David W Andrews

David W Andrews

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David W Andrews

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Improved IRE1 and PERK Pathway Sensors for Multiplex Endoplasmic Reticulum Stress Assay Reveal Stress Response to Nuclear Dyes Used for Image Segmentation.

Assay Drug Dev Technol 2018 Aug/Sep;16(6):350-360. Epub 2018 Aug 8.

1 Biological Sciences Platform, Sunnybrook Research Institute , Sunnybrook Health Science Centre, Toronto, Ontario, Canada .

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https://www.liebertpub.com/doi/10.1089/adt.2018.862
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http://dx.doi.org/10.1089/adt.2018.862DOI Listing
October 2019

Peak emission wavelength and fluorescence lifetime are coupled in far-red, GFP-like fluorescent proteins.

PLoS One 2018 28;13(11):e0208075. Epub 2018 Nov 28.

Department of Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208075PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261627PMC
May 2019

Rapid Imaging of BCL-2 Family Interactions in Live Cells Using FLIM-FRET.

Methods Mol Biol 2019 ;1877:305-335

Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-8861-7_19DOI Listing
May 2019

Rapid Early Tumor Progression is Prognostic in Glioblastoma Patients.

Am J Clin Oncol 2019 May;42(5):481-486

Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.

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http://dx.doi.org/10.1097/COC.0000000000000537DOI Listing
May 2019

Phase I trial of alisertib with concurrent fractionated stereotactic re-irradiation for recurrent high grade gliomas.

Radiother Oncol 2019 Mar 4;132:135-141. Epub 2019 Jan 4.

Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2018.12.019DOI Listing
March 2019

Bevacizumab and re-irradiation for recurrent high grade gliomas: does sequence matter?

J Neurooncol 2018 Dec 4;140(3):623-628. Epub 2018 Sep 4.

Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

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http://dx.doi.org/10.1007/s11060-018-2989-zDOI Listing
December 2018

Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove.

Cancer Discov 2018 12;8(12):1511-1514

Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-1167DOI Listing
December 2018

Onco-metabolism: defining the prognostic significance of obesity and diabetes in women with brain metastases from breast cancer.

Breast Cancer Res Treat 2018 Nov 18;172(1):221-230. Epub 2018 Jul 18.

Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Bodine Center, Suite G-301, 111 South 11th Street, Philadelphia, PA, 19107, USA.

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http://link.springer.com/10.1007/s10549-018-4880-1
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http://dx.doi.org/10.1007/s10549-018-4880-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558990PMC
November 2018

miRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation.

Mol Oncol 2018 08 14;12(8):1324-1341. Epub 2018 Jun 14.

Biological Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada.

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http://dx.doi.org/10.1002/1878-0261.12328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068351PMC
August 2018

Spheno-Orbital Meningiomas: An Analysis Based on World Health Organization Classification and Ki-67 Proliferative Index.

Ophthalmic Plast Reconstr Surg 2018 Mar/Apr;34(2):143-150

Skull Base Division, Neuro-Ophthalmology Service, Wills Eye Hospital, Philadelphia, Pennsylvania, Department of Ophthalmology, New York University Langone Medical Center, New York, New York, and Department of Neurological Surgery, Department of Pathology, and Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, U.S.A.

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http://dx.doi.org/10.1097/IOP.0000000000000904DOI Listing
July 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

BCL-2 family proteins: changing partners in the dance towards death.

Cell Death Differ 2018 01 17;25(1):65-80. Epub 2017 Nov 17.

Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.

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http://www.nature.com/doifinder/10.1038/cdd.2017.186
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http://dx.doi.org/10.1038/cdd.2017.186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729540PMC
January 2018

Using Förster-Resonance Energy Transfer to Measure Protein Interactions Between Bcl-2 Family Proteins on Mitochondrial Membranes.

Methods Mol Biol 2016 ;1419:197-212

Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-3581-9_15DOI Listing
December 2017

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.

Cell Chem Biol 2017 Apr 6;24(4):493-506.e5. Epub 2017 Apr 6.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON M4N 3M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508953PMC
April 2017

High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells.

Blood 2016 08 13;128(7):934-47. Epub 2016 Jun 13.

Biology Platform, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Sunnybrook Odette Cancer Center, Toronto, ON, Canada; and Department of Medical Biophysics and Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2015-12-687814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000578PMC
August 2016

Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation.

Sci Rep 2016 07 6;6:29502. Epub 2016 Jul 6.

Department of Chemistry, University of Vermont, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1038/srep29502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933972PMC
July 2016

Phase I trial of panobinostat and fractionated stereotactic re-irradiation therapy for recurrent high grade gliomas.

J Neurooncol 2016 May 29;127(3):535-9. Epub 2016 Jan 29.

Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, 111 South 11th Street, Philadelphia, PA, 19107, USA.

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http://dx.doi.org/10.1007/s11060-016-2059-3DOI Listing
May 2016

Lipid Droplet-Associated Proteins (LDAPs) Are Required for the Dynamic Regulation of Neutral Lipid Compartmentation in Plant Cells.

Plant Physiol 2016 04 19;170(4):2052-71. Epub 2016 Feb 19.

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1 (S.K.G., M.P., R.T.M.);United States Department of Agriculture, Agricultural Research Service, United States Arid-Land Agricultural Research Center, Maricopa, Arizona 85138 (S.P., O.Y., J.M.D.);Department of Biological Sciences, Center for Plant Lipid Research, University of North Texas, Denton, Texas 76203 (Y.C., K.D.C.); andSunnybrook Research Institute and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada M4N 3M5 (P.W., D.W.A.)

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http://dx.doi.org/10.1104/pp.15.01977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825156PMC
April 2016

Serum exosomes and cytokines promote a T-helper cell type 2 environment in the peripheral blood of glioblastoma patients.

Neuro Oncol 2016 Feb 14;18(2):206-15. Epub 2015 Jul 14.

Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania (L.A.H., B.J.N., D.W.A., D.C.H.); Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania (D.C.H.); Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania (L.C.K.).

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/nov107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724173PMC
February 2016

Fractionated Stereotactic Radiotherapy for Facial Nerve Schwannomas.

J Neurol Surg B Skull Base 2016 Feb 14;77(1):75-80. Epub 2015 Sep 14.

Department of Neurological Surgery, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1055/s-0035-1564056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777614PMC
February 2016

BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes.

EMBO J 2016 Jan 23;35(2):208-36. Epub 2015 Dec 23.

Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

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http://dx.doi.org/10.15252/embj.201591552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718459PMC
January 2016

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.

Sci Rep 2016 Jan 27;6:19725. Epub 2016 Jan 27.

Département de Biologie Structurale Intégrative, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR 7104, INSERM U964, 1 rue Laurent Fries, BP 10142, F-67404 Illkirch, France.

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http://dx.doi.org/10.1038/srep19725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728560PMC
January 2016

A Versatile Cell Death Screening Assay Using Dye-Stained Cells and Multivariate Image Analysis.

Assay Drug Dev Technol 2015 Nov 30;13(9):547-57. Epub 2015 Sep 30.

2 Department of Biological Sciences, Sunnybrook Research Institute , Toronto, Ontario, Canada .

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http://www.liebertpub.com/doi/10.1089/adt.2015.661
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http://dx.doi.org/10.1089/adt.2015.661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652219PMC
November 2015

The use of FLIM-FRET for the detection of mitochondria-associated protein interactions.

Methods Mol Biol 2015 ;1264:395-419

Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-2257-4_34DOI Listing
October 2015

High-speed multifocal array scanning using refractive window tilting.

Biomed Opt Express 2015 Oct 2;6(10):3737-47. Epub 2015 Sep 2.

Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4L7, Canada ; Department of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4L7, Canada.

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https://www.osapublishing.org/abstract.cfm?URI=boe-6-10-3737
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http://dx.doi.org/10.1364/BOE.6.003737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605034PMC
October 2015

Re-resection for recurrent high-grade glioma in the setting of re-irradiation: more is not always better.

J Neurooncol 2015 Sep 30;124(2):215-21. Epub 2015 May 30.

Department of Radiation Oncology, Sidney Kimmel Cancer Center and Sidney Kimmel Medical College at Thomas Jefferson University, Bodine Center for Cancer Treatment, 111 South 11th Street, Philadelphia, PA, 19107, USA.

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http://dx.doi.org/10.1007/s11060-015-1825-yDOI Listing
September 2015

Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells--Mitochondrial Outer Membrane Permeabilization and Beyond.

Clin Cancer Res 2015 Jun 2;21(12):2671-6. Epub 2015 Apr 2.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0959DOI Listing
June 2015

Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.

Biochem J 2015 May;467(3):495-505

*Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada.

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http://www.biochemj.org/content/ppbiochemj/467/3/495.full.pd
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http://biochemj.org/lookup/doi/10.1042/BJ20141291
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http://dx.doi.org/10.1042/BJ20141291DOI Listing
May 2015

Tunable hydrogel thin films from reactive synthetic polymers as potential two-dimensional cell scaffolds.

Langmuir 2015 May 12;31(20):5623-32. Epub 2015 May 12.

†Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4M1, Canada.

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http://dx.doi.org/10.1021/acs.langmuir.5b00376DOI Listing
May 2015

Tumor volume threshold for achieving improved conformity in VMAT and Gamma Knife stereotactic radiosurgery for vestibular schwannoma.

Radiother Oncol 2015 May 18;115(2):229-34. Epub 2015 May 18.

Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, United States. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2015.03.031DOI Listing
May 2015

Glioblastoma exosomes and IGF-1R/AS-ODN are immunogenic stimuli in a translational research immunotherapy paradigm.

Cancer Immunol Immunother 2015 Mar 14;64(3):299-309. Epub 2014 Nov 14.

Department of Neurological Surgery, Thomas Jefferson University, 1020 Locust St, rm 454, Philadelphia, PA, 19107, USA,

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http://link.springer.com/10.1007/s00262-014-1622-z
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http://dx.doi.org/10.1007/s00262-014-1622-zDOI Listing
March 2015

5-Aminolevulinic acid induced protoporphyrin IX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett's esophagus cellular models.

J Biomed Opt 2015 03;20(3):036010

McMaster University, School of Biomedical Engineering, 1280 Main Street West, Hamilton, Ontario L8S 4K1, CanadabMcMaster University, Department of Engineering Physics, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.

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http://dx.doi.org/10.1117/1.JBO.20.3.036010DOI Listing
March 2015

5-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett's esophagus cellular models.

J Biomed Opt 2015 Feb;20(2):28002

McMaster University, School of Biomedical Engineering, 1280 Main Street West, Hamilton, Ontario, L8S 4K1 CanadabMcMaster University, Department of Engineering Physics, 1280 Main Street West, Hamilton, Ontario, L8S 4K1 Canada.

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http://dx.doi.org/10.1117/1.JBO.20.2.028002DOI Listing
February 2015

The relative biological effectiveness of low-dose mammography quality X rays in the human breast MCF-10A cell line.

Radiat Res 2015 Jan 23;183(1):42-51. Epub 2014 Dec 23.

a  Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://www.bioone.org/doi/10.1667/RR13821.1
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http://dx.doi.org/10.1667/RR13821.1DOI Listing
January 2015

Pores of no return.

Authors:
David W Andrews

Mol Cell 2014 Nov 20;56(4):465-6. Epub 2014 Nov 20.

Sunnybrook Research Institute and Department of Biochemistry, University of Toronto, Toronto, ON M4N 3M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.11.005DOI Listing
November 2014

A pilot study of hypofractionated stereotactic radiation therapy and sunitinib in previously irradiated patients with recurrent high-grade glioma.

Int J Radiat Oncol Biol Phys 2014 Oct 4;90(2):369-75. Epub 2014 Aug 4.

Department of Radiation Oncology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.ijrobp.2014.05.034DOI Listing
October 2014

Regulating cell death at, on, and in membranes.

Biochim Biophys Acta 2014 Sep 11;1843(9):2100-13. Epub 2014 Jun 11.

Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://www.dwalab.ca/common/pdf/BBA2014_1843_9.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S016748891400205
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http://dx.doi.org/10.1016/j.bbamcr.2014.06.002DOI Listing
September 2014

The proapoptotic protein tBid forms both superficially bound and membrane-inserted oligomers.

Biophys J 2014 May;106(10):2085-95

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada; Department of Physics and Astronomy, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.03.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052270PMC
May 2014

Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme.

J Neurooncol 2014 Mar 19;117(1):125-31. Epub 2014 Jan 19.

Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC CancerCenter at UPMC St. Margaret, 200 Delafield Road, Pittsburgh, PA, 15215, USA,

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http://dx.doi.org/10.1007/s11060-014-1362-0DOI Listing
March 2014

Spine Stereotactic Body Radiation Therapy Residual Setup Errors and Intra-Fraction Motion Using the Stereotactic X-Ray Image Guidance Verification System.

Int J Med Phys Clin Eng Radiat Oncol 2014 Feb;3(1):1-8

Department of Radiation Oncology, Jefferson Medical College and Kimmel Cancer Center of Thomas Jefferson University, Philadelphia, USA.

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http://dx.doi.org/10.4236/ijmpcero.2014.31001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766040PMC
February 2014

We can control the tumor but can we stop the pain?

World Neurosurg 2013 Sep-Oct;80(3-4):290-2. Epub 2012 May 24.

Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2012.05.003DOI Listing
December 2013

Stereotactic radiosurgery for cavernous malformations: is it effective?

World Neurosurg 2013 Dec 27;80(6):e185-6. Epub 2012 Oct 27.

Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.wneu.2012.10.056DOI Listing
December 2013

Chemical and biosynthetic evolution of the antimycin-type depsipeptides.

Mol Biosyst 2013 Nov;9(11):2712-9

Department Chemistry & Chemical Biology, McMaster University, M.G. DeGroote Institute for Infectious Disease Research, 1200 Main St. W, Hamilton, Ontario L8N 3Z5, Canada.

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http://dx.doi.org/10.1039/c3mb70219gDOI Listing
November 2013

The somatic genomic landscape of glioblastoma.

Cell 2013 Oct;155(2):462-77

Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, Department of Neurological Surgery, Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address:

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https://www.genome.gov/Multimedia/Slides/TCGA2/27_Verhaak.pd
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http://linkinghub.elsevier.com/retrieve/pii/S009286741301208
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http://dx.doi.org/10.1016/j.cell.2013.09.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910500PMC
October 2013

Reduced-dose fractionated stereotactic radiotherapy for acoustic neuromas: maintenance of tumor control with improved hearing preservation.

Neurosurgery 2013 Sep;73(3):489-96

Department of Radiation Oncology, Kimmel Cancer Center and Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1227/NEU.0000000000000019DOI Listing
September 2013

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response.

Mol Cell 2013 Sep;51(6):751-65

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.08.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164233PMC
September 2013

Optimizing the acquisition and analysis of confocal images for quantitative single-mobile-particle detection.

Chemphyschem 2013 Aug 3;14(11):2476-90. Epub 2013 Jul 3.

Department of Physics & Astronomy, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1002/cphc.201201047DOI Listing
August 2013

Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers.

Clin Cancer Res 2013 Jul 5;19(14):3776-86. Epub 2013 Jun 5.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1940DOI Listing
July 2013

tBid undergoes multiple conformational changes at the membrane required for Bax activation.

J Biol Chem 2013 Jul 6;288(30):22111-27. Epub 2013 Jun 6.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724664PMC
July 2013

Mechanisms of action of Bcl-2 family proteins.

Cold Spring Harb Perspect Biol 2013 Apr 1;5(4):a008714. Epub 2013 Apr 1.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S4K1, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683897PMC
April 2013

Shedding light on apoptosis at subcellular membranes.

Cell 2012 Dec;151(6):1179-84

Department of Biochemistry, McMaster University, Hamilton, Ontario L8S 4L8, Canada.

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http://dx.doi.org/10.1016/j.cell.2012.11.013DOI Listing
December 2012

Evaluating changes in radiation treatment volumes from post-operative to same-day planning MRI in High-grade gliomas.

Radiat Oncol 2012 Dec 21;7:220. Epub 2012 Dec 21.

Department of Radiation Oncology, Kimmel Cancer Center and Jefferson Medical College of Thomas Jefferson University, 111 S, 11th Street, Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552717PMC
December 2012

Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET.

Cell Cycle 2012 Oct 16;11(19):3536-42. Epub 2012 Aug 16.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.4161/cc.21462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478303PMC
October 2012

Improving prognosis of glioblastoma in the 21st century: who has benefited most?

Cancer 2012 Sep 16;118(17):4228-34. Epub 2011 Dec 16.

Department of Radiation Oncology, Sheba Medical Center affiliated with Sackler School of Medicine, Tel Aviv University, Ramat Gan, Israel.

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September 2012

Reirradiation of recurrent meningioma.

J Clin Neurosci 2012 Sep 10;19(9):1261-4. Epub 2012 Jul 10.

Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884216PMC
September 2012

Stereotactic radiotherapy for trigeminal schwannomas.

Neurosurgery 2012 Aug;71(2):270-7; discussion 277

Department of Radiation Oncology, Kimmel Cancer Center and Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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August 2012

Multiple post-translational modifications regulate E-cadherin transport during apoptosis.

J Cell Sci 2012 Jun 28;125(Pt 11):2615-25. Epub 2012 Feb 28.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706076PMC
June 2012

Combined role of whole-brain radiation therapy and radiosurgery for the treatment of brain metastasis.

Prog Neurol Surg 2012 6;25:228-35. Epub 2012 Jan 6.

Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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May 2012

Characterization and outcomes of optic nerve gliomas: a population-based analysis.

J Neurooncol 2012 May 12;107(3):591-7. Epub 2012 Jan 12.

Department of Radiation Oncology, Jefferson Medical College, Philadelphia, PA, USA.

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May 2012

Interaction of the full-length Bax protein with biomimetic mitochondrial liposomes: a small-angle neutron scattering and fluorescence study.

Biochim Biophys Acta 2012 Mar 15;1818(3):384-401. Epub 2011 Oct 15.

Department of Biochemistry and Biomedical Sciences, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada.

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March 2012

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells.

Mol Cell 2012 Mar;45(6):754-63

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.

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March 2012

Streak camera crosstalk reduction using a multiple delay optical fiber bundle.

Opt Lett 2012 Jan;37(2):250-2

Department of Engineering Physics, McMaster University, Hamilton, Ontario, Canada.

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January 2012

Removing bias against membrane proteins in interaction networks.

BMC Syst Biol 2011 Oct 19;5:169. Epub 2011 Oct 19.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

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October 2011

Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence.

Biochem J 2011 Jun;436(2):291-303

Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, ON, Canada, L8N 3Z5.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095691PMC
June 2011

Multiple courses of stereotactic re-irradiation in recurrent oligodendroglioma: a case report.

J Med Case Rep 2011 May 14;5:183. Epub 2011 May 14.

Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Ave, Room L-08, Box 0226, San Francisco, CA 94143, USA.

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May 2011

BH3-only proteins: Orchestrators of apoptosis.

Biochim Biophys Acta 2011 Apr 10;1813(4):508-20. Epub 2010 Dec 10.

Department of Biochemistry and Biomedical Sciences and McMaster University, Hamilton, Ontario, Canada.

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April 2011

Hydrophobic-domain-dependent protein-protein interactions mediate the localization of GPAT enzymes to ER subdomains.

Traffic 2011 Apr 8;12(4):452-72. Epub 2011 Feb 8.

Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.

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April 2011

Radiotherapy for brain metastases.

Neurosurg Clin N Am 2011 Jan;22(1):37-44, vi

Department of Radiation Oncology, Thomas Jefferson University, 111 South 11th Street, Bodine Cancer Center, Philadelphia, PA 19107, USA.

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January 2011

Apoptosis: embedded in membranes.

Curr Opin Cell Biol 2010 Dec 26;22(6):845-51. Epub 2010 Aug 26.

Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Room 4H-41, Hamilton, Ontario, Canada L8N 3Z5.

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December 2010

Closing in on the link between apoptosis and autophagy.

F1000 Biol Rep 2010 Dec 17;2:88. Epub 2010 Dec 17.

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December 2010

Outcomes after a purely endoscopic transsphenoidal resection of growth hormone-secreting pituitary adenomas.

Neurosurg Focus 2010 Oct;29(4):E5

Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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October 2010

Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif.

J Biol Chem 2010 Sep 28;285(37):28749-63. Epub 2010 Jun 28.

Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937903PMC
September 2010

Drugs targeting Bcl-2 family members as an emerging strategy in cancer.

Expert Rev Mol Med 2010 Sep 8;12:e28. Epub 2010 Sep 8.

Departments of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada.

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September 2010

FimH can directly activate human and murine natural killer cells via TLR4.

Mol Ther 2010 Jul 4;18(7):1379-88. Epub 2010 May 4.

Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911256PMC
July 2010

Perceptions of alcohol policy and drinking behavior: Results of a latent class analysis of college student drinkers.

Addict Behav 2010 Jun 29;35(6):628-31. Epub 2010 Jan 29.

Department of Human Development and Family Science, The Ohio State University, United States.

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http://dx.doi.org/10.1016/j.addbeh.2010.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839029PMC
June 2010

Bax forms an oligomer via separate, yet interdependent, surfaces.

J Biol Chem 2010 Jun 9;285(23):17614-27. Epub 2010 Apr 9.

Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878526PMC
June 2010

Hypofractionated stereotactic radiation therapy: an effective therapy for recurrent high-grade gliomas.

J Clin Oncol 2010 Jun 17;28(18):3048-53. Epub 2010 May 17.

Department of Radiation Oncology, Neurological Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. [corrected]

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http://dx.doi.org/10.1200/JCO.2009.25.6941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982785PMC
June 2010

Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma.

Radiat Oncol 2010 May 30;5:46. Epub 2010 May 30.

Department of Stich Radiation Oncology, Weill Cornell School of Medicine at Cornell University, 525 East 68th Street, New York, New York 10065, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890616PMC
May 2010