Dawn M Riddle

Dawn M Riddle

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Dawn M Riddle

Dawn M Riddle

Publications by authors named "Dawn M Riddle"

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Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease.

Neurobiol Dis 2020 Mar 16;136:104712. Epub 2019 Dec 16.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026836PMC
March 2020

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau.

J Exp Med 2020 Feb;217(2)

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia PA.

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http://dx.doi.org/10.1084/jem.20190783DOI Listing
February 2020

Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.

Neuron 2020 Jan 20;105(2):260-275.e6. Epub 2019 Nov 20.

The Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981053PMC
January 2020

Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.

Neuron 2019 Dec 18. Epub 2019 Dec 18.

Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.neuron.2019.12.004DOI Listing
December 2019

α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons.

J Neurosci 2019 Jun 29;39(26):5080-5094. Epub 2019 Apr 29.

Departments of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research,

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http://dx.doi.org/10.1523/JNEUROSCI.0060-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595958PMC
June 2019

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity.

Acta Neuropathol 2018 06 3;135(6):855-875. Epub 2018 Mar 3.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Philadelphia, PA, 19104-4283, USA.

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http://dx.doi.org/10.1007/s00401-018-1829-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955788PMC
June 2018

Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies.

J Neuropathol Exp Neurol 2018 03;77(3):216-228

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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https://academic.oup.com/jnen/article/77/3/216/4839220
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http://dx.doi.org/10.1093/jnen/nly010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251598PMC
March 2018

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.

J Neurosci 2017 11 6;37(47):11485-11494. Epub 2017 Oct 6.

Department of Pathology and Laboratory Medicine and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104

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http://dx.doi.org/10.1523/JNEUROSCI.2393-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700428PMC
November 2017

Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

J Neurosci 2017 06 18;37(24):5870-5884. Epub 2017 May 18.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, and

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http://dx.doi.org/10.1523/JNEUROSCI.2705-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473205PMC
June 2017

Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.

Mol Biol Cell 2014 Dec 8;25(25):4010-23. Epub 2014 Oct 8.

Department of Pathology and Laboratory Medicine, Institute on Aging, and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104.

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http://dx.doi.org/10.1091/mbc.E14-02-0741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263445PMC
December 2014

Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins.

Acta Neuropathol Commun 2014 Mar 31;2:33. Epub 2014 Mar 31.

Center for Neurodegenerative Disease Research & Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-4283, USA.

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http://dx.doi.org/10.1186/2051-5960-2-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023626PMC
March 2014

Distinct α-synuclein strains differentially promote tau inclusions in neurons.

Cell 2013 Jul;154(1):103-17

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cell.2013.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820001PMC
July 2013

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.

Neuron 2011 Oct;72(1):57-71

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 USA.

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http://dx.doi.org/10.1016/j.neuron.2011.08.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204802PMC
October 2011