Publications by authors named "David Webb"

100Publications

Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease.

iScience 2021 Jan 13;24(1):101937. Epub 2020 Dec 13.

University/British Heart Foundation Centre of Research Excellence, Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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January 2021

In-shoe pressure thresholds for people with diabetes and neuropathy at risk of ulceration: A systematic review.

J Diabetes Complications 2020 Nov 26:107815. Epub 2020 Nov 26.

Leicester Diabetes Centre, Leicester General Hospital, University Hospitals of Leicester, UK; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.

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November 2020

Toe gaps and their assessment in footwear for people with diabetes: a narrative review.

J Foot Ankle Res 2020 Dec 4;13(1):70. Epub 2020 Dec 4.

Leicester Diabetes Centre, Leicester General Hospital, University Hospitals of Leicester, Gwendolen Road, Leicester, LE5 4PW, UK.

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December 2020

Where Does Metformin Stand in Modern Day Management of Type 2 Diabetes?

Pharmaceuticals (Basel) 2020 Nov 27;13(12). Epub 2020 Nov 27.

Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK.

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November 2020

Serial troponin measurements to monitor risk and response to endothelin A antagonism in chronic kidney disease.

Nephrol Dial Transplant 2020 Sep 27. Epub 2020 Sep 27.

University/British Heart Foundation Centre of Research Excellence, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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September 2020

Cardiovascular Determinants of Aerobic Exercise Capacity in Adults With Type 2 Diabetes.

Diabetes Care 2020 Sep 17;43(9):2248-2256. Epub 2020 Jul 17.

Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Leicester, U.K.

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September 2020

Deletion of the myeloid endothelin-B receptor confers long-term protection from angiotensin II-mediated kidney, eye and vessel injury.

Kidney Int 2020 11 20;98(5):1193-1209. Epub 2020 Jun 20.

Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris, Paris, France; University/BHF Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK. Electronic address:

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November 2020

Adults with early-onset type 2 diabetes (aged 18-39 years) are severely underrepresented in diabetes clinical research trials.

Diabetologia 2020 08 2;63(8):1516-1520. Epub 2020 Jun 2.

Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK.

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August 2020

The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons.

Kidney Int 2020 08 27;98(2):323-342. Epub 2020 Feb 27.

University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK; Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK. Electronic address:

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August 2020

Number needed to treat in cardiovascular outcome trials of glucagon-like peptide-1 receptor agonists: A systematic review with temporal analysis.

Diabetes Obes Metab 2020 Sep 26;22(9):1670-1677. Epub 2020 May 26.

Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK.

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September 2020

Chronotherapy in hypertension: the devil is in the details.

Eur Heart J 2020 Apr;41(16):1606-1607

Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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April 2020

Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation.

Hypertension 2020 May 23;75(5):1213-1222. Epub 2020 Mar 23.

From the University/British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Scotland, United Kingdom (N.K.J., K.S., A.C., R.I.M., A.T., C.M.M., C.C., B.R.C., L.D., D.E.W.L., P.W.H., D.J.W., N.D., J.W.D., J.J.M., M.A.B.).

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May 2020

Amplifying the impact of clinical pharmacology and therapeutics.

BMJ 2020 02 27;368:m717. Epub 2020 Feb 27.

University of Edinburgh, Edinburgh, UK.

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February 2020

Multiorgan involvement and management in children with Down syndrome.

Acta Paediatr 2020 06 24;109(6):1096-1111. Epub 2020 Jan 24.

Paediatrics, Academic Centre, Tallaght Hospital, Trinity College, The University of Dublin, Ireland.

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June 2020

Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease.

Br J Pharmacol 2020 Dec 4;177(24):5467-5488. Epub 2020 Feb 4.

British Heart Foundation/University Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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December 2020

Endothelin signalling mediates experience-dependent myelination in the CNS.

Elife 2019 10 28;8. Epub 2019 Oct 28.

MRC Centre for Regenerative Medicine, MS Society Edinburgh Centre, University of Edinburgh, Edinburgh, United Kingdom.

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October 2019

Prediction of Diabetic Foot Ulceration: The Value of Using Microclimate Sensor Arrays.

J Diabetes Sci Technol 2020 01 9;14(1):55-64. Epub 2019 Oct 9.

Leicester Diabetes Centre, Leicester General Hospital, University Hospitals of Leicester, UK.

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January 2020

The right place for Sulphonylureas today.

Diabetes Res Clin Pract 2019 Nov 31;157:107836. Epub 2019 Aug 31.

University of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. Electronic address:

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November 2019

Patient Satisfaction With Venous Thromboembolism Treatment.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619864663

1 Department of Pharmacotherapy, University of Utah, Salt Lake City, UT, USA.

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January 2020

Renal denervation therapy for hypertension: still on trial.

Heart 2019 10 11;105(19):1452-1453. Epub 2019 Jul 11.

Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK.

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October 2019

Improving medication safety: focus on prescribers and systems.

Lancet 2019 Jul 1;394(10195):283-285. Epub 2019 Jul 1.

Clinical Pharmacology Unit, University of Edinburgh, Clinical Research Centre, Western General Hospital, Edinburgh EH4 2XU, UK.

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July 2019

Pharmacoepidemiology: Using randomised control trials and observational studies in clinical decision-making.

Br J Clin Pharmacol 2019 09 24;85(9):1907-1924. Epub 2019 Jul 24.

Queen's Medical Research Institute, University of Edinburgh, UK.

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September 2019

Endothelin Receptor Antagonism Improves Lipid Profiles and Lowers PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) in Patients With Chronic Kidney Disease.

Hypertension 2019 08 10;74(2):323-330. Epub 2019 Jun 10.

From the University/British Heart Foundation Centre of Research Excellence, Centre of Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute (T.E.F., A.A., P.J.G., R.K., E.C., J.W.D., N.L.M., D.J.W., N.D.).

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August 2019

A fitting problem: Standardising shoe fit standards to reduce related diabetic foot ulcers.

Diabetes Res Clin Pract 2019 Aug 22;154:66-74. Epub 2019 May 22.

Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK.

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August 2019

Retinal fingerprints for precision profiling of cardiovascular risk.

Nat Rev Cardiol 2019 07;16(7):379-381

University/British Heart Foundation Centre of Research Excellence, Centre of Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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July 2019

An ultra-sensitive aptasensor on optical fibre for the direct detection of bisphenol A.

Biosens Bioelectron 2019 Jun 22;135:102-110. Epub 2019 Feb 22.

Dipartimento di Chimica "Ugo Schiff" and CSGI, Università degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.

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June 2019

Efficacy of low- and very-low-energy diets in people with type 2 diabetes mellitus: A systematic review and meta-analysis of interventional studies.

Diabetes Obes Metab 2019 07 29;21(7):1695-1705. Epub 2019 Apr 29.

Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.

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July 2019

Endothelins in cardiovascular biology and therapeutics.

Nat Rev Cardiol 2019 08;16(8):491-502

University of Edinburgh/British Heart Foundation Centre of Research Excellence, Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh, UK.

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August 2019

Percutaneous endoscopic gastrostomy for refractory epilepsy and medication refusal.

Arch Dis Child 2019 07 4;104(7):690-692. Epub 2019 Mar 4.

Department of Neurology, Our Lady's Children's Hospital, Dublin, Ireland.

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July 2019

Viscosupplementation for knee osteoarthritis: a focus on Hylan G-F 20.

Orthop Res Rev 2018 23;10:73-81. Epub 2018 Oct 23.

Medical Affairs, Sanofi House, Midrand, South Africa,

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October 2018

A novel role for myeloid endothelin-B receptors in hypertension.

Eur Heart J 2019 03;40(9):768-784

BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, UK.

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March 2019

Impaired pressure natriuresis and non-dipping blood pressure in rats with early type 1 diabetes mellitus.

J Physiol 2019 02 23;597(3):767-780. Epub 2018 Dec 23.

The British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

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February 2019

Haemodynamic differences amongst women who were screened for gestational diabetes in comparison to healthy controls.

Pregnancy Hypertens 2018 Oct 27;14:23-28. Epub 2018 Jul 27.

Consultant/Honorary Senior Lecturer in Maternal and Fetal Medicine, University of Leicester, United Kingdom. Electronic address:

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October 2018

Cardiovascular and mortality events in type 2 diabetes cardiovascular outcomes trials: a systematic review with trend analysis.

Acta Diabetol 2019 Mar 19;56(3):331-339. Epub 2018 Nov 19.

Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Gwendolen Rd, Leicester, LE5 4PW, England, UK.

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March 2019

Psychometric Properties of Two Developmental Screening Instruments for Hispanic Children in the Philadelphia Region.

Acad Pediatr 2019 08 10;19(6):638-645. Epub 2018 Oct 10.

Maternal-Fetal Medicine (J Culhane), Department of Obstetrics and Gynecology, Yale School of Medicine, New Haven, Conn.

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August 2019

Biomechanical Comparison of Fibrin Sealants for Mesh Fixation.

Am Surg 2018 May;84(5):633-636

Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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May 2018

The Problem of Seroma After Ventral Hernia Repair.

Surg Technol Int 2018 06;32:93-98

Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.

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June 2018

Migrated embolization coil causes intestinal obstruction.

J Vasc Surg Cases Innov Tech 2018 Mar 27;4(1):8-11. Epub 2017 Dec 27.

Division of Vascular Surgery, University of Tennessee, Memphis, Tenn.

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March 2018

Global burden of hypoglycaemia-related mortality in 109 countries, from 2000 to 2014: an analysis of death certificates.

Diabetologia 2018 07 1;61(7):1592-1602. Epub 2018 May 1.

Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Rd, Leicester, LE5 4PW, UK.

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July 2018

Relation of Aortic Stiffness to Left Ventricular Remodeling in Younger Adults With Type 2 Diabetes.

Diabetes 2018 07 16;67(7):1395-1400. Epub 2018 Apr 16.

Department of Cardiovascular Sciences, University of Leicester and Leicester National Institute for Health Research Biomedical Research Centre, Glenfield Hospital, Leicester, U.K.

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July 2018

Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.

Lancet Diabetes Endocrinol 2018 06 11;6(6):464-475. Epub 2018 Apr 11.

William Harvey Research Institute, Queen Mary University of London, London, UK; NIHR Barts Hospital Biomedical Research Centre, London, UK. Electronic address:

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June 2018

An Exploration of the Relationship between Improvements in Energy Efficiency and Life-Cycle Energy and Carbon Emissions using the BIRDS Low-Energy Residential Database.

Energy Build 2018 Feb 15;160:19-33. Epub 2017 Nov 15.

National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899.

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February 2018

Endothelin antagonism reduces circulating galectin-3 in patients with proteinuric chronic kidney disease.

Kidney Int 2018 01;93(1):270

University/British Heart Foundation Centre of Research Excellence, Centre of Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK; Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK. Electronic address:

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January 2018

The association between depressive symptoms and insulin resistance, inflammation and adiposity in men and women.

PLoS One 2017 30;12(11):e0187448. Epub 2017 Nov 30.

National Institute for Health Research Biomedical Research Centre-Leicester, University Hospitals of Leicester, Leicester, England.

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December 2017

Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women.

Pregnancy Hypertens 2017 Oct 16;10:256-261. Epub 2017 Oct 16.

University Hospitals of Leicester, United Kingdom; University of Leicester, United Kingdom. Electronic address:

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October 2017

Nelarabine-induced peripheral and central neurotoxicity: can sequential MRI brain imaging help to define its natural history?

Br J Haematol 2017 10 29;179(2):294-297. Epub 2017 Sep 29.

Department of Paediatric Haematology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

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October 2017

Diurnal variation and repeatability of arterial stiffness and cardiac output measurements in the third trimester of uncomplicated pregnancy.

J Hypertens 2017 12;35(12):2436-2442

aUniversity Hospitals of Leicester bDepartment of Obstetrics and Gynaecology, Health Sciences Division, University of Leicester, Leicester cDepartment of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester dSt George's University of London, and St Georges University Hospitals NHS Foundation Trust. Molecular and Clinical Sciences Research Institute, London eDiabetes Research Centre and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.

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December 2017

Mini PCNL for renal calculi: does size matter?

BJU Int 2017 05;119 Suppl 5:39-46

Department of Urology, Austin Health, Heidelberg, Vic., Australia.

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May 2017

Cardiovascular disease biomarkers are associated with declining renal function in type 2 diabetes.

Diabetologia 2017 08 20;60(8):1400-1408. Epub 2017 May 20.

Centre for Population Health Sciences, University of Edinburgh, Old Medical School, Teviot Place, Edinburgh, EH8 9AG, UK.

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August 2017

First-in-Man Demonstration of Direct Endothelin-Mediated Natriuresis and Diuresis.

Hypertension 2017 07 15;70(1):192-200. Epub 2017 May 15.

From the British Heart Foundation Centre of Research Excellence and The Queen's Medical Research Institute, University of Edinburgh, United Kingdom.

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July 2017

Prescribing Safety Assessment 2016: Delivery of a national prescribing assessment to 7343 UK final-year medical students.

Br J Clin Pharmacol 2017 Oct 13;83(10):2249-2258. Epub 2017 Jun 13.

Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

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October 2017

Onlay with Adhesive Use Compared with Sublay Mesh Placement in Ventral Hernia Repair: Was Chevrel Right? An Americas Hernia Society Quality Collaborative Analysis.

J Am Coll Surg 2017 May 2;224(5):962-970. Epub 2017 Feb 2.

Comprehensive Hernia Center, Digestive Disease and Surgical Institute, The Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

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May 2017

Smooth Muscle Endothelin B Receptors Regulate Blood Pressure but Not Vascular Function or Neointimal Remodeling.

Hypertension 2017 02 27;69(2):275-285. Epub 2016 Dec 27.

From the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).

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February 2017

Predicting Energy Performance of a Net-Zero Energy Building: A Statistical Approach.

Appl Energy 2016 09 25;178:468-483. Epub 2016 Jun 25.

National Institute of Standards and Technology, 100 Bureau Drive, Stop 8603, Gaithersburg, MD 20899, United States.

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September 2016