Publications by authors named "David Wedge"

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Antifungal activities of cytochalasins produced by Diaporthe miriciae, an endophytic fungus associated with tropical medicinal plants.
Can J Microbiol 2018 Jun 6. Epub 2018 Jun 6.
Universidade Federal de Minas Gerais , Av. Ant�nio Carlos, 6627, Campus Pampulha, CP 486. , Instituto de Ci�ncais Biol�gicas , Belo Horizonte, Minas Gerais, Brazil , 31270-901 ;

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.
Nat Genet 2018 May 16;50(5):682-692. Epub 2018 Apr 16.
The Institute of Cancer Research, London, UK.

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.
Oncotarget 2016 Nov;7(45):72685-72698
Center for Hematology and Regenerative Medicine, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Molecular Phylogeny, Diversity, and Bioprospecting of Endophytic Fungi Associated with wild Ethnomedicinal North American Plant Echinacea purpurea (Asteraceae).
Chem Biodivers 2016 Jul 6;13(7):918-30. Epub 2016 Jul 6.
Department of Microbiology, Institute of Biological Science, Federal University of Minas Gerais, P.O. Box 486, Belo Horizonte, MG, CEP 31270-901, Brazil.

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.
Haematologica 2015 Nov 6;100(11):e438-42. Epub 2015 Aug 6.
Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK

Diversity and antifungal activity of the endophytic fungi associated with the native medicinal cactus Opuntia humifusa (Cactaceae) from the United States.
Microbiol Res 2015 Jun 21;175:67-77. Epub 2015 Mar 21.
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics.
J Pathol Clin Res 2015 Apr 16;1(2):113-23. Epub 2015 Mar 16.
UCL Cancer Institute, University College LondonHuntley StreetLondonUK; Sarah Cannon-University College London Advanced Diagnostics Molecular Profiling Research LaboratoriesUCL Cancer Institute, UCLLondonUK; Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustMiddlesexUK.

Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.
Nat Commun 2015 Apr 1;6:6605. Epub 2015 Apr 1.
1] Department of Surgery, Division of Urology, Royal Melbourne Hospital and University of Melbourne, Parkville 3050, Victoria, Australia [2] The Epworth Prostate Centre, Epworth Hospital, Richmond 3121, Victoria, Australia.

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.
Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.
1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

Effect of mutation order on myeloproliferative neoplasms.
N Engl J Med 2015 Feb;372(7):601-612
Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Stem Cell Institute (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., A.R.G.) and Department of Hematology (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., G.S.V., P.J.C., A.R.G.), University of Cambridge, Department of Haematology, Addenbrooke's Hospital (C.A.O., J.N., J.G., E.J.B., A.L.G., G.S.V., P.J.C., A.R.G.), Wellcome Trust Sanger Institute (D.C.W., E.P., G.S.V., P.J.C.), and Cancer Research U.K. Cambridge Institute, Li Ka Shing Centre (S.M.), Cambridge, and Guy's and St. Thomas' National Health Service Foundation Trust, Guy's Hospital, London (C.N.H.) - all in the United Kingdom; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy (P.G., A.V.); Departments of Pathology (B.B.) and Hematology (C.B.), Hospital del Mar, Barcelona; and the Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany (K.D.).

Antifungal compounds from turmeric and nutmeg with activity against plant pathogens.
Fitoterapia 2014 Dec 27;99:341-6. Epub 2014 Aug 27.
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. Electronic address:

Differential and limited expression of mutant alleles in multiple myeloma.
Blood 2014 Nov 18;124(20):3110-7. Epub 2014 Sep 18.
Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Department of Hematology/Oncology, Boston Veterans Administration Healthcare System, West Roxbury, MA;

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing.
Science 2014 Oct;346(6206):256-9
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Honorary Faculty, Wellcome Trust Sanger Institute, Hinxton, UK CB10 1SA.

Fast randomization of large genomic datasets while preserving alteration counts.
Bioinformatics 2014 Sep;30(17):i617-23
Fondazione Bruno Kessler, I-38100 Povo (Trento), Italy, European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge CB10 1SD, UK, Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK and Universitat Pompeu Fabra, Barcelona 08003, Spain.

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.
Cancer Cell 2014 Jun 15;25(6):794-808. Epub 2014 May 15.
Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

Insecticidal, repellent and fungicidal properties of novel trifluoromethylphenyl amides.
Pestic Biochem Physiol 2013 Sep 18;107(1):138-47. Epub 2013 Jun 18.
Emerging Pathogens Institute, Department of Entomology and Nematology, University of Florida, Gainesville, FL 32610-0009, USA.

Antifungal activity of extracts from endophytic fungi associated with Smallanthus maintained in vitro as autotrophic cultures and as pot plants in the greenhouse.
Can J Microbiol 2012 Oct 15;58(10):1202-11. Epub 2012 Oct 15.
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, P.O. Box 486, CEP 31270-901, Brazil.

Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids.
J Agric Food Chem 2011 Mar 11;59(5):1673-82. Epub 2011 Feb 11.
National Peanut Research Laboratory, Agricultural Research Service, United States Department of Agriculture , Dawson, Georgia 39842, United States.

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.
Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma.
Cancer Res 2016 09 3;76(17):5092-102. Epub 2016 Aug 3.
Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. Department for Environmental Health and Science, University College of Southeast Norway, Bø, Norway.