David Weiner

David Weiner

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David Weiner

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Increased opioid consumption in diabetics with operative ankle fractures: a retrospective case-control study.

Eur J Orthop Surg Traumatol 2019 Aug 8;29(6):1319-1323. Epub 2019 Apr 8.

Department of Orthopedic Surgery, MedStar Union Memorial Hospital, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s00590-019-02428-0DOI Listing
August 2019

Intradermal Synthetic DNA Vaccination Generates -Specific T Cells in the Skin and Protection against Leishmania major.

Infect Immun 2019 Aug 23;87(8). Epub 2019 Jul 23.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/IAI.00227-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652766PMC
August 2019

Differences in Acidosis-Stimulated Renal Ammonia Metabolism in the Male and Female Kidney.

Am J Physiol Renal Physiol 2019 Aug 7. Epub 2019 Aug 7.

Div. of Nephrol., Hypertension & Transplant., University of Florida College of Medicine, United States.

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http://dx.doi.org/10.1152/ajprenal.00244.2019DOI Listing
August 2019

Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance.

Semin Nephrol 2019 Jul;39(4):394-405

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, FL.

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http://dx.doi.org/10.1016/j.semnephrol.2019.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629433PMC
July 2019

Regulation of Renal NaDC1 Expression and Citrate Excretion by NBCe1-A.

Am J Physiol Renal Physiol 2019 Jun 12. Epub 2019 Jun 12.

Div. of Nephrol., Hypertension & Transplant., University of Florida College of Medicine, United States.

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http://dx.doi.org/10.1152/ajprenal.00015.2019DOI Listing
June 2019

Designed DNA-Encoded IL-36 Gamma Acts as a Potent Molecular Adjuvant Enhancing Zika Synthetic DNA Vaccine-Induced Immunity and Protection in a Lethal Challenge Model.

Vaccines (Basel) 2019 May 22;7(2). Epub 2019 May 22.

Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.3390/vaccines7020042DOI Listing
May 2019

Novel Synthetic DNA Immunogens Targeting Latent Expressed Antigens of Epstein-Barr Virus Elicit Potent Cellular Responses and Inhibit Tumor Growth.

Vaccines (Basel) 2019 May 24;7(2). Epub 2019 May 24.

Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.3390/vaccines7020044DOI Listing
May 2019

Clock gene expression is altered in veterans with sleep apnea.

Physiol Genomics 2019 Mar 18;51(3):77-82. Epub 2019 Jan 18.

Department of Medicine, Division of Nephrology, University of Florida , Gainesville, Florida.

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http://dx.doi.org/10.1152/physiolgenomics.00091.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459375PMC
March 2019

Engineered DNA Vaccination against Follicle-Stimulating Hormone Receptor Delays Ovarian Cancer Progression in Animal Models.

Mol Ther 2019 02 13;27(2):314-325. Epub 2018 Dec 13.

Vaccine and Immunotherapy Center, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183055
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http://dx.doi.org/10.1016/j.ymthe.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369450PMC
February 2019

Engineered transfer RNAs for suppression of premature termination codons.

Nat Commun 2019 02 18;10(1):822. Epub 2019 Feb 18.

Department of Molecular Physiology and Biophysics, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.

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http://dx.doi.org/10.1038/s41467-019-08329-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379413PMC
February 2019

Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics.

Mol Ther 2019 01 15;27(1):188-199. Epub 2018 Nov 15.

Vaccine and Immunotherapy Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183050
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http://dx.doi.org/10.1016/j.ymthe.2018.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319316PMC
January 2019

It Takes a Matured mAb to Treat Ebolavirus Infection.

Cell Host Microbe 2019 01;25(1):10-12

Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128183064
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http://dx.doi.org/10.1016/j.chom.2018.12.013DOI Listing
January 2019

Designing consensus immunogens to break tolerance to self-antigens for cancer therapy.

Oncotarget 2018 Oct 30;9(85):35513-35514. Epub 2018 Oct 30.

David B. Weiner: Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.26275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238978PMC
October 2018

Expression of the B splice variant of NBCe1 (SLC4A4) in the mouse kidney.

Am J Physiol Renal Physiol 2018 09 4;315(3):F417-F428. Epub 2018 Apr 4.

Division of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine , Gainesville, Florida.

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http://dx.doi.org/10.1152/ajprenal.00515.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172571PMC
September 2018

Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig.

EBioMedicine 2018 Sep 30;35:97-105. Epub 2018 Aug 30.

Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161476PMC
September 2018

Differences in renal ammonia metabolism in male and female kidney.

Am J Physiol Renal Physiol 2018 08 21;315(2):F211-F222. Epub 2018 Mar 21.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine , Gainesville, Florida.

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https://www.physiology.org/doi/10.1152/ajprenal.00084.2018
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http://dx.doi.org/10.1152/ajprenal.00084.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139524PMC
August 2018

Broad cross-protective anti-hemagglutination responses elicited by influenza microconsensus DNA vaccine.

Vaccine 2018 05;36(22):3079-3089

The Wistar Institute of Anatomy & Biology, 3601 Spruce St, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2017.09.086DOI Listing
May 2018

Mechanism of Hyperkalemia-Induced Metabolic Acidosis.

J Am Soc Nephrol 2018 May 26;29(5):1411-1425. Epub 2018 Feb 26.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida;

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http://dx.doi.org/10.1681/ASN.2017111163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967781PMC
May 2018

Herd immunity: hyperimmune globulins for the 21st century.

Lancet Infect Dis 2018 04 9;18(4):361-363. Epub 2018 Jan 9.

The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30003-3DOI Listing
April 2018

NBCe1-A Regulates Proximal Tubule Ammonia Metabolism under Basal Conditions and in Response to Metabolic Acidosis.

J Am Soc Nephrol 2018 Apr 26;29(4):1182-1197. Epub 2018 Feb 26.

Division of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida;

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http://www.jasn.org/lookup/doi/10.1681/ASN.2017080935
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http://dx.doi.org/10.1681/ASN.2017080935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875958PMC
April 2018

Protocols for Developing Novel Chikungunya Virus DNA Vaccines.

Methods Mol Biol 2016 ;1426:311-32

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/978-1-4939-3618-2_28DOI Listing
December 2017

Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH.

Kidney Int Rep 2017 Nov 21;2(6):1111-1121. Epub 2017 Jun 21.

Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1016/j.ekir.2017.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733879PMC
November 2017

Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine - Preliminary Report.

N Engl J Med 2017 Oct 4. Epub 2017 Oct 4.

From the Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania (P.T.), and Wistar Institute (K.M., E.L.R., S.B.K., F.I.Z., H.C., D.B.W.), Philadelphia, and Inovio Pharmaceuticals, Plymouth Meeting (S.W., A.S.K., J.B., M.B.) - all in Pennsylvania; GeneOne Life Science, Seoul, South Korea (C.C.R., Y.K.P., C.R., S.E.S., J.N.M.); Infectious Diseases Research Centre-Université Laval, Quebec, QC, Canada (T.R., S.T., G.P.K.); QPS-Miami Research Associates, Miami, (D.K.); and the Department of Medicine, Morristown Medical Center, Morristown, NJ (J.N.M.).

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http://dx.doi.org/10.1056/NEJMoa1708120DOI Listing
October 2017

Proximal tubule glutamine synthetase expression is necessary for the normal response to dietary protein restriction.

Am J Physiol Renal Physiol 2017 07 22;313(1):F116-F125. Epub 2017 Mar 22.

Division of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida; and

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http://dx.doi.org/10.1152/ajprenal.00048.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538840PMC
July 2017

Roles of renal ammonia metabolism other than in acid-base homeostasis.

Authors:
I David Weiner

Pediatr Nephrol 2017 06 12;32(6):933-942. Epub 2016 May 12.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, PO Box 100224, Gainesville, FL, 32610-0224, USA.

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http://dx.doi.org/10.1007/s00467-016-3401-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107182PMC
June 2017

Ammonia Transporters and Their Role in Acid-Base Balance.

Physiol Rev 2017 04;97(2):465-494

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida; and Nephrology and Hypertension Section, North Florida/South Georgia Veterans Health System, Gainesville, Florida.

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http://dx.doi.org/10.1152/physrev.00011.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539407PMC
April 2017

Expression of sodium-dependent dicarboxylate transporter 1 (NaDC1/SLC13A2) in normal and neoplastic human kidney.

Am J Physiol Renal Physiol 2017 03 7;312(3):F427-F435. Epub 2016 Dec 7.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida;

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http://dx.doi.org/10.1152/ajprenal.00559.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374311PMC
March 2017

DNA Vaccines: A Strategy for Developing Novel Multivalent TB Vaccines.

Methods Mol Biol 2016 ;1403:355-61

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 505 Stellar-Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/978-1-4939-3387-7_18DOI Listing
December 2016

A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis.

Hum Vaccin Immunother 2016 10 20;12(10):2649-2653. Epub 2016 Jun 20.

a Department of Molecular Microbiology , Washington University in St. Louis , St. Louis , MO , USA.

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http://dx.doi.org/10.1080/21645515.2016.1197454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085007PMC
October 2016

Hydration status affects osteopontin expression in the rat kidney.

J Vet Sci 2016 Sep;17(3):269-77

Department of Anatomy, Ewha Womans University School of Medicine, Seoul 03760, Korea.

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http://dx.doi.org/10.4142/jvs.2016.17.3.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037293PMC
September 2016

Recent advances in understanding renal ammonia metabolism and transport.

Curr Opin Nephrol Hypertens 2016 09;25(5):436-43

aDivision of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine bNephrology and Hypertension Section, North Florida/South Georgia Veterans Health System, Gainesville, Florida, USA.

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http://dx.doi.org/10.1097/MNH.0000000000000255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974126PMC
September 2016

Untangling the complex relationship between dietary acid load and glucocorticoid metabolism.

Authors:
I David Weiner

Kidney Int 2016 08;90(2):247-249

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida, USA; and Nephrology and Hypertension Section, Gainesville VA Medical Center, Gainesville, Florida, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361884PMC
August 2016

New insights into the molecular regulation of urine concentration.

Authors:
I David Weiner

Am J Physiol Renal Physiol 2016 07 30;311(1):F184-5. Epub 2016 Mar 30.

Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida College Of Medicine, Gainesville, Florida; and Nephrology and Hypertension Section, Gainesville Veterans Affairs Medical Center, Gainesville, Florida

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http://dx.doi.org/10.1152/ajprenal.00161.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967159PMC
July 2016

Proximal tubule-specific glutamine synthetase deletion alters basal and acidosis-stimulated ammonia metabolism.

Am J Physiol Renal Physiol 2016 06 23;310(11):F1229-42. Epub 2016 Mar 23.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida; Nephrology and Hypertension Section, North Florida/South Georgia Veterans Health System, Gainesville, Florida

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http://dx.doi.org/10.1152/ajprenal.00547.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935770PMC
June 2016

Alarmin IL-33 elicits potent TB-specific cell-mediated responses.

Hum Vaccin Immunother 2015 ;11(8):1954-60

a Department of Pathology and Laboratory Medicine ; Perelman School of Medicine; University of Pennsylvania ; Philadelphia , PA USA.

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http://dx.doi.org/10.1080/21645515.2015.1026499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635936PMC
May 2016

DNA vaccines 2014 meeting: Highlights and overview.

Hum Vaccin Immunother 2015 ;11(8):1887-8

a University of South Florida Morsani College of Medicine ; Tampa , FL USA.

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http://dx.doi.org/10.1080/21645515.2015.1066947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635935PMC
May 2016

REDD1 Is Essential for Optimal T Cell Proliferation and Survival.

PLoS One 2015 24;10(8):e0136323. Epub 2015 Aug 24.

Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America; Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136323PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547781PMC
May 2016

Effect of NBCe1 deletion on renal citrate and 2-oxoglutarate handling.

Physiol Rep 2016 Apr;4(8)

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida Nephrology and Hypertension Section, North Florida/South Georgia Veterans Health System, Gainesville, Florida

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http://dx.doi.org/10.14814/phy2.12778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848728PMC
April 2016

Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity.

Mol Ther 2015 Oct 30;23(10):1653-62. Epub 2015 Jun 30.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15250016163029
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http://dx.doi.org/10.1038/mt.2015.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817913PMC
October 2015

NBCe1 expression is required for normal renal ammonia metabolism.

Am J Physiol Renal Physiol 2015 Oct 29;309(7):F658-66. Epub 2015 Jul 29.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida; Nephrology and Hypertension Section, Gainesville Veterans Administration Medical Center, Gainesville, Florida

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http://www.physiology.org/doi/10.1152/ajprenal.00219.2015
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http://dx.doi.org/10.1152/ajprenal.00219.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593816PMC
October 2015

Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion.

Clin J Am Soc Nephrol 2015 Aug 30;10(8):1444-58. Epub 2014 Jul 30.

Nephrology Division, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.2215/CJN.10311013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527031PMC
August 2015

Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model.

Vaccine 2015 Aug 14;33(35):4313-20. Epub 2015 Apr 14.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.03.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546882PMC
August 2015

Multivalent TB vaccines targeting the esx gene family generate potent and broad cell-mediated immune responses superior to BCG.

Hum Vaccin Immunother 2014 ;10(8):2188-98

a Department of Pathology and Laboratory Medicine; University of Pennsylvania School of Medicine; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/hv.29574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896768PMC
July 2015

Synthetic DNA approach to cytomegalovirus vaccine/immune therapy.

Adv Exp Med Biol 2015 ;848:131-48

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, 505A Stellar-Chance Laboratories Curie Blvd, Philadelphia, 19104, PA, USA.

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http://dx.doi.org/10.1007/978-1-4939-2432-5_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573556PMC
July 2015

Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy.

Sci Rep 2015 Jul 29;5:12616. Epub 2015 Jul 29.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/srep12616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518257PMC
July 2015

Effect of dietary protein restriction on renal ammonia metabolism.

Am J Physiol Renal Physiol 2015 Jun 29;308(12):F1463-73. Epub 2015 Apr 29.

Division of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida, Nephrology and Hypertension Section, Medical Service, North Florida/South Georgia Veterans Health System, Gainesville, Florida

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http://ajprenal.physiology.org/content/ajprenal/early/2015/0
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http://ajprenal.physiology.org/content/ajprenal/308/12/F1463
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http://ajprenal.physiology.org/lookup/doi/10.1152/ajprenal.0
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http://dx.doi.org/10.1152/ajprenal.00077.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469882PMC
June 2015

IL-33 isoforms: their future as vaccine adjuvants?

Expert Rev Vaccines 2015 Apr 6;14(4):489-92. Epub 2015 Feb 6.

Department of Pathology, University of Pennsylvania, 505A Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1586/14760584.2015.1011135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573560PMC
April 2015

An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo.

Infect Immun 2014 Oct 14;82(10):4080-91. Epub 2014 Jul 14.

Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/IAI.01950-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187890PMC
October 2014

Highly optimized DNA vaccine targeting human telomerase reverse transcriptase stimulates potent antitumor immunity.

Cancer Immunol Res 2013 Sep 17;1(3):179-189. Epub 2013 Jul 17.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096936PMC
September 2013