David V Hansen, PhD - Genentech - Scientist

David V Hansen

PhD

Genentech

Scientist

South San Francisco, CA | United States

Main Specialties: Neurology

Additional Specialties: Neurodegeneration, Neuroinflammation, Neural stem cells


Top Author

David V Hansen, PhD - Genentech - Scientist

David V Hansen

PhD

Introduction

Primary Affiliation: Genentech - South San Francisco, CA , United States

Specialties:

Additional Specialties:

Education

Apr 2011
University of California, San Francisco
Postdoc
Neural stem cells / Neurodevelopment
Jun 2006
Stanford University School of Medicine
Ph.D.
Cancer Biology
Apr 2000
Brigham Young University
B.S.
Molecular Biology

Publications

24Publications

341Reads

431Profile Views

1321PubMed Central Citations

Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences.

Nat Neurosci 2013 Nov 6;16(11):1576-87. Epub 2013 Oct 6.

1] Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA. [2] Department of Neurology, University of California, San Francisco, San Francisco, California, USA. [3].

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http://dx.doi.org/10.1038/nn.3541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191718PMC
November 2013
5 Reads
76 Citations
16.095 Impact Factor

Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex.

Nat Commun 2013 ;4:1665

Department of Neurology, University of California, San Francisco, 35 Medical Center Way, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/ncomms2647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625970PMC
October 2013
10 Reads
45 Citations
10.742 Impact Factor

Development and evolution of the human neocortex.

Cell 2011 Jul;146(1):18-36

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.cell.2011.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610574PMC
July 2011
2 Reads
296 Citations
32.242 Impact Factor

Deriving excitatory neurons of the neocortex from pluripotent stem cells.

Neuron 2011 May;70(4):645-60

Department of Neurology, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124445PMC
May 2011
4 Reads
44 Citations
15.054 Impact Factor

Neurogenic radial glia in the outer subventricular zone of human neocortex.

Nature 2010 Mar;464(7288):554-561

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature08845DOI Listing
March 2010
4 Reads
299 Citations
42.351 Impact Factor

Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.

Mol Biol Cell 2008 Aug 11;19(8):3536-43. Epub 2008 Jun 11.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1091/mbc.e08-04-0417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488281PMC
August 2008
8 Reads
10 Citations
4.470 Impact Factor

Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A.

Proc Natl Acad Sci U S A 2007 Oct 19;104(42):16564-9. Epub 2007 Sep 19.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0707537104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034268PMC
October 2007
6 Reads
23 Citations
9.810 Impact Factor

Emi2 at the crossroads: where CSF meets MPF.

Cell Cycle 2007 Mar 14;6(6):732-8. Epub 2007 Mar 14.

Department of Tumor Biology and Angiogenesis, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.4161/cc.6.6.3937DOI Listing
March 2007
10 Reads
5 Citations

Translational unmasking of Emi2 directs cytostatic factor arrest in meiosis II.

Cell Cycle 2007 Mar 1;6(6):725-31. Epub 2007 Mar 1.

Genentech, Inc., South San Francisco, California, USA.

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http://dx.doi.org/10.4161/cc.6.6.3936DOI Listing
March 2007
5 Reads
10 Citations

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

Genes Dev 2006 Sep 18;20(17):2410-20. Epub 2006 Aug 18.

Program in Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1454006
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http://dx.doi.org/10.1101/gad.1454006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560415PMC
September 2006
8 Reads
84 Citations
10.800 Impact Factor

Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis.

J Cell Biol 2006 Sep;174(6):791-801

Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Newcastle NE2 4HH, England, UK.

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http://dx.doi.org/10.1083/jcb.200604140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064334PMC
September 2006
20 Reads
54 Citations
9.834 Impact Factor

The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.

Cell 2006 Jan;124(2):367-80

Department of Cancer Biology, Stanford University School of Medicine, CA 94305, USA.

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http://dx.doi.org/10.1016/j.cell.2005.10.038DOI Listing
January 2006
4 Reads
32 Citations
32.242 Impact Factor

CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit.

Proc Natl Acad Sci U S A 2006 Jan 9;103(3):608-13. Epub 2006 Jan 9.

Program in Cancer Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.0509549102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325965PMC
January 2006
8 Reads
35 Citations
9.810 Impact Factor

A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.

Proc Natl Acad Sci U S A 2005 Mar 7;102(12):4318-23. Epub 2005 Mar 7.

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.0501108102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC552977PMC
March 2005
13 Reads
43 Citations
9.810 Impact Factor

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.

Mol Biol Cell 2004 Dec 6;15(12):5623-34. Epub 2004 Oct 6.

Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

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http://dx.doi.org/10.1091/mbc.e04-07-0598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC532041PMC
December 2004
8 Reads
85 Citations
4.470 Impact Factor

Control of the centriole and centrosome cycles by ubiquitination enzymes.

Oncogene 2002 Sep;21(40):6209-21

Programs in Chemical Biology and Cancer Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, CA 94305-5324, USA.

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http://dx.doi.org/10.1038/sj.onc.1205824DOI Listing
September 2002
3 Reads
5 Citations
8.460 Impact Factor

Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function.

DNA Seq 2002 Apr;13(2):77-83

Division of Developmental Biology, Children's Hospital Medical Center, TCHRF 3007, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

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April 2002
5 Reads
2 Citations

Selenium regulates expression in rat liver of genes for proteins involved in iron metabolism.

Biol Trace Elem Res 2000 Apr;74(1):55-70

Department of Food Science and Nutrition, Brigham Young University, Provo, UT 84602, USA.

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http://dx.doi.org/10.1385/BTER:74:1:55DOI Listing
April 2000
3 Reads
3 Citations
1.750 Impact Factor

Top co-authors

Peter K Jackson
Peter K Jackson

Stanford University School of Medicine

11
Arnold R Kriegstein
Arnold R Kriegstein

University of California

6
Karpagam Srinivasan
Karpagam Srinivasan

Department of Neuroscience

5
Jeffrey J Tung
Jeffrey J Tung

Stanford University School of Medicine

4
Jan H Lui
Jan H Lui

University of California

4
Ryan J Watts
Ryan J Watts

Department of Neuroscience

3
Matthew K Summers
Matthew K Summers

Department of Cellular Regulation

3
Alexander V Loktev
Alexander V Loktev

Stanford University School of Medicine

3
Joshua S Kaminker
Joshua S Kaminker

Department of Bioinformatics

2