Dax A Hoffman

Dax A Hoffman

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Dax A Hoffman

Dax A Hoffman

Publications by authors named "Dax A Hoffman"

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Disruption of GpI mGluR-Dependent Cav2.3 Translation in a Mouse Model of Fragile X Syndrome.

J Neurosci 2019 Sep 26;39(38):7453-7464. Epub 2019 Jul 26.

Molecular Neurophysiology and Biophysics Section, Program in Development Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, and

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http://dx.doi.org/10.1523/JNEUROSCI.1443-17.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750941PMC
September 2019

A novel bungarotoxin binding site-tagged construct reveals MAPK-dependent Kv4.2 trafficking.

Mol Cell Neurosci 2019 07 15;98:121-130. Epub 2019 Jun 15.

Section on Molecular Neurophysiology & Biophysics, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2019.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639039PMC
July 2019

A polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca regulation of Kv4 channels.

J Biol Chem 2019 03 8;294(10):3683-3695. Epub 2019 Jan 8.

Section on Molecular Neurophysiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892

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http://dx.doi.org/10.1074/jbc.RA118.006549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416424PMC
March 2019

Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus.

Front Cell Neurosci 2019 21;13:27. Epub 2019 Feb 21.

Molecular Neurophysiology and Biophysics Section, Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fncel.2019.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393364PMC
February 2019

DPP6 Loss Impacts Hippocampal Synaptic Development and Induces Behavioral Impairments in Recognition, Learning and Memory.

Front Cell Neurosci 2018 29;12:84. Epub 2018 Mar 29.

Molecular Neurophysiology and Biophysics Section, Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fncel.2018.00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884885PMC
March 2018

Idiopathic Autism: Cellular and Molecular Phenotypes in Pluripotent Stem Cell-Derived Neurons.

Mol Neurobiol 2017 08 29;54(6):4507-4523. Epub 2016 Jun 29.

Laboratory of Clinical and Developmental Genomics, National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), 10 Center Drive, MSC 1255, Building 10, Room 1C-250, Bethesda, MD, 20892-1255, USA.

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http://dx.doi.org/10.1007/s12035-016-9961-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199629PMC
August 2017

Functional characterization of two novel germline mutations of the KCNJ5 gene in hypertensive patients without primary aldosteronism but with ACTH-dependent aldosterone hypersecretion.

Clin Endocrinol (Oxf) 2016 Dec 12;85(6):845-851. Epub 2016 Jul 12.

Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, Athens, Greece.

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http://dx.doi.org/10.1111/cen.13132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118167PMC
December 2016

Matrix Metalloproteinase-9 Regulates Neuronal Circuit Development and Excitability.

Mol Neurobiol 2016 07 21;53(5):3477-3493. Epub 2015 Jun 21.

Department of Biology and Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, MD, 20742, USA.

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http://dx.doi.org/10.1007/s12035-015-9295-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686372PMC
July 2016

Human endogenous retrovirus-K contributes to motor neuron disease.

Sci Transl Med 2015 Sep;7(307):307ra153

Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/scitranslmed.aac8201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344353PMC
September 2015

DPP6 domains responsible for its localization and function.

J Biol Chem 2014 Nov 4;289(46):32153-65. Epub 2014 Sep 4.

From the Molecular Neurophysiology and Biophysics Section, Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1074/jbc.M114.578070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231691PMC
November 2014

Editorial.

Authors:
Dax A Hoffman

Brain Res Bull 2014 Apr 7;103. Epub 2014 Feb 7.

Molecular Neurophysiology and Biophysics Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2014.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180212PMC
April 2014

DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development.

Nat Commun 2013 ;4:2270

Molecular Neurophysiology and Biophysics Section, Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/ncomms3270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775611PMC
February 2014

K+ channel regulation of multicompartmental signal integration.

Authors:
Dax A Hoffman

Neuron 2013 Aug;79(3):403-5

Molecular Neurophysiology and Biophysics Section, Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771385PMC
August 2013

Repeated cocaine exposure increases fast-spiking interneuron excitability in the rat medial prefrontal cortex.

J Neurophysiol 2013 Jun 13;109(11):2781-92. Epub 2013 Mar 13.

Molecular Neurophysiology and Biophysics Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-3715, USA.

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http://dx.doi.org/10.1152/jn.00596.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680802PMC
June 2013

Synaptic plasticity by antidromic firing during hippocampal network oscillations.

Proc Natl Acad Sci U S A 2013 Mar 11;110(13):5175-80. Epub 2013 Mar 11.

Nervous System Development and Plasticity Section, Program in Development Neuroscience, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1210735110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612622PMC
March 2013

Dynamic regulation of synaptic maturation state by voltage-gated A-type K+ channels in CA1 hippocampal pyramidal neurons.

J Neurosci 2012 Oct;32(41):14427-32

Molecular Neurophysiology and Biophysics Unit, Program in Development Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2373-12.2
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http://dx.doi.org/10.1523/JNEUROSCI.2373-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489019PMC
October 2012

Loss of signal transducer and activator of transcription 3 (STAT3) signaling during elevated activity causes vulnerability in hippocampal neurons.

J Neurosci 2012 Oct;32(44):15511-20

Laboratory of Molecular Biology, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2940-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504487PMC
October 2012

A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension.

J Clin Endocrinol Metab 2012 Aug 24;97(8):E1532-9. Epub 2012 May 24.

Division of Endocrinology, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children's Hospital, Athens 11527, Greece.

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http://dx.doi.org/10.1210/jc.2012-1334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410272PMC
August 2012

Aberrant dendritic excitability: a common pathophysiology in CNS disorders affecting memory?

Mol Neurobiol 2012 Jun 22;45(3):478-87. Epub 2012 Apr 22.

Molecular Neurophysiology and Biophysics Unit, NICHD, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892-4995, USA.

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http://dx.doi.org/10.1007/s12035-012-8265-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496255PMC
June 2012

Differential cycling rates of Kv4.2 channels in proximal and distal dendrites of hippocampal CA1 pyramidal neurons.

Hippocampus 2012 May 6;22(5):969-80. Epub 2011 Apr 6.

Molecular Neurophysiology and Biophysics Unit, Laboratory of Cellular and Synaptic Neurophysiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892-3715, USA.

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http://doi.wiley.com/10.1002/hipo.20899
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http://dx.doi.org/10.1002/hipo.20899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134164PMC
May 2012

Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors.

Biol Mood Anxiety Disord 2012 Mar 2;2. Epub 2012 Mar 2.

Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.

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http://biolmoodanxietydisord.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/2045-5380-2-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384232PMC
March 2012

DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons.

Neuron 2011 Sep 21;71(6):1102-15. Epub 2011 Sep 21.

Molecular Neurophysiology and Biophysics Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184237PMC
September 2011

A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density.

J Biol Chem 2011 Jul 7;286(30):26496-506. Epub 2011 Jun 7.

Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1074/jbc.M111.254912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143614PMC
July 2011

Kv4.2 block of long-term potentiation is partially dependent on synaptic NMDA receptor remodeling.

Brain Res Bull 2011 Jan 8;84(1):17-21. Epub 2010 Oct 8.

Department of Physiology, Jeju National University, Republic of Korea.

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http://dx.doi.org/10.1016/j.brainresbull.2010.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496256PMC
January 2011

AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.

J Neurosci 2011 Jan;31(4):1323-32

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.5383-10.2
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http://dx.doi.org/10.1523/JNEUROSCI.5383-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035425PMC
January 2011

Dendritic ion channel trafficking and plasticity.

Trends Neurosci 2010 Jul 1;33(7):307-16. Epub 2010 Apr 1.

Department of Pharmacology, The School of Pharmacy, University of London, London, WC1N 1AX, UK.

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http://www.cell.com/trends/neurosciences/pdf/S0166-2236(10)0
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http://linkinghub.elsevier.com/retrieve/pii/S016622361000036
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http://dx.doi.org/10.1016/j.tins.2010.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902701PMC
July 2010

KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.

Mol Cell Neurosci 2010 Mar 4;43(3):315-25. Epub 2010 Jan 4.

Molecular Neurophysiology and Biophysics Unit, Laboratory of Cellular and Synaptic Neurophysiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.mcn.2009.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823810PMC
March 2010

Biphasic somatic A-type K channel downregulation mediates intrinsic plasticity in hippocampal CA1 pyramidal neurons.

PLoS One 2009 Aug 7;4(8):e6549. Epub 2009 Aug 7.

Molecular Neurophysiology and Biophysics Unit, Laboratory of Cellular and Synaptic Neurophysiology, NICHD, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006549PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717216PMC
August 2009

Kv4 accessory protein DPPX (DPP6) is a critical regulator of membrane excitability in hippocampal CA1 pyramidal neurons.

J Neurophysiol 2008 Oct 30;100(4):1835-47. Epub 2008 Jul 30.

Molecular Neurophysiology and Biophysics Unit, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Dr., Rm. 3C-905, Bethesda, MD 20892-3715, USA.

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http://dx.doi.org/10.1152/jn.90261.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576216PMC
October 2008

Protein kinase a mediates activity-dependent Kv4.2 channel trafficking.

J Neurosci 2008 Jul;28(30):7513-9

Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-3715, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1951-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665045PMC
July 2008

Potassium channels: newly found players in synaptic plasticity.

Neuroscientist 2008 Jun 15;14(3):276-86. Epub 2008 Apr 15.

Molecular Neurophysiology and Biophysics Unit, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1177/1073858408315041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665047PMC
June 2008

Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons.

Neuron 2007 Jun;54(6):933-47

Molecular Neurophysiology and Biophysics Unit, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuron.2007.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950443PMC
June 2007

Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones.

J Physiol 2005 Nov 1;569(Pt 1):41-57. Epub 2005 Sep 1.

Molecular Neurophysiology and Biophysics Unit, Laboratory of Synaptic and Cellular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3715, USA.

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http://dx.doi.org/10.1113/jphysiol.2005.095042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464206PMC
November 2005

Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses.

J Neurosci 2005 Oct;25(41):9378-83

National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-3714, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2100-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725708PMC
October 2005

Neuronal co-expression of EGFP and beta-galactosidase in mice causes neuropathology and premature death.

Neurobiol Dis 2004 Nov;17(2):310-8

Department of Molecular Neurobiology, Max-Planck-Institute for Medical Research, 69120 Heidelberg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S096999610400124
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http://dx.doi.org/10.1016/j.nbd.2004.05.012DOI Listing
November 2004

Active dendrites, potassium channels and synaptic plasticity.

Philos Trans R Soc Lond B Biol Sci 2003 Apr;358(1432):667-74

Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1098/rstb.2002.1248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693145PMC
April 2003

Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons.

Proc Natl Acad Sci U S A 2002 Jun 4;99(12):8366-71. Epub 2002 Jun 4.

Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.122210599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123073PMC
June 2002