David W Hein

David W Hein

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David W Hein

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Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4'-methylenedianiline.

Arch Toxicol 2019 Jul 10. Epub 2019 Jul 10.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, 505 South Hancock Street, Louisville, KY, 40202-1617, USA.

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http://dx.doi.org/10.1007/s00204-019-02516-4DOI Listing
July 2019

Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1.

Biochem Pharmacol 2018 10 25;156:340-347. Epub 2018 Aug 25.

Translational and Molecular Medicine Department, Research Center for Health Sciences and Biomedicine, Autonomous University of San Luis Potosí, Mexico; Chemical Sciences School, Autonomous University of San Luis Potosí, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350916PMC
October 2018

Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review.

Pharmacogenet Genomics 2018 10;28(10):238-244

Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.

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http://dx.doi.org/10.1097/FPC.0000000000000350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208141PMC
October 2018

Retrospective analysis of estrogen receptor 1 and N‑acetyltransferase gene expression in normal breast tissue, primary breast tumors, and established breast cancer cell lines.

Int J Oncol 2018 Aug 11;53(2):694-702. Epub 2018 Jun 11.

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.

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http://dx.doi.org/10.3892/ijo.2018.4436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017241PMC
August 2018

Design and Success of a 21st Century Cancer Education Program at the University of Louisville.

J Cancer Educ 2018 04;33(2):298-308

Department of Pharmacology & Toxicology and James Graham Brown Cancer Center, University of Louisville, Kosair Charities Clinical and Translational Research, 505 South Hancock Street, Louisville, KY, USA.

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http://dx.doi.org/10.1007/s13187-016-1083-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5280580PMC
April 2018

Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231.

Mol Carcinog 2018 04 3;57(4):549-558. Epub 2018 Feb 3.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky.

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http://dx.doi.org/10.1002/mc.22779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832614PMC
April 2018

High N-Acetyltransferase 1 Expression Is Associated with Estrogen Receptor Expression in Breast Tumors, but Is not Under Direct Regulation by Estradiol, 5-androstane-3,17-Diol, or Dihydrotestosterone in Breast Cancer Cells.

J Pharmacol Exp Ther 2018 04 16;365(1):84-93. Epub 2018 Jan 16.

Departments of Pharmacology and Toxicology (X.Z., S.M.C., M.A.D., J.C.S., D.W.H.), Surgery (R.C.G.M.), Biochemistry and Molecular Genetics (C.M.K.), and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky

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http://dx.doi.org/10.1124/jpet.117.247031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830641PMC
April 2018

Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype.

Arch Toxicol 2018 Feb 17;92(2):661-668. Epub 2017 Oct 17.

Laboratory of Immunology and Cellular and Molecular Biology, Faculty of Chemical Sciences, Autonomous University of San Luis Potosí, San Luis Potosí, Mexico.

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http://dx.doi.org/10.1007/s00204-017-2082-yDOI Listing
February 2018

Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation.

Toxicol Lett 2018 Feb 24;283:100-105. Epub 2017 Nov 24.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY USA.

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http://dx.doi.org/10.1016/j.toxlet.2017.11.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745265PMC
February 2018

-Acetyltransferase 2 Genotype-Dependent -Acetylation of Hydralazine in Human Hepatocytes.

Drug Metab Dispos 2017 12 10;45(12):1276-1281. Epub 2017 Oct 10.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky

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http://dx.doi.org/10.1124/dmd.117.078543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706087PMC
December 2017

Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens.

Arch Toxicol 2017 Sep 23;91(9):3185-3188. Epub 2017 May 23.

Department of Pharmacology & Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Kosair Charities CTR, 505 South Hancock Street, Louisville, KY, 40202, USA.

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http://dx.doi.org/10.1007/s00204-017-1997-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700865PMC
September 2017

Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype.

Arch Toxicol 2017 Aug 18;91(8):2827-2835. Epub 2017 May 18.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA.

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http://dx.doi.org/10.1007/s00204-017-1989-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710007PMC
August 2017

Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes.

Arch Toxicol 2017 Jul 17;91(7):2655-2661. Epub 2017 May 17.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Kosair Charities CTR, 505 South Hancock Street, Louisville, KY, 40202, USA.

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http://dx.doi.org/10.1007/s00204-017-1988-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713641PMC
July 2017

Arylamine -acetyltransferase 2 genotype-dependent -acetylation of isoniazid in cryopreserved human hepatocytes.

Acta Pharm Sin B 2017 07 7;7(4):517-522. Epub 2017 Jun 7.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1016/j.apsb.2017.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518664PMC
July 2017

Daily Rhythm in Plasma N-acetyltryptamine.

J Biol Rhythms 2017 06 3;32(3):195-211. Epub 2017 May 3.

Section on Neuroendocrinology, Program in Developmental Endocrinology and Genetics.

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http://dx.doi.org/10.1177/0748730417700458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571864PMC
June 2017

Role of the N-acetylation polymorphism in solithromycin metabolism.

Pharmacogenomics 2017 Jun 24;18(8):765-772. Epub 2017 Apr 24.

Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.

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http://dx.doi.org/10.2217/pgs-2017-0045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704091PMC
June 2017

Folate-Dependent Hydrolysis of Acetyl-Coenzyme A by Recombinant Human and Rodent Arylamine N-Acetyltransferases.

Biochem Biophys Rep 2015 Sep;3:45-50

Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, School of Medicine, University of Louisville.

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https://linkinghub.elsevier.com/retrieve/pii/S24055808150004
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http://dx.doi.org/10.1016/j.bbrep.2015.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545580PMC
September 2015

Evaluation of Oxidative Stress Response Related Genetic Variants, Pro-oxidants, Antioxidants and Prostate Cancer.

AIMS Med Sci 2015;2(4):271-294. Epub 2015 Sep 10.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville, Louisville, KY.

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http://www.aimspress.com/article/10.3934/medsci.2015.4.271
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http://dx.doi.org/10.3934/medsci.2015.4.271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664461PMC
September 2015

PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.

Pharmacogenet Genomics 2014 Aug;24(8):409-25

Departments of aGenetics bBioengineering, Stanford University, Palo Alto, California cDepartment of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville, Kentucky, USA dDepartment of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece eDepartment of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/FPC.0000000000000062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109976PMC
August 2014

Interaction of cigarette smoking and carcinogen-metabolizing polymorphisms in the risk of colorectal polyps.

Carcinogenesis 2013 Apr 8;34(4):779-86. Epub 2013 Jan 8.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.

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http://dx.doi.org/10.1093/carcin/bgs410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616674PMC
April 2013

TaqMan real time-polymerase chain reaction methods for determination of nucleotide polymorphisms in human N-acetyltransferase-1 (NAT1) and -2 (NAT2).

Curr Protoc Toxicol 2005 ;Chapter 4:Unit4.15

University of Louisville School of Medicine, Louisville, KY, USA.

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http://dx.doi.org/10.1002/0471140856.tx0415s22DOI Listing
February 2013

Using gene-environment interaction analyses to clarify the role of well-done meat and heterocyclic amine exposure in the etiology of colorectal polyps.

Am J Clin Nutr 2012 Nov 26;96(5):1119-28. Epub 2012 Sep 26.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.

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http://dx.doi.org/10.3945/ajcn.112.040345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471199PMC
November 2012

NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl.

Mol Carcinog 2012 Aug 11;51(8):636-46. Epub 2011 Aug 11.

Department of Pharmacology and Toxicology, James Graham Brown Cancer Center and Center for Environmental Genomics and Integrative Biology, University of Louisville, Louisville, Kentucky 40202-1617, USA.

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http://dx.doi.org/10.1002/mc.20836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217153PMC
August 2012

Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice.

Cancer Lett 2012 May 19;318(2):206-13. Epub 2011 Dec 19.

Department of Pharmacology & Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.canlet.2011.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303986PMC
May 2012

Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer.

BMC Med Genomics 2012 Apr 30;5:11. Epub 2012 Apr 30.

Department of Pharmacology & Toxicology, School of Medicine, University of Louisville-UofL, Louisville, KY, USA.

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http://dx.doi.org/10.1186/1755-8794-5-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355002PMC
April 2012

Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.

Carcinogenesis 2012 Feb 22;33(2):348-55. Epub 2011 Nov 22.

Department of Pharmacology and Toxicology, James Graham Brown Cancer Center and Center for Environmental Genomics and Integrative Biology, University of Louisville, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1093/carcin/bgr273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271262PMC
February 2012

Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent.

Drug Metab Dispos 2012 Jan 18;40(1):198-204. Epub 2011 Oct 18.

Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.

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http://dx.doi.org/10.1124/dmd.111.041855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250052PMC
January 2012

Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes.

Pharmacogenomics 2012 Jan 17;13(1):31-41. Epub 2011 Nov 17.

Department of Pharmacology & Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40202-1617, USA.

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http://dx.doi.org/10.2217/pgs.11.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285565PMC
January 2012

Hair dye use and risk of bladder cancer in the New England bladder cancer study.

Int J Cancer 2011 Dec 12;129(12):2894-904. Epub 2011 Aug 12.

Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/ijc.26245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203248PMC
December 2011

Lack of association of the N-acetyltransferase NAT1*10 allele with prostate cancer incidence, grade, or stage among smokers in Finland.

Biochem Genet 2011 Feb 8;49(1-2):73-82. Epub 2010 Oct 8.

Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville Health Sciences Center, 505 S. Hancock St., Louisville, KY 40292, USA.

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http://link.springer.com/10.1007/s10528-010-9386-4
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http://dx.doi.org/10.1007/s10528-010-9386-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155982PMC
February 2011

Functional effects of genetic polymorphisms in the N-acetyltransferase 1 coding and 3' untranslated regions.

Birth Defects Res A Clin Mol Teratol 2011 Feb 2;91(2):77-84. Epub 2011 Feb 2.

Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, Birth Defects Center and Center for Environmental Genomics and Integrative Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1002/bdra.20763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252750PMC
February 2011

Manganese superoxide dismutase expression as a function of genotype and lung cancer pathology.

Cancer Invest 2010 Oct;28(8):813-9

Department of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA.

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http://dx.doi.org/10.3109/07357900903405918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196322PMC
October 2010

Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.

J Pharmacol Exp Ther 2010 Aug 29;334(2):540-4. Epub 2010 Apr 29.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40202-1617, USA.

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http://dx.doi.org/10.1124/jpet.110.168567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913773PMC
August 2010

An alternative cyclin-D1 splice site is not linked to inflammatory bowel disease-associated neoplasia.

Int J Biol Markers 2010 Jan-Mar;25(1):27-31

Price Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY - USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873677PMC
June 2010

Variability in drug metabolizing enzyme activity in HIV-infected patients.

Eur J Clin Pharmacol 2010 May 19;66(5):475-85. Epub 2010 Jan 19.

School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/s00228-009-0777-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855129PMC
May 2010

Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).

Mutat Res 2010 Feb 11;684(1-2):66-73. Epub 2009 Dec 11.

Department of Pharmacology & Toxicology, James Graham Brown Cancer Center and Center for Environmental Genomics and Integrative Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2009.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820402PMC
February 2010

Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphoma.

Cancer Causes Control 2010 Jan 7;21(1):127-33. Epub 2009 Oct 7.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA.

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http://dx.doi.org/10.1007/s10552-009-9442-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972187PMC
January 2010

Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.

Mutat Res 2009 Dec 12;671(1-2):13-9. Epub 2009 Aug 12.

Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, United States.

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http://dx.doi.org/10.1016/j.mrfmmm.2009.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783811PMC
December 2009

Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.

Drug Metab Dispos 2009 Nov 10;37(11):2123-6. Epub 2009 Aug 10.

Department of Pharmacology and Toxicology, James Graham Brown Cancer Center and Center for Environmental Genomics and Integrative Biology, University of Louisville School of Medicine, Louisville, Kentucky, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.109.029512
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http://dx.doi.org/10.1124/dmd.109.029512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774981PMC
November 2009

N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and non-hispanic white women.

Toxicol Sci 2009 Nov 19;112(1):211-20. Epub 2009 Aug 19.

Department of Epidemiology & Population Health, University of Louisville, Louisville, Kentucky 40292, USA.

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http://dx.doi.org/10.1093/toxsci/kfp199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782353PMC
November 2009

Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study.

BMC Cancer 2009 Nov 16;9:397. Epub 2009 Nov 16.

Department of Pharmacology & Toxicology, University of Louisville (UofL), School of Medicine, 500 South Preston Street, Room 1319 Research Tower, UofL Health Science Center, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1186/1471-2407-9-397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783040PMC
November 2009

Effects of dietary factors and the NAT2 acetylator status on gastric cancer in Koreans.

Int J Cancer 2009 Jul;125(1):139-45

Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea.

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http://dx.doi.org/10.1002/ijc.24328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766547PMC
July 2009

The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole.

Chem Res Toxicol 2009 Apr;22(4):726-33

Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA.

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http://dx.doi.org/10.1021/tx800473wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673018PMC
April 2009

N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine.

Authors:
David W Hein

Expert Opin Drug Metab Toxicol 2009 Apr;5(4):353-66

University of Louisville School of Medicine, James Graham Brown Cancer Center, Center for Environmental Genomics and Integrative Biology, Department of Pharmacology & Toxicology, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1517/17425250902877698 DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762189PMC
April 2009

4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats.

Toxicol Sci 2009 Jan 8;107(1):293-7. Epub 2008 Oct 8.

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA.

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http://dx.doi.org/10.1093/toxsci/kfn216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605175PMC
January 2009

Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat.

Drug Metab Dispos 2008 Dec 17;36(12):2452-9. Epub 2008 Sep 17.

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1124/dmd.108.023960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596689PMC
December 2008

Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat.

Drug Metab Dispos 2008 Dec 17;36(12):2445-51. Epub 2008 Sep 17.

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1124/dmd.108.023564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596640PMC
December 2008

Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children.

Pharmacotherapy 2008 Dec;28(12):1495-501

Kosair Charities Pediatric Clinical Research Unit, Department of Pediatrics, School of Medicine, University of Louisville, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1592/phco.28.12.1495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642612PMC
December 2008

METHODS FOR AROMATIC AND HETEROCYCLIC AMINE CARCINOGEN-DNA ADDUCT ANALYSIS BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY.

Polycycl Aromat Compd 2008 Aug;28(4-5):402-417

Department of Pharmacology & Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292.

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http://dx.doi.org/10.1080/10406630802377773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613356PMC
August 2008

Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.

Curr Drug Metab 2008 Jul;9(6):471-86

Department of Pharmacology & Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2507886PMC
July 2008

Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population.

DNA Cell Biol 2008 Jun;27(6):321-3

Department of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.

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http://dx.doi.org/10.1089/dna.2007.0725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576292PMC
June 2008

Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.

Carcinogenesis 2008 Jun 21;29(6):1184-91. Epub 2008 May 21.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/carcin/bgn085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443278PMC
June 2008

Changes in consensus arylamine N-acetyltransferase gene nomenclature.

Pharmacogenet Genomics 2008 Apr;18(4):367-8

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3282f60db0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386960PMC
April 2008

Structure-function analyses of single nucleotide polymorphisms in human N-acetyltransferase 1.

Drug Metab Rev 2008 ;40(1):169-84

Department of Pharmacology & Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA.

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http://dx.doi.org/10.1080/03602530701852917 DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265210PMC
March 2008

Dose-dependent reduction of 3,2'-dimethyl-4-aminobiphenyl-derived DNA adducts in colon and liver of rats administered celecoxib.

Mutat Res 2008 Feb 14;638(1-2):103-9. Epub 2007 Sep 14.

James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40202, United States.

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http://dx.doi.org/10.1016/j.mrfmmm.2007.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812008PMC
February 2008

Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.

Cancer Epidemiol Biomarkers Prev 2008 Feb;17(2):320-9

Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 8th Floor, 2525 West End Avenue, Nashville, TN 37203, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-07-0615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572782PMC
February 2008

Chemoprevention of arylamine-induced colorectal aberrant crypts.

Exp Biol Med (Maywood) 2008 Jan;233(1):71-5

Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.3181/0707-RM-180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2153439PMC
January 2008

Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer.

Cancer Epidemiol Biomarkers Prev 2007 Nov;16(11):2379-86

Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-06-0992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215308PMC
November 2007

Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant.

Toxicol Sci 2007 Oct 12;99(2):413-21. Epub 2007 Jun 12.

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA.

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http://dx.doi.org/10.1093/toxsci/kfm159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094101PMC
October 2007

Clinical pharmacogenetics in pediatric patients.

Pharmacogenomics 2007 Oct;8(10):1403-11

University of Louisville, Department of Pharmacology & Toxicology and James Graham Brown Center, School of Medicine, Louisville, KY, USA.

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http://dx.doi.org/10.2217/14622416.8.10.1403DOI Listing
October 2007

Functional analysis of the human N-acetyltransferase 1 major promoter: quantitation of tissue expression and identification of critical sequence elements.

Drug Metab Dispos 2007 Sep 25;35(9):1649-56. Epub 2007 Jun 25.

Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1124/dmd.107.016485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2085369PMC
September 2007

Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.

Carcinogenesis 2007 Aug 13;28(8):1665-71. Epub 2007 Apr 13.

Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1093/carcin/bgm085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2085371PMC
August 2007

2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N-acetyltransferase 2.

Mol Carcinog 2007 Jul;46(7):553-63

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1002/mc.20302DOI Listing
July 2007

Computational and experimental analyses of mammalian arylamine N-acetyltransferase structure and function.

Drug Metab Dispos 2007 Jun 19;35(6):1001-7. Epub 2007 Mar 19.

Department of Pharmacology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1124/dmd.107.015040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2085365PMC
June 2007

Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues.

Drug Metab Dispos 2007 May 7;35(5):721-7. Epub 2007 Feb 7.

Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1124/dmd.106.014621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1931608PMC
May 2007

Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma.

BMC Med Genet 2007 May 30;8:28. Epub 2007 May 30.

Price Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1186/1471-2350-8-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1903350PMC
May 2007

Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned.

Int J Epidemiol 2007 Feb;36(1):23-8

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DHHS, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/ije/dym026DOI Listing
February 2007

Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival.

Breast Cancer Res 2006 ;8(4):R45

Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA.

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http://dx.doi.org/10.1186/bcr1532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779484PMC
January 2007

Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2.

Pharmacogenet Genomics 2007 Jan;17(1):37-45

Department of Pharmacology and Toxicology, Center for Genetics and Molecular Medicine and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA.

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http://dx.doi.org/10.1097/01.fpc.0000236325.73186.2cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1989107PMC
January 2007

N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice.

J Pharmacol Exp Ther 2006 Nov 20;319(2):724-8. Epub 2006 Jul 20.

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1124/jpet.106.108662DOI Listing
November 2006

Identification and characterization of functional rat arylamine N-acetyltransferase 3: comparisons with rat arylamine N-acetyltransferases 1 and 2.

J Pharmacol Exp Ther 2006 Oct 7;319(1):369-75. Epub 2006 Jul 7.

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1124/jpet.106.108399DOI Listing
October 2006

Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.

Int J Cancer 2006 Sep;119(5):1208-11

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, KY 40292, USA.

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http://dx.doi.org/10.1002/ijc.21957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582010PMC
September 2006

Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts.

Toxicol Appl Pharmacol 2006 Sep 17;215(2):158-67. Epub 2006 Apr 17.

Division of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.taap.2006.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615915PMC
September 2006

Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma.

Pharmacogenomics 2006 Sep;7(6):819-29

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd., EPS 8047, Rockville, MD 20852 USA.

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http://dx.doi.org/10.2217/14622416.7.6.819DOI Listing
September 2006

Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma.

Pharmacogenet Genomics 2006 Aug;16(8):537-45

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA.

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http://dx.doi.org/10.1097/01.fpc.0000215071.59836.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986787PMC
August 2006

Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1.

Pharmacogenet Genomics 2006 Jul;16(7):515-25

Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1097/01.fpc.0000215066.29342.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955765PMC
July 2006

Simultaneous determination of 7 N-acetyltransferase-2 single-nucleotide variations by allele-specific primer extension assay.

Clin Chem 2006 Jun 23;52(6):1033-9. Epub 2006 Mar 23.

Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.

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http://dx.doi.org/10.1373/clinchem.2005.063198DOI Listing
June 2006

Tissue distribution of N-acetyltransferase 1 and 2 catalyzing the N-acetylation of 4-aminobiphenyl and O-acetylation of N-hydroxy-4-aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster.

Mol Carcinog 2006 Apr;45(4):230-8

Department of Pharmacology & Toxicology and James Graham Brown Cancer Center, The University of Louisville School of Medicine, Louisville, Kentucky 40292, USA.

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http://dx.doi.org/10.1002/mc.20164DOI Listing
April 2006

Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.

Carcinogenesis 2006 Jan 29;27(1):103-11. Epub 2005 Jun 29.

Department of Gastrointestinal Medical Oncology, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/carcin/bgi171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350610PMC
January 2006

4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat.

J Pharmacol Exp Ther 2006 Jan 28;316(1):289-94. Epub 2005 Sep 28.

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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http://dx.doi.org/10.1124/jpet.105.093302DOI Listing
January 2006

No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1).

J Surg Res 2005 Mar;124(1):92-7

Department of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.

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http://dx.doi.org/10.1016/j.jss.2004.09.009DOI Listing
March 2005