Publications by authors named "David Tollervey"

100Publications

Integrative vectors for regulated expression of SARS-CoV-2 proteins implicated in RNA metabolism.

Wellcome Open Res 2020 3;5:261. Epub 2020 Nov 3.

Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh, EH9 3BF, UK.

View Article and Find Full Text PDF
November 2020

The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase.

Nucleic Acids Res 2020 12;48(21):12252-12268

Department of Genetics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland.

View Article and Find Full Text PDF
December 2020

Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors.

Mol Cell 2020 11 13;80(3):470-484.e8. Epub 2020 Oct 13.

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK. Electronic address:

View Article and Find Full Text PDF
November 2020

Nascent Transcript Folding Plays a Major Role in Determining RNA Polymerase Elongation Rates.

Mol Cell 2020 08 24;79(3):488-503.e11. Epub 2020 Jun 24.

Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK. Electronic address:

View Article and Find Full Text PDF
August 2020

Substrate specificity of the TRAMP nuclear surveillance complexes.

Nat Commun 2020 06 19;11(1):3122. Epub 2020 Jun 19.

Wellcome Center for Cell Biology, University of Edinburgh, Kings Buildings, Swann Building, Edinburgh, EH9 3BF, UK.

View Article and Find Full Text PDF
June 2020

Extended ncRNAs Interfere with Promoter Nucleosome Dynamics.

Trends Genet 2020 09 13;36(9):637-639. Epub 2020 Jun 13.

Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK. Electronic address:

View Article and Find Full Text PDF
September 2020

Mapping Exosome-Substrate Interactions In Vivo by UV Cross-Linking.

Methods Mol Biol 2020 ;2062:105-126

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.

View Article and Find Full Text PDF
December 2020

Defining the RNA interactome by total RNA-associated protein purification.

Mol Syst Biol 2019 04 8;15(4):e8689. Epub 2019 Apr 8.

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK

View Article and Find Full Text PDF
April 2019

Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control.

Nat Commun 2019 02 4;10(1):563. Epub 2019 Feb 4.

Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh, EH9 3BF, Scotland.

View Article and Find Full Text PDF
February 2019

Mapping targets for small nucleolar RNAs in yeast.

Wellcome Open Res 2018 22;3:120. Epub 2018 Nov 22.

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK.

View Article and Find Full Text PDF
November 2018

Transcriptome-Wide Analysis of Protein-RNA and RNA-RNA Interactions in Pathogenic Bacteria.

Methods Enzymol 2018 22;612:467-488. Epub 2018 Sep 22.

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom. Electronic address:

View Article and Find Full Text PDF
July 2019

Tailing Off: PABP and CNOT Generate Cycles of mRNA Deadenylation.

Mol Cell 2018 06;70(6):987-988

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK. Electronic address:

View Article and Find Full Text PDF
June 2018

Ribosome maturation by the endoribonuclease YbeY stabilizes a type 3 secretion system transcript required for virulence of enterohemorrhagic .

J Biol Chem 2018 06 20;293(23):9006-9016. Epub 2018 Apr 20.

School of Biotechnology and Biomolecular Sciences, University of New South Wales Sydney, Sydney 2033, Australia, and

View Article and Find Full Text PDF
June 2018

Surveillance-ready transcription: nuclear RNA decay as a default fate.

Open Biol 2018 03;8(3)

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK

View Article and Find Full Text PDF
March 2018

High-Resolution, High-Throughput Analysis of Hfq-Binding Sites Using UV Crosslinking and Analysis of cDNA (CRAC).

Methods Mol Biol 2018 ;1737:251-272

School of Biotechnology and Biomolecular Sciences, University of New South Wales Sydney, Sydney, Australia.

View Article and Find Full Text PDF
January 2019

An RNA-dependent mechanism for transient expression of bacterial translocation filaments.

Nucleic Acids Res 2018 04;46(7):3366-3381

Division of Infection and Immunity, The Roslin Institute and R(D)SVS, University of Edinburgh, Edinburgh EH25 9RG, UK.

View Article and Find Full Text PDF
April 2018

Immunoprecipitation of RNA:DNA Hybrids from Budding Yeast.

Methods Mol Biol 2018 ;1703:109-129

Wellcome Centre for Cell Biology, University of Edinburgh, Max Born Crescent, Edinburgh, EH9 3BF, UK.

View Article and Find Full Text PDF
July 2018

RNA substrate length as an indicator of exosome interactions .

Wellcome Open Res 2017 3;2:34. Epub 2017 Jul 3.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK.

View Article and Find Full Text PDF
July 2017

RNA Binding by Histone Methyltransferases Set1 and Set2.

Mol Cell Biol 2017 07 29;37(14). Epub 2017 Jun 29.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland

View Article and Find Full Text PDF
July 2017

Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex.

PLoS Genet 2017 03 29;13(3):e1006699. Epub 2017 Mar 29.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom.

View Article and Find Full Text PDF
March 2017

Transcription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction.

Genes Dev 2017 02 13;31(4):347-352. Epub 2017 Mar 13.

Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.

View Article and Find Full Text PDF
February 2017

Nuclear RNA Decay Pathways Aid Rapid Remodeling of Gene Expression in Yeast.

Mol Cell 2017 Mar 9;65(5):787-800.e5. Epub 2017 Feb 9.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Edinburgh EH9 3BF, Scotland. Electronic address:

View Article and Find Full Text PDF
March 2017

Transcription by RNA polymerase III: insights into mechanism and regulation.

Biochem Soc Trans 2016 10;44(5):1367-1375

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, U.K.

View Article and Find Full Text PDF
October 2016

VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation.

Nucleic Acids Res 2016 Nov 5;44(20):9860-9871. Epub 2016 Sep 5.

Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark

View Article and Find Full Text PDF
November 2016

The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans.

Nucleic Acids Res 2016 10 14;44(18):9016. Epub 2016 Jul 14.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

View Article and Find Full Text PDF
October 2016

Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases.

Nat Commun 2016 06 2;7:11789. Epub 2016 Jun 2.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK.

View Article and Find Full Text PDF
June 2016

Global analysis of transcriptionally engaged yeast RNA polymerase III reveals extended tRNA transcripts.

Genome Res 2016 07 20;26(7):933-44. Epub 2016 May 20.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland;

View Article and Find Full Text PDF
July 2016

Network of epistatic interactions within a yeast snoRNA.

Science 2016 May 14;352(6287):840-4. Epub 2016 Apr 14.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland, UK.

View Article and Find Full Text PDF
May 2016

The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans.

Nucleic Acids Res 2016 Jun 31;44(11):5399-409. Epub 2016 Mar 31.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

View Article and Find Full Text PDF
June 2016

Motoring toward pre-60S-ribosome export.

Nat Struct Mol Biol 2016 Jan;23(1):3-4

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.

View Article and Find Full Text PDF
January 2016

Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough.

PLoS Genet 2015 Dec 22;11(12):e1005735. Epub 2015 Dec 22.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

View Article and Find Full Text PDF
December 2015

Identification of miRNA-Target RNA Interactions Using CLASH.

Methods Mol Biol 2016 ;1358:229-51

Wellcome Trust Centre for Cell Biology, The University of Edinburgh, King's Buildings, Edinburgh, EH9 3BF, UK.

View Article and Find Full Text PDF
July 2016

RNA surveillance and the exosome.

Authors:
David Tollervey

RNA 2015 Apr;21(4):492-3

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BH, United Kingdom

View Article and Find Full Text PDF
April 2015

The DEAH-box helicase Dhr1 dissociates U3 from the pre-rRNA to promote formation of the central pseudoknot.

PLoS Biol 2015 Feb 24;13(2):e1002083. Epub 2015 Feb 24.

Department of Molecular Biosciences and the Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, United States of America.

View Article and Find Full Text PDF
February 2015

Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria.

PLoS Genet 2014 Oct 30;10(10):e1004716. Epub 2014 Oct 30.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom.

View Article and Find Full Text PDF
October 2014

Rio1 mediates ATP-dependent final maturation of 40S ribosomal subunits.

Nucleic Acids Res 2014 Oct 7;42(19):12189-99. Epub 2014 Oct 7.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, UK

View Article and Find Full Text PDF
October 2014

Lighting Up pre-mRNA recognition.

Mol Cell 2014 Sep;55(5):649-51

Wellcome Trust Center for Cell Biology, Michael Swann Building, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR. Electronic address:

View Article and Find Full Text PDF
September 2014

Cotranscriptional events in eukaryotic ribosome synthesis.

Wiley Interdiscip Rev RNA 2015 Jan-Feb;6(1):129-39. Epub 2014 Aug 29.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.

View Article and Find Full Text PDF
August 2015

Integrity of SRP RNA is ensured by La and the nuclear RNA quality control machinery.

Nucleic Acids Res 2014 26;42(16):10698-710. Epub 2014 Aug 26.

RNA Biology Group and Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

View Article and Find Full Text PDF
January 2015

Identification of bacteriophage-encoded anti-sRNAs in pathogenic Escherichia coli.

Mol Cell 2014 Jul 5;55(2):199-213. Epub 2014 Jun 5.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, UK. Electronic address:

View Article and Find Full Text PDF
July 2014

RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis.

PLoS Biol 2014 May 13;12(5):e1001860. Epub 2014 May 13.

Laboratoire de Cristallographie et RMN Biologiques, UMR CNRS 8015, Université Paris Descartes, Faculté de Pharmacie, Sorbonne Paris Cité, Paris, France.

View Article and Find Full Text PDF
May 2014

Final pre-40S maturation depends on the functional integrity of the 60S subunit ribosomal protein L3.

PLoS Genet 2014 Mar 6;10(3):e1004205. Epub 2014 Mar 6.

Departamento de Genética, Universidad de Sevilla, and Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

View Article and Find Full Text PDF
March 2014

Mapping the miRNA interactome by cross-linking ligation and sequencing of hybrids (CLASH).

Nat Protoc 2014 Mar 27;9(3):711-28. Epub 2014 Feb 27.

Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK.

View Article and Find Full Text PDF
March 2014

Kinetic analysis demonstrates a requirement for the Rat1 exonuclease in cotranscriptional pre-rRNA cleavage.

PLoS One 2014 3;9(2):e85703. Epub 2014 Feb 3.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland.

View Article and Find Full Text PDF
December 2014

Looking into the barrel of the RNA exosome.

Nat Struct Mol Biol 2014 Jan;21(1):17-8

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.

View Article and Find Full Text PDF
January 2014

Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export.

Nature 2014 Jan 17;505(7481):112-116. Epub 2013 Nov 17.

Biochemie-Zentrum der Universität Heidelberg, Im Neuenheimer Feld 328, Heidelberg D-69120, Germany.

View Article and Find Full Text PDF
January 2014

Rrp5 binding at multiple sites coordinates pre-rRNA processing and assembly.

Mol Cell 2013 Dec 14;52(5):707-19. Epub 2013 Nov 14.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland. Electronic address:

View Article and Find Full Text PDF
December 2013

Hyb: a bioinformatics pipeline for the analysis of CLASH (crosslinking, ligation and sequencing of hybrids) data.

Methods 2014 Feb 6;65(3):263-73. Epub 2013 Nov 6.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom. Electronic address:

View Article and Find Full Text PDF
February 2014

A transcriptome-wide atlas of RNP composition reveals diverse classes of mRNAs and lncRNAs.

Cell 2013 Aug;154(5):996-1009

The University of Edinburgh, Wellcome Trust Centre for Cell Biology, Michael Swann Building, Kings Buildings, Edinburgh EH9 3JR, UK. Electronic address:

View Article and Find Full Text PDF
August 2013

Threading the barrel of the RNA exosome.

Trends Biochem Sci 2013 Oct 2;38(10):485-93. Epub 2013 Aug 2.

Institute for Cell and Molecular Biosciences (ICaMB), Newcastle University, Newcastle upon Tyne, UK. Electronic address:

View Article and Find Full Text PDF
October 2013

Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding.

Cell 2013 Apr;153(3):654-65

Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK.

View Article and Find Full Text PDF
April 2013

Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing.

J Cell Biol 2013 Mar 25;200(5):577-88. Epub 2013 Feb 25.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, England, UK.

View Article and Find Full Text PDF
March 2013

Multiple RNA interactions position Mrd1 at the site of the small subunit pseudoknot within the 90S pre-ribosome.

Nucleic Acids Res 2013 Jan 27;41(2):1178-90. Epub 2012 Nov 27.

Department of Molecular Biology and Functional Genomics, Stockholm University SE-106 91, Stockholm, Sweden.

View Article and Find Full Text PDF
January 2013

Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning.

Genes Dev 2012 Nov;26(21):2408-21

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom.

View Article and Find Full Text PDF
November 2012

Kinetic analysis of pre-ribosome structure in vivo.

RNA 2012 Dec 23;18(12):2187-200. Epub 2012 Oct 23.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland.

View Article and Find Full Text PDF
December 2012

Transcriptome-wide analysis of exosome targets.

Mol Cell 2012 Nov 20;48(3):422-33. Epub 2012 Sep 20.

Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh UK.

View Article and Find Full Text PDF
November 2012

Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits.

Nat Struct Mol Biol 2012 Aug 1;19(8):744-53. Epub 2012 Jul 1.

Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh, Scotland, UK.

View Article and Find Full Text PDF
August 2012

Identification of RNA helicase target sites by UV cross-linking and analysis of cDNA.

Methods Enzymol 2012 ;511:275-88

Cluster of Excellence Macromolecular Complexes, Institute for Molecular Biosciences, Goethe University Frankfurt, Frankfurt, Germany.

View Article and Find Full Text PDF
October 2012

An RNA reset button.

Mol Cell 2012 Feb;45(4):435-6

Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Scotland.

View Article and Find Full Text PDF
February 2012

Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target.

Proc Natl Acad Sci U S A 2012 Jan 19;109(1):279-84. Epub 2011 Dec 19.

Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

View Article and Find Full Text PDF
January 2012

A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease.

EMBO J 2011 Aug 2;30(19):4006-19. Epub 2011 Aug 2.

Wellcome Trust Centre for Cell Biology and Centre for Systems Biology at Edinburgh, University of Edinburgh, Edinburgh, Scotland.

View Article and Find Full Text PDF
August 2011

Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery.

Nucleic Acids Res 2011 Nov 17;39(20):8778-91. Epub 2011 Jul 17.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK.

View Article and Find Full Text PDF
November 2011

RNA in pieces.

Trends Genet 2011 Oct 6;27(10):422-32. Epub 2011 Jul 6.

Wellcome Trust Centre for Cell Biology, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK.

View Article and Find Full Text PDF
October 2011

Finding the exosome.

Adv Exp Med Biol 2011 ;702:1-8

Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK,

View Article and Find Full Text PDF
April 2016

Cross-linking, ligation, and sequencing of hybrids reveals RNA-RNA interactions in yeast.

Proc Natl Acad Sci U S A 2011 Jun 24;108(24):10010-5. Epub 2011 May 24.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom.

View Article and Find Full Text PDF
June 2011

Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing.

EMBO J 2011 May 10;30(12):2420-30. Epub 2011 May 10.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.

View Article and Find Full Text PDF
May 2011

The nuclear RNA polymerase II surveillance system targets polymerase III transcripts.

EMBO J 2011 May 1;30(9):1790-803. Epub 2011 Apr 1.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.

View Article and Find Full Text PDF
May 2011

Distinguishing the roles of Topoisomerases I and II in relief of transcription-induced torsional stress in yeast rRNA genes.

Mol Cell Biol 2011 Feb 22;31(3):482-94. Epub 2010 Nov 22.

Department of Microbiology, Box 800734, University of Virginia Health System, Charlottesville, VA 22908-0734, USA.

View Article and Find Full Text PDF
February 2011

Apparent non-canonical trans-splicing is generated by reverse transcriptase in vitro.

PLoS One 2010 Aug 18;5(8):e12271. Epub 2010 Aug 18.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom.

View Article and Find Full Text PDF
August 2010

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis.

Genes Dev 2010 Jul;24(14):1546-58

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom.

View Article and Find Full Text PDF
July 2010

Cracking pre-40S ribosomal subunit structure by systematic analyses of RNA-protein cross-linking.

EMBO J 2010 Jun 7;29(12):2026-36. Epub 2010 May 7.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, UK.

View Article and Find Full Text PDF
June 2010

Yeast pre-rRNA processing and modification occur cotranscriptionally.

Mol Cell 2010 Mar;37(6):809-20

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK.

View Article and Find Full Text PDF
March 2010

Finding the exosome.

Adv Exp Med Biol 2010 ;702:1-8

Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK.

View Article and Find Full Text PDF
July 2011

The final step in 5.8S rRNA processing is cytoplasmic in Saccharomyces cerevisiae.

Mol Cell Biol 2010 Feb 14;30(4):976-84. Epub 2009 Dec 14.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK.

View Article and Find Full Text PDF
February 2010

RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1.

J Biol Chem 2009 Dec 29;284(50):35079-91. Epub 2009 Sep 29.

Biochemie-Zentrum der Universität Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.

View Article and Find Full Text PDF
December 2009

Identification of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs.

Proc Natl Acad Sci U S A 2009 Jun 29;106(24):9613-8. Epub 2009 May 29.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland.

View Article and Find Full Text PDF
June 2009

Coding-sequence determinants of gene expression in Escherichia coli.

Science 2009 Apr;324(5924):255-8

Department of Biology and Program in Applied Mathematics and Computational Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article and Find Full Text PDF
April 2009

The many pathways of RNA degradation.

Cell 2009 Feb;136(4):763-76

Wellcome Trust Centre for Cell Biology, University of Edinburgh, EH9 3JR, UK.

View Article and Find Full Text PDF
February 2009

The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome.

Nucleic Acids Res 2009 Mar 7;37(4):1127-40. Epub 2009 Jan 7.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK.

View Article and Find Full Text PDF
March 2009

A ncRNA modulates histone modification and mRNA induction in the yeast GAL gene cluster.

Mol Cell 2008 Dec;32(5):685-95

Wellcome Trust Centre for Cell Biology, Institute for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK.

View Article and Find Full Text PDF
December 2008

Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase.

EMBO Rep 2008 Dec 3;9(12):1230-6. Epub 2008 Oct 3.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK.

View Article and Find Full Text PDF
December 2008

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.

Mol Cell Biol 2008 Sep 30;28(17):5446-57. Epub 2008 Jun 30.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom.

View Article and Find Full Text PDF
September 2008

Efficient termination of transcription by RNA polymerase I requires the 5' exonuclease Rat1 in yeast.

Genes Dev 2008 Apr;22(8):1069-81

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom.

View Article and Find Full Text PDF
April 2008