Dawn C Newcomb

Dawn C Newcomb

UNVERIFIED PROFILE

Are you Dawn C Newcomb?   Register this Author

Register author
Dawn C Newcomb

Dawn C Newcomb

Publications by authors named "Dawn C Newcomb"

Are you Dawn C Newcomb?   Register this Author

54Publications

979Reads

49Profile Views

IL-33 Is a Cell-Intrinsic Regulator of Fitness during Early B Cell Development.

J Immunol 2019 Sep 7;203(6):1457-1467. Epub 2019 Aug 7.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1900408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736727PMC
September 2019

Association of estrogen receptor α polymorphism rs1999805 with asthma.

Ann Allergy Asthma Immunol 2019 Feb 16;122(2):208-210. Epub 2018 Nov 16.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2018.11.005DOI Listing
February 2019

Sex-specific association between prenatal life stress exposure and infant pro-inflammatory cytokine levels during acute respiratory infection.

Brain Behav Immun 2019 02 11;76:275-279. Epub 2018 Dec 11.

Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-2650, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbi.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380181PMC
February 2019

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.

Cell 2018 12 1;175(7):1780-1795.e19. Epub 2018 Nov 1.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Immunobiology, Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00928674183130
Publisher Site
http://dx.doi.org/10.1016/j.cell.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361668PMC
December 2018

Sex Bias in Asthma Prevalence and Pathogenesis.

Front Immunol 2018 18;9:2997. Epub 2018 Dec 18.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.02997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305471PMC
December 2018

Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo.

J Allergy Clin Immunol 2018 11 10;142(5):1515-1528.e8. Epub 2018 Jan 10.

Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tenn. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749183002
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2017.11.043DOI Listing
November 2018

The PGI Analog Cicaprost Inhibits IL-33-Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4 T Cells.

J Immunol 2018 10 20;201(7):1936-1945. Epub 2018 Aug 20.

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1700605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162094PMC
October 2018

Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.

J Immunol 2018 10 20;201(7):1843-1854. Epub 2018 Aug 20.

Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1800293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143420PMC
October 2018

Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology.

J Allergy Clin Immunol 2018 08 17;142(2):683-687.e12. Epub 2018 Apr 17.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749183056
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2018.01.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078807PMC
August 2018

Hormones, sex, and asthma.

Ann Allergy Asthma Immunol 2018 05 2;120(5):488-494. Epub 2018 Feb 2.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2018.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936670PMC
May 2018

Endogenous PGI signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model.

Prostaglandins Other Lipid Mediat 2018 05 13;136:33-43. Epub 2018 Apr 13.

Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prostaglandins.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970997PMC
May 2018

IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow.

J Exp Med 2018 01 8;215(1):263-281. Epub 2017 Dec 8.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20170449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748848PMC
January 2018

Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation.

Cell Rep 2017 11;21(9):2487-2499

Department of Medicine, Vanderbilt University Medical Center, T-1221 Medical Center North, 1161 21(st) Avenue, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Medical Center North, 1161 21(st) Avenue, Nashville, TN 37232, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.10.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731254PMC
November 2017

Mechanisms Driving Gender Differences in Asthma.

Curr Allergy Asthma Rep 2017 Mar;17(3):19

Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, 37232, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11882-017-0686-1
Publisher Site
http://dx.doi.org/10.1007/s11882-017-0686-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629917PMC
March 2017

Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin.

J Allergy Clin Immunol 2016 09 9;138(3):814-824.e11. Epub 2016 Apr 9.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.01.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014571PMC
September 2016

Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation.

J Immunol 2016 09 25;197(5):1577-86. Epub 2016 Jul 25.

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232; and Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1501063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992670PMC
September 2016

The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation.

Thorax 2016 07 12;71(7):633-45. Epub 2016 Apr 12.

Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2015-207728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941189PMC
July 2016

STAT6 Signaling Attenuates Interleukin-17-Producing γδ T Cells during Acute Klebsiella pneumoniae Infection.

Infect Immun 2016 May 22;84(5):1548-1555. Epub 2016 Apr 22.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/IAI.00646-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862712PMC
May 2016

STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.

J Virol 2014 Sep 11;88(17):9655-72. Epub 2014 Jun 11.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.03299-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136353PMC
September 2014

Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner.

Infect Immun 2014 Sep 23;82(9):3723-39. Epub 2014 Jun 23.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

View Article

Download full-text PDF

Source
http://iai.asm.org/lookup/doi/10.1128/IAI.00035-14
Publisher Site
http://dx.doi.org/10.1128/IAI.00035-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187810PMC
September 2014

Th17-mediated inflammation in asthma.

Curr Opin Immunol 2013 Dec 11;25(6):755-60. Epub 2013 Sep 11.

Vanderbilt University Medical Center, Department of Medicine, Nashville, TN 37232, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coi.2013.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855890PMC
December 2013

Deficiency of gp91phox inhibits allergic airway inflammation.

Am J Respir Cell Mol Biol 2013 Sep;49(3):396-402

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232-2650, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2012-0442OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824054PMC
September 2013

PGI₂ signaling inhibits antigen uptake and increases migration of immature dendritic cells.

J Leukoc Biol 2013 Jul 26;94(1):77-88. Epub 2013 Apr 26.

Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, 1161 21st Ave., T-1218 MCN, Nashville, TN 37232-2650, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1189/jlb.1112559
Publisher Site
http://dx.doi.org/10.1189/jlb.1112559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685021PMC
July 2013

β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin.

Am J Respir Crit Care Med 2013 Mar 10;187(6):630-9. Epub 2013 Jan 10.

Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232-2650, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201205-0972OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733436PMC
March 2013

Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice.

Exp Lung Res 2012 Apr;38(3):135-46

Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2650, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/01902148.2012.658595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046254PMC
April 2012

PGI2 as a regulator of CD4+ subset differentiation and function.

Prostaglandins Other Lipid Mediat 2011 Nov 12;96(1-4):21-6. Epub 2011 Aug 12.

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prostaglandins.2011.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215832PMC
November 2011

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs.

Proc Natl Acad Sci U S A 2011 Jun 13;108(26):10562-7. Epub 2011 Jun 13.

Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1107559108
Publisher Site
http://dx.doi.org/10.1073/pnas.1107559108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127925PMC
June 2011

Bugs and asthma: a different disease?

Proc Am Thorac Soc 2009 May;6(3):266-71

Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232-2650, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1513/pats.200806-056RMDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677401PMC
May 2009

Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses.

J Immunol 2008 Oct;181(8):5360-7

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.181.8.5360DOI Listing
October 2008

Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression.

Am J Physiol Lung Cell Mol Physiol 2007 Oct 13;293(4):L1021-8. Epub 2007 Jul 13.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109-0688, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00060.2007DOI Listing
October 2007

Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells.

J Virol 2007 Feb 22;81(3):1186-94. Epub 2006 Nov 22.

Department of Pediatrics, University of Michigan, 1150 W. Medical Center Dr., Room 3570, MSRBII, Box 0688, Ann Arbor, MI 48109-0688, USA.

View Article

Download full-text PDF

Source
http://jvi.asm.org/content/81/3/1186.full.pdf
Web Search
http://jvi.asm.org/cgi/doi/10.1128/JVI.02309-06
Publisher Site
http://dx.doi.org/10.1128/JVI.02309-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797503PMC
February 2007

H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression.

FASEB J 2006 Oct 16;20(12):2121-3. Epub 2006 Aug 16.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.06-5806fjeDOI Listing
October 2006

Phosphatidylinositol 3-kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression.

J Biol Chem 2005 Nov 24;280(44):36952-61. Epub 2005 Aug 24.

Department of Pediatrics, Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M502449200DOI Listing
November 2005

Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.

Am J Respir Crit Care Med 2004 Mar 23;169(6):703-11. Epub 2003 Dec 23.

Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109-0688, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.200307-964OCDOI Listing
March 2004

Proliferation of the airway epithelium in asthma: are inflammatory cells required?

Chest 2003 Mar;123(3 Suppl):384S-5S

North Carolina State University, Raleigh, NC 27606, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1378/chest.123.3_suppl.384sDOI Listing
March 2003