David W Ray

David W Ray

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David W Ray

Publications by authors named "David W Ray"

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Circadian rhythm of exhaled biomarkers in health and asthma.

Eur Respir J 2019 Jun 20. Epub 2019 Jun 20.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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http://dx.doi.org/10.1183/13993003.01068-2019DOI Listing
June 2019

An improved method for quantitative ChIP studies of nuclear receptor function.

J Mol Endocrinol 2019 May;62(4):169-177

Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1530/JME-18-0243DOI Listing
May 2019

How do glucocorticoids used in rheumatic disease affect body weight? A narrative review of the evidence.

Arthritis Care Res (Hoboken) 2019 Mar 15. Epub 2019 Mar 15.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, School of Biological Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/acr.23879DOI Listing
March 2019

Reply to Moitra et al.: Individual Chronotype May Confound Asthma Symptoms and Therapy.

Am J Respir Crit Care Med 2019 Feb;199(3):392-394

1 University of Manchester Manchester, United Kingdom and.

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http://dx.doi.org/10.1164/rccm.201809-1712LEDOI Listing
February 2019

Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells.

FASEB J 2019 01 2;33(1):126-139. Epub 2018 Jul 2.

Division of Diabetes, Endocrinology, and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1096/fj.201800026RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355062PMC
January 2019

The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis.

Arthritis Res Ther 2019 Jan 6;21(1). Epub 2019 Jan 6.

Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester, UK.

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http://dx.doi.org/10.1186/s13075-018-1770-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322248PMC
January 2019

Cardiomyocyte transcription is controlled by combined MR and circadian clock signalling.

J Endocrinol 2019 01 1. Epub 2019 Jan 1.

M Young, Cardiovascular Endocrinology, Hudson Institute of Medical Research, Clayton, 3166, Australia.

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http://dx.doi.org/10.1530/JOE-18-0584DOI Listing
January 2019

Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

Endocr Rev 2018 10;39(5):760-802

Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.

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https://academic.oup.com/edrv/article/39/5/760/5055100
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http://dx.doi.org/10.1210/er.2018-00064DOI Listing
October 2018

Low salivary cortisol levels in patients with rheumatoid arthritis exposed to oral glucocorticoids: a cross-sectional study set within UK electronic health records.

RMD Open 2018 1;4(2):e000700. Epub 2018 Oct 1.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, School of Biological Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2018-00070
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http://dx.doi.org/10.1136/rmdopen-2018-000700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173262PMC
October 2018

'In a dark place, we find ourselves': light intensity in critical care units.

Intensive Care Med Exp 2017 Dec 7;5(1). Epub 2017 Feb 7.

Division of Metabolism and Endocrinology, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester, M139PT, UK.

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http://dx.doi.org/10.1186/s40635-017-0122-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293701PMC
December 2017

Misalignment with the external light environment drives metabolic and cardiac dysfunction.

Nat Commun 2017 09 12;8(1):417. Epub 2017 Sep 12.

Division of Diabetes, Endocrinology and Gastroenterology, School of Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PL, UK.

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http://dx.doi.org/10.1038/s41467-017-00462-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595905PMC
September 2017

Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1.

Sci Rep 2017 07 27;7(1):6725. Epub 2017 Jul 27.

Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, England.

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http://dx.doi.org/10.1038/s41598-017-06810-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532274PMC
July 2017

The circadian clock regulates inflammatory arthritis.

FASEB J 2016 11 3;30(11):3759-3770. Epub 2016 Aug 3.

Faculty of Biology, Medicine and Health, University of Manchester and Manchester Academic Health Sciences Centre, Manchester, United Kingdom

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http://dx.doi.org/10.1096/fj.201600353RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067252PMC
November 2016

Systemic glucocorticoid therapy and adrenal insufficiency in adults: A systematic review.

Semin Arthritis Rheum 2016 08 9;46(1):133-41. Epub 2016 Mar 9.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987145PMC
August 2016

Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production.

Sci Rep 2016 05 26;6:26419. Epub 2016 May 26.

Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, UK, M13 9PT.

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http://dx.doi.org/10.1038/srep26419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881047PMC
May 2016

Glucocorticoid receptors in lung cancer: new perspectives.

J Endocrinol 2016 04 21;229(1):R17-28. Epub 2016 Jan 21.

Division of GeneticsSchool of Life Sciences, University of KwaZulu-Natal, Durban, South Africa

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http://dx.doi.org/10.1530/JOE-15-0496DOI Listing
April 2016

A matter of time: study of circadian clocks and their role in inflammation.

J Leukoc Biol 2016 Apr 8;99(4):549-60. Epub 2016 Feb 8.

*Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry, and Health, University of Sheffield, United Kingdom; Faculty of Medical and Human Sciences, Institute of Human Development, Manchester, United Kingdom; and Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1189/jlb.3RU1015-451RDOI Listing
April 2016

Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus.

Sci Rep 2016 Mar 1;6:22341. Epub 2016 Mar 1.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/srep22341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772382PMC
March 2016

Characterization of the molecular genetic pathology in patients with 11β-hydroxylase deficiency.

Clin Endocrinol (Oxf) 2015 Nov 14;83(5):629-35. Epub 2015 Jul 14.

Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1111/cen.12834DOI Listing
November 2015

Circadian biology: rhythms leave their imprint.

Authors:
David W Ray

Curr Biol 2015 Mar;25(5):R201-3

Faculty of Medical and Health Sciences, University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.12.045DOI Listing
March 2015

The N-terminal transactivation domain of the glucocorticoid receptor mediates apoptosis of human small cell lung cancer cells.

Genes Chromosomes Cancer 2014 Dec 13;53(12):999-1007. Epub 2014 Aug 13.

Division of Genetics, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1002/gcc.22209DOI Listing
December 2014

Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK.

J Endocrinol 2014 Nov 26;223(2):155-66. Epub 2014 Aug 26.

Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human DevelopmentFaculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UKInstitute of Cardiovascular SciencesFaculty of Medical and Human Sciences, University of Manchester, CTF Building, Grafton Street, Manchester, M13 9PT, UK

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http://joe.endocrinology-journals.org/content/early/2014/08/
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http://joe.endocrinology-journals.org/cgi/doi/10.1530/JOE-14
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http://dx.doi.org/10.1530/JOE-14-0456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191185PMC
November 2014

The effect of type 1 IFN on human aortic endothelial cell function in vitro: relevance to systemic lupus erythematosus.

J Interferon Cytokine Res 2014 May 20;34(5):404-12. Epub 2014 Jan 20.

1 Arthritis Research UK Epidemiology Unit, Institute of Inflammation and Repair, Manchester Academic Health Sciences Centre, The University of Manchester , Manchester, United Kingdom .

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http://dx.doi.org/10.1089/jir.2013.0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015474PMC
May 2014

The circadian clock and asthma.

Thorax 2014 Jan 23;69(1):90-2. Epub 2013 May 23.

Faculty of Medical and Human Sciences, Institute of Human Development, , Manchester, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2013-203482DOI Listing
January 2014

Identification of multiple, oxygen-stable HIF1 alpha isoforms, and augmented expression of adrenomedullin in rheumatoid arthritis.

Clin Exp Rheumatol 2013 Sep-Oct;31(5):672-82. Epub 2013 Apr 22.

School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, UK.

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December 2013

Pin1 promotes GR transactivation by enhancing recruitment to target genes.

Nucleic Acids Res 2013 Oct 25;41(18):8515-25. Epub 2013 Jul 25.

Centre in Endocrinology and Diabetes, Institute of Human Development, University of Manchester, Manchester, M13 9PT, UK, Respiratory Therapy Area, GSK, Stevenage, SG1 2NY, UK, Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK and Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.

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http://dx.doi.org/10.1093/nar/gkt624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794586PMC
October 2013

A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function.

J Cell Sci 2013 Jul 17;126(Pt 14):3159-69. Epub 2013 May 17.

Manchester Centre for Nuclear Hormone Research in Disease, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1242/jcs.124784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711205PMC
July 2013

The role of the circadian clock in rheumatoid arthritis.

Arthritis Res Ther 2013 Feb 21;15(1):205. Epub 2013 Feb 21.

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http://dx.doi.org/10.1186/ar4146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672712PMC
February 2013

Regulation of cortisol bioavailability--effects on hormone measurement and action.

Nat Rev Endocrinol 2012 Dec 14;8(12):717-27. Epub 2012 Aug 14.

Endocrine Sciences Research Group, School of Medicine, University of Manchester, A. V. Hill Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/nrendo.2012.134DOI Listing
December 2012

Current concepts in glucocorticoid resistance.

Steroids 2012 Sep 20;77(11):1041-9. Epub 2012 Jun 20.

Endocrine Sciences Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1016/j.steroids.2012.05.007DOI Listing
September 2012

The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.

Proc Natl Acad Sci U S A 2012 Jan 19;109(2):582-7. Epub 2011 Dec 19.

Faculty of Life Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1106750109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258648PMC
January 2012

Thematic reviews.

J Endocrinol 2011 Jun;209(3):257

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http://dx.doi.org/10.1530/JOE-11-0091DOI Listing
June 2011

Ultradian cortisol pulsatility encodes a distinct, biologically important signal.

PLoS One 2011 Jan 18;6(1):e15766. Epub 2011 Jan 18.

Endocrine Sciences Research Group, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015766PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022879PMC
January 2011

Simultaneous measurement of cortisol and cortisone in human saliva using liquid chromatography-tandem mass spectrometry: application in basal and stimulated conditions.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Nov 18;877(29):3771-5. Epub 2009 Sep 18.

Department of Endocrinology, The Christie, Manchester, UK.

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http://dx.doi.org/10.1016/j.jchromb.2009.09.014DOI Listing
November 2009

MNAR functionally interacts with both NH2- and COOH-terminal GR domains to modulate transactivation.

Am J Physiol Endocrinol Metab 2008 Nov 5;295(5):E1047-55. Epub 2008 Aug 5.

Faculty of Medical and Human Sciences, Centre for Molecular Medicine, School of Clinical and Laboratory Sciences, University of Manchester, United Kingdom.

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http://dx.doi.org/10.1152/ajpendo.90429.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584814PMC
November 2008

Novel therapeutic agents targeting the glucocorticoid receptor for inflammation and cancer.

Curr Opin Investig Drugs 2008 Oct;9(10):1070-7

University of Kwa-Zulu Natal, School of Biological and Conservation Sciences, Durban, South Africa.

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October 2008

Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor.

J Endocrinol 2008 Sep 26;198(3):499-509. Epub 2008 Jun 26.

Faculty of Medical and Human Sciences, School of Medicine, University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1677/JOE-08-0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518725PMC
September 2008

VEGF polymorphisms are associated with severity of diabetic retinopathy.

Invest Ophthalmol Vis Sci 2008 Aug 25;49(8):3611-6. Epub 2008 Apr 25.

Unit of Ophthalmology, Bristol Eye Hospital, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1167/iovs.07-1383DOI Listing
August 2008

Drug insight: selective agonists and antagonists of the glucocorticoid receptor.

Nat Clin Pract Endocrinol Metab 2008 Feb;4(2):91-101

Centre for Molecular Medicine, School of Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/ncpendmet0745DOI Listing
February 2008

Glucocorticoid sensitivity: pathology, mutations and clinical implications.

Expert Rev Endocrinol Metab 2006 May;1(3):403-412

c Graduate Student, University of Manchester, Centre for Molecular Medicine, Stopford Building, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1586/17446651.1.3.403DOI Listing
May 2006

The effect of atorvastatin on serum lipoproteins in acromegaly.

Clin Endocrinol (Oxf) 2005 Jun;62(6):650-5

Cardiovascular, Medicine and Surgery Central Clinical Academic Group, University of Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1111/j.1365-2265.2005.02273.xDOI Listing
June 2005

Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis.

J Invest Dermatol 2004 Sep;123(3):484-7

Arthritis Research Campaign Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/j.0022-202X.2004.23314.xDOI Listing
September 2004

Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype.

J Clin Endocrinol Metab 2004 Feb;89(2):892-7

Endocrine Sciences Research Group and Centre for Molecular Medicine, Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1210/jc.2003-031235DOI Listing
February 2004

NF-kappaB signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms.

J Cell Sci 2003 Jun 6;116(Pt 12):2495-503. Epub 2003 May 6.

Biosciences Building, School of Biological Sciences, University of Liverpool, Crown Street, UK.

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http://dx.doi.org/10.1242/jcs.00461DOI Listing
June 2003

Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter.

Cancer Res 2003 Feb;63(4):812-6

Endocrine Sciences Research Group, University of Manchester, Manchester M13 9PT, United Kingdom.

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February 2003