David W Dunne

David W Dunne

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David W Dunne

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Schistosoma mansoni schistosomula antigens induce Th1/Pro-inflammatory cytokine responses.

Parasite Immunol 2018 Dec 21;40(12):e12592. Epub 2018 Oct 21.

Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

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http://doi.wiley.com/10.1111/pim.12592
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http://dx.doi.org/10.1111/pim.12592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492251PMC
December 2018

Antibody responses to Schistosoma mansoni schistosomula antigens.

Parasite Immunol 2018 Dec 14;40(12):e12591. Epub 2018 Oct 14.

Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

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http://dx.doi.org/10.1111/pim.12591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492298PMC
December 2018

Precision global health and comorbidity: a population-based study of 16 357 people in rural Uganda.

J R Soc Interface 2018 10 31;15(147). Epub 2018 Oct 31.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

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http://rsif.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rsif.2018.0248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6228477PMC
October 2018

Schistosomiasis.

Nat Rev Dis Primers 2018 08 9;4(1):13. Epub 2018 Aug 9.

National Institute of Parasitic Diseases, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1038/s41572-018-0013-8DOI Listing
August 2018

Diffusion of treatment in social networks and mass drug administration.

Nat Commun 2017 12 5;8(1):1929. Epub 2017 Dec 5.

Department of Pathology, University of Cambridge, Tennis Ct. Rd., Cambridge, CB2 1QP, UK.

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http://dx.doi.org/10.1038/s41467-017-01499-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717046PMC
December 2017

IgE-tailpiece associates with α-1-antitrypsin (A1AT) to protect IgE from proteolysis without compromising its ability to interact with FcεRI.

Sci Rep 2016 Feb 4;6:20509. Epub 2016 Feb 4.

Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.

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http://dx.doi.org/10.1038/srep20509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740804PMC
February 2016

Immunology in Africa.

Trop Med Int Health 2015 Dec 12;20(12):1771-7. Epub 2015 Oct 12.

MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.

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http://dx.doi.org/10.1111/tmi.12599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737115PMC
December 2015

The Schistosoma mansoni T2 ribonuclease omega-1 modulates inflammasome-dependent IL-1β secretion in macrophages.

Int J Parasitol 2015 Nov 16;45(13):809-13. Epub 2015 Sep 16.

Department of Pathology, University of Cambridge, Tennis Court Road, CB2 1QP Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2015.08.005DOI Listing
November 2015

Development of a Schistosoma mansoni shotgun O-glycan microarray and application to the discovery of new antigenic schistosome glycan motifs.

Int J Parasitol 2015 Jun 26;45(7):465-75. Epub 2015 Mar 26.

Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ijpara.2015.02.008DOI Listing
June 2015

Periportal fibrosis, liver and spleen sizes among S. mansoni mono or co-infected individuals with human immunodeficiency virus-1 in fishing villages along Lake Victoria shores, North-Western, Tanzania.

Parasit Vectors 2015 May 7;8:260. Epub 2015 May 7.

Department of Disease Control and Environmental Health, School of Public Health, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.

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http://dx.doi.org/10.1186/s13071-015-0876-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424565PMC
May 2015

Praziquantel efficacy against Schistosoma mansoni among HIV-1 infected and uninfected adults living in fishing villages along Lake Victoria, Northwest Tanzania.

Infect Dis Poverty 2014 15;3(1):47. Epub 2014 Dec 15.

Department of Disease Control and Environmental Health, School of Public Health, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.

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http://dx.doi.org/10.1186/2049-9957-3-47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322465PMC
February 2015

Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties.

Biochimie 2015 Jan 5;108:40-7. Epub 2014 Nov 5.

School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK; Institute for Global Food Security, Queen's University Belfast, 18-30 Malone Road, Belfast, BT9 5BN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300400PMC
January 2015

Co-infection with Schistosoma mansoni and Human Immunodeficiency Virus-1 (HIV-1) among residents of fishing villages of north-western Tanzania.

Parasit Vectors 2014 Dec 16;7:587. Epub 2014 Dec 16.

Department of Disease Control and Environmental Health, School of Public Health, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.

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http://dx.doi.org/10.1186/s13071-014-0587-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271490PMC
December 2014

Effect of maternal Schistosoma mansoni infection and praziquantel treatment during pregnancy on Schistosoma mansoni infection and immune responsiveness among offspring at age five years.

PLoS Negl Trop Dis 2013 17;7(10):e2501. Epub 2013 Oct 17.

Department of Veterinary Pharmacy, Clinical and Comparative Medicine, Makerere University, Kampala, Uganda ; Uganda Virus Research Institute, Entebbe, Uganda.

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http://dx.doi.org/10.1371/journal.pntd.0002501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798616PMC
May 2014

Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection.

PLoS Negl Trop Dis 2014 Feb 20;8(2):e2701. Epub 2014 Feb 20.

Centre for Immunity, Infection and Evolution, Ashworth Laboratories, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0002701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930507PMC
February 2014

Triose phosphate isomerase from the blood fluke Schistosoma mansoni: biochemical characterisation of a potential drug and vaccine target.

FEBS Lett 2013 Nov 23;587(21):3422-7. Epub 2013 Sep 23.

School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1016/j.febslet.2013.09.022DOI Listing
November 2013

Comparative study of transcriptome profiles of mechanical- and skin-transformed Schistosoma mansoni schistosomula.

PLoS Negl Trop Dis 2013 14;7(3):e2091. Epub 2013 Mar 14.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0002091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597483PMC
August 2013

Exploring network theory for mass drug administration.

Trends Parasitol 2013 Aug 3;29(8):370-9. Epub 2013 Jun 3.

Department of Land Economy, University of Cambridge, Cambridge CB3 9EP, UK.

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http://dx.doi.org/10.1016/j.pt.2013.04.005DOI Listing
August 2013

Differential anti-glycan antibody responses in Schistosoma mansoni-infected children and adults studied by shotgun glycan microarray.

PLoS Negl Trop Dis 2012 29;6(11):e1922. Epub 2012 Nov 29.

Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0001922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510071PMC
April 2013

Epidemiology and interactions of Human Immunodeficiency Virus - 1 and Schistosoma mansoni in sub-Saharan Africa.

Infect Dis Poverty 2013 Jan 24;2(1). Epub 2013 Jan 24.

Department of Medical Parasitology and Entomology, School of Medicine, Catholic University of Health and Allied Sciences, P,O, Box 1464, Mwanza, Tanzania.

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http://dx.doi.org/10.1186/2049-9957-2-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707091PMC
January 2013

Epidemiology and control of human schistosomiasis in Tanzania.

Parasit Vectors 2012 Nov 28;5:274. Epub 2012 Nov 28.

Department of Medical Parasitology and Entomology, School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.

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http://dx.doi.org/10.1186/1756-3305-5-274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549774PMC
November 2012

Aflatoxin exposure may contribute to chronic hepatomegaly in Kenyan school children.

Environ Health Perspect 2012 Jun 27;120(6):893-6. Epub 2012 Feb 27.

Division of Epidemiology, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1289/ehp.1104357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385435PMC
June 2012

Advances in our understanding of the epidemiology of Plasmodium and schistosome infection: informing coinfection studies.

Curr Opin HIV AIDS 2012 May;7(3):225-30

Department of Pathology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1097/COH.0b013e328351b9fbDOI Listing
May 2012

The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4⁺ T cells.

Eur J Immunol 2011 Sep 4;41(9):2709-18. Epub 2011 Aug 4.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, UK.

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http://dx.doi.org/10.1002/eji.201141429DOI Listing
September 2011

Chronic hepatosplenomegaly in African school children: a common but neglected morbidity associated with schistosomiasis and malaria.

PLoS Negl Trop Dis 2011 Aug 30;5(8):e1149. Epub 2011 Aug 30.

Department of Pathology, University of Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0001149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166045PMC
August 2011

Understanding ethnic differences in behaviour relating to Schistosoma mansoni re-infection after mass treatment.

J Biosoc Sci 2011 Mar 22;43(2):185-209. Epub 2010 Nov 22.

Department of Pathology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1017/S002193201000060XDOI Listing
March 2011

Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens.

Eur J Immunol 2010 Aug;40(8):2221-9

Department of Pathology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/eji.200939998DOI Listing
August 2010

Immune modulation by Schistosoma mansoni antigens in NOD mice: effects on both innate and adaptive immune systems.

J Biomed Biotechnol 2010 1;2010:795210. Epub 2010 Mar 1.

Department of Pathology, University of Cambridge, Tennis Court Road, CB21QP Cambridge, UK.

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http://dx.doi.org/10.1155/2010/795210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830582PMC
May 2010

Locating irregularly shaped clusters of infection intensity.

Geospat Health 2010 May;4(2):191-200

School of Geography and Earth Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.4081/gh.2010.200DOI Listing
May 2010

Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni.

PLoS Negl Trop Dis 2010 Mar 23;4(3):e637. Epub 2010 Mar 23.

Department of Microbiology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0000637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843635PMC
March 2010

Pulmonary vascular remodeling correlates with lung eggs and cytokines in murine schistosomiasis.

Am J Respir Crit Care Med 2010 Feb 3;181(3):279-88. Epub 2009 Dec 3.

Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1164/rccm.200903-0355OCDOI Listing
February 2010

Survival of the fittest: allergology or parasitology?

Trends Parasitol 2009 Oct 9;25(10):447-51. Epub 2009 Sep 9.

Department of Pathology, University of Cambridge, Cambridge, UK, CB2 1QP.

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http://dx.doi.org/10.1016/j.pt.2009.07.004DOI Listing
October 2009

Schistosoma mansoni egg antigens induce Treg that participate in diabetes prevention in NOD mice.

Eur J Immunol 2009 Apr;39(4):1098-107

Department of Pathology, University of Cambridge, Cambridge, UK.

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http://doi.wiley.com/10.1002/eji.200838871
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http://dx.doi.org/10.1002/eji.200838871DOI Listing
April 2009

Assessment of Schistosoma mansoni induced intestinal inflammation by means of eosinophil cationic protein, eosinophil protein X and myeloperoxidase before and after treatment with praziquantel.

Acta Trop 2008 Mar 29;105(3):253-9. Epub 2007 Nov 29.

DBL Centre for Health Research and Development, Department of Veterinary Pathology, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871, Frederiksberg C, Denmark.

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http://dx.doi.org/10.1016/j.actatropica.2007.11.004DOI Listing
March 2008

Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions.

Mol Immunol 2008 Jan 12;45(2):567-74. Epub 2007 Jul 12.

Institute of Genetics, University of Nottingham, Queen's Medical Centre, Nottingham, UK.

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http://dx.doi.org/10.1016/j.molimm.2007.05.021DOI Listing
January 2008

Schistosoma mansoni, nematode infections, and progression to active tuberculosis among HIV-1-infected Ugandans.

Am J Trop Med Hyg 2006 May;74(5):819-25

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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May 2006

Spatial awareness in parasite immuno-epidemiology.

Parasite Immunol 2004 Nov-Dec;26(11-12):499-507

University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK.

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http://dx.doi.org/10.1111/j.0141-9838.2004.00735.xDOI Listing
May 2005

A worm's eye view of the immune system: consequences for evolution of human autoimmune disease.

Nat Rev Immunol 2005 05;5(5):420-6

Department of Pathology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/nri1601DOI Listing
May 2005

Human IgE response to the Schistosoma haematobium 22.6 kDa antigen.

Parasite Immunol 2004 Aug-Sep;26(8-9):371-6

Department of Pathology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/j.0141-9838.2004.00721.xDOI Listing
April 2005

Can helminth antigens be exploited therapeutically to downregulate pathological Th1 responses?

Curr Opin Investig Drugs 2004 Nov;5(11):1184-91

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

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November 2004

The impact of infection on the incidence of autoimmune disease.

Curr Top Med Chem 2004 ;4(5):521-9

Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK.

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http://dx.doi.org/10.2174/1568026043451258DOI Listing
October 2004

Morbidity in schistosomiasis: an update.

Curr Opin Infect Dis 2004 Oct;17(5):439-47

Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark.

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http://dx.doi.org/10.1097/00001432-200410000-00009DOI Listing
October 2004

Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan children.

BMC Med 2004 Sep 27;2:36. Epub 2004 Sep 27.

Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.

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http://dx.doi.org/10.1186/1741-7015-2-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC522803PMC
September 2004

Gender-associated gene expression in two related strains of Schistosoma japonicum.

Mol Biochem Parasitol 2004 Aug;136(2):191-209

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2004.03.014DOI Listing
August 2004

Infection and autoimmunity: are we winning the war, only to lose the peace?

Trends Parasitol 2004 Jul;20(7):316-21

Pathology Department, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

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http://dx.doi.org/10.1016/j.pt.2004.04.010DOI Listing
July 2004