David W Beasley

David W Beasley

UNVERIFIED PROFILE

Are you David W Beasley?   Register this Author

Register author
David W Beasley

David W Beasley

Publications by authors named "David W Beasley"

Are you David W Beasley?   Register this Author

69Publications

956Reads

8Profile Views

Defining a correlate of protection for chikungunya virus vaccines.

Vaccine 2019 Nov 15;37(50):7427-7436. Epub 2018 Nov 15.

WHO Collaborating Center for Vaccine Research, Evaluation and Training on Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0264410X183139
Publisher Site
http://dx.doi.org/10.1016/j.vaccine.2018.10.033DOI Listing
November 2019

Propagation and Titration of West Nile Virus on Vero Cells.

Methods Mol Biol 2016 ;1435:19-27

Department of Microbiology and Immunology, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, University of Texas Medical Branch, Keiller Building, Route 0609, 301 University Blvd., Galveston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-3670-0_3DOI Listing
December 2017

ELISA and Neutralization Methods to Measure Anti-West Nile Virus Antibody Responses.

Methods Mol Biol 2016 ;1435:129-41

Department of Microbiology and Immunology, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, University of Texas Medical Branch, Keiller Building, Route 0609, 301 University Blvd., Galveston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-3670-0_11DOI Listing
December 2017

Supramolecular peptide hydrogel adjuvanted subunit vaccine elicits protective antibody responses against West Nile virus.

Vaccine 2016 11 23;34(46):5479-5482. Epub 2016 Sep 23.

Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston 77555, TX, USA; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston 77555, TX, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2016.09.044DOI Listing
November 2016

Plasticity of a critical antigenic determinant in the West Nile virus NY99 envelope protein domain III.

Virology 2016 09 7;496:97-105. Epub 2016 Jun 7.

Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2016.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969113PMC
September 2016

First vaccine approval under the FDA Animal Rule.

NPJ Vaccines 2016 25;1:16013. Epub 2016 Aug 25.

Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/npjvaccines.2016.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707879PMC
August 2016

Status of research and development of vaccines for chikungunya.

Vaccine 2016 06 26;34(26):2976-2981. Epub 2016 Mar 26.

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, USA; World Health Organization Collaborating Center for Vaccine Research, Evaluation and Training on Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2016.03.076DOI Listing
June 2016

Recovery of West Nile Virus Envelope Protein Domain III Chimeras with Altered Antigenicity and Mouse Virulence.

J Virol 2016 May 14;90(9):4757-4770. Epub 2016 Apr 14.

Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02861-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836310PMC
May 2016

Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection.

PLoS Negl Trop Dis 2015 22;9(10):e0004119. Epub 2015 Oct 22.

Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas, United States of America; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America; Institute for Human Infections and Immunity, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0004119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619601PMC
March 2016

Yellow fever virus: genetic and phenotypic diversity and implications for detection, prevention and therapy.

Antiviral Res 2015 Mar 26;115:48-70. Epub 2014 Dec 26.

Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, United States; Sealy Center for Vaccine Development, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, United States; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, United States; Institute for Human Infections and Immunity, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.antiviral.2014.12.010DOI Listing
March 2015

Thermodynamic mechanism for the evasion of antibody neutralization in flaviviruses.

J Am Chem Soc 2014 Jul 8;136(29):10315-24. Epub 2014 Jul 8.

Department of Biochemistry & Molecular Biology, ‡Department of Microbiology & Immunology, §Department of Pathology, ∥Sealy Center for Vaccine Development, ⊥Institute for Human Infections and Immunity and #Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch , Galveston, Texas 77555, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja503318xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111217PMC
July 2014

Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs.

Proc Natl Acad Sci U S A 2014 Jul 7;111(29):10708-13. Epub 2014 Jul 7.

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1408677111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115546PMC
July 2014

GeneSV - an Approach to Help Characterize Possible Variations in Genomic and Protein Sequences.

Bioinform Biol Insights 2014 Jan 8;8:1-16. Epub 2014 Jan 8.

Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/BBI.S13076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893053PMC
January 2014

Adaptation of yellow fever virus 17D to Vero cells is associated with mutations in structural and non-structural protein genes.

Virus Res 2013 Sep 16;176(1-2):280-4. Epub 2013 Apr 16.

Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virusres.2013.04.003DOI Listing
September 2013

Resurgence of West Nile neurologic disease in the United States in 2012: what happened? What needs to be done?

Antiviral Res 2013 Jul 26;99(1):1-5. Epub 2013 Apr 26.

Departments of Microbiology and Immunology, and Pathology, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, The University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01663542130010
Publisher Site
http://dx.doi.org/10.1016/j.antiviral.2013.04.015DOI Listing
July 2013

Molecular evolution of lineage 2 West Nile virus.

J Gen Virol 2013 Feb 7;94(Pt 2):318-25. Epub 2012 Nov 7.

Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.046888-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709619PMC
February 2013

Mutational analysis of the West Nile virus NS4B protein.

Virology 2012 Apr 6;426(1):22-33. Epub 2012 Feb 6.

Department of Microbiology and Immunology, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2011.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583194PMC
April 2012

Conservation of the DENV-2 type-specific and DEN complex-reactive antigenic sites among DENV-2 genotypes.

Virology 2012 Jan 5;422(2):386-92. Epub 2011 Dec 5.

Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0436, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2011.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142575PMC
January 2012

Safety and immunogenicity of a chimeric vaccine for West Nile virus in aged subjects.

Expert Rev Vaccines 2011 May;10(5):601-4

Department of Microbiology and Immunology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Disease, Institute for Human Infections and Immunity, Galveston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/erv.11.47DOI Listing
May 2011

Vaccines and immunotherapeutics for the prevention and treatment of infections with West Nile virus.

Immunotherapy 2011 Feb;3(2):269-85

Department of Microbiology & Immunology, Sealy Center for Vaccine Development, Center for Biodefense & Emerging Infectious Diseases, Institute for Human Infections & Immunity, & Galveston National Laboratory, The University of Texas Medical Branch, Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/imt.10.93DOI Listing
February 2011

Development and characterization of non-glycosylated E and NS1 mutant viruses as a potential candidate vaccine for West Nile virus.

Vaccine 2010 Jan 5;28(4):1075-83. Epub 2009 Nov 5.

Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections, Immunity and Department of Pathology, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2009.10.112DOI Listing
January 2010

Persistent infection with West Nile virus years after initial infection.

J Infect Dis 2010 Jan;201(1):2-4

School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1086/648731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791189PMC
January 2010

Structure of yellow fever virus envelope protein domain III.

Virology 2009 Nov 8;394(1):12-8. Epub 2009 Oct 8.

Departments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-1157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2009.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787094PMC
November 2009

Development pathway for biodefense vaccines.

Vaccine 2009 Nov;27 Suppl 4:D2-7

Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0436, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2009.07.094DOI Listing
November 2009

Characterization of Culex Flavivirus (Flaviviridae) strains isolated from mosquitoes in the United States and Trinidad.

Virology 2009 Mar 3;386(1):154-9. Epub 2009 Feb 3.

Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2008.12.034DOI Listing
March 2009

NMR assignments of the sylvatic dengue 1 virus envelope protein domain III.

Biomol NMR Assign 2008 Dec 12;2(2):155-7. Epub 2008 Aug 12.

Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX 77555-1157, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12104-008-9109-5
Publisher Site
http://dx.doi.org/10.1007/s12104-008-9109-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593834PMC
December 2008

Genetic variation of St. Louis encephalitis virus.

J Gen Virol 2008 Aug;89(Pt 8):1901-10

Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.2008/000190-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696384PMC
August 2008

Long range communication in the envelope protein domain III and its effect on the resistance of West Nile virus to antibody-mediated neutralization.

J Biol Chem 2008 Jan 6;283(1):613-22. Epub 2007 Nov 6.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-1055, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M706031200
Publisher Site
http://dx.doi.org/10.1074/jbc.M706031200DOI Listing
January 2008

Current use and development of vaccines for Japanese encephalitis.

Expert Opin Biol Ther 2008 Jan;8(1):95-106

University of Texas Medical Branch, Department of Microbiology and Immunology, Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/14712598.8.1.95DOI Listing
January 2008

Solution structure of the envelope protein domain III of dengue-4 virus.

Virology 2007 Jul 29;364(1):147-54. Epub 2007 Mar 29.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-1157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2007.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950219PMC
July 2007

Selection of thioaptamers for diagnostics and therapeutics.

Ann N Y Acad Sci 2006 Oct;1082:116-9

Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology, University of Texas Medical Branch at Galveston, Texas 77555-1157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1348.065DOI Listing
October 2006

A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus.

Virology 2006 Sep 27;353(1):35-40. Epub 2006 Jun 27.

Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2006.05.025DOI Listing
September 2006

Structure of the envelope protein domain III of Omsk hemorrhagic fever virus.

Virology 2006 Jul 2;351(1):188-95. Epub 2006 May 2.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-1157, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2006.03.030DOI Listing
July 2006

A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice.

Virology 2006 Jun 19;349(2):245-53. Epub 2006 Apr 19.

Department of Microbiology and Immunology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, and Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2006.03.007DOI Listing
June 2006

Recent advances in the molecular biology of west nile virus.

Curr Mol Med 2005 Dec;5(8):835-50

Department of Microbiology and Immunology, and Institute for Human Infections and Immunity, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/156652405774962272DOI Listing
December 2005

Phylogenetic analysis of North American West Nile virus isolates, 2001-2004: evidence for the emergence of a dominant genotype.

Virology 2005 Nov 31;342(2):252-65. Epub 2005 Aug 31.

Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, and Sealy Center for Vaccine Development, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77550-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2005.07.022DOI Listing
November 2005

Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains.

J Virol 2005 Jul;79(13):8339-47

Department of Pathology, Cancer Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd., Galveston, Texas 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.79.13.8339-8347.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143769PMC
July 2005

Short report: serological evidence of West Nile virus activity in El Salvador.

Am J Trop Med Hyg 2005 May;72(5):612-5

Field Epidemiology Training Program, Ministry of Public Health and Social Welfare, San Salvador, El Salvador.

View Article

Download full-text PDF

Source
May 2005

Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains.

Virology 2005 Apr;335(1):99-105

Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, and Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2005.02.011DOI Listing
April 2005

Emergence of attenuated West Nile virus variants in Texas, 2003.

Virology 2004 Dec;330(1):342-50

Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2004.09.016DOI Listing
December 2004

Characterization of a West Nile virus isolate from a human on the Gulf Coast of Texas.

J Clin Microbiol 2004 Nov;42(11):5375-7

Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.42.11.5375-5377.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC525281PMC
November 2004

Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus.

J Biol Chem 2004 Sep 9;279(37):38755-61. Epub 2004 Jun 9.

Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, Texas 77555-1147, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M402385200DOI Listing
September 2004

Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax-JE experimental vaccine.

Vaccine 2004 Sep;22(27-28):3722-6

Department of Pathology, Sealy Center for Vaccine Development, and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2004.03.027DOI Listing
September 2004

Natural and nosocomial infection in a patient with West Nile encephalitis and extrapyramidal movement disorders.

Clin Infect Dis 2003 Jun 19;36(11):E140-5. Epub 2003 May 19.

Department of Pathology, University Texas Medical Branch, Galveston, TX, USA; and Departments of Neurological Science and Medical Microbiology, University of Liverpool, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1086/374936DOI Listing
June 2003

West Nile encephalitis.

BMJ 2003 Apr;326(7394):865-9

Department of Neurological Science, University of Liverpool, Liverpool L9 7LJ, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmj.326.7394.865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1125772PMC
April 2003

Origin and evolution of Japanese encephalitis virus in southeast Asia.

J Virol 2003 Mar;77(5):3091-8

Department of Neurological Science, University of Liverpool, Liverpool L9 7LJ, United Kingdom.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149749PMC
http://dx.doi.org/10.1128/jvi.77.5.3091-3098.2003DOI Listing
March 2003

Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein.

J Virol 2002 Dec;76(24):13097-100

WHO Collaborating Center for Tropical Diseases, Sealy Center for Vaccine Development, Department of Pathology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136710PMC
http://dx.doi.org/10.1128/jvi.76.24.13097-13100.2002DOI Listing
December 2002

Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype.

Virology 2002 Apr;296(1):17-23

Department of Pathology, The University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1006/viro.2002.1372DOI Listing
April 2002