Publications by authors named "David U Gorkin"

22Publications

Multi-platform discovery of haplotype-resolved structural variation in human genomes.

Nat Commun 2019 04 16;10(1):1784. Epub 2019 Apr 16.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.

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April 2019

N-methyladenine DNA Modification in Glioblastoma.

Cell 2018 11 1;175(5):1228-1243.e20. Epub 2018 Nov 1.

Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92037, USA. Electronic address:

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November 2018

Improved regulatory element prediction based on tissue-specific local epigenomic signatures.

Proc Natl Acad Sci U S A 2017 02 13;114(9):E1633-E1640. Epub 2017 Feb 13.

Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037;

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February 2017

Chromatin Domains: The Unit of Chromosome Organization.

Mol Cell 2016 06;62(5):668-80

Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, CA 92093-0653, USA; University of California, San Diego School of Medicine, Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, and Moores Cancer Center, 9500 Gilman Drive, La Jolla, CA 92093-0653, USA. Electronic address:

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June 2016

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function.

Cell 2015 Aug;162(4):900-10

Center for Comparative Biomedicine, MOE Key Laboratory of Systems Biomedicine, Institute of Systems Biomedicine, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University (SJTU), Shanghai 200240, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, SJTU, Shanghai 200240, China; Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (MOE), Bio-X Center, School of Life Sciences and Biotechnology, SJTU, Shanghai 200240, China. Electronic address:

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August 2015

A method to predict the impact of regulatory variants from DNA sequence.

Nat Genet 2015 Aug 15;47(8):955-61. Epub 2015 Jun 15.

1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

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August 2015

The 3D genome in transcriptional regulation and pluripotency.

Cell Stem Cell 2014 Jun;14(6):762-75

Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, Institute of Genome Medicine, Moores Cancer Center, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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June 2014

Genetics: Closing the distance on obesity culprits.

Nature 2014 Mar 12;507(7492):309-10. Epub 2014 Mar 12.

1] Ludwig Institute for Cancer Research, La Jolla, California 92093, USA. [2] Department of Cellular and Molecular Medicine, University of California, La Jolla, USA.

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March 2014

Integration of ChIP-seq and machine learning reveals enhancers and a predictive regulatory sequence vocabulary in melanocytes.

Genome Res 2012 Nov 27;22(11):2290-301. Epub 2012 Sep 27.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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November 2012