David W Courtman

David W Courtman

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David W Courtman

David W Courtman

Publications by authors named "David W Courtman"

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Marked Strain-Specific Differences in the SU5416 Rat Model of Severe Pulmonary Arterial Hypertension.

Am J Respir Cell Mol Biol 2016 Apr;54(4):461-8

1 Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; and.

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http://dx.doi.org/10.1165/rcmb.2014-0488OCDOI Listing
April 2016

Endothelial NO-Synthase Gene-Enhanced Progenitor Cell Therapy for Pulmonary Arterial Hypertension: The PHACeT Trial.

Circ Res 2015 Sep 20;117(7):645-54. Epub 2015 Jul 20.

From the Division of Respirology, Pulmonary Hypertension Program, University Health Network (J. Granton) and Division of Cardiology, Keenan Research Center for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael's Hospital (M.B.K.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada (J. Granton, M.B.K.); Center for Pulmonary Vascular Disease, Division of Cardiology, and Lady Davis Research Institute, Jewish General Hospital, Department of Medicine, McGill University, Montreal, Quebec, Canada (D.L.); Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (N.C., D.W.C., D.J.S.); Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.W.C., D.J.S.); Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, GA (J. Galipeau); and Northern Therapeutics, Montreal, Quebec, Canada (D.W.C., D.J.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.114.30595
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http://dx.doi.org/10.1161/CIRCRESAHA.114.305951DOI Listing
September 2015

Proteomic analysis implicates translationally controlled tumor protein as a novel mediator of occlusive vascular remodeling in pulmonary arterial hypertension.

Circulation 2014 May 21;129(21):2125-35. Epub 2014 Mar 21.

From the Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research and Regenerative Medicine Program, Ottawa, ON, Canada (J.R.L., C.P.-I., D.W.C., B.J., W.S.F., D.J.S.); University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada (J.R.L., W.S.F., D.J.S.); University of Cambridge, Department of Medicine, Addenbrooke's Hospital, Cambridge, UK (M.L.O., E.F., P.C., N.W.M.); and Papworth Hospital, Department of Pathology, Papworth, UK (M.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.008777DOI Listing
May 2014

Derivation of human peripheral blood derived endothelial progenitor cells and the role of osteopontin surface modification and eNOS transfection.

Biomaterials 2013 Oct 28;34(30):7292-301. Epub 2013 Jun 28.

Ottawa Hospital Research Institute, Ottawa, ON, Canada.

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http://dx.doi.org/10.1016/j.biomaterials.2013.06.003DOI Listing
October 2013

A lymphocyte-dependent mode of action for imatinib mesylate in experimental pulmonary hypertension.

Am J Pathol 2013 May 19;182(5):1541-51. Epub 2013 Mar 19.

Terrence Donnelly Cardiovascular Research Laboratories, St. Michael's Hospital, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00029440130011
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http://dx.doi.org/10.1016/j.ajpath.2013.01.031DOI Listing
May 2013

Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice.

Am J Pathol 2011 Sep 29;179(3):1549-59. Epub 2011 Jun 29.

Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ajpath.2011.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157254PMC
September 2011

The role of transglutaminase 2 and osteopontin in matrix protein supplemented microencapsulation of marrow stromal cells.

Biomaterials 2010 Dec;31(35):9256-65

The Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01429612100109
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http://dx.doi.org/10.1016/j.biomaterials.2010.08.060DOI Listing
December 2010

Innate immunity in the therapeutic actions of endothelial progenitor cells in pulmonary hypertension.

Am J Respir Cell Mol Biol 2010 Nov 7;43(5):546-54. Epub 2009 Dec 7.

Ottawa Hospital Research Institute and the University of Ottawa, Ottawa, Ontario, K1H 8L6 Canada.

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http://dx.doi.org/10.1165/rcmb.2009-0152OCDOI Listing
November 2010

Enhanced translation of heme oxygenase-2 preserves human endothelial cell viability during hypoxia.

J Biol Chem 2010 Mar 29;285(13):9452-61. Epub 2010 Jan 29.

Terrence Donnelly Laboratories, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada.

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http://dx.doi.org/10.1074/jbc.M109.077230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843195PMC
March 2010

The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension.

Am J Physiol Lung Cell Mol Physiol 2010 Feb 13;298(2):L148-57. Epub 2009 Nov 13.

Terrence Donnelly Cardiovascular Research Laboratories, Rm. 8-038, Queen Wing, St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1W8 Canada.

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http://dx.doi.org/10.1152/ajplung.00097.2009DOI Listing
February 2010

Elevated platelet angiostatin and circulating endothelial microfragments in idiopathic pulmonary arterial hypertension: a preliminary study.

Thromb Res 2010 Jan 9;125(1):53-60. Epub 2009 May 9.

St. Michael's Hospital, Toronto; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.thromres.2009.04.005DOI Listing
January 2010

Single-cell hydrogel encapsulation for enhanced survival of human marrow stromal cells.

Biomaterials 2009 Oct;30(29):5445-55

University of Toronto and St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.biomaterials.2009.06.035DOI Listing
October 2009

A population analysis of VEGF transgene expression and secretion.

Biotechnol Bioeng 2008 Dec;101(5):1083-93

Division of General Thoracic Surgery, University Hospital Berne, 35 Murtenstrasse, Berne CH3010, Switzerland.

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http://doi.wiley.com/10.1002/bit.21993
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http://dx.doi.org/10.1002/bit.21993DOI Listing
December 2008

Capture of flowing endothelial cells using surface-immobilized anti-kinase insert domain receptor antibody.

Tissue Eng Part C Methods 2008 Jun;14(2):97-105

Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1089/ten.tec.2007.0300DOI Listing
June 2008

MRI characterization of agarose gel micro-droplets at acute time-points within the rabbit lumbar muscle.

Biomaterials 2008 Apr 21;29(12):1844-52. Epub 2008 Feb 21.

Department of Cardiology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.biomaterials.2007.12.012DOI Listing
April 2008

Oxygen regulation of arterial smooth muscle cell proliferation and survival.

Am J Physiol Heart Circ Physiol 2008 Feb 30;294(2):H839-52. Epub 2007 Nov 30.

Institute of Medical Science, University of Toronto, St. Michael's Hospital, Ontario, Canada.

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http://www.physiology.org/doi/10.1152/ajpheart.00587.2007
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http://dx.doi.org/10.1152/ajpheart.00587.2007DOI Listing
February 2008

Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer.

Am J Respir Cell Mol Biol 2006 Aug 16;35(2):182-9. Epub 2006 Mar 16.

Division of Cardiology, The Terrence Donnelly Vascular Biology Laboratories, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1165/rcmb.2005-0115OCDOI Listing
August 2006

Development of a reinforced porcine elastin composite vascular scaffold.

J Biomed Mater Res A 2006 Jun;77(3):458-69

Department of Biomedical Engineering, Oregon Health and Science University, Portland, 97006, USA.

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http://dx.doi.org/10.1002/jbm.a.30571DOI Listing
June 2006

Fluorescent microangiography (FMA): an improved tool to visualize the pulmonary microvasculature.

Lab Invest 2006 Apr;86(4):409-16

Division of General Thoracic Surgery, University Hospital of Berne, Berne, Switzerland.

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http://dx.doi.org/10.1038/labinvest.3700399DOI Listing
April 2006

Inward remodeling of the rabbit aorta is blocked by the matrix metalloproteinase inhibitor doxycycline.

J Vasc Res 2004 Mar-Apr;41(2):157-65. Epub 2004 Mar 3.

Terrence Donnelly Cardiovascular Research Laboratories, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1159/000077145DOI Listing
May 2004

Biocompatibility of a xenogenic elastin-based biomaterial in a murine implantation model: the role of aluminum chloride pretreatment.

J Biomed Mater Res A 2004 Apr;69(1):55-64

Oregon Medical Laser Center, Providence St. Vincent Medical Center, Portland, Oregon 97225, USA.

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http://dx.doi.org/10.1002/jbm.a.20109DOI Listing
April 2004

A nonantibiotic chemically modified tetracycline (CMT-3) inhibits intimal thickening.

Am J Pathol 2003 Oct;163(4):1557-66

Departments of Laboratory Medicine and Pathobiology and Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868303PMC
http://dx.doi.org/10.1016/S0002-9440(10)63512-2DOI Listing
October 2003