Publications

Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration.
Metabolism 2017 May 11;70:31-41. Epub 2017 Feb 11.
Division of Endocrinology, Metabolism & Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Center for Cystic Fibrosis and Airways Disease Research, Children's Healthcare of Atlanta, Atlanta, GA, USA; Section of Endocrinology, Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA.

Metabolic Phenotypes of Response to Vaccination in Humans.
Cell 2017 May 11;169(5):862-877.e17. Epub 2017 May 11.
Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Pathology, School of Medicine, Emory University, Atlanta, GA 30329, USA. Electronic address:

Corrigendum to "Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration" [Metabolism vol. 70, May 2017, pages 31-41].
Metabolism 2017 Apr 26. Epub 2017 Apr 26.
Division of Endocrinology, Metabolism & Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Center for Cystic Fibrosis and Airways Disease Research, Children's Healthcare of Atlanta, Atlanta, GA, USA; Section of Endocrinology, Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA.


Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice.
Am J Physiol Regul Integr Comp Physiol 2016 Nov 24;311(5):R906-R916. Epub 2016 Aug 24.
Division of Pulmonary Medicine, Department of Medicine, Emory University, Atlanta, Georgia; and

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice.
Sci Transl Med 2016 Sep;8(357):357ra122
Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive Northeast, Atlanta, GA 30322, USA. Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, Atlanta, GA 30322, USA.

Metabolic Pathways and Networks Associated With Tobacco Use in Military Personnel.
J Occup Environ Med 2016 Aug;58(8 Suppl 1):S111-6
Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory School of Medicine, Atlanta, Georgia (Dr Jones, Mr Walker, Drs Uppal, Go); Department of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts (Mr Walker); 779th Aerospace Medicine Squadron, 79th Medical Wing, Joint Base Andrews (Dr Rohrbeck); and Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon).

Deployment-Associated Exposure Surveillance With High-Resolution Metabolomics.
J Occup Environ Med 2016 Aug;58(8 Suppl 1):S12-21
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia (Mr Walker, Drs Uppal, Go, Jones); Department of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts (Mr Walker, Dr Pennell); Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon); Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York (Dr Hopke); and 779th Aerospace Medicine Squadron, 79th Medical Wing, Joint Base Andrews, MD (Dr Rohrbeck).

Introduction to Department of Defense Research on Burn Pits, Biomarkers, and Health Outcomes Related to Deployment in Iraq and Afghanistan.
J Occup Environ Med 2016 Aug;58(8 Suppl 1):S3-S11
Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon); 779th Aerospace Medical Squadron, 79th Medical WingJoint Base Andrews, Maryland (Dr Rohrbeck); Bioenvironmental Engineering Flight Commander, 30th Medical Group, 338 South Dakota Ave, Vandenberg AFB, CA 93437 (Maj Haines); Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Atlanta, Georgia (Dr Jones, Mr Walker); Departments of Medicine and Environmental Medicine, University of Rochester Medical Center (Drs Utell, Phipps, Thatcher, Woeller); Center for Air Resources Engineering and Science, Institute for a Sustainable Environment, Clarkson University, Potsdam, New York (Dr Hopke); U.S Army Center for Public Health (Provisional), Aberdeen Proving Ground (Drs Baird, Gaydos); and Anatomy and Cell Biology, Uniformed Services University, Bethesda, Maryland (Drs Pollard, Dalgard).

Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel.
J Occup Environ Med 2016 Aug;58(8 Suppl 1):S44-52
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia (Mr Walker, Drs Uppal and Jones); Department of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts (Mr Walker, Dr Pennell); Center for Air Resources Engineering and Science, Clarkson University, Potsdam (Drs Xia, Hopke); Pulmonary Division, Department of Medicine (Drs Utell, Phipps, Sime), Department of Environmental Medicine, University of Rochester Medical Center, New York (Drs Utell, Phipps, Sime); 779th Aerospace Medicine Squadron, 79th Medical Wing, Joint Base Andrews, MD (Dr Rohrbeck); and Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon).

High-Resolution Metabolomics Assessment of Military Personnel: Evaluating Analytical Strategies for Chemical Detection.
J Occup Environ Med 2016 Aug;58(8 Suppl 1):S53-61
Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory School of Medicine, Atlanta, Georgia (Mr Liu, Mr Walker, Dr Uppal, Tran, Dr Jones); Department of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts (Mr Walker); 779th Aerospace Medicine Squadron, 79th Medical Wing, Joint Base Andrews, MD (Dr Rohrbeck); and Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon).

High-Resolution Metabolomics for Nutrition and Health Assessment of Armed Forces Personnel.
J Occup Environ Med 2016 Aug;58(8 Suppl 1):S80-8
Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory School of Medicine, Atlanta, Georgia (Dr Accardi, Mr Walker, Drs Uppal, Jones); Department of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts (Mr Walker, Dr Pennell); Division of Cardiology, Emory School of Medicine, Atlanta, Georgia (Dr Quyyumi); 779th Aerospace Medicine Squadron, 79th Medical Wing, Joint Base Andrews (Dr Rohrbeck); and Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon).

Efficacy and Safety of Glutamine-supplemented Parenteral Nutrition in Surgical ICU Patients: An American Multicenter Randomized Controlled Trial.
Ann Surg 2016 Apr;263(4):646-55
*Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA †Center for Clinical and Molecular Nutrition, Emory University School of Medicine, Atlanta, GA ‡Emory University Hospital Nutrition and Metabolic Support Service, Atlanta, GA §Department of Surgery, Vanderbilt University Medical Center, Nashville, TN ¶Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA ||Department of Surgery, Virginia Technical Institute Carilion School of Medicine, Roanoke, VA **Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA ††Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA ‡‡Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA §§Department of Surgery, Miriam Hospital, Providence, RI ¶¶Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA ||||Department of Surgery, University of Wisconsin, Schools of Medicine and Public Health, Madison, WI ***Department of Surgery, Emory University School of Medicine, Atlanta, GA †††Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA; Hubert Department of Global Health Rollins School of Public Health, Emory University, Atlanta, GA ‡‡‡National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD §§§Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO.

A longitudinal analysis of the effects of age on the blood plasma metabolome in the common marmoset, Callithrix jacchus.
Exp Gerontol 2016 Apr 21;76:17-24. Epub 2016 Jan 21.
Department of Pathology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA; Department of Biology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA.


Macronutrient intake and body composition changes during anti-tuberculosis therapy in adults.
Clin Nutr 2016 Feb 26;35(1):205-12. Epub 2015 Feb 26.
Graduate Division of Biological and Biomedical Sciences, Nutrition and Health Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA 30322, United States; Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States; Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States. Electronic address:

Novel Biomarker of Oxidative Stress Is Associated With Risk of Death in Patients With Coronary Artery Disease.
Circulation 2016 Jan 16;133(4):361-9. Epub 2015 Dec 16.
From Department of Medicine, Emory University School of Medicine, Atlanta, GA (R.S.P., N.G., D.J.E., S.S., S.A., H.S., A.M.Z., L.S., V.V., D.P.J., A.A.Q.); Institute of Cardiovascular Science, University College London, United Kingdom (R.S.P.); Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Atlanta, GA (Y.K.); Department of Medicine, Baptist Health South Florida, Miami, FL (E.V.); Department of Epidemiology, Rollins School of Public Health, Atlanta, GA (E.V., V.V.); and Department of Medicine, Atlanta Veterans Affairs Medical Center, Decatur, GA (A.M.Z.).

Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection.
Microbiome 2016 Jan 20;4. Epub 2016 Jan 20.
Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Reference Standardization for Mass Spectrometry and High-resolution Metabolomics Applications to Exposome Research.
Toxicol Sci 2015 Dec 9;148(2):531-43. Epub 2015 Sep 9.
*Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia 30322;


Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction.
Biomed Res Int 2015 4;2015:825027. Epub 2015 Oct 4.
Cardiovascular Research Center and Cardiovascular Institute of Lifespan, The Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.

Redox theory of aging.
Redox Biol 2015 Aug 2;5:71-9. Epub 2015 Apr 2.
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address:

Metabolic Consequences of Chronic Alcohol Abuse in Non-Smokers: A Pilot Study.
PLoS One 2015 23;10(6):e0129570. Epub 2015 Jun 23.
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America; Children's Healthcare of Atlanta Center for Developmental Lung Biology, Atlanta, Georgia, United States of America.

Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease.
Parkinsonism Relat Disord 2015 May 28;21(5):500-3. Epub 2015 Feb 28.
Neurology Service, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA; Department of Neurology, University of California, San Francisco Medical Center, 675 Nelson Rising Lane, San Francisco, CA 94143, USA.

Metabolome-wide association study of phenylalanine in plasma of common marmosets.
Amino Acids 2015 Mar 21;47(3):589-601. Epub 2014 Dec 21.
Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, 205 Whitehead Research Center, Atlanta, GA, 30322, USA.

Differential effects of nebivolol and metoprolol on arterial stiffness, circulating progenitor cells, and oxidative stress.
J Am Soc Hypertens 2015 Mar 31;9(3):206-13. Epub 2014 Dec 31.
Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

Disturbed flow induces systemic changes in metabolites in mouse plasma: a metabolomics study using ApoE⁻/⁻ mice with partial carotid ligation.
Am J Physiol Regul Integr Comp Physiol 2015 Jan 5;308(1):R62-72. Epub 2014 Nov 5.
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia;

Autophagy is essential for effector CD8(+) T cell survival and memory formation.
Nat Immunol 2014 Dec 2;15(12):1152-61. Epub 2014 Nov 2.
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.

Short-term oral atrazine exposure alters the plasma metabolome of male C57BL/6 mice and disrupts α-linolenate, tryptophan, tyrosine and other major metabolic pathways.
Toxicology 2014 Dec 4;326:130-41. Epub 2014 Nov 4.
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA. Electronic address:


Transcriptome-metabolome wide association study (TMWAS) of maneb and paraquat neurotoxicity reveals network level interactions in toxicologic mechanism.
Toxicol Rep 2014 24;1:435-444. Epub 2014 Jul 24.
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, United States; Clinical Biomarkers Laboratory, Emory University, Atlanta, GA 30322, United States.

Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry.
Methods Mol Biol 2014 ;1198:43-73
Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, 615 Michael Street, Atlanta, GA, 30322, USA.

Plasma metabolomics in human pulmonary tuberculosis disease: a pilot study.
PLoS One 2014 15;9(10):e108854. Epub 2014 Oct 15.
Nutrition and Health Sciences, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, Georgia, United States of America; Center for Clinical and Molecular Nutrition, Emory University School of Medicine, Atlanta, Georgia, United States of America; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.

Disturbed flow enhances inflammatory signaling and atherogenesis by increasing thioredoxin-1 level in endothelial cell nuclei.
PLoS One 2014 29;9(9):e108346. Epub 2014 Sep 29.
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America.


Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation.
Science 2014 Jan 5;343(6168):313-317. Epub 2013 Dec 5.
Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.

Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects.
PLoS One 2013 11;8(6):e63544. Epub 2013 Jun 11.
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, United States of America.

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