Publications

Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.
Cancer Res 2016 Nov 20;76(21):6193-6204. Epub 2016 Sep 20.
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.
Proc Natl Acad Sci U S A 2016 Feb 21;113(6):E772-81. Epub 2016 Jan 21.
ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain

Essential role for autophagy during invariant NKT cell development.
Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5678-87. Epub 2014 Dec 15.
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom;

High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients.
J Immunol 2014 Sep 25;193(5):2118-26. Epub 2014 Jul 25.
Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom;

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.
Proc Natl Acad Sci U S A 2013 Dec 18;110(49):E4753-61. Epub 2013 Nov 18.
Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom.




Some lessons from the systematic production and structural analysis of soluble (alpha)(beta) T-cell receptors.
J Immunol Methods 2009 Oct 26;350(1-2):14-21. Epub 2009 Aug 26.
Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK.


Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.
Proc Natl Acad Sci U S A 2007 Dec 11;104(51):20490-5. Epub 2007 Dec 11.
Tumor Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.


Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.
J Exp Med 2006 Mar 6;203(3):699-710. Epub 2006 Mar 6.
Department of Rheumathology and Clinical Immunology, University of Bern, Inselspital, Berne CH-3010, Switzerland.

The crystal structure of human CD1d with and without alpha-galactosylceramide.
Nat Immunol 2005 Aug 10;6(8):819-26. Epub 2005 Jul 10.
Cancer Research UK Receptor Structure Research Group, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK.


Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.
J Clin Invest 2004 Dec;114(12):1800-11
Tumour Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.


Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.
Nat Immunol 2002 Aug 15;3(8):721-6. Epub 2002 Jul 15.
Cancer Research UK Tumour Immunology Group, The Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DS, UK. stephan.gadola@inselch

OF