De-Chen Lin

De-Chen Lin

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De-Chen Lin

De-Chen Lin

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dbInDel: a database of enhancer-associated insertion and deletion variants by analysis of H3K27ac ChIP-Seq.

Bioinformatics 2020 Mar;36(5):1649-1651

Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.

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http://dx.doi.org/10.1093/bioinformatics/btz770DOI Listing
March 2020

EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs).

Nucleic Acids Res 2020 Jan;48(D1):D307-D313

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

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http://dx.doi.org/10.1093/nar/gkz823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943034PMC
January 2020

Identification of key genes by integrating DNA methylation and next-generation transcriptome sequencing for esophageal squamous cell carcinoma.

Aging (Albany NY) 2020 Jan 21;12(2):1332-1365. Epub 2020 Jan 21.

The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou 515041, Guangdong, P.R. China.

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http://dx.doi.org/10.18632/aging.102686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053602PMC
January 2020

Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma.

Cancers (Basel) 2019 Aug 12;11(8). Epub 2019 Aug 12.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen University, Guangzhou 510120, China.

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http://dx.doi.org/10.3390/cancers11081156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721624PMC
August 2019

SEanalysis: a web tool for super-enhancer associated regulatory analysis.

Nucleic Acids Res 2019 Jul;47(W1):W248-W255

Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

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http://dx.doi.org/10.1093/nar/gkz302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602466PMC
July 2019

Super-Enhancer-Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma.

Cancer Res 2019 02 27;79(3):572-584. Epub 2018 Nov 27.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-0367DOI Listing
February 2019

ARID1A and CEBPα cooperatively inhibit UCA1 transcription in breast cancer.

Oncogene 2018 11 6;37(45):5939-5951. Epub 2018 Jul 6.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41388-018-0371-4DOI Listing
November 2018

Maftools: efficient and comprehensive analysis of somatic variants in cancer.

Genome Res 2018 11 19;28(11):1747-1756. Epub 2018 Oct 19.

Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.239244.118
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http://dx.doi.org/10.1101/gr.239244.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211645PMC
November 2018

SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer.

Cell Mol Life Sci 2018 07 10;75(14):2643-2661. Epub 2018 Feb 10.

The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, China.

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http://dx.doi.org/10.1007/s00018-018-2757-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003972PMC
July 2018

Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma.

Gastroenterology 2018 06 15;154(8):2137-2151.e1. Epub 2018 Feb 15.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; Cancer Science Institute of Singapore, National University of Singapore, Singapore; National University Cancer Institute, National University Hospital Singapore, Singapore.

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http://dx.doi.org/10.1053/j.gastro.2018.02.018DOI Listing
June 2018

Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients.

Gastroenterology 2018 01 27;154(2):374-389. Epub 2017 Jul 27.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; Cancer Science Institute of Singapore, National University of Singapore, Singapore; National University Cancer Institute, National University Hospital Singapore, Singapore.

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http://dx.doi.org/10.1053/j.gastro.2017.06.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951382PMC
January 2018

ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation.

EMBO Rep 2018 01 7;19(1):73-88. Epub 2017 Dec 7.

Cell-Bionomics Research Unit, Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Ishikawa, Japan

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http://dx.doi.org/10.15252/embr.201744523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757218PMC
January 2018

Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia.

Neoplasia 2017 Oct 29;19(10):750-761. Epub 2017 Aug 29.

Department of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Cancer Science Institute of Singapore, National University of Singapore, Singapore; National University Cancer Institute of Singapore, National University Hospital, Singapore.

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http://dx.doi.org/10.1016/j.neo.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576979PMC
October 2017

Genomic lesions drive the metastasis of esophageal squamous cell carcinoma.

J Thorac Dis 2017 Oct;9(10):3523-3524

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA.

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http://dx.doi.org/10.21037/jtd.2017.09.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723768PMC
October 2017

Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma.

Clin Cancer Res 2017 Aug 23;23(15):4376-4387. Epub 2017 Mar 23.

Department of Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2185DOI Listing
August 2017

Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma.

Cancer Res 2017 05 20;77(9):2255-2265. Epub 2017 Feb 20.

Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413372PMC
May 2017

CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1-Dependent IGF-1 Signaling.

Cancer Res 2016 05 8;76(9):2687-97. Epub 2016 Mar 8.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California. Cancer Science Institute of Singapore, National University of Singapore, Singapore. National University Cancer Institute, National University Hospital Singapore, Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1572DOI Listing
May 2016

Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma.

Cancer Res 2015 May 15;75(9):1815-27. Epub 2015 Apr 15.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. National University Cancer Institute, National University Health System and National University of Singapore, Singapore, Singapore. Division of Hematology/Oncology, Cedars-Sinai Medical Center, University of California School of Medicine, Los Angeles, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417379PMC
May 2015

Targeting genetic lesions in esophageal cancer.

Cell Cycle 2014 5;13(13):2013-4. Epub 2014 Jun 5.

Cancer Science Institute of Singapore; National University of Singapore; Singapore; Cedars-Sinai Medical Center; Division of Hematology/Oncology; UCLA School of Medicine; Los Angeles, CA USA.

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http://dx.doi.org/10.4161/cc.29458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111687PMC
January 2015

The genomic landscape of nasopharyngeal carcinoma.

Nat Genet 2014 Aug 22;46(8):866-71. Epub 2014 Jun 22.

1] Cancer Science Institute of Singapore, National University of Singapore, Singapore. [2] Division of Hematology/Oncology, Cedars-Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, California, USA. [3] National University Cancer Institute, National University Hospital Singapore, Singapore. [4].

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http://dx.doi.org/10.1038/ng.3006DOI Listing
August 2014

Genomic and molecular characterization of esophageal squamous cell carcinoma.

Nat Genet 2014 May 30;46(5):467-73. Epub 2014 Mar 30.

1] Cedars-Sinai Medical Center, Division of Hematology/Oncology, University of California Los Angeles School of Medicine, Los Angeles, California, USA. [2] Cancer Science Institute of Singapore, National University of Singapore, Singapore. [3] National University Cancer Institute, National University Hospital Singapore, Singapore.

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http://dx.doi.org/10.1038/ng.2935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070589PMC
May 2014

An emerging role of PARK2 in cancer.

J Mol Med (Berl) 2014 Jan 3;92(1):31-42. Epub 2013 Dec 3.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.

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http://dx.doi.org/10.1007/s00109-013-1107-0DOI Listing
January 2014

Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization.

Clin Cancer Res 2013 Nov 5;19(21):5867-78. Epub 2013 Sep 5.

Authors' Affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

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http://clincancerres.aacrjournals.org/content/19/21/5867.ful
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-3753DOI Listing
November 2013

Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells.

Gastroenterology 2012 Mar 19;142(3):521-530.e3. Epub 2011 Nov 19.

State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1053/j.gastro.2011.11.023DOI Listing
March 2012

Genomic alterations with impact on survival in esophageal squamous cell carcinoma identified by array comparative genomic hybridization.

Genes Chromosomes Cancer 2011 Jul 11;50(7):518-26. Epub 2011 Apr 11.

State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

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http://doi.wiley.com/10.1002/gcc.20875
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http://dx.doi.org/10.1002/gcc.20875DOI Listing
July 2011

PLK1 Is transcriptionally activated by NF-κB during cell detachment and enhances anoikis resistance through inhibiting β-catenin degradation in esophageal squamous cell carcinoma.

Clin Cancer Res 2011 Jul 24;17(13):4285-95. Epub 2011 May 24.

Authors' Affiliations: State Key Laboratory of Molecular Oncology and Department of Pathology, Cancer Institute (Hospital), Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-3236DOI Listing
July 2011

Atypical protein kinase Cι (PKCι) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCι-SKP2-AKT pathway.

Mol Cancer Res 2011 Apr 10;9(4):390-402. Epub 2011 Feb 10.

State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Chinese Academy of Medical Sciences, 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0359DOI Listing
April 2011

[Expression of cell cycle related proteins cyclin D1, p53 and p21WAF1/Cip1 in esophageal squamous cell carcinoma].

Yi Chuan 2010 May;32(5):455-60

State Key Laboratory of Molecular Oncology, Cancer Institute, Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China.

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http://dx.doi.org/10.3724/sp.j.1005.2010.00455DOI Listing
May 2010

Overexpression of PLK1 is associated with poor survival by inhibiting apoptosis via enhancement of survivin level in esophageal squamous cell carcinoma.

Int J Cancer 2009 Feb;124(3):578-88

State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1002/ijc.23990DOI Listing
February 2009

Suppression of anoikis by SKP2 amplification and overexpression promotes metastasis of esophageal squamous cell carcinoma.

Mol Cancer Res 2009 Jan;7(1):12-22

State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, P.O. Box 2258, Beijing 100021, China.

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http://dx.doi.org/10.1158/1541-7786.MCR-08-0092DOI Listing
January 2009

Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma.

J Mol Med (Berl) 2007 Aug 22;85(8):863-75. Epub 2007 Feb 22.

State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China.

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http://dx.doi.org/10.1007/s00109-007-0159-4DOI Listing
August 2007