David Warburton

David Warburton

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David Warburton

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Mesenchyme-specific deletion of Tgf-β1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasia.

Lab Invest 2019 Sep 25;99(9):1363-1375. Epub 2019 Apr 25.

Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children's Hospital Los Angeles, 4661 Sunset Boulevard, Los Angeles, CA, 90027, USA.

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http://dx.doi.org/10.1038/s41374-019-0256-3DOI Listing
September 2019

Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung.

Am J Physiol Lung Cell Mol Physiol 2019 Sep 3;317(3):L347-L360. Epub 2019 Jul 3.

The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1152/ajplung.00475.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766718PMC
September 2019

YAP and TAZ in Lung Development: The Timing is Important.

Authors:
David Warburton

Am J Respir Cell Mol Biol 2019 Sep 13. Epub 2019 Sep 13.

Children's Hospital Los Angeles, Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Los Angeles, California, United States;

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http://dx.doi.org/10.1165/rcmb.2019-0300EDDOI Listing
September 2019

Approaching Clinical Trials in Childhood ILD (chILD) and Pediatric Pulmonary Fibrosis.

Am J Respir Crit Care Med 2019 Jul 19. Epub 2019 Jul 19.

Children's Hospital of Philadelphia, 6567, Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1164/rccm.201903-0544CIDOI Listing
July 2019

Normal lung development needs self-eating.

J Clin Invest 2019 06 4;129(7):2658-2659. Epub 2019 Jun 4.

The Saban Research Institute, Children's Hospital Los Angeles, USC, Los Angeles, California, USA.

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http://dx.doi.org/10.1172/JCI129442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597221PMC
June 2019

Differential epithelial growth in tissue-engineered larynx and trachea generated from postnatal and fetal progenitor cells.

Biochem Biophys Res Commun 2019 Mar 25;510(2):205-210. Epub 2019 Jan 25.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA; Division of Otolaryngology, Children's Hospital Los Angeles, Los Angeles, CA, USA; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.01.060DOI Listing
March 2019

Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation.

Sci Rep 2019 Mar 28;9(1):5296. Epub 2019 Mar 28.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, 90027, USA.

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http://www.nature.com/articles/s41598-019-41777-y
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http://dx.doi.org/10.1038/s41598-019-41777-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439218PMC
March 2019

Discordant roles for FGF ligands in lung branching morphogenesis between human and mouse.

J Pathol 2019 Feb 13;247(2):254-265. Epub 2018 Dec 13.

Department of Pediatric Surgery, Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.

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http://doi.wiley.com/10.1002/path.5188
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http://dx.doi.org/10.1002/path.5188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342657PMC
February 2019

Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development.

Sci Rep 2018 05 29;8(1):8334. Epub 2018 May 29.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, 90027, USA.

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http://dx.doi.org/10.1038/s41598-018-26673-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974327PMC
May 2018

Overview of Lung Development in the Newborn Human.

Authors:
David Warburton

Neonatology 2017 25;111(4):398-401. Epub 2017 May 25.

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http://dx.doi.org/10.1159/000458465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538827PMC
March 2018

Fiber pattern removal and image reconstruction method for snapshot mosaic hyperspectral endoscopic images.

Biomed Opt Express 2018 Feb 25;9(2):780-790. Epub 2018 Jan 25.

Translational Imaging Center, University of Southern California, Los Angeles, California, 90089, USA.

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http://dx.doi.org/10.1364/BOE.9.000780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854078PMC
February 2018

Human lung branching morphogenesis is orchestrated by the spatiotemporal distribution of ACTA2, SOX2, and SOX9.

Am J Physiol Lung Cell Mol Physiol 2018 01 28;314(1):L144-L149. Epub 2017 Sep 28.

Developmental Biology and Regenerative Medicine Program, Department of Pediatric Surgery, The Saban Research Institute, Children's Hospital Los Angeles , Los Angeles, California.

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http://dx.doi.org/10.1152/ajplung.00379.2017DOI Listing
January 2018

Inhaled resveratrol treatments slow ageing-related degenerative changes in mouse lung.

Thorax 2017 05 9;72(5):451-459. Epub 2017 Jan 9.

Developmental Biology and Regenerative Medicine, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.

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http://thorax.bmj.com/content/early/2017/01/19/thoraxjnl-201
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http://dx.doi.org/10.1136/thoraxjnl-2016-208964DOI Listing
May 2017

Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes.

Am J Physiol Lung Cell Mol Physiol 2017 Feb 9;312(2):L196-L207. Epub 2016 Dec 9.

Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children's Hospital Los Angeles, and Keck School of Medicine, Ostrow School of Dentistry, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1152/ajplung.00127.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336580PMC
February 2017

Collagenolytic Activity Is Associated with Scar Resolution in Zebrafish Hearts after Cryoinjury.

J Cardiovasc Dev Dis 2017 Feb 24;4(1). Epub 2017 Feb 24.

Heart Institute of Children's Hospital Los Angeles, 4661 Sunset Blvd, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.3390/jcdd4010002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715691PMC
February 2017

Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.

Am J Pathol 2016 12 18;186(12):3261-3272. Epub 2016 Oct 18.

Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California; Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225296PMC
December 2016

Can Alveolar Macrophages Made from Stem Cells Achieve Functional Rescue of Lung Diseases?

Am J Respir Crit Care Med 2016 06;193(11):1187-8

3 The Saban Research Institute Children's Hospital Los Angeles Los Angeles, California and.

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http://dx.doi.org/10.1164/rccm.201512-2400EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910901PMC
June 2016

Morphogenetic Implications of Peristalsis-Driven Fluid Flow in the Embryonic Lung.

PLoS One 2015 6;10(7):e0132015. Epub 2015 Jul 6.

Department of Mathematics, North Carolina State University, Raleigh, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132015PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493131PMC
April 2016

Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease.

J Clin Med 2016 Feb 19;5(2). Epub 2016 Feb 19.

Division of Cardiothoracic Surgery, University of Southern California, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.3390/jcm5020027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773783PMC
February 2016

Increased alveolar soluble annexin V promotes lung inflammation and fibrosis.

Eur Respir J 2015 Nov 9;46(5):1417-29. Epub 2015 Jul 9.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA

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http://dx.doi.org/10.1183/09031936.00002115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767328PMC
November 2015

Quantifying stretch and secretion in the embryonic lung: Implications for morphogenesis.

Mech Dev 2015 Nov 16;138 Pt 3:356-63. Epub 2015 Jul 16.

North Carolina State University, Raleigh, NC 27695-8205, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254773153000
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http://dx.doi.org/10.1016/j.mod.2015.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762038PMC
November 2015

Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung.

J Theor Biol 2015 Oct 10;382:378-85. Epub 2015 Jul 10.

North Carolina State University, Raleigh, NC 27695, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2015.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762031PMC
October 2015

Developmental responses to lung injury: repair or fibrosis.

Authors:
David Warburton

Fibrogenesis Tissue Repair 2012 6;5(Suppl 1):S2. Epub 2012 Jun 6.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine and Ostrow School of Dentistry, University of Southern California, 4650 Sunset Boulevard, Los Angeles, California, 90027, USA.

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http://dx.doi.org/10.1186/1755-1536-5-S1-S2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368777PMC
May 2015

Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis.

Nat Commun 2015 Apr 13;6:6798. Epub 2015 Apr 13.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1038/ncomms7798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403347PMC
April 2015

Differential regenerative capacity of neonatal mouse hearts after cryoinjury.

Dev Biol 2015 Mar 31;399(1):91-99. Epub 2014 Dec 31.

Heart Institute, Los Angeles, California; The Saban Research Institute of Children׳s Hospital Los Angeles, Los Angeles, California; Department of Surgery, Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2014.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339535PMC
March 2015

A Grhl2-dependent gene network controls trophoblast branching morphogenesis.

Development 2015 Mar;142(6):1125-36

Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, Berlin 13125, Germany Experimental and Clinical Research Center, a collaboration between the Max Delbrück Center and the Medical Faculty of the Charité, Robert-Rössle-Str. 10, Berlin 13125, Germany Department of Nephrology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany

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http://dx.doi.org/10.1242/dev.113829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517833PMC
March 2015

Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission.

BMC Biol 2014 Nov 11;12:92. Epub 2014 Nov 11.

Division of Biological Sciences, California Institute of Technology, Pasadena, USA.

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http://dx.doi.org/10.1186/s12915-014-0092-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255442PMC
November 2014

Seasonal ambient air pollution correlates strongly with spontaneous abortion in Mongolia.

BMC Pregnancy Childbirth 2014 Apr 23;14:146. Epub 2014 Apr 23.

The Lifespan Environmental Pollution Global Impact Center at The Saban Research Institute, Children's Hospital of Los Angeles, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1186/1471-2393-14-146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024019PMC
April 2014

Branching patterns emerge in a mathematical model of the dynamics of lung development.

J Physiol 2014 Jan 18;592(2):313-24. Epub 2013 Nov 18.

Department of Medicine, A2-237 Center for Health Sciences, Los Angeles, California, USA 90095-1679. X. Zhao: Institute of Robotics and Automatic Information Systems, Nankai University, Tianjin 300071, China. Email:

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http://dx.doi.org/10.1113/jphysiol.2013.261099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922496PMC
January 2014

Dredging and contaminant exposure to tree swallows nesting on the upper Mississippi River.

Environ Monit Assess 2013 Nov 11;185(11):9043-53. Epub 2013 May 11.

US Geological Survey, Upper Midwest Environmental Sciences Center, 2630 Fanta Reed Road, La Crosse, WI, 54603, USA,

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http://dx.doi.org/10.1007/s10661-013-3234-zDOI Listing
November 2013

Stem cells: a recapitulation of development.

Respirology 2013 Nov;18(8):1167-76

Lung Institute of Western Australia, Nedlands, Western Australia, Australia; School of Medicine and Pharmacology, Royal Perth Hospital, Perth, Western Australia, Australia; Department of Respiratory and Sleep Medicine, Royal Perth Hospital, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1111/resp.12186DOI Listing
November 2013

Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer.

BMC Biol 2013 Nov 13;11:111. Epub 2013 Nov 13.

Developmental Biology and Regenerative Medicine Program, Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd,, MS 35, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1186/1741-7007-11-111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907025PMC
November 2013

Lung mesenchymal expression of Sox9 plays a critical role in tracheal development.

BMC Biol 2013 Nov 25;11:117. Epub 2013 Nov 25.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine and Ostrow School of Dentistry, University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1186/1741-7007-11-117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222279PMC
November 2013

Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling.

Dev Biol 2013 Oct 26;382(1):110-23. Epub 2013 Jul 26.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1016/j.ydbio.2013.07.019DOI Listing
October 2013

Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin α6β1-ADAM17/tumor necrosis factor-α-converting enzyme (TACE) signaling pathway.

J Biol Chem 2013 Aug 25;288(35):25646-57. Epub 2013 Jul 25.

Department of Pediatrics, Women & Infants Hospital of Rhode Island and the Warren Alpert Medical School, Brown University, Providence, Rhode Island 02905, USA.

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http://dx.doi.org/10.1074/jbc.M113.473777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757225PMC
August 2013

Environmental pollution in Mongolia: effects across the lifespan.

Environ Res 2013 Jul 11;124:65-6. Epub 2013 May 11.

Fogarty/NIEHS Lifespan Environmental Pollution Global Impact Center, Developmental Biology, Regenerative Medicine and Stem Cell Program, Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine and Ostrow School of Dentistry, University of Southern California, USA.

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http://dx.doi.org/10.1016/j.envres.2013.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043223PMC
July 2013

Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation.

PLoS One 2012 9;7(7):e40314. Epub 2012 Jul 9.

Developmental Biology and Regenerative Medicine Program, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040314PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392250PMC
April 2013

TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?

Am J Physiol Lung Cell Mol Physiol 2013 Jan 16;304(2):L83-5. Epub 2012 Nov 16.

Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Blvd. MS35, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1152/ajplung.00258.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073936PMC
January 2013

New ideas in lung regeneration: a personal view from Estoril.

Expert Rev Respir Med 2012 Nov;6(5):507-8

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital, Los Angeles, CA, USA.

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http://dx.doi.org/10.1586/ers.12.41DOI Listing
November 2012

Impact of stem cells in craniofacial regenerative medicine.

Front Physiol 2012 21;3:188. Epub 2012 Jun 21.

Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California Los Angeles, CA, USA.

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http://dx.doi.org/10.3389/fphys.2012.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380335PMC
October 2012

Isolation and characterization of distal lung progenitor cells.

Methods Mol Biol 2012 ;879:109-22

The Saban Institute for Research, Department of Surgery, University of Southern California, Los Angeles, CA, USA.

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http://link.springer.com/10.1007/978-1-61779-815-3_7
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http://dx.doi.org/10.1007/978-1-61779-815-3_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710291PMC
September 2012

Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium.

J Cell Sci 2012 Sep 8;125(Pt 17):4036-48. Epub 2012 Jun 8.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1242/jcs.102848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482315PMC
September 2012

Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium.

J Histochem Cytochem 2012 Sep 19;60(9):675-82. Epub 2012 Jun 19.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine of University of Southern California, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1369/0022155412451582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524558PMC
September 2012

FGF9-Pitx2-FGF10 signaling controls cecal formation in mice.

Dev Biol 2012 Sep 20;369(2):340-8. Epub 2012 Jul 20.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Children's Hospital Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1016/j.ydbio.2012.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725282PMC
September 2012

Wound healing in development.

Birth Defects Res C Embryo Today 2012 Sep;96(3):213-22

Division of Developmetal Biology, Regenerative Medicine, and Surgery, The Saban Research Institute of Children's Hospital Los Angeles, California, USA.

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http://doi.wiley.com/10.1002/bdrc.21017
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http://dx.doi.org/10.1002/bdrc.21017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678537PMC
September 2012

MIR-99a and MIR-99b modulate TGF-β induced epithelial to mesenchymal plasticity in normal murine mammary gland cells.

PLoS One 2012 27;7(1):e31032. Epub 2012 Jan 27.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031032PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267767PMC
July 2012

Modulating the alveolar milieu to enhance resolution of fibrotic lung injury.

Proc Am Thorac Soc 2012 Jul;9(3):117-9

Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1513/pats.201201-013AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830702PMC
July 2012

Cell-based therapies for lung disease.

Br Med Bull 2012 25;101:147-61. Epub 2012 Jan 25.

Developmental Biology and Regenerative Medicine Program,The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1093/bmb/ldr051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695661PMC
May 2012

Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner.

Endocr Relat Cancer 2012 Apr 10;19(2):111-122. Epub 2012 Apr 10.

Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA.

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http://dx.doi.org/10.1530/ERC-10-0327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217534PMC
April 2012

Injection of amniotic fluid stem cells delays progression of renal fibrosis.

J Am Soc Nephrol 2012 Apr 2;23(4):661-73. Epub 2012 Feb 2.

GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics, Children's Hospital Los Angeles, Division of Urology, Saban Research Institute, University of Southern California, Los Angeles, California 90027, USA.

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http://www.stemcellcenters.com/wp-content/uploads/2015/11/am
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http://www.jasn.org/cgi/doi/10.1681/ASN.2011030243
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http://dx.doi.org/10.1681/ASN.2011030243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312511PMC
April 2012

Mesenchymal-specific inhibition of vascular endothelial growth factor (VEGF) attenuates growth in neonatal mice.

J Surg Res 2012 Jan 17;172(1):40-7. Epub 2011 May 17.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/j.jss.2011.04.043DOI Listing
January 2012

The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors.

Am J Respir Cell Mol Biol 2011 Dec 23;45(6):1212-21. Epub 2011 Jun 23.

Developmental Biology and Regenerative Medicine, Saban Research Institute, Childrens Hospital Los Angeles, California, USA.

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http://dx.doi.org/10.1165/rcmb.2010-0325OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262671PMC
December 2011

Aspects of nicotine utilization.

Behav Brain Sci 2011 Dec;34(6):326-7

Reading University, Psychology, Reading University, Reading RG6 6AL, United Kingdom.

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http://www.journals.cambridge.org/abstract_S0140525X11000811
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http://dx.doi.org/10.1017/S0140525X11000811DOI Listing
December 2011

Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice.

Am J Physiol Lung Cell Mol Physiol 2011 Oct 8;301(4):L391-401. Epub 2011 Jul 8.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1152/ajplung.00369.2010DOI Listing
October 2011

VEGF optimizes the formation of tissue-engineered small intestine.

Regen Med 2011 Sep;6(5):559-67

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, 4650 W Sunset Blvd, MS#100, Los Angeles, CA 90027, USA.

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https://www.futuremedicine.com/doi/10.2217/rme.11.49
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http://dx.doi.org/10.2217/rme.11.49DOI Listing
September 2011

Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs.

Am J Respir Cell Mol Biol 2011 Jun 12;44(6):870-8. Epub 2010 Aug 12.

Departments of Medicine, Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2010-0070OC
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135847PMC
June 2011

A modified technique for partial pneumonectomy in the mouse.

J Invest Surg 2011 ;24(2):81-6

Department of Pediatric Surgery, Developmental Biology Program and Regenerative Medicine, The Saban Institute for Research, Children's Hospital Los Angeles, University of Southern California School of Medicine, Los Angeles, California 90027, USA.

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http://www.tandfonline.com/doi/full/10.3109/08941939.2010.54
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June 2011

Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response.

Am J Physiol Lung Cell Mol Physiol 2011 Jun 1;300(6):L898-909. Epub 2011 Apr 1.

Department of Surgery and Developmental Biology, Regenerative Medicine Program, The Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California Keck School of Medicine, USA.

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http://www.physiology.org/doi/10.1152/ajplung.00409.2010
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119124PMC
June 2011

A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways.

Development 2011 Jun;138(11):2359-68

Department of Molecular Biology, Hebrew University-Hadassah Medical School, and Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1242/dev.060723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091498PMC
June 2011

Stem cells and cell therapies in lung biology and lung diseases.

Proc Am Thorac Soc 2011 Jun;8(3):223-72

Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont 05405, USA.

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http://dx.doi.org/10.1513/pats.201012-071DWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132784PMC
June 2011

Carbon monoxide pollution and lung function in urban compared with rural Mongolian children.

Respirology 2011 May;16(4):653-8

Department of Pediatrics, Maternal and Child Health Research Center, Health Sciences University of Mongolia, Ulaanbaatar, Mongolia.

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http://dx.doi.org/10.1111/j.1440-1843.2011.01958.xDOI Listing
May 2011

Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung.

Dev Biol 2011 May 6;353(2):242-58. Epub 2011 Mar 6.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1016/j.ydbio.2011.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114882PMC
May 2011

Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium.

Development 2011 Apr;138(7):1395-407

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1242/dev.058479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050666PMC
April 2011

Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung.

Dev Biol 2011 Feb 1;350(1):112-26. Epub 2010 Dec 1.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00121606100122
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022116PMC
February 2011

Cell polarity and spindle orientation in the distal epithelium of embryonic lung.

Dev Dyn 2011 Feb;240(2):441-5

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children's Hospital Los Angeles, California, USA.

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http://dx.doi.org/10.1002/dvdy.22551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023987PMC
February 2011

Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty.

Cancer Biol Ther 2011 Jan 1;11(1):122-4. Epub 2011 Jan 1.

The Saban Research Institute of Children's Hospital Los Angeles, CA, USA.

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http://dx.doi.org/10.4161/cbt.11.1.14176DOI Listing
January 2011

FGF10 controls the patterning of the tracheal cartilage rings via Shh.

Development 2011 Jan 9;138(2):273-82. Epub 2010 Dec 9.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1242/dev.051680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005603PMC
January 2011

Entrained pulmonary clocks: epithelium and vasculature keeping pace.

Am J Physiol Lung Cell Mol Physiol 2010 Oct 6;299(4):L453-4. Epub 2010 Aug 6.

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http://www.physiology.org/doi/10.1152/ajplung.00263.2010
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October 2010

On the derivation and clinical implications of "driver" mutations in lung cancer.

Am J Respir Crit Care Med 2010 Jul 12;182(1):4-5. Epub 2010 May 12.

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http://dx.doi.org/10.1164/rccm.201003-0381EDDOI Listing
July 2010

Mouse embryonic lung culture, a system to evaluate the molecular mechanisms of branching.

J Vis Exp 2010 Jun 30(40). Epub 2010 Jun 30.

Saban Research Institute, Childrens Hospital Los Angeles, USA.

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http://dx.doi.org/10.3791/2035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156062PMC
June 2010

Genes and signals regulating murine trophoblast cell development.

Mech Dev 2010 Jan-Feb;127(1-2):1-20. Epub 2009 Sep 13.

Developmental Biology, Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine of University of Southern California, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1016/j.mod.2009.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865247PMC
May 2010

Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications.

J Urol 2010 Mar 22;183(3):1193-200. Epub 2010 Jan 22.

Division of Urology, Laboratory for Organ Regenerative Research and Cell Therapeutics, Saban Research Institute, Children's Hospital Los Angeles and Developmental Biology Program, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA.

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http://dx.doi.org/10.1016/j.juro.2009.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174101PMC
March 2010

Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis.

PLoS One 2010 Feb 24;5(2):e9357. Epub 2010 Feb 24.

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827539PMC
February 2010

O-GlcNAc mediated glycosylation down-regulation in mice with cyclophosphamide induced cystitis.

J Urol 2010 Jan;183(1):351-6

Developmental Biology, Regenerative Medicine and Surgery Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/j.juro.2009.08.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840040PMC
January 2010

Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease?

Proc Am Thorac Soc 2009 Dec;6(7):614-7

Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198-5910, USA.

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http://dx.doi.org/10.1513/pats.200908-094RMDOI Listing
December 2009

Bcr and Abr cooperate in negatively regulating acute inflammatory responses.

Mol Cell Biol 2009 Nov 24;29(21):5742-50. Epub 2009 Aug 24.

Division of Hematology/Oncology, Saban Research Institute of Childrens Hospital, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1128/MCB.00357-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772743PMC
November 2009

Development, repair and fibrosis: what is common and why it matters.

Respirology 2009 Jul;14(5):656-65

Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, 4650 Sunset Blvd., MS 35, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1111/j.1440-1843.2009.01565.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747658PMC
July 2009