David Wedge

David Wedge

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David Wedge

David Wedge

Publications by authors named "David Wedge"

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100Publications

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Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 May 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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May 2018

Principles of Reconstructing the Subclonal Architecture of Cancers.

Cold Spring Harb Perspect Med 2017 Aug 1;7(8). Epub 2017 Aug 1.

The Francis Crick Institute, London NW1 1AT, United Kingdom.

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August 2017

Synthesis and insecticidal activity of novel pyrimidine derivatives containing urea pharmacophore against Aedes aegypti.

Pest Manag Sci 2017 May 1;73(5):953-959. Epub 2016 Sep 1.

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.

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May 2017

How Subclonal Modeling Is Changing the Metastatic Paradigm.

Clin Cancer Res 2017 Feb 18;23(3):630-635. Epub 2016 Nov 18.

Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Australia.

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February 2017

ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data.

Curr Protoc Bioinformatics 2016 12 8;56:15.9.1-15.9.17. Epub 2016 Dec 8.

Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

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December 2016

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.

Oncotarget 2016 Nov;7(45):72685-72698

Center for Hematology and Regenerative Medicine, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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November 2016

Synthesis and Biological Evaluation of 3,5-Dimethoxystilbene Analogs.

Chem Biodivers 2016 Sep 8;13(9):1165-1177. Epub 2016 Sep 8.

Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 1848, University, Mississippi, 38677, USA.

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September 2016

The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma.

Cancer Res 2016 09 3;76(17):5092-102. Epub 2016 Aug 3.

Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. Department for Environmental Health and Science, University College of Southeast Norway, Bø, Norway.

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September 2016

Molecular Phylogeny, Diversity, and Bioprospecting of Endophytic Fungi Associated with wild Ethnomedicinal North American Plant Echinacea purpurea (Asteraceae).

Chem Biodivers 2016 Jul 6;13(7):918-30. Epub 2016 Jul 6.

Department of Microbiology, Institute of Biological Science, Federal University of Minas Gerais, P.O. Box 486, Belo Horizonte, MG, CEP 31270-901, Brazil.

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July 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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June 2016

Clock-like mutational processes in human somatic cells.

Nat Genet 2015 Dec 9;47(12):1402-7. Epub 2015 Nov 9.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.

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December 2015

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.

Haematologica 2015 Nov 6;100(11):e438-42. Epub 2015 Aug 6.

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK

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November 2015

Phomalactone from a Phytopathogenic Fungus Infecting ZINNIA elegans (ASTERACEAE) Leaves.

J Chem Ecol 2015 Jul 2;41(7):602-12. Epub 2015 Jul 2.

United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P.O. Box 1848, University, MS, 38677, USA,

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July 2015

Diversity and antifungal activity of the endophytic fungi associated with the native medicinal cactus Opuntia humifusa (Cactaceae) from the United States.

Microbiol Res 2015 Jun 21;175:67-77. Epub 2015 Mar 21.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

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June 2015

Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics.

J Pathol Clin Res 2015 Apr 16;1(2):113-23. Epub 2015 Mar 16.

UCL Cancer Institute, University College LondonHuntley StreetLondonUK; Sarah Cannon-University College London Advanced Diagnostics Molecular Profiling Research LaboratoriesUCL Cancer Institute, UCLLondonUK; Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustMiddlesexUK.

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April 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

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March 2015

Effect of mutation order on myeloproliferative neoplasms.

N Engl J Med 2015 Feb;372(7):601-612

Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Stem Cell Institute (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., A.R.G.) and Department of Hematology (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., G.S.V., P.J.C., A.R.G.), University of Cambridge, Department of Haematology, Addenbrooke's Hospital (C.A.O., J.N., J.G., E.J.B., A.L.G., G.S.V., P.J.C., A.R.G.), Wellcome Trust Sanger Institute (D.C.W., E.P., G.S.V., P.J.C.), and Cancer Research U.K. Cambridge Institute, Li Ka Shing Centre (S.M.), Cambridge, and Guy's and St. Thomas' National Health Service Foundation Trust, Guy's Hospital, London (C.N.H.) - all in the United Kingdom; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy (P.G., A.V.); Departments of Pathology (B.B.) and Hematology (C.B.), Hospital del Mar, Barcelona; and the Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany (K.D.).

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February 2015

Antifungal compounds from turmeric and nutmeg with activity against plant pathogens.

Fitoterapia 2014 Dec 27;99:341-6. Epub 2014 Aug 27.

National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. Electronic address:

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December 2014

Differential and limited expression of mutant alleles in multiple myeloma.

Blood 2014 Nov 18;124(20):3110-7. Epub 2014 Sep 18.

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Department of Hematology/Oncology, Boston Veterans Administration Healthcare System, West Roxbury, MA;

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November 2014

A comparison of different chemometrics approaches for the robust classification of electronic nose data.

Anal Bioanal Chem 2014 Nov 7;406(29):7581-90. Epub 2014 Oct 7.

School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.

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November 2014

Fast randomization of large genomic datasets while preserving alteration counts.

Bioinformatics 2014 Sep;30(17):i617-23

Fondazione Bruno Kessler, I-38100 Povo (Trento), Italy, European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge CB10 1SD, UK, Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK and Universitat Pompeu Fabra, Barcelona 08003, Spain.

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September 2014

Metabolism and resistance of Fusarium spp. to the manzamine alkaloids via a putative retro pictet-spengler reaction and utility of the rational design of antimalarial and antifungal agents.

Mar Biotechnol (NY) 2014 Aug 20;16(4):412-22. Epub 2014 Feb 20.

Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, Oxford, MS, USA,

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August 2014

Insecticidal, repellent and fungicidal properties of novel trifluoromethylphenyl amides.

Pestic Biochem Physiol 2013 Sep 18;107(1):138-47. Epub 2013 Jun 18.

Emerging Pathogens Institute, Department of Entomology and Nematology, University of Florida, Gainesville, FL 32610-0009, USA.

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September 2013

Antifungal activity against plant pathogens of metabolites from the endophytic fungus Cladosporium cladosporioides.

J Agric Food Chem 2013 May 7;61(19):4551-5. Epub 2013 May 7.

Department of Medicinal Chemistry, University of Mississippi, University, Mississippi 38677, USA.

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May 2013

Synthesis and biological activity of substituted urea and thiourea derivatives containing 1,2,4-triazole moieties.

Molecules 2013 Mar 19;18(3):3562-76. Epub 2013 Mar 19.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Haydarpasa 34668, Istanbul, Turkey.

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March 2013

Deciphering signatures of mutational processes operative in human cancer.

Cell Rep 2013 Jan 10;3(1):246-59. Epub 2013 Jan 10.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

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January 2013

Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion.

Anal Chem 2012 Nov 29;84(22):9848-57. Epub 2012 Oct 29.

School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.

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November 2012

Antifungal activity of extracts from endophytic fungi associated with Smallanthus maintained in vitro as autotrophic cultures and as pot plants in the greenhouse.

Can J Microbiol 2012 Oct 15;58(10):1202-11. Epub 2012 Oct 15.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, P.O. Box 486, CEP 31270-901, Brazil.

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October 2012

Bioassay-directed isolation and identification of phytotoxic and fungitoxic acetylenes from Conyza canadensis.

J Agric Food Chem 2012 Jun 31;60(23):5893-8. Epub 2012 May 31.

EMBRAPA Environment , C.P. 69, Jaguariúna, SP, 13820-000, Brazil.

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June 2012

Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography.

Chem Biodivers 2011 Dec;8(12):2331-40

Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

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December 2011

CONSeQuence: prediction of reference peptides for absolute quantitative proteomics using consensus machine learning approaches.

Mol Cell Proteomics 2011 Nov 3;10(11):M110.003384. Epub 2011 Aug 3.

Michael Barber Centre for Mass Spectrometry, The University of Manchester, Manchester, M1 7DN, UK.

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November 2011

FDRAnalysis: a tool for the integrated analysis of tandem mass spectrometry identification results from multiple search engines.

J Proteome Res 2011 Apr 21;10(4):2088-94. Epub 2011 Feb 21.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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April 2011

Triterpenoidal saponins: bioactive secondary metabolites from Zygophyllum coccineum.

Planta Med 2011 Mar 26;77(5):488-91. Epub 2010 Oct 26.

Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt.

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March 2011

Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids.

J Agric Food Chem 2011 Mar 11;59(5):1673-82. Epub 2011 Feb 11.

National Peanut Research Laboratory, Agricultural Research Service, United States Department of Agriculture , Dawson, Georgia 39842, United States.

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March 2011

Bioactive xanthones from the roots of Hypericum perforatum (common St John's wort).

J Sci Food Agric 2011 Feb 27;91(3):428-34. Epub 2010 Oct 27.

Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-University, 8010 Graz, Austria.

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February 2011

Pterocarpenes elicited by Aspergillus caelatus in peanut (Arachis hypogaea) seeds.

Phytochemistry 2010 Dec 26;71(17-18):2099-107. Epub 2010 Oct 26.

National Peanut Research Laboratory, Agricultural Research Service, US Department of Agriculture, Dawson, GA 39842, USA.

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December 2010

Microdistillation and analysis of volatiles from eight ornamental Salvia taxa.

Nat Prod Commun 2010 Sep;5(9):1421-6

USDA-ARS-NPURU, University of Mississippi, University, MS 38677, USA.

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September 2010