018 10;240(3):179-180. Epub 2018 Apr 10.

Disha Eye Hospitals, Sheoraphully, India.

Purpose: To describe innovative ways of removal of complicated difficult large retained intraocular foreign bodies (RIOFBs).

Settings: Both cases were treated at Disha Eye Hospitals, Kolkata, a tertiary eye hospital in eastern India.

Methods: Innovative approaches were taken to remove 2 difficult RIOFBs. In the first case, a large RIOFB was just beyond the posterior exit wound, trapped in the sclera. A 23-G MVR blade was used to create multiple radial releasing scleral nicks and bimanually moving the RIOFB into the vitreous cavity using a bent-tip 24G needle and magnet, and the RIOFB was removed through the limbal section. In the second case, a 21-mm long thick nail was deeply embedded in the superior sclera with partial localised retinal detachment with its bulbous end just behind the clear lens. A lasso technique was used to remove the RIOFB without lens touch.

Results: In the first case, the patient finally achieved logMAR 0.2 vision after silicone oil removal and glued scleral fixation of the intraocular lens. In the second case, the patient finally achieved logMAR 0.3 vision after silicone oil removal and phacoemulsification with intraocular lens implantation.

Conclusion: Each case of RIOFB is unique and challenging. Here, innovative techniques are helpful to rescue these difficult RIOFB situations, which can result in excellent outcomes.
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http://dx.doi.org/10.1159/000487549DOI Listing
October 2018

Cut Throat Injury: Our Experience in Rural Set-Up.

Indian J Otolaryngol Head Neck Surg 2017 Mar 29;69(1):35-41. Epub 2016 Nov 29.

BSMCH, Bankura, India.

Cut throat injuries are one of the emergency conditions managed by ENT specialists. If not treated in time, they may lead to death. Prevention of these complications depends on immediate resuscitation by securing the airway by tracheostomy or intubation, prompt control of hemorrhage and blood replacement. The present study was conducted to study the sociodemographic profile of patients of cut throat injury, motives behind cut throat injury, site and depth of the injury, treatment given at our hospital and outcome. A prospective study was done in the department of ENT in a tertiary care hospital of rural West Bengal between January 2014 and December 2015. Patients who were brought dead and minor neck injury were excluded from the study. Endotracheal intubation where possible, or emergency tracheostomy was done below the level of injury. Ryle's tube was inserted where necessary. Injured structures were repaired in layers. Among 22 patients there were 18 male and 4 female. The peak age of incidence was in the 4th decade of life. Suicidal cut throat injury was the most common mode of injury. Most of the injuries were in the zone II (72.73%). Three patients died due to severe haemorrhage and/or aspiration. Decannulation was possible in 9 out of 12 patients. Cut throat injuries have become a major cause of morbidity and mortality in our society. Patients with injury of larynx or upper trachea need preliminary tracheostomy. Post-operative endoscopy identifies nerve injuries and stenosis problems.
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http://dx.doi.org/10.1007/s12070-016-1033-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305637PMC
March 2017

Cutaneous matastasis from sino-nasal malignant melanoma - a rare case report.

Indian J Otolaryngol Head Neck Surg 2008 Dec 28;60(4):369-72. Epub 2009 Jan 28.

Department of Plastic Surgery, R.G. Kar Medical College, Calcutta, India.

To report a case of disseminated cutaneous metastasis from malignant melanoma of sino-nasal region. A 53-year-old man from rural parts of West Bengal presented with progressive nasal obstruction. CT scanning was done to know the extent of the mass and punch biopsy from the mass was performed. Malignant melanoma of sino-nasal region was diagnosed and chemotherapy was started. The patient developed cutaneous deposits after two cycles of chemotherapy. The patient developed cutaneous deposits during the course of chemotherapy. Excision biopsy from cutaneous deposits revealed malignant melanoma. A rare case of diffuse cutaneous metastasis of malignant melanoma is presented here along with review of literature.
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http://dx.doi.org/10.1007/s12070-008-0118-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476808PMC
December 2008

Neurofibroma of the external ear - a case report.

Indian J Otolaryngol Head Neck Surg 2008 Sep 22;60(3):289-90. Epub 2008 Oct 22.

ENT Department, B.S. Medical College, Bankura, India.

Neurofibromas are relatively common tumours of the nervous system, but only a few cases involving the external ear have been reported. We are reporting here a case of a 20-year-old female with neurofibroma of the external ear. The primary complaint was cosmetic deformity. There was partial occlusion of the external auditory canal. The swelling was excised by postauricular approach. Surgery resulted in an excellent functional and cosmetic outcome.
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http://dx.doi.org/10.1007/s12070-008-0097-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3450637PMC
September 2008

Sarcomas of head and neck - A 10 yrs experience.

Indian J Otolaryngol Head Neck Surg 2007 Dec 11;59(4):322-6. Epub 2007 Dec 11.

Department of ENT, Medical College and Hospital, Calcutta, 700 073 India ; Sundaram Apartments, Barat, Lake Town, Calcutta, 700 089 India.

38 cases of sarcoma of head and neck region were analysed in a retrospective way in relation to age, anatomic location, histological, clinical profile, and surgical approaches. Compared to other types of head and neck neoplasms, such as squamous cell carcinoma, soft tissue sarcomas have low rates of regional metastases. However the biological behaviour of soft tissue sarcoma is more aggressive specially in paediatric age group. In the present series, CT scan was considered as the primary modality of investigation. Surgery generally has been recommended as the primary method of treatment for achieving local control, except in those high-grade tumours arising in sites not amenable to resection. 3-year and 5-year survival rates in this present series 50% and 31.6% respectively.
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http://dx.doi.org/10.1007/s12070-007-0093-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452262PMC
December 2007

Phacotrabeculectomy study.

J Cataract Refract Surg 2007 Feb;33(2):176; author reply 176-7

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http://dx.doi.org/10.1016/j.jcrs.2006.09.040DOI Listing
February 2007

Management of a posteriorly dislocated endocapsular tension ring and a foldable acrylic intraocular lens.

J Cataract Refract Surg 2004 Jan;30(1):243-6

Sri Sankaradeva Nethralaya, Beltola, Guwahati, Assam, India.

We report a rare case of late spontaneous extension of a posterior capsule tear from lateral traction of an endocapsular ring, resulting in dislocation of the capsular tension ring and acrylic intraocular lens (IOL) into the vitreous cavity. A 3-port pars plana vitrectomy was performed to explant the prostheses; the eye was made pseudophakic by placement of a scleral-fixated posterior chamber IOL. The combined triple procedure was safe and effective.
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http://dx.doi.org/10.1016/j.jcrs.2003.11.024DOI Listing
January 2004

Cataract surgery and intraocular lens implantation in a retinoblastoma case treated by external-beam radiation therapy.

J Cataract Refract Surg 2003 Sep;29(9):1837-41

Sri Sankaradeva Nethralaya, Beltola, Guwahati, Assam, India.

We report a case of extracapsular cataract extraction with posterior chamber intraocular lens implantation in a pediatric patient with a radiation-induced cataract that developed after combined external-beam radiation therapy and chemotherapy for retinoblastoma. A 12-year follow-up revealed effective tumor regression and sustained visual recovery.
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http://dx.doi.org/10.1016/s0886-3350(03)00119-6DOI Listing
September 2003
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