Dax Fu

Dax Fu

UNVERIFIED PROFILE

Are you Dax Fu?   Register this Author

Register author
Dax Fu

Dax Fu

Publications by authors named "Dax Fu"

Are you Dax Fu?   Register this Author

25Publications

321Reads

33Profile Views

Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress.

J Biol Chem 2019 Oct 7. Epub 2019 Oct 7.

Johns Hopkins University School of Medicine, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA119.010937DOI Listing
October 2019

Water molecules mediate zinc mobility in the bacterial zinc diffusion channel ZIPB.

J Biol Chem 2019 Sep 18;294(36):13327-13335. Epub 2019 Jul 18.

Department of Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA119.009239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737223PMC
September 2019

Induction of the metal transporter ZIP8 by interferon gamma in intestinal epithelial cells: Potential role of metal dyshomeostasis in Crohn's disease.

Biochem Biophys Res Commun 2019 Jul 29;515(2):325-331. Epub 2019 May 29.

Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.05.137DOI Listing
July 2019

Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8.

J Biol Chem 2018 10 4;293(42):16206-16216. Epub 2018 Sep 4.

From the Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.005136
Publisher Site
http://dx.doi.org/10.1074/jbc.RA118.005136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200924PMC
October 2018

A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells.

J Biol Chem 2018 01 28;293(2):579-587. Epub 2017 Nov 28.

From the Department of Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA117.000195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767863PMC
January 2018

Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform.

Proc Natl Acad Sci U S A 2017 09 5;114(38):10196-10201. Epub 2017 Sep 5.

Department of Chemistry, Bio-X, and the Biophysics Program, Stanford University, Stanford, CA 94305;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1711169114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617307PMC
September 2017

Coupling of Insulin Secretion and Display of a Granule-resident Zinc Transporter ZnT8 on the Surface of Pancreatic Beta Cells.

J Biol Chem 2017 03 27;292(10):4034-4043. Epub 2017 Jan 27.

From the Department of Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.772152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354490PMC
March 2017

Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes.

J Biol Chem 2016 12 8;291(53):26950-26957. Epub 2016 Nov 8.

From the Department of Physiology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205 and

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M116.764605
Publisher Site
http://dx.doi.org/10.1074/jbc.M116.764605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207130PMC
December 2016

Visualizing the kinetic power stroke that drives proton-coupled zinc(II) transport.

Nature 2014 Aug 22;512(7512):101-4. Epub 2014 Jun 22.

1] Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA [2] Department of Physiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature13382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144069PMC
August 2014

Metalloproteomics: challenges and prospective for clinical research applications.

Authors:
Dax Fu Lydia Finney

Expert Rev Proteomics 2014 Feb 16;11(1):13-9. Epub 2014 Jan 16.

Department of Physiology, Johns Hopkins School of Medicine, 202 Physiology Building, 725 North Wolfe Street, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/14789450.2014.876365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598182PMC
February 2014

Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.

Proc Natl Acad Sci U S A 2012 May 23;109(19):7202-7. Epub 2012 Apr 23.

Department of Physiology, Morphology, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B. 653, Beer-Sheva 84105, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1200362109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358884PMC
May 2012

Selective electrodiffusion of zinc ions in a Zrt-, Irt-like protein, ZIPB.

J Biol Chem 2010 Dec 28;285(50):39013-20. Epub 2010 Sep 28.

Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.180620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998139PMC
December 2010

Structural basis for autoregulation of the zinc transporter YiiP.

Nat Struct Mol Biol 2009 Oct 13;16(10):1063-7. Epub 2009 Sep 13.

Biology Department, Brookhaven National Laboratory, Upton, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.1662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758918PMC
October 2009

The structural basis of water permeation and proton exclusion in aquaporins.

Authors:
Dax Fu Min Lu

Mol Membr Biol 2007 Sep-Dec;24(5-6):366-74

Department of Biology, Brookhaven National Laboratory, Upton, New York 11973, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09687680701446965DOI Listing
November 2007

Structure of the zinc transporter YiiP.

Authors:
Min Lu Dax Fu

Science 2007 Sep 23;317(5845):1746-8. Epub 2007 Aug 23.

Department of Biology, Brookhaven National Laboratory, Upton, NY 11973, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1143748DOI Listing
September 2007

Binding and transport of metal ions at the dimer interface of the Escherichia coli metal transporter YiiP.

Authors:
Yinan Wei Dax Fu

J Biol Chem 2006 Aug 21;281(33):23492-502. Epub 2006 Jun 21.

Department of Biology, Brookhaven National Laboratory, Upton, New York 11973, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M602254200DOI Listing
August 2006

Crystal structure of AqpZ tetramer reveals two distinct Arg-189 conformations associated with water permeation through the narrowest constriction of the water-conducting channel.

J Biol Chem 2006 Jan 20;281(1):454-60. Epub 2005 Oct 20.

Department of Biology, Brookhaven National Laboratory, Upton, New York 11973, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M508926200DOI Listing
January 2006

Selective metal binding to a membrane-embedded aspartate in the Escherichia coli metal transporter YiiP (FieF).

Authors:
Yinan Wei Dax Fu

J Biol Chem 2005 Oct 27;280(40):33716-24. Epub 2005 Jul 27.

Department of Biology, Brookhaven National Laboratory, Upton, New York 11973, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M506107200DOI Listing
October 2005

Oligomeric state of the Escherichia coli metal transporter YiiP.

J Biol Chem 2004 Sep 16;279(38):39251-9. Epub 2004 Jul 16.

Department of Biology, Brookhaven National Laboratory, Upton, New York 11973, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M407044200DOI Listing
September 2004

Thermodynamic studies of the mechanism of metal binding to the Escherichia coli zinc transporter YiiP.

Authors:
Yang Chao Dax Fu

J Biol Chem 2004 Apr 11;279(17):17173-80. Epub 2004 Feb 11.

Department of Biology, Brookhaven National Laboratory, Upton, New York 11973, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M400208200DOI Listing
April 2004

Kinetic study of the antiport mechanism of an Escherichia coli zinc transporter, ZitB.

Authors:
Yang Chao Dax Fu

J Biol Chem 2004 Mar 10;279(13):12043-50. Epub 2004 Jan 10.

Department of Biology, Building 463, Brookhaven National Laboratory, Upton, NY 11973, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M313510200DOI Listing
March 2004

Crystallization and preliminary crystallographic analysis of the Escherichia coli water channel AqpZ.

Acta Crystallogr D Biol Crystallogr 2004 Mar 25;60(Pt 3):561-3. Epub 2004 Feb 25.

Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S090744490302972XDOI Listing
March 2004

The structure of GlpF, a glycerol conducting channel.

Novartis Found Symp 2002 ;245:51-61; discussion 61-5, 165-8

Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA.

View Article

Download full-text PDF

Source
November 2002