Dean W Felsher

Dean W Felsher

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Dean W Felsher

Publications by authors named "Dean W Felsher"

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Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index.

Sci Rep 2019 Nov 14;9(1):16775. Epub 2019 Nov 14.

Department of Computer Science, Stanford University, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1038/s41598-019-53290-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856101PMC
November 2019

A Tale of Two Complications of Obesity: NASH and Hepatocellular Carcinoma.

Hepatology 2019 Sep 27;70(3):1056-1058. Epub 2019 May 27.

Division of Medical Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA.

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http://dx.doi.org/10.1002/hep.30649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717523PMC
September 2019

Conditional Upregulation of IFN-α Alone Is Sufficient to Induce Systemic Lupus Erythematosus.

J Immunol 2019 Aug 19;203(4):835-843. Epub 2019 Jul 19.

Department of Biophysics, Kobe University Graduate School of Health Science, Kobe 654-0142, Japan;

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http://dx.doi.org/10.4049/jimmunol.1801617DOI Listing
August 2019

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.

Cell Chem Biol 2019 05 14;26(5):711-723.e14. Epub 2019 Mar 14.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.02.009DOI Listing
May 2019

Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma.

J Immunother Cancer 2018 11 20;6(1):125. Epub 2018 Nov 20.

Division of Medical Oncology, Departments of Medicine and Pathology, Stanford University, CA, Stanford, USA.

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http://dx.doi.org/10.1186/s40425-018-0431-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247677PMC
November 2018

The MYC oncogene is a global regulator of the immune response.

Blood 2018 05 7;131(18):2007-2015. Epub 2018 Mar 7.

Division of Oncology, Department of Medicine, and.

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http://dx.doi.org/10.1182/blood-2017-11-742577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934797PMC
May 2018

Administration of low-dose combination anti-CTLA4, anti-CD137, and anti-OX40 into murine tumor or proximal to the tumor draining lymph node induces systemic tumor regression.

Cancer Immunol Immunother 2018 01 13;67(1):47-60. Epub 2017 Sep 13.

Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1007/s00262-017-2059-yDOI Listing
January 2018

Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC).

Oncotarget 2018 Jan 9;9(5):5517-5528. Epub 2017 Nov 9.

Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.22342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814155PMC
January 2018

DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma.

Oncotarget 2017 Sep 10;8(44):76898-76920. Epub 2017 Aug 10.

Augusta University, Department of Biochemistry and Molecular Biology, Augusta, GA 30912, USA.

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http://dx.doi.org/10.18632/oncotarget.20176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652751PMC
September 2017

MYC: Master Regulator of Immune Privilege.

Trends Immunol 2017 04 21;38(4):298-305. Epub 2017 Feb 21.

Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378645PMC
April 2017

Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma.

Proc Natl Acad Sci U S A 2017 04 11;114(17):4300-4305. Epub 2017 Apr 11.

Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1617709114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410819PMC
April 2017

BIM-mediated apoptosis and oncogene addiction.

Aging (Albany NY) 2016 09;8(9):1834-1835

Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.18632/aging.101072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076438PMC
September 2016

miR-17-92 explains MYC oncogene addiction.

Mol Cell Oncol 2014 Oct-Dec;1(4):e970092. Epub 2014 Dec 31.

Division of Oncology; Departments of Medicine and Pathology; Stanford University ; Stanford, CA USA.

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http://dx.doi.org/10.4161/23723548.2014.970092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905255PMC
June 2016

Affordable Cancer Medications Are Within Reach but We Need a Different Approach.

J Clin Oncol 2016 06 9;34(18):2194-5. Epub 2016 May 9.

Lancaster University, Lancaster, United Kingdom.

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http://ascopubs.org/doi/10.1200/JCO.2016.67.2436
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http://dx.doi.org/10.1200/JCO.2016.67.2436DOI Listing
June 2016

Metabolic vulnerabilities of MYC-induced cancer.

Oncotarget 2016 05;7(21):29879-80

Departments of Medicine and Pathology, Division of Oncology, Stanford University School of Medicine, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.7223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058649PMC
May 2016

BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia.

Oncotarget 2016 May;7(19):26926-34

Division of Oncology, Department of Medicine and Pathology, Stanford University, Stanford, CA, United States of America.

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http://dx.doi.org/10.18632/oncotarget.8731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053622PMC
May 2016

MYC regulates the antitumor immune response through CD47 and PD-L1.

Science 2016 Apr 10;352(6282):227-31. Epub 2016 Mar 10.

Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/science.aac9935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940030PMC
April 2016

Activation of Cre recombinase alone can induce complete tumor regression.

PLoS One 2014 10;9(9):e107589. Epub 2014 Sep 10.

Department of Medicine, Division of Oncology, School of Medicine, Stanford University, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107589PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160265PMC
March 2016

NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.

Nature 2016 Mar 2;531(7593):253-7. Epub 2016 Mar 2.

Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature16969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786464PMC
March 2016

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

Cell Metab 2015 Dec 17;22(6):1009-19. Epub 2015 Sep 17.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818967PMC
December 2015

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819002PMC
December 2015

ARF: connecting senescence and innate immunity for clearance.

Aging (Albany NY) 2015 Sep;7(9):613-5

Division of Oncology, Departments of Medicine and Pathology, Molecular Imaging Program, Stanford University, Stanford, CA 94305, USA.

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http://www.aging-us.com/article/100813
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600620PMC
http://dx.doi.org/10.18632/aging.100813DOI Listing
September 2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Authors:
William H Goodson Leroy Lowe David O Carpenter Michael Gilbertson Abdul Manaf Ali Adela Lopez de Cerain Salsamendi Ahmed Lasfar Amancio Carnero Amaya Azqueta Amedeo Amedei Amelia K Charles Andrew R Collins Andrew Ward Anna C Salzberg Annamaria Colacci Ann-Karin Olsen Arthur Berg Barry J Barclay Binhua P Zhou Carmen Blanco-Aparicio Carolyn J Baglole Chenfang Dong Chiara Mondello Chia-Wen Hsu Christian C Naus Clement Yedjou Colleen S Curran Dale W Laird Daniel C Koch Danielle J Carlin Dean W Felsher Debasish Roy Dustin G Brown Edward Ratovitski Elizabeth P Ryan Emanuela Corsini Emilio Rojas Eun-Yi Moon Ezio Laconi Fabio Marongiu Fahd Al-Mulla Ferdinando Chiaradonna Firouz Darroudi Francis L Martin Frederik J Van Schooten Gary S Goldberg Gerard Wagemaker Gladys N Nangami Gloria M Calaf Graeme Williams Gregory T Wolf Gudrun Koppen Gunnar Brunborg H Kim Lyerly Harini Krishnan Hasiah Ab Hamid Hemad Yasaei Hideko Sone Hiroshi Kondoh Hosni K Salem Hsue-Yin Hsu Hyun Ho Park Igor Koturbash Isabelle R Miousse A Ivana Scovassi James E Klaunig Jan Vondráček Jayadev Raju Jesse Roman John Pierce Wise Jonathan R Whitfield Jordan Woodrick Joseph A Christopher Josiah Ochieng Juan Fernando Martinez-Leal Judith Weisz Julia Kravchenko Jun Sun Kalan R Prudhomme Kannan Badri Narayanan Karine A Cohen-Solal Kim Moorwood Laetitia Gonzalez Laura Soucek Le Jian Leandro S D'Abronzo Liang-Tzung Lin Lin Li Linda Gulliver Lisa J McCawley Lorenzo Memeo Louis Vermeulen Luc Leyns Luoping Zhang Mahara Valverde Mahin Khatami Maria Fiammetta Romano Marion Chapellier Marc A Williams Mark Wade Masoud H Manjili Matilde E Lleonart Menghang Xia Michael J Gonzalez Michalis V Karamouzis Micheline Kirsch-Volders Monica Vaccari Nancy B Kuemmerle Neetu Singh Nichola Cruickshanks Nicole Kleinstreuer Nik van Larebeke Nuzhat Ahmed Olugbemiga Ogunkua P K Krishnakumar Pankaj Vadgama Paola A Marignani Paramita M Ghosh Patricia Ostrosky-Wegman Patricia A Thompson Paul Dent Petr Heneberg Philippa Darbre Po Sing Leung Pratima Nangia-Makker Qiang Shawn Cheng R Brooks Robey Rabeah Al-Temaimi Rabindra Roy Rafaela Andrade-Vieira Ranjeet K Sinha Rekha Mehta Renza Vento Riccardo Di Fiore Richard Ponce-Cusi Rita Dornetshuber-Fleiss Rita Nahta Robert C Castellino Roberta Palorini Roslida Abd Hamid Sabine A S Langie Sakina E Eltom Samira A Brooks Sandra Ryeom Sandra S Wise Sarah N Bay Shelley A Harris Silvana Papagerakis Simona Romano Sofia Pavanello Staffan Eriksson Stefano Forte Stephanie C Casey Sudjit Luanpitpong Tae-Jin Lee Takemi Otsuki Tao Chen Thierry Massfelder Thomas Sanderson Tiziana Guarnieri Tove Hultman Valérian Dormoy Valerie Odero-Marah Venkata Sabbisetti Veronique Maguer-Satta W Kimryn Rathmell Wilhelm Engström William K Decker William H Bisson Yon Rojanasakul Yunus Luqmani Zhenbang Chen Zhiwei Hu

Carcinogenesis 2015 Jun;36 Suppl 1:S254-96

Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://www.ilcambiamento.it/files/carcinogenesi.pdf
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480130PMC
June 2015

Oncogene addiction: resetting the safety switch?

Oncotarget 2014 Sep;5(18):7986-7

Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226662PMC
http://dx.doi.org/10.18632/oncotarget.2474DOI Listing
September 2014

Addiction to multiple oncogenes can be exploited to prevent the emergence of therapeutic resistance.

Proc Natl Acad Sci U S A 2014 Aug 28;111(32):E3316-24. Epub 2014 Jul 28.

Division of Oncology, Departments of Medicine, Pathology, and Molecular Imaging, Stanford University School of Medicine, Stanford, CA 94305

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http://dx.doi.org/10.1073/pnas.1406123111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136575PMC
August 2014

Oncogene withdrawal engages the immune system to induce sustained cancer regression.

J Immunother Cancer 2014 15;2:24. Epub 2014 Jul 15.

Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1105, Stanford 94305-5151, CA, USA.

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http://dx.doi.org/10.1186/2051-1426-2-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118610PMC
August 2014

MYC through miR-17-92 suppresses specific target genes to maintain survival, autonomous proliferation, and a neoplastic state.

Cancer Cell 2014 Aug;26(2):262-72

Division of Oncology, Department of Medicine and Pathology, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191901PMC
August 2014

Alteration of the lipid profile in lymphomas induced by MYC overexpression.

Proc Natl Acad Sci U S A 2014 Jul 3;111(29):10450-5. Epub 2014 Jul 3.

Department of Chemistry, Stanford University, Stanford, CA 94305-5080;

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http://dx.doi.org/10.1073/pnas.1409778111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115527PMC
July 2014

Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo.

Nat Chem 2014 Jun 28;6(6):519-26. Epub 2014 Apr 28.

Molecular Imaging Program at Stanford, Departments of Radiology and Chemistry, Stanford University, Stanford, California 94305-5484, USA.

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http://dx.doi.org/10.1038/nchem.1920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031611PMC
June 2014

MYC activation is a hallmark of cancer initiation and maintenance.

Cold Spring Harb Perspect Med 2014 Jun 2;4(6). Epub 2014 Jun 2.

Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, California 94305.

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http://dx.doi.org/10.1101/cshperspect.a014241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031954PMC
June 2014

An essential role for the immune system in the mechanism of tumor regression following targeted oncogene inactivation.

Immunol Res 2014 May;58(2-3):282-91

Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1105, Stanford, CA, 94305-5151, USA.

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http://dx.doi.org/10.1007/s12026-014-8503-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201505PMC
May 2014

Generation of a tetracycline regulated mouse model of MYC-induced T-cell acute lymphoblastic leukemia.

Methods Mol Biol 2013 ;1012:221-35

Department of Medicine-Oncology and Pathology, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1007/978-1-62703-429-6_15DOI Listing
March 2014

Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance.

Cancer Cell 2014 Mar;25(3):350-65

Ansary Stem Cell Institute, Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017921PMC
March 2014

Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma.

J Hepatol 2013 Nov 22;59(5):1007-13. Epub 2013 Jun 22.

Gastrointestinal Malignancy Section, Medical Oncology Branch, National Cancer Institute, Bethesda, USA; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.jhep.2013.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805787PMC
November 2013

Real-time nanoscale proteomic analysis of the novel multi-kinase pathway inhibitor rigosertib to measure the response to treatment of cancer.

Expert Opin Investig Drugs 2013 Nov 12;22(11):1495-509. Epub 2013 Aug 12.

Stanford University School of Medicine, Division of Oncology, Departments of Medicine and Pathology , Stanford, CA , USA

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http://dx.doi.org/10.1517/13543784.2013.829453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111569PMC
November 2013

A c-Myc activation sensor-based high-throughput drug screening identifies an antineoplastic effect of nitazoxanide.

Mol Cancer Ther 2013 Sep 3;12(9):1896-905. Epub 2013 Jul 3.

Corresponding Author: Sanjiv S. Gambhir, Molecular Imaging Program at Stanford, Stanford University School of Medicine, 318 Campus Drive, East Wing, 1st Floor, Stanford, CA 94305-5427.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-1243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772774PMC
September 2013

Tumor dormancy, oncogene addiction, cellular senescence, and self-renewal programs.

Adv Exp Med Biol 2013 ;734:91-107

Department of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA 94305-5151, USA.

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http://link.springer.com/10.1007/978-1-4614-1445-2_6
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http://dx.doi.org/10.1007/978-1-4614-1445-2_6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773491PMC
April 2013

Role of MYCN in retinoblastoma.

Authors:
Dean W Felsher

Lancet Oncol 2013 Apr 13;14(4):270-1. Epub 2013 Mar 13.

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http://dx.doi.org/10.1016/S1470-2045(13)70070-6DOI Listing
April 2013

Noncanonical roles of the immune system in eliciting oncogene addiction.

Curr Opin Immunol 2013 Apr 6;25(2):246-58. Epub 2013 Apr 6.

Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.coi.2013.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683588PMC
April 2013

SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.

PLoS One 2012 14;7(9):e45119. Epub 2012 Sep 14.

Department of Pathology, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045119PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443243PMC
February 2013

Metabolic changes in cancer cells upon suppression of MYC.

Cancer Metab 2013 Feb 4;1(1). Epub 2013 Feb 4.

Department of Medicine, Feinberg School of Medicine, Northwestern University, 60611, Chicago, IL, USA.

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http://dx.doi.org/10.1186/2049-3002-1-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178210PMC
February 2013

CD271(+) bone marrow mesenchymal stem cells may provide a niche for dormant Mycobacterium tuberculosis.

Sci Transl Med 2013 Jan;5(170):170ra13

Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/scitranslmed.3004912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616630PMC
January 2013

HIF-2α suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells.

Stem Cells 2012 Aug;30(8):1685-95

Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1002/stem.1142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584519PMC
August 2012

"Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo.

Oncotarget 2012 Jan;3(1):58-66

Departments of Chemistry and Chemical and Systems Biology, Stanford University, Stanford, CA 94305-5080.

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http://dx.doi.org/10.18632/oncotarget.438DOI Listing
January 2012

Lymphomas that recur after MYC suppression continue to exhibit oncogene addiction.

Proc Natl Acad Sci U S A 2011 Oct 3;108(42):17432-7. Epub 2011 Oct 3.

Division of Oncology, Department of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.1107303108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198348PMC
October 2011

Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma.

PLoS One 2011 May 6;6(5):e19758. Epub 2011 May 6.

Department of Pediatrics, Stanford University, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019758PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089631PMC
May 2011

Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.

J Biol Chem 2011 Apr 17;286(13):11035-46. Epub 2011 Jan 17.

Department of Medicine, Divisions of Oncology and Hematology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1074/jbc.M110.208470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064158PMC
April 2011

MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase.

Cancer Res 2011 Mar 24;71(6):2286-97. Epub 2011 Jan 24.

Division of Medical Oncology, Department of Medicine and Pathology, Molecular Imaging Program at Stanford, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059327PMC
March 2011

Noninvasive molecular imaging of c-Myc activation in living mice.

Proc Natl Acad Sci U S A 2010 Sep 16;107(36):15892-7. Epub 2010 Aug 16.

Department of Radiology, Stanford University School of Medicine, CA 94305-5427, USA.

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http://dx.doi.org/10.1073/pnas.1007443107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936612PMC
September 2010

MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms.

Authors:
Dean W Felsher

Genes Cancer 2010 Jun;1(6):597-604

Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1177/1947601910377798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965623PMC
June 2010

MYC as a regulator of ribosome biogenesis and protein synthesis.

Nat Rev Cancer 2010 Apr;10(4):301-9

Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nrc2819DOI Listing
April 2010

Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice.

Mol Ther 2010 Jan 20;18(1):161-70. Epub 2009 Oct 20.

Department of Medicine, Division of Oncology, School of Medicine, Center for Clinical Sciences Research, Stanford University, Stanford, California 94305-5151, USA.

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http://dx.doi.org/10.1038/mt.2009.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839214PMC
January 2010

Myc and a Cdk2 senescence switch.

Nat Cell Biol 2010 Jan;12(1):7-9

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http://dx.doi.org/10.1038/ncb0110-7DOI Listing
January 2010

Reversing cancer from inside and out: oncogene addiction, cellular senescence, and the angiogenic switch.

Authors:
Dean W Felsher

Lymphat Res Biol 2008 ;6(3-4):149-54

Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

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http://www.liebertpub.com/doi/10.1089/lrb.2008.63403
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http://dx.doi.org/10.1089/lrb.2008.63403DOI Listing
March 2009

(18)F and (18)FDG PET imaging of osteosarcoma to non-invasively monitor in situ changes in cellular proliferation and bone differentiation upon MYC inactivation.

Cancer Biol Ther 2008 Dec 7;7(12):1947-51. Epub 2008 Dec 7.

Department of Chemical and Systems Biology, Stanford School of Medicine, Stanford, California 94403, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158945PMC
http://dx.doi.org/10.4161/cbt.7.12.6947DOI Listing
December 2008

The current STATe of biomarkers to predict the response to anti-angiogenic therapies.

Cancer Biol Ther 2008 Dec;7(12):2004-6

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305-5151, USA.

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http://dx.doi.org/10.4161/cbt.7.12.7191DOI Listing
December 2008

Tumor dormancy and oncogene addiction.

Authors:
Dean W Felsher

APMIS 2008 Jul-Aug;116(7-8):629-37

Division of Oncology, Department of Medicine, Stanford University, Palo Alto, CA, USA.

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http://dx.doi.org/10.1111/j.1600-0463.2008.01037.xDOI Listing
November 2008

A quantitative PCR method to detect blood microRNAs associated with tumorigenesis in transgenic mice.

Mol Cancer 2008 Sep 30;7:74. Epub 2008 Sep 30.

Stanford University, School of Medicine, Division of Oncology, Department of Medicine, Stanford, CA 94305-5151, USA.

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http://dx.doi.org/10.1186/1476-4598-7-74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572631PMC
September 2008

Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance.

Cancer Res 2008 Jul;68(13):5132-42

Department of Medicine and Pathology, Division of Medical Oncology, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191850PMC
July 2008

Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis.

PLoS Genet 2008 Jun 6;4(6):e1000090. Epub 2008 Jun 6.

Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390767PMC
June 2008

Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesis.

PLoS One 2008 Jun 18;3(6):e2493. Epub 2008 Jun 18.

Department of Medicine, Division of Oncology, School of Medicine, Center for Clinical Sciences Research, Stanford University, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002493PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423614PMC
June 2008

Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit?

Authors:
Dean W Felsher

Cancer Res 2008 May;68(9):3081-6; discussion 3086

Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-07-5832DOI Listing
May 2008

Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis.

Proc Natl Acad Sci U S A 2007 Sep 19;104(39):15400-5. Epub 2007 Sep 19.

Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0706307104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000495PMC
September 2007