Debby Laukens

Debby Laukens

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Debby Laukens

Debby Laukens

Publications by authors named "Debby Laukens"

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Cellular diversity in the colon: another brick in the wall.

Nat Rev Gastroenterol Hepatol 2019 07;16(7):391-392

Department of Gastroenterology, Ghent University and VIB Center for Inflammation Research, Ghent, Belgium.

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http://dx.doi.org/10.1038/s41575-019-0161-7DOI Listing
July 2019

Unmet Needs in IBD: the Case of Fatigue.

Clin Rev Allergy Immunol 2018 Dec;55(3):368-378

Department of Gastroenterology, Humanitas University, Milan, Italy.

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http://dx.doi.org/10.1007/s12016-017-8641-4DOI Listing
December 2018

T84 monolayers are superior to Caco-2 as a model system of colonocytes.

Histochem Cell Biol 2017 Jul 6;148(1):85-93. Epub 2017 Mar 6.

Department of Gastroenterology, Ghent University, De Pintelaan 185, 0MRB2, 9000, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00418-017-1539-7DOI Listing
July 2017

Assessment of faecal microbial transfer in irritable bowel syndrome with severe bloating.

Gut 2017 05 10;66(5):980-982. Epub 2016 Aug 10.

KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1136/gutjnl-2016-312513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531219PMC
May 2017

Detection and Manipulation of the Stress Response Protein Metallothionein.

Curr Protoc Toxicol 2017 Feb 1;71:17.19.1-17.19.28. Epub 2017 Feb 1.

Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut.

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http://dx.doi.org/10.1002/cptx.17DOI Listing
February 2017

Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut.

Environ Microbiol 2016 05 22;18(5):1352-63. Epub 2015 Jul 22.

Laboratory of Microbial Ecology and Technology (LabMET), Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1111/1462-2920.12934DOI Listing
May 2016

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease.

Inflamm Bowel Dis 2016 Mar;22(3):505-15

*Department of Clinical and Experimental Medicine, TARGID, KU Leuven, Leuven, Belgium; †Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium; ‡iMinds Department of Medical Information Technologies, KU Leuven, Leuven, Belgium; §Department of Human Genetics, KU Leuven, Leuven, Belgium; ‖Department of Gastroenterology, Ghent University Hospital, Gent, Belgium; ¶Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium; **Unit of Animal Genomics, Groupe Interdisciplinaire de Genoproteomique Appliquee (GIGA-R) and Faculty of Veterinary Medicine, University of Liege, Liege, Belgium; ††Division of Gastroenterology, Centre Hospitalier Universitaire, Université de Liege, Liège, Belgium; ‡‡Division of Gastroenterology, UZ Leuven, Leuven, Belgium; and §§Department of Electrical Engineering and Computer Science, Bioinformatics-Statistical Genetics, Montefiore Institute, Universty of Liège, Liège, Belgium.

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http://dx.doi.org/10.1097/MIB.0000000000000623DOI Listing
March 2016

Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design.

FEMS Microbiol Rev 2016 Jan 30;40(1):117-32. Epub 2015 Aug 30.

Inflammation Research Center, VIB, B-9052 Ghent, Belgium Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium Methusalem Program, Ghent University, B-9000 Ghent, Belgium

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http://dx.doi.org/10.1093/femsre/fuv036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703068PMC
January 2016

Validated High Resolution Mass Spectrometry-Based Approach for Metabolomic Fingerprinting of the Human Gut Phenotype.

Anal Chem 2015 Nov 21;87(21):10927-34. Epub 2015 Oct 21.

Laboratory of Chemical Analysis, Ghent University , Merelbeke, 9820, Belgium.

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http://pubs.acs.org/doi/10.1021/acs.analchem.5b02688
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http://dx.doi.org/10.1021/acs.analchem.5b02688DOI Listing
November 2015

Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis.

Int J Exp Pathol 2014 Oct 12;95(5):309-20. Epub 2014 Aug 12.

Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium; Department of Endocrinology, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/iep.12090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209923PMC
October 2014

Metallothionein and stress combine to affect multiple organ systems.

Cell Stress Chaperones 2014 Sep 2;19(5):605-11. Epub 2014 Mar 2.

Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, 06269, USA,

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http://dx.doi.org/10.1007/s12192-014-0501-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147071PMC
September 2014

Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent.

Eur J Gastroenterol Hepatol 2014 Aug;26(8):861-70

aDepartment of Hepatology and Gastroenterology bInfinity Imaging Lab, Medisip, iMinds cDepartment of Respiratory Medicine dGROUP-ID Consortium, Ghent University eDepartment of Pathology, Ghent University Hospital fUnit Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, Ghent, Belgium.

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http://dx.doi.org/10.1097/MEG.0000000000000066DOI Listing
August 2014

Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?

Liver Int 2014 Jul 27;34(6):e10-8. Epub 2014 Jan 27.

Department of Gastroenterology and Hepatology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1111/liv.12457DOI Listing
July 2014

Role of metallothioneins as danger signals in the pathogenesis of colitis.

J Pathol 2014 May 24;233(1):89-100. Epub 2014 Feb 24.

Department of Gastroenterology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1002/path.4330DOI Listing
May 2014

The paradox of the unfolded protein response in cancer.

Anticancer Res 2013 Nov;33(11):4683-94

Department of Hepatology and Gastroenterology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium.

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http://ar.iiarjournals.org/content/33/11/4683.full.pdf
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November 2013

Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls.

J Inflamm (Lond) 2013 Nov 20;10(1):36. Epub 2013 Nov 20.

Department of Gastroenterology, Ghent University Hospital, De Pintelaan 185, 3K12-IE, Ghent B-9000, Belgium.

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http://dx.doi.org/10.1186/1476-9255-10-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842628PMC
November 2013

Pharmacologic activation of tumor hypoxia: a means to increase tumor 2-deoxy-2-[18F]fluoro-D-glucose uptake?

Mol Imaging 2013 Jan-Feb;12(1):49-58

Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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July 2013

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors:
Luke Jostins Stephan Ripke Rinse K Weersma Richard H Duerr Dermot P McGovern Ken Y Hui James C Lee L Philip Schumm Yashoda Sharma Carl A Anderson Jonah Essers Mitja Mitrovic Kaida Ning Isabelle Cleynen Emilie Theatre Sarah L Spain Soumya Raychaudhuri Philippe Goyette Zhi Wei Clara Abraham Jean-Paul Achkar Tariq Ahmad Leila Amininejad Ashwin N Ananthakrishnan Vibeke Andersen Jane M Andrews Leonard Baidoo Tobias Balschun Peter A Bampton Alain Bitton Gabrielle Boucher Stephan Brand Carsten Büning Ariella Cohain Sven Cichon Mauro D'Amato Dirk De Jong Kathy L Devaney Marla Dubinsky Cathryn Edwards David Ellinghaus Lynnette R Ferguson Denis Franchimont Karin Fransen Richard Gearry Michel Georges Christian Gieger Jürgen Glas Talin Haritunians Ailsa Hart Chris Hawkey Matija Hedl Xinli Hu Tom H Karlsen Limas Kupcinskas Subra Kugathasan Anna Latiano Debby Laukens Ian C Lawrance Charlie W Lees Edouard Louis Gillian Mahy John Mansfield Angharad R Morgan Craig Mowat William Newman Orazio Palmieri Cyriel Y Ponsioen Uros Potocnik Natalie J Prescott Miguel Regueiro Jerome I Rotter Richard K Russell Jeremy D Sanderson Miquel Sans Jack Satsangi Stefan Schreiber Lisa A Simms Jurgita Sventoraityte Stephan R Targan Kent D Taylor Mark Tremelling Hein W Verspaget Martine De Vos Cisca Wijmenga David C Wilson Juliane Winkelmann Ramnik J Xavier Sebastian Zeissig Bin Zhang Clarence K Zhang Hongyu Zhao Mark S Silverberg Vito Annese Hakon Hakonarson Steven R Brant Graham Radford-Smith Christopher G Mathew John D Rioux Eric E Schadt Mark J Daly Andre Franke Miles Parkes Severine Vermeire Jeffrey C Barrett Judy H Cho

Nature 2012 Nov;491(7422):119-24

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1038/nature11582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803PMC
November 2012

Intrarectal nitric oxide administration prevents cellular infiltration but not colonic injury during dextran sodium sulfate colitis.

Dig Dis Sci 2012 Jul 15;57(7):1832-7. Epub 2012 Mar 15.

Faculty of Bioscience Engineering, Laboratory of Microbial Ecology and Technology, Ghent University, Ghent, Belgium.

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http://link.springer.com/10.1007/s10620-012-2105-8
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http://dx.doi.org/10.1007/s10620-012-2105-8DOI Listing
July 2012

Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis.

Biochem Biophys Res Commun 2011 Dec 15;416(3-4):307-12. Epub 2011 Nov 15.

Department of Gastroenterology, Ghent University, De Pintelaan 185, 1K12IE, B-9000 Ghent, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1102030
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http://dx.doi.org/10.1016/j.bbrc.2011.11.031DOI Listing
December 2011

Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia.

Lab Invest 2011 Sep 27;91(9):1266-76. Epub 2011 Jun 27.

Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1038/labinvest.2011.102DOI Listing
September 2011

Boosting the hypoxia-induced adaptive response in inflammatory bowel disease: a novel concept of treatment.

Inflamm Bowel Dis 2011 Sep 16;17(9):2019-22. Epub 2010 Dec 16.

Department of Gastroenterology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

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https://academic.oup.com/ibdjournal/article/17/9/2019-2022/4
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http://dx.doi.org/10.1002/ibd.21589DOI Listing
September 2011

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:
Carl A Anderson Gabrielle Boucher Charlie W Lees Andre Franke Mauro D'Amato Kent D Taylor James C Lee Philippe Goyette Marcin Imielinski Anna Latiano Caroline Lagacé Regan Scott Leila Amininejad Suzannah Bumpstead Leonard Baidoo Robert N Baldassano Murray Barclay Theodore M Bayless Stephan Brand Carsten Büning Jean-Frédéric Colombel Lee A Denson Martine De Vos Marla Dubinsky Cathryn Edwards David Ellinghaus Rudolf S N Fehrmann James A B Floyd Timothy Florin Denis Franchimont Lude Franke Michel Georges Jürgen Glas Nicole L Glazer Stephen L Guthery Talin Haritunians Nicholas K Hayward Jean-Pierre Hugot Gilles Jobin Debby Laukens Ian Lawrance Marc Lémann Arie Levine Cecile Libioulle Edouard Louis Dermot P McGovern Monica Milla Grant W Montgomery Katherine I Morley Craig Mowat Aylwin Ng William Newman Roel A Ophoff Laura Papi Orazio Palmieri Laurent Peyrin-Biroulet Julián Panés Anne Phillips Natalie J Prescott Deborah D Proctor Rebecca Roberts Richard Russell Paul Rutgeerts Jeremy Sanderson Miquel Sans Philip Schumm Frank Seibold Yashoda Sharma Lisa A Simms Mark Seielstad A Hillary Steinhart Stephan R Targan Leonard H van den Berg Morten Vatn Hein Verspaget Thomas Walters Cisca Wijmenga David C Wilson Harm-Jan Westra Ramnik J Xavier Zhen Z Zhao Cyriel Y Ponsioen Vibeke Andersen Leif Torkvist Maria Gazouli Nicholas P Anagnou Tom H Karlsen Limas Kupcinskas Jurgita Sventoraityte John C Mansfield Subra Kugathasan Mark S Silverberg Jonas Halfvarson Jerome I Rotter Christopher G Mathew Anne M Griffiths Richard Gearry Tariq Ahmad Steven R Brant Mathias Chamaillard Jack Satsangi Judy H Cho Stefan Schreiber Mark J Daly Jeffrey C Barrett Miles Parkes Vito Annese Hakon Hakonarson Graham Radford-Smith Richard H Duerr Séverine Vermeire Rinse K Weersma John D Rioux

Nat Genet 2011 Mar 6;43(3):246-52. Epub 2011 Feb 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597PMC
March 2011

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Nat Genet 2010 Dec;42(12):1118-25

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551PMC
December 2010

Role of placental growth factor in mesenteric neoangiogenesis in a mouse model of portal hypertension.

Gastroenterology 2009 Dec 12;137(6):2112-24.e1-6. Epub 2009 Sep 12.

Faculty of Medicine and Health Sciences, Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1053/j.gastro.2009.08.068DOI Listing
December 2009

Human metallothionein expression under normal and pathological conditions: mechanisms of gene regulation based on in silico promoter analysis.

Crit Rev Eukaryot Gene Expr 2009 ;19(4):301-17

Department of Gastroenterology, Ghent University,Gent, Belgium.

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December 2009

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Authors:
Marcin Imielinski Robert N Baldassano Anne Griffiths Richard K Russell Vito Annese Marla Dubinsky Subra Kugathasan Jonathan P Bradfield Thomas D Walters Patrick Sleiman Cecilia E Kim Aleixo Muise Kai Wang Joseph T Glessner Shehzad Saeed Haitao Zhang Edward C Frackelton Cuiping Hou James H Flory George Otieno Rosetta M Chiavacci Robert Grundmeier Massimo Castro Anna Latiano Bruno Dallapiccola Joanne Stempak Debra J Abrams Kent Taylor Dermot McGovern Gary Silber Iwona Wrobel Antonio Quiros Jeffrey C Barrett Sarah Hansoul Dan L Nicolae Judy H Cho Richard H Duerr John D Rioux Steven R Brant Mark S Silverberg Kent D Taylor M Michael Barmuda Alain Bitton Themistocles Dassopoulos Lisa Wu Datta Todd Green Anne M Griffiths Emily O Kistner Michael T Murtha Miguel D Regueiro Jerome I Rotter L Philip Schumm A Hillary Steinhart Stephen R Targan Ramnik J Xavier Cécile Libioulle Cynthia Sandor Mark Lathrop Jacques Belaiche Olivier Dewit Ivo Gut Simon Heath Debby Laukens Myriam Mni Paul Rutgeerts André Van Gossum Diana Zelenika Denis Franchimont J P Hugot Martine de Vos Severine Vermeire Edouard Louis Lon R Cardon Carl A Anderson Hazel Drummond Elaine Nimmo Tariq Ahmad Natalie J Prescott Clive M Onnie Sheila A Fisher Jonathan Marchini Jilur Ghori Suzannah Bumpstead Rhian Gwillam Mark Tremelling Panos Delukas John Mansfield Derek Jewell Jack Satsangi Christopher G Mathew Miles Parkes Michel Georges Mark J Daly Melvin B Heyman George D Ferry Barbara Kirschner Jessica Lee Jonah Essers Richard Grand Michael Stephens Arie Levine David Piccoli John Van Limbergen Salvatore Cucchiara Dimitri S Monos Stephen L Guthery Lee Denson David C Wilson Straun F A Grant Mark Daly Mark S Silverberg Jack Satsangi Hakon Hakonarson

Nat Genet 2009 Dec 15;41(12):1335-40. Epub 2009 Nov 15.

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267927PMC
December 2009

Evidence for a potential role of metallothioneins in inflammatory bowel diseases.

Mediators Inflamm 2009 26;2009:729172. Epub 2009 Aug 26.

Department of Gastroenterology, Ghent University, De Pintelaan 185, 9000 Gent, Belgium.

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http://dx.doi.org/10.1155/2009/729172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734936PMC
November 2009