David Waterson

David Waterson

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David Waterson

David Waterson

Publications by authors named "David Waterson"

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Screening a protein kinase inhibitor library against Plasmodium falciparum.

Malar J 2017 11 7;16(1):446. Epub 2017 Nov 7.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1186/s12936-017-2085-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678585PMC
November 2017

Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines.

J Med Chem 2015 Sep 8;58(18):7572-9. Epub 2015 Sep 8.

Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch, Cape Town 7701, South Africa.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01156DOI Listing
September 2015

Antimalarial drug discovery - the path towards eradication.

Parasitology 2014 Jan 17;141(1):128-39. Epub 2013 Jul 17.

Medicines for Malaria Venture, ICC, 20 Route de Pré-Bois - PO Box 1826, 1215 Geneva 15, Switzerland.

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http://www.journals.cambridge.org/abstract_S0031182013000826
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http://dx.doi.org/10.1017/S0031182013000826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884835PMC
January 2014

Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. Part 2: hits from SoftFocus kinase and other libraries.

J Med Chem 2013 Oct 30;56(20):7750-4. Epub 2013 Aug 30.

Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.

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http://dx.doi.org/10.1021/jm400279yDOI Listing
October 2013

Hydantoin based inhibitors of MMP13--discovery of AZD6605.

Bioorg Med Chem Lett 2013 Aug 10;23(16):4705-12. Epub 2013 Jun 10.

Oncology Innovative Medicines, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.05.089DOI Listing
August 2013

Antimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.

Future Med Chem 2012 Dec;4(18):2265-77

Department of Chemistry, University of Cape Town, Private Bag X3, Rondebosch 7701, South Africa.

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http://dx.doi.org/10.4155/fmc.12.176DOI Listing
December 2012

Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit-to-Lead Chemistry.

ACS Med Chem Lett 2012 Jul 28;3(7):570-3. Epub 2012 May 28.

Medical Research Council Technology , 1-3 Burtonhole Lane, Mill Hill, London, United Kingdom.

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http://dx.doi.org/10.1021/ml300091cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025777PMC
July 2012

The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity.

Bioorg Med Chem Lett 2012 Jun 2;22(12):3895-9. Epub 2012 May 2.

Respiratory and Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.

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http://dx.doi.org/10.1016/j.bmcl.2012.04.118DOI Listing
June 2012

Novel orally active antimalarial thiazoles.

J Med Chem 2011 Nov 11;54(21):7713-9. Epub 2011 Oct 11.

Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.

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http://dx.doi.org/10.1021/jm201108kDOI Listing
November 2011

Challenges in antimalarial drug discovery.

Future Med Chem 2011 Sep;3(11):1401-12

Medicines for Malaria Venture, Route de Pré-Bois 20, PO Box 1826, 1215 Geneva 15, Switzerland.

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http://dx.doi.org/10.4155/fmc.11.91DOI Listing
September 2011