David Wedge

David Wedge

UNVERIFIED PROFILE

Are you David Wedge?   Register this Author

Register author
David Wedge

David Wedge

Publications by authors named "David Wedge"

Are you David Wedge?   Register this Author

100Publications

4768Reads

20Profile Views

Fungicidal Properties of Some Novel Trifluoromethylphenyl Amides.

Chem Biodivers 2019 May 25;16(5):e1800618. Epub 2019 Apr 25.

U.S. Department of Agriculture-Agricultural Research Service, Center for Medical, Agricultural, and Veterinary Entomology, Gainesville, FL 32608, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbdv.201800618DOI Listing
May 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41586-019-0883-2
Publisher Site
http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

New Phytotoxic Cassane-like Diterpenoids from Eragrostis plana.

J Agric Food Chem 2019 Feb 11;67(7):1973-1981. Epub 2019 Feb 11.

Agronomy Graduate Program , University of Passo Fundo , Passo Fundo , Rio Grande do Sul 99052-900 , Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.8b06832DOI Listing
February 2019

Bioassay-Guided Isolation and Structure Elucidation of Fungicidal and Herbicidal Compounds from Ambrosia salsola (Asteraceae).

Molecules 2019 Feb 26;24(5). Epub 2019 Feb 26.

Agricultural Research Service, U.S. Department of Agriculture, Natural Products Utilization Research Unit, P.O. Box 1848, University, Oxford, MS 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24050835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429092PMC
February 2019

Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

N Engl J Med 2018 10;379(15):1416-1430

From the Wellcome-MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research (J.G., C.E.M., F.L.N., A.R.G., P.J.C.), the Department of Haematology, University of Cambridge (J.G., E.J.B., C.M., J.C., C.E.M., F.L.N., A.R.G.), and the Department of Haematology, Cambridge University Hospitals NHS Foundation Trust (J.G., E.J.B., A.L.G., C.M., J.C., A.R.G.), Cambridge, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus (J.N., D.C.W., N.A., E.P., G.G., L.O., S.O., J.W.T., A.P.B., N.W., P.J.C.), and the European Molecular Biology Laboratory, European Bioinformatics Institute (R.C., M.G.), Hinxton, Big Data Institute, University of Oxford, Oxford (D.C.W.), the Department of Haematology, Queen's University Belfast, Belfast (M.F.M.), and the Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London (C.N.H.) - all in the United Kingdom; the Center for Molecular Oncology and the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York (E.P., G.G.); the Department of Hematology, Zealand University Hospital, Roskilde, and the University of Copenhagen, Copenhagen (C.L.A., H.C.H.); and the Department of Experimental and Clinical Medicine, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy (P.G., A.M.V.).

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMoa1716614
Publisher Site
http://dx.doi.org/10.1056/NEJMoa1716614DOI Listing
October 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41588-018-0086-z
Publisher Site
http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Principles of Reconstructing the Subclonal Architecture of Cancers.

Cold Spring Harb Perspect Med 2017 Aug 1;7(8). Epub 2017 Aug 1.

The Francis Crick Institute, London NW1 1AT, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a026625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538405PMC
August 2017

Synthesis and insecticidal activity of novel pyrimidine derivatives containing urea pharmacophore against Aedes aegypti.

Pest Manag Sci 2017 May 1;73(5):953-959. Epub 2016 Sep 1.

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ps.4370DOI Listing
May 2017

Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution.

Br J Haematol 2017 03 7;176(5):825-829. Epub 2016 Apr 7.

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.13999DOI Listing
March 2017

How Subclonal Modeling Is Changing the Metastatic Paradigm.

Clin Cancer Res 2017 Feb 18;23(3):630-635. Epub 2016 Nov 18.

Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-16-0234DOI Listing
February 2017

ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data.

Curr Protoc Bioinformatics 2016 12 8;56:15.9.1-15.9.17. Epub 2016 Dec 8.

Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpbi.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097604PMC
December 2016

Chemical and Biological Study of Cladosporin, an Antimicrobial Inhibitor: A Review.

Nat Prod Commun 2016 Oct;11(10):1595-1600

View Article

Download full-text PDF

Source
October 2016

Synthesis and Biological Evaluation of 3,5-Dimethoxystilbene Analogs.

Chem Biodivers 2016 Sep 8;13(9):1165-1177. Epub 2016 Sep 8.

Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 1848, University, Mississippi, 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbdv.201500516DOI Listing
September 2016

The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma.

Cancer Res 2016 09 3;76(17):5092-102. Epub 2016 Aug 3.

Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. Department for Environmental Health and Science, University College of Southeast Norway, Bø, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-0658DOI Listing
September 2016

Molecular Phylogeny, Diversity, and Bioprospecting of Endophytic Fungi Associated with wild Ethnomedicinal North American Plant Echinacea purpurea (Asteraceae).

Chem Biodivers 2016 Jul 6;13(7):918-30. Epub 2016 Jul 6.

Department of Microbiology, Institute of Biological Science, Federal University of Minas Gerais, P.O. Box 486, Belo Horizonte, MG, CEP 31270-901, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbdv.201500299DOI Listing
July 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature17676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.

Elife 2016 05 17;5. Epub 2016 May 17.

Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.14552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869914PMC
May 2016

Clock-like mutational processes in human somatic cells.

Nat Genet 2015 Dec 9;47(12):1402-7. Epub 2015 Nov 9.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783858PMC
December 2015

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.

Haematologica 2015 Nov 6;100(11):e438-42. Epub 2015 Aug 6.

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2015.129510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825297PMC
November 2015

Phomalactone from a Phytopathogenic Fungus Infecting ZINNIA elegans (ASTERACEAE) Leaves.

J Chem Ecol 2015 Jul 2;41(7):602-12. Epub 2015 Jul 2.

United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P.O. Box 1848, University, MS, 38677, USA,

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s10886-015-0602
Web Search
http://link.springer.com/10.1007/s10886-015-0602-x
Publisher Site
http://dx.doi.org/10.1007/s10886-015-0602-xDOI Listing
July 2015

Diversity and antifungal activity of the endophytic fungi associated with the native medicinal cactus Opuntia humifusa (Cactaceae) from the United States.

Microbiol Res 2015 Jun 21;175:67-77. Epub 2015 Mar 21.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

View Article

Download full-text PDF

Source
http://ac.els-cdn.com/S0944501315000488/1-s2.0-S094450131500
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S094450131500048
Publisher Site
http://dx.doi.org/10.1016/j.micres.2015.03.007DOI Listing
June 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

View Article

Download full-text PDF

Source
https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
Web Search
http://www.nature.com/doifinder/10.1038/ng.3221
Publisher Site
http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics.

J Pathol Clin Res 2015 Apr 16;1(2):113-23. Epub 2015 Mar 16.

UCL Cancer Institute, University College LondonHuntley StreetLondonUK; Sarah Cannon-University College London Advanced Diagnostics Molecular Profiling Research LaboratoriesUCL Cancer Institute, UCLLondonUK; Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustMiddlesexUK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cjp2.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858131PMC
April 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3202DOI Listing
March 2015

Effect of mutation order on myeloproliferative neoplasms.

N Engl J Med 2015 Feb;372(7):601-612

Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Stem Cell Institute (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., A.R.G.) and Department of Hematology (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., G.S.V., P.J.C., A.R.G.), University of Cambridge, Department of Haematology, Addenbrooke's Hospital (C.A.O., J.N., J.G., E.J.B., A.L.G., G.S.V., P.J.C., A.R.G.), Wellcome Trust Sanger Institute (D.C.W., E.P., G.S.V., P.J.C.), and Cancer Research U.K. Cambridge Institute, Li Ka Shing Centre (S.M.), Cambridge, and Guy's and St. Thomas' National Health Service Foundation Trust, Guy's Hospital, London (C.N.H.) - all in the United Kingdom; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy (P.G., A.V.); Departments of Pathology (B.B.) and Hematology (C.B.), Hospital del Mar, Barcelona; and the Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany (K.D.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1412098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660033PMC
February 2015

Antifungal compounds from turmeric and nutmeg with activity against plant pathogens.

Fitoterapia 2014 Dec 27;99:341-6. Epub 2014 Aug 27.

National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2014.08.021DOI Listing
December 2014

Differential and limited expression of mutant alleles in multiple myeloma.

Blood 2014 Nov 18;124(20):3110-7. Epub 2014 Sep 18.

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Department of Hematology/Oncology, Boston Veterans Administration Healthcare System, West Roxbury, MA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-04-569327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231420PMC
November 2014

A comparison of different chemometrics approaches for the robust classification of electronic nose data.

Anal Bioanal Chem 2014 Nov 7;406(29):7581-90. Epub 2014 Oct 7.

School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00216-014-8216-7
Publisher Site
http://dx.doi.org/10.1007/s00216-014-8216-7DOI Listing
November 2014

Fast randomization of large genomic datasets while preserving alteration counts.

Bioinformatics 2014 Sep;30(17):i617-23

Fondazione Bruno Kessler, I-38100 Povo (Trento), Italy, European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge CB10 1SD, UK, Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK and Universitat Pompeu Fabra, Barcelona 08003, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btu474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147926PMC
September 2014

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Cancer Cell 2014 Jun 15;25(6):794-808. Epub 2014 May 15.

Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.03.036DOI Listing
June 2014

Insecticidal, repellent and fungicidal properties of novel trifluoromethylphenyl amides.

Pestic Biochem Physiol 2013 Sep 18;107(1):138-47. Epub 2013 Jun 18.

Emerging Pathogens Institute, Department of Entomology and Nematology, University of Florida, Gainesville, FL 32610-0009, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00483575130011
Publisher Site
http://dx.doi.org/10.1016/j.pestbp.2013.06.006DOI Listing
September 2013

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

Antifungal activity against plant pathogens of metabolites from the endophytic fungus Cladosporium cladosporioides.

J Agric Food Chem 2013 May 7;61(19):4551-5. Epub 2013 May 7.

Department of Medicinal Chemistry, University of Mississippi, University, Mississippi 38677, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jf400212yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663488PMC
May 2013

Synthesis and biological activity of substituted urea and thiourea derivatives containing 1,2,4-triazole moieties.

Molecules 2013 Mar 19;18(3):3562-76. Epub 2013 Mar 19.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Haydarpasa 34668, Istanbul, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules18033562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270039PMC
March 2013

Deciphering signatures of mutational processes operative in human cancer.

Cell Rep 2013 Jan 10;3(1):246-59. Epub 2013 Jan 10.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2012.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588146PMC
January 2013

Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion.

Anal Chem 2012 Nov 29;84(22):9848-57. Epub 2012 Oct 29.

School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/ac302227c
Publisher Site
http://dx.doi.org/10.1021/ac302227cDOI Listing
November 2012

Antifungal activity of extracts from endophytic fungi associated with Smallanthus maintained in vitro as autotrophic cultures and as pot plants in the greenhouse.

Can J Microbiol 2012 Oct 15;58(10):1202-11. Epub 2012 Oct 15.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, P.O. Box 486, CEP 31270-901, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1139/w2012-088DOI Listing
October 2012

Bioassay-directed isolation and identification of phytotoxic and fungitoxic acetylenes from Conyza canadensis.

J Agric Food Chem 2012 Jun 31;60(23):5893-8. Epub 2012 May 31.

EMBRAPA Environment , C.P. 69, Jaguariúna, SP, 13820-000, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jf3010367DOI Listing
June 2012