Publications by authors named "David T Denhardt"

71Publications

Effect of stress on human biology: Epigenetics, adaptation, inheritance, and social significance.

Authors:
David T Denhardt

J Cell Physiol 2018 Mar 27;233(3):1975-1984. Epub 2017 Apr 27.

Division of Life Sciences, Rutgers University, New Brunswick, New Jersey.

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http://dx.doi.org/10.1002/jcp.25837DOI Listing
March 2018

Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.

Circ Res 2015 Jul 11;117(2):e13-26. Epub 2015 May 11.

From the Department of Vascular Biology and Inflammation (M.M.-A., A.A., N.M.-B., A.P., J.M.R., A.G.A.), Proteomics Unit (E.C., J.V.) and Bioinformatics Unit (F.M.), Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Department of Pharmacology/Nephrology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain (A.B.G.-R., M.S.); Department of Internal Medicine, University of Texas Health Science Center at Houston, TX (D.G., D.M.); Department of Basic Biomedical Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain (C.S.-C.); Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ (D.T.D.); and Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan (M.S.).

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http://circres.ahajournals.org/content/early/2015/05/11/CIRC
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http://circres.ahajournals.org/lookup/doi/10.1161/CIRCRESAHA
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http://dx.doi.org/10.1161/CIRCRESAHA.117.305108DOI Listing
July 2015

Hindlimb-unloading suppresses B cell population in the bone marrow and peripheral circulation associated with OPN expression in circulating blood cells.

J Bone Miner Metab 2015 Jan 16;33(1):48-54. Epub 2014 May 16.

Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 5-45 Yushima 1-Chome, Bunkyo-ku, Tokyo, 113-8510, Japan,

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http://dx.doi.org/10.1007/s00774-014-0568-8DOI Listing
January 2015

An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells.

Stem Cells 2014 Feb;32(2):327-37

Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://doi.wiley.com/10.1002/stem.1567
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http://dx.doi.org/10.1002/stem.1567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961005PMC
February 2014

Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: reduction of oxidant levels.

J Cell Physiol 2013 Oct;228(10):2006-14

Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA.

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http://dx.doi.org/10.1002/jcp.24367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739938PMC
October 2013

Osteopontin regulates interleukin-17 production in hepatitis.

Cytokine 2012 Oct 19;60(1):129-37. Epub 2012 Jul 19.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang 310003, China.

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http://dx.doi.org/10.1016/j.cyto.2012.06.287DOI Listing
October 2012

Sympathetic control of bone mass regulated by osteopontin.

Proc Natl Acad Sci U S A 2011 Oct 11;108(43):17767-72. Epub 2011 Oct 11.

Department of Molecular Pharmacology, Medical Research Institute, and Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8510 Tokyo, Japan.

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http://dx.doi.org/10.1073/pnas.1109402108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203767PMC
October 2011

Osteopontin deficiency protects against aldosterone-induced inflammation, oxidative stress, and interstitial fibrosis in the kidney.

Am J Physiol Renal Physiol 2011 Oct 6;301(4):F833-44. Epub 2011 Jul 6.

Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.

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http://dx.doi.org/10.1152/ajprenal.00557.2010DOI Listing
October 2011

Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen.

PLoS One 2011 Jan 21;6(1):e14568. Epub 2011 Jan 21.

Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024983PMC
January 2011

Involvement of osteopontin in the matrix-degrading and proangiogenic changes mediated by nicotine in pancreatic cancer cells.

J Gastrointest Surg 2010 Oct 8;14(10):1566-77. Epub 2010 Sep 8.

Department of Surgery, Jefferson Pancreatic, Biliary and Related Cancer Center, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA.

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http://link.springer.com/10.1007/s11605-010-1338-0
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http://dx.doi.org/10.1007/s11605-010-1338-0DOI Listing
October 2010

Crystallographically engineered, hydrothermally crystallized hydroxyapatite films: an in vitro study of bioactivity.

J Mater Sci Mater Med 2010 May 16;21(5):1531-42. Epub 2010 Mar 16.

Department of Material Science and Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

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http://link.springer.com/10.1007/s10856-010-4031-7
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http://dx.doi.org/10.1007/s10856-010-4031-7DOI Listing
May 2010

Osteopontin deficiency impairs wear debris-induced osteolysis via regulation of cytokine secretion from murine macrophages.

Arthritis Rheum 2010 May;62(5):1329-37

International Research Center for Molecular Science in Tooth and Bone Diseases, and Tokyo Medical and Dental University, Tokyo, Japan.

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http://doi.wiley.com/10.1002/art.27400
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http://dx.doi.org/10.1002/art.27400DOI Listing
May 2010

Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice.

Arthritis Rheum 2009 Aug;60(8):2362-71

Institute for Genetic Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1002/art.24705DOI Listing
August 2009

Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus.

Viral Immunol 2009 Apr;22(2):139-44

Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

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http://dx.doi.org/10.1089/vim.2008.0054DOI Listing
April 2009

Plasma osteopontin modulates chronic restraint stress-induced thymus atrophy by regulating stress hormones: inhibition by an anti-osteopontin monoclonal antibody.

J Immunol 2009 Feb;182(4):2485-91

Graduate Program in Cell and Developmental Biology, The State University of New Jersey, Nelson Biological Laboratories, Piscataway, NJ 08854, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0803023
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http://dx.doi.org/10.4049/jimmunol.0803023DOI Listing
February 2009

Osteopontin: role in immune regulation and stress responses.

Cytokine Growth Factor Rev 2008 Oct-Dec;19(5-6):333-45. Epub 2008 Oct 25.

Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S135961010800065
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http://dx.doi.org/10.1016/j.cytogfr.2008.08.001DOI Listing
February 2009

Osteopontin regulates development and function of invariant natural killer T cells.

Proc Natl Acad Sci U S A 2008 Oct 3;105(41):15884-9. Epub 2008 Oct 3.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang 310003, China.

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http://dx.doi.org/10.1073/pnas.0806089105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2560993PMC
October 2008

Osteopontin is dispensable for protection against high load systemic fungal infection.

Int Immunopharmacol 2008 Oct 30;8(10):1441-8. Epub 2008 Jun 30.

Fermentation Research Laboratories, Astellas Pharmaceutical Inc., Tokodai 5-2-3, Tsukuba, Ibaraki, 300-2698, Japan.

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http://dx.doi.org/10.1016/j.intimp.2008.06.001DOI Listing
October 2008

Characterization of osteopontin expression and function after status epilepticus.

Epilepsia 2008 Oct 3;49(10):1675-85. Epub 2008 Jun 3.

Department of Pharmaceutical Sciences, Texas Tech Health Sciences Center, Amarillo, Texas 79106, USA.

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http://dx.doi.org/10.1111/j.1528-1167.2008.01613.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090704PMC
October 2008

Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts.

J Biol Chem 2008 Jul 16;283(28):19400-9. Epub 2008 Apr 16.

Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, 113-8510, Tokyo, Japan.

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http://dx.doi.org/10.1074/jbc.M800005200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762377PMC
July 2008

Corneal wound healing in an osteopontin-deficient mouse.

Invest Ophthalmol Vis Sci 2008 Apr;49(4):1367-75

Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan.

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http://dx.doi.org/10.1167/iovs.07-1007DOI Listing
April 2008

Control of osteopontin signaling and function by post-translational phosphorylation and protein folding.

J Cell Biochem 2007 Nov;102(4):912-24

Division of Life Sciences, Rutgers University, Piscataway, New Jersey, USA.

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http://doi.wiley.com/10.1002/jcb.21558
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http://dx.doi.org/10.1002/jcb.21558DOI Listing
November 2007

OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application.

J Cell Physiol 2008 Mar;214(3):614-20

Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1002/jcp.21250DOI Listing
March 2008

Characterization of anti-osteopontin monoclonal antibodies: Binding sensitivity to post-translational modifications.

J Cell Biochem 2007 Nov;102(4):925-35

Department of Cell Biology and Neuroscience, Rutgers University, Piscataway New Jersey, USA.

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http://dx.doi.org/10.1002/jcb.21487DOI Listing
November 2007

Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy and weight loss by modulating corticosteroid production.

Proc Natl Acad Sci U S A 2007 Sep 4;104(37):14777-82. Epub 2007 Sep 4.

Graduate Program in Cell and Developmental Biology, the State University of New Jersey, Nelson Biological Laboratories, 604 Allison Road, Piscataway, NJ 08854, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0703236104
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http://dx.doi.org/10.1073/pnas.0703236104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976226PMC
September 2007

Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive properties.

J Biol Chem 2007 Jul 11;282(27):19463-72. Epub 2007 May 11.

Protein Chemistry Laboratory, Department of Molecular Biology, University of Aarhus, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1074/jbc.M703055200DOI Listing
July 2007

Osteopontin is required for mechanical stress-dependent signals to bone marrow cells.

J Endocrinol 2007 May;193(2):235-43

Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Tokyo, Japan.

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http://dx.doi.org/10.1677/joe.1.06704DOI Listing
May 2007

Osteopontin deficiency enhances anabolic action of EP4 agonist at a sub-optimal dose in bone.

J Endocrinol 2007 Apr;193(1):171-82

Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Tokyo, Japan.

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https://joe.bioscientifica.com/doi/10.1677/joe.1.06917
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http://dx.doi.org/10.1677/joe.1.06917DOI Listing
April 2007

Osteopontin deficiency and aging on nanomechanics of mouse bone.

J Biomed Mater Res A 2007 Oct;83(1):136-44

Department of Materials Science and Engineering, Rutgers University, New Jersey 08854, USA.

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http://dx.doi.org/10.1002/jbm.a.31081DOI Listing
October 2007

The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation.

Matrix Biol 2007 Jan 15;26(1):42-53. Epub 2006 Sep 15.

Department of Orthopaedic Surgery, Hokkaido University School of Medicine, Sapporo, Japan.

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http://dx.doi.org/10.1016/j.matbio.2006.09.002DOI Listing
January 2007

Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss.

Exp Cell Res 2006 Oct 7;312(16):3075-83. Epub 2006 Jun 7.

Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Chiyoda-Ku, Tokyo 101-0062, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S001448270600219
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http://dx.doi.org/10.1016/j.yexcr.2006.06.003DOI Listing
October 2006

Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice.

Brain 2006 Jun 24;129(Pt 6):1426-37. Epub 2006 Apr 24.

Department of Neurology, Heinrich Heine University Düsseldorf, Germany.

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http://dx.doi.org/10.1093/brain/awl094DOI Listing
June 2006

Tissue inhibitor of metalloproteinases-1 stimulates gene expression in MDA-MB-435 human breast cancer cells by means of its ability to inhibit metalloproteinases.

Breast Cancer Res Treat 2005 Nov;94(2):185-93

The Graduate Program in Microbiology and Molecular Genetics, Nelson Laboratories, Rutgers University, Piscataway, NJ 08854, USA.

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http://link.springer.com/10.1007/s10549-005-7728-4
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http://dx.doi.org/10.1007/s10549-005-7728-4DOI Listing
November 2005

Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer.

Oncogene 2005 Sep;24(43):6555-63

Department of Radiation Oncology, 875 Blake Wilbur Dr, R. CC-G228, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1038/sj.onc.1208800DOI Listing
September 2005

Osteoclasts resorb protein-free mineral (Osteologic discs) efficiently in the absence of osteopontin.

In Vivo 2005 Mar-Apr;19(2):335-41

Program in BioTechnology, Kean University, 1000 Morris Avenue, Union, NJ 07083, USA.

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July 2005

Osteopontin-deficiency suppresses growth of B16 melanoma cells implanted in bone and osteoclastogenesis in co-cultures.

J Bone Miner Res 2004 Oct;19(10):1706-11

Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1359/jbmr.2004.19.10.1706DOI Listing
October 2004

Osteopontin affects the persistence of beta-glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms.

Int Immunol 2004 Mar;16(3):477-88

Divison of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan.

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http://dx.doi.org/10.1093/intimm/dxh044DOI Listing
March 2004

Prenatal detection of embryo resorption in osteopontin-deficient mice using serial noninvasive magnetic resonance microscopy.

Pediatr Res 2004 Mar 7;55(3):419-24. Epub 2004 Jan 7.

The Mount Sinai School of Medicine, Box 1508, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1203/01.PDR.0000112034.98387.B2DOI Listing
March 2004

Osteopontin expression in osteoblasts and osteocytes during bone formation under mechanical stress in the calvarial suture in vivo.

J Bone Miner Res 2003 Sep;18(9):1706-15

Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1359/jbmr.2003.18.9.1706DOI Listing
September 2003

Osteopontin traffic in hypoxic renal epithelial cells.

Nephron Exp Nephrol 2003 ;94(2):e66-76

Department of Medicine, Division of Nephrology and Hypertension, State University of New York at Stony Brook, Stony Brook, NY, USA.

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http://dx.doi.org/10.1159/000071285DOI Listing
August 2003

Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts.

J Biol Chem 2003 Aug 1;278(31):29086-97. Epub 2003 May 1.

Department of Oral Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1074/jbc.M211074200DOI Listing
August 2003

Osteopontin deficiency induces parathyroid hormone enhancement of cortical bone formation.

Endocrinology 2003 May;144(5):2132-40

Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1210/en.2002-220996DOI Listing
May 2003

Commentary re: Q-T Le et al, identification of osteopontin as a prognostic marker for head and neck squamous cell carcinomas. clin cancer res, 9: 31-32, 2003.

Authors:
David T Denhardt

Clin Cancer Res 2003 Jan;9(1):31-2

Cell Biology & Neurosciences, Rutgers, The State University of New Jersey, Nelson Biology Laboratories, Piscataway, New Jersey 08854, USA.

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January 2003

Regulation of collagenase-3 and osteocalcin gene expression by collagen and osteopontin in differentiating MC3T3-E1 cells.

J Biol Chem 2002 Jul 18;277(27):24788-98. Epub 2002 Apr 18.

Department of Physiology and Biophysics, Robert Wood Johnson Medical School and the Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/jbc.M202604200DOI Listing
July 2002

Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.

Proc Natl Acad Sci U S A 2002 Apr;99(7):4556-61

Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101-0062, Japan.

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http://dx.doi.org/10.1073/pnas.052523599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123686PMC
April 2002

Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice.

J Bone Miner Res 2002 Apr;17(4):661-7

Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan.

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http://dx.doi.org/10.1359/jbmr.2002.17.4.661DOI Listing
April 2002

Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi.

Infect Immun 2002 Mar;70(3):1372-81

Department of Pathology, Division of Cell Biology and Immunology, University of Utah School of Medicine, Salt Lake City, Utah 84132-2501, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127811PMC
http://dx.doi.org/10.1128/iai.70.3.1372-1381.2002DOI Listing
March 2002

Osteopontin expression and function: Role in bone remodeling.

J Cell Biochem 1998 ;72 Suppl 30-31(S30-31):92-102

Tokyo Medical Dental University, Medical Research Institute, Tokyo 101, Japan.

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http://dx.doi.org/10.1002/(SICI)1097-4644(1998)72:30/31+<92::AID-JCB13>3.0.CO;2-ADOI Listing
January 1998