David W Cescon

David W Cescon

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David W Cescon

David W Cescon

Publications by authors named "David W Cescon"

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Integrative Pharmacogenomics Analysis of Patient-Derived Xenografts.

Cancer Res 2019 Sep 29;79(17):4539-4550. Epub 2019 May 29.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0349DOI Listing
September 2019

Evolution in sites of recurrence over time in breast cancer patients treated with adjuvant endocrine therapy.

Cancer Treat Rev 2018 Nov 24;70:138-143. Epub 2018 Aug 24.

Division of Medical Oncology, Princess Margaret Cancer Centre and the University of Toronto, Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03057372183014
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http://dx.doi.org/10.1016/j.ctrv.2018.08.009DOI Listing
November 2018

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition.

Proc Natl Acad Sci U S A 2018 11 30;115(46):E10810-E10811. Epub 2018 Oct 30.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.

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http://dx.doi.org/10.1073/pnas.1813967115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243257PMC
November 2018

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.

Cancer Cell 2018 10;34(4):579-595.e8

Princess Margaret Cancer Centre, Toronto, ON M5G1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183041
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http://dx.doi.org/10.1016/j.ccell.2018.09.001DOI Listing
October 2018

Influence of control group therapy on the benefit from dose-dense chemotherapy in early breast cancer: a systemic review and meta-analysis.

Breast Cancer Res Treat 2018 Jun 8;169(3):413-425. Epub 2018 Feb 8.

Division of Medical Oncology, Princess Margaret Cancer Centre and the University of Toronto, 610 University Ave, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s10549-018-4710-5DOI Listing
June 2018

Gene Expression Analyses in Breast Cancer: Sample Matters.

JNCI Cancer Spectr 2018 Apr 22;2(2):pky019. Epub 2018 May 22.

Campbell Family Institute for Breast Cancer Research, Department of Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/jncics/pky019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649719PMC
April 2018

Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization.

Bioorg Med Chem Lett 2018 03 9;28(5):934-941. Epub 2018 Feb 9.

Frost Biologic, Inc., 5201 South Green St., Suite 160, Salt Lake City, UT 84123, USA; Department of Physiology and Developmental Biology, Brigham Young University, 4005 LSB, Provo, UT 84602, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.01.053DOI Listing
March 2018

Toxicity of Extended Adjuvant Therapy With Aromatase Inhibitors in Early Breast Cancer: A Systematic Review and Meta-analysis.

J Natl Cancer Inst 2018 01;110(1)

Division of Medical Oncology, University of Toronto and Princess Margaret Cancer Centre, Toronto, Canada; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia; Research Unit, Albacete University Hospital, Albacete, Spain; Translational Oncology Laboratory, Regional Center for Biomedical Research, Castilla La Mancha University, Albacete, Spain.

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http://academic.oup.com/jnci/article/110/1/31/4065461
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http://dx.doi.org/10.1093/jnci/djx141DOI Listing
January 2018

Capecitabine in early breast cancer: A meta-analysis of randomised controlled trials.

Eur J Cancer 2017 05 27;77:40-47. Epub 2017 Mar 27.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada; Division of Medical Oncology and Hematology, Department of Medicine, University of Toronto, 200 Elizabeth Street, Suite RFE3-805, Toronto, Ontario, M5G 2C4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.02.024DOI Listing
May 2017

DNA replication stress: a source of APOBEC3B expression in breast cancer.

Genome Biol 2016 09 30;17(1):202. Epub 2016 Sep 30.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/s13059-016-1069-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045630PMC
September 2016

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Cancer Cell 2016 08 14;30(2):337-348. Epub 2016 Jul 14.

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada; The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022794PMC
August 2016

NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma.

Clin Cancer Res 2015 Jun 4;21(11):2499-505. Epub 2015 Mar 4.

Department of Pathology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-14-2206DOI Listing
June 2015

PIK3CA genotype and treatment decisions in human epidermal growth factor receptor 2-positive breast cancer.

J Clin Oncol 2015 Apr 5;33(12):1318-21. Epub 2015 Jan 5.

Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1200/JCO.2014.59.3160DOI Listing
April 2015

APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation.

Proc Natl Acad Sci U S A 2015 Mar 17;112(9):2841-6. Epub 2015 Feb 17.

Princess Margaret Cancer Centre, University Health Network, M5G 2M9 Toronto, Canada; Campbell Family Institute for Breast Cancer Research, M5G 2M9 Toronto, Canada; Department of Medical Biophysics, University of Toronto, M5G 1L7 Toronto, Canada; and

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http://dx.doi.org/10.1073/pnas.1424869112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352793PMC
March 2015

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

Cancer Cell 2015 Feb 22;27(2):211-22. Epub 2015 Jan 22.

The Campbell Family Institute for Breast Cancer Research, University Health Network, 620 University Avenue, Toronto, ON M5G 2M9, Canada; Department of Medical Biophysics, University Health Network, 620 University Avenue, Toronto, ON M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.019DOI Listing
February 2015

Extended adjuvant tamoxifen for early breast cancer: a meta-analysis.

PLoS One 2014 20;9(2):e88238. Epub 2014 Feb 20.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre and Department of Medicine, University of Toronto, Toronto, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088238PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930532PMC
January 2015

Breaking up is hard to do: PI3K isoforms on the rebound.

Cancer Cell 2015 Jan;27(1):5-7

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre/University Health Network, Toronto, ON M5T 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.12.003DOI Listing
January 2015

Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent.

Cancer Cell 2014 Aug 17;26(2):163-76. Epub 2014 Jul 17.

The Campbell Family Institute for Breast Cancer Research, 620 University Avenue, Toronto, ON M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.05.006DOI Listing
August 2014

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.

Proc Natl Acad Sci U S A 2014 Mar 24;111(12):4472-7. Epub 2014 Feb 24.

The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1324136111
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http://dx.doi.org/10.1073/pnas.1324136111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970526PMC
March 2014

Feasibility of a randomized controlled trial of vitamin D vs. placebo in women with recently diagnosed breast cancer.

Breast Cancer Res Treat 2012 Jul 16;134(2):759-67. Epub 2012 Jun 16.

Mount Sinai Hospital, 1284-600 University Avenue, Toronto, ON, M5G 1X5, Canada.

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http://dx.doi.org/10.1007/s10549-012-2120-7DOI Listing
July 2012

Pharmacogenetic and germline prognostic markers of lung cancer.

J Thorac Oncol 2011 Feb;6(2):296-304

Department of Medical Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JTO.0b013e3181ffe909DOI Listing
February 2011

Presentation of nonfinal results of randomized controlled trials at major oncology meetings.

J Clin Oncol 2009 Aug 20;27(24):3938-44. Epub 2009 Jul 20.

National Cancer Institute of Canada Clinical Trials Group, Cancer Research Institute, Queen's University, Kingston, ON, Canada.

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http://dx.doi.org/10.1200/JCO.2008.18.8771DOI Listing
August 2009

Evolution of the randomized controlled trial in oncology over three decades.

J Clin Oncol 2008 Nov 27;26(33):5458-64. Epub 2008 Oct 27.

National Cancer Institute of Canada Clinical Trials Group, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2008.16.5456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651075PMC
November 2008

Bowel loops and eyelid droops.

CMAJ 2008 Oct;179(9):927-9

Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ont.

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http://www.cmaj.ca/cgi/doi/10.1503/cmaj.080651
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http://dx.doi.org/10.1503/cmaj.080651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565713PMC
October 2008

Invasive pulmonary aspergillosis associated with marijuana use in a man with colorectal cancer.

J Clin Oncol 2008 May;26(13):2214-5

Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1200/JCO.2007.15.2777DOI Listing
May 2008

Barcoded medication administration: a last line of defense.

JAMA 2008 May;299(18):2200-2

Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.29
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http://dx.doi.org/10.1001/jama.299.18.2200DOI Listing
May 2008

Genetic polymorphisms and head and neck cancer outcomes: a review.

Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):490-9

Community Medicine Residency Program and Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-07-2714DOI Listing
March 2008