David W Gray

David W Gray

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David W Gray

David W Gray

Publications by authors named "David W Gray"

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Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

PLoS One 2019 31;14(5):e0217828. Epub 2019 May 31.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217828PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544269PMC
January 2020

Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function.

Br J Pharmacol 2019 Dec 11;176(23):4521-4536. Epub 2019 Dec 11.

School of Science, Engineering and Technology, Abertay University, Dundee, UK.

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http://dx.doi.org/10.1111/bph.14814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932944PMC
December 2019

Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment.

Antimicrob Agents Chemother 2019 10 23;63(10). Epub 2019 Sep 23.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1128/AAC.01082-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761512PMC
October 2019

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay.

Antimicrob Agents Chemother 2019 09 23;63(9). Epub 2019 Aug 23.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1128/AAC.00309-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709497PMC
September 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2018 Nov;16(11):714

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1038/s41579-018-0085-1DOI Listing
November 2018

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery.

PLoS Negl Trop Dis 2018 07 12;12(7):e0006612. Epub 2018 Jul 12.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0006612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057682PMC
July 2018

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2017 Feb 27;15(4):217-231. Epub 2017 Feb 27.

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/nrmicro.2016.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582623PMC
February 2017

Identification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput Screening.

J Biomol Screen 2016 Oct 29;21(9):978-88. Epub 2016 Jun 29.

School of Biology, University of St Andrews, St Andrews, Fife, UK Biomedical Sciences Research Complex (BSRC), University of St Andrews, St Andrews, Fife, UK

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030734PMC
http://dx.doi.org/10.1177/1087057116656314DOI Listing
October 2016

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade.

PLoS Negl Trop Dis 2016 Apr 15;10(4):e0004584. Epub 2016 Apr 15.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

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https://dx.plos.org/10.1371/journal.pntd.0004584
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http://dx.doi.org/10.1371/journal.pntd.0004584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833300PMC
April 2016

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA.

J Mol Biol 2016 Jan 10;428(1):108-120. Epub 2015 Nov 10.

Biomedical Sciences Research Complex and EaStCHEM, School of Chemistry, University of St. Andrews, North Haugh, St. Andrews, Fife KY16 9ST, United Kingdom; State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, China 610065. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840175PMC
January 2016

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

Antimicrob Agents Chemother 2013 Jul 9;57(7):2913-22. Epub 2013 Apr 9.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1128/AAC.02398-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697379PMC
July 2013

A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes.

PLoS Negl Trop Dis 2012 29;6(11):e1932. Epub 2012 Nov 29.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0001932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510075PMC
April 2013

Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands.

Bioorg Med Chem Lett 2008 Sep 5;18(18):5075-7. Epub 2008 Aug 5.

GlaxoSmithKline Research, 5 Moore Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.07.121DOI Listing
September 2008

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines.

Bioorg Med Chem Lett 2006 Jul 5;16(14):3777-9. Epub 2006 May 5.

Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709-3398, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.04.055DOI Listing
July 2006

Evaluation of cell-based assays for steroid nuclear receptors delivered by recombinant baculoviruses.

J Biomol Screen 2005 Oct 29;10(7):715-24. Epub 2005 Aug 29.

Assay Development and Compound Profiling, GlaxoSmithKline, Stevenage, Hertfordshire, UK.

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http://dx.doi.org/10.1177/1087057105278873DOI Listing
October 2005

Functional pharmacology of human prostanoid EP2 and EP4 receptors.

Eur J Pharmacol 2004 Oct;501(1-3):49-58

Receptor Pharmacology Unit, Department of In-vitro Pharmacology, GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK.

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http://dx.doi.org/10.1016/j.ejphar.2004.08.025DOI Listing
October 2004