David Sachs

David Sachs

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David Sachs

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Pharmacokinetic and pharmacodynamic study of a clinically effective anti-CD2 monoclonal antibody.

Scand J Immunol 2020 Jan 10;91(1):e12839. Epub 2019 Nov 10.

Department of Surgery, Columbia Center for Translational Immunology, Columbia University Medical Center, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1111/sji.12839DOI Listing
January 2020

Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture.

FEBS Lett 2019 Dec 12;593(23):3266-3287. Epub 2019 Oct 12.

Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1002/1873-3468.13621DOI Listing
December 2019

Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses.

Cell Rep 2019 Dec;29(12):3997-4009.e5

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010214PMC
December 2019

Transplanting organs from pigs to humans.

Sci Immunol 2019 Nov;4(41)

Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, NY, USA.

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http://dx.doi.org/10.1126/sciimmunol.aau6298DOI Listing
November 2019

Development of transplantable B-cell lymphomas in the MHC-defined miniature swine model.

Cancer Cell Int 2019 9;19:236. Epub 2019 Sep 9.

1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129 USA.

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http://dx.doi.org/10.1186/s12935-019-0954-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734256PMC
September 2019

Telehealth Intervention Programs for Seniors: An Observational Study of a Community-Embedded Health Monitoring Initiative.

Telemed J E Health 2019 Apr 17. Epub 2019 Apr 17.

1 Department of Telemedicine and Virtual Rehabilitation, Burke Medical Research Institute, White Plains, New York.

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http://dx.doi.org/10.1089/tmj.2018.0248DOI Listing
April 2019

Amino acid and lipid profiles following pig-to-primate liver xenotransplantation.

Xenotransplantation 2019 03 16;26(2):e12473. Epub 2018 Nov 16.

Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1111/xen.12473DOI Listing
March 2019

Absence of interaction between porcine endogenous retrovirus and porcine cytomegalovirus in pig-to-baboon renal xenotransplantation in vivo.

Xenotransplantation 2018 09 6;25(5):e12395. Epub 2018 Apr 6.

Infectious Disease Division and MGH Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/xen.12395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158079PMC
September 2018

The effects of galectin-3 depletion apheresis on induced skin inflammation in a porcine model.

J Clin Apher 2018 Aug 23;33(4):486-493. Epub 2018 Mar 23.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jca.21624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105514PMC
August 2018

Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4 Treg in nonhuman primates.

Mol Oncol 2018 08 3;12(8):1374-1382. Epub 2018 Jul 3.

Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/1878-0261.12331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068354PMC
August 2018

Vascularized Composite Allotransplantation-An Emerging Concept for Burn Reconstruction.

J Burn Care Res 2017 Nov/Dec;38(6):371-378

From the *Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School; and †Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/BCR.0000000000000532DOI Listing
July 2018

A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine.

Int J Inflam 2018 24;2018:6916920. Epub 2018 Jun 24.

Center for Transplantation Sciences, Massachusetts General Hospital, 149 13 Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1155/2018/6916920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035809PMC
June 2018

Preclinical and clinical studies for transplant tolerance via the mixed chimerism approach.

Hum Immunol 2018 May 22;79(5):258-265. Epub 2017 Nov 22.

Department of surgery, Center for transplant science, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963722PMC
May 2018

Transplantation tolerance through mixed chimerism: From allo to xeno.

Authors:
David H Sachs

Xenotransplantation 2018 05;25(3):e12420

Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1111/xen.12420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010074PMC
May 2018

Blockade of IgM-Mediated Inflammation Alters Wound Progression in a Swine Model of Partial-Thickness Burn.

J Burn Care Res 2017 May/Jun;38(3):148-160

From the *Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; †Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts; and ‡Department of Surgery, Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

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http://dx.doi.org/10.1097/BCR.0000000000000459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397333PMC
February 2018

miRNA-mediated targeting of human cytomegalovirus reveals biological host and viral targets of IE2.

Proc Natl Acad Sci U S A 2018 01 16;115(5):1069-1074. Epub 2018 Jan 16.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;

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http://dx.doi.org/10.1073/pnas.1719036115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798380PMC
January 2018

Tolerance in xenotransplantation.

Curr Opin Organ Transplant 2017 Dec;22(6):522-528

aColumbia Center for Translational Immunology, Department of Medicine bDepartment of Surgery cDepartment of Microbiology & Immunology, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1097/MOT.0000000000000466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737964PMC
December 2017

Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.

Biomaterials 2017 Dec 19;147:116-132. Epub 2017 Sep 19.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine Yale School of Medicine, New Haven, CT 06511, USA; Yale Stem Cell Center, New Haven, CT 06520, USA; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638652PMC
December 2017

Dynamics of B Cell Recovery In Kidney/Bone Marrow Transplant Recipients.

Transplantation 2017 11;101(11):2722-2730

1 Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2 Transplant Center, The First Hospital of Jilin University, Changchun, China. 3 Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY. 4 The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China. 5 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://Insights.ovid.com/crossref?an=00007890-201711000-0001
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http://dx.doi.org/10.1097/TP.0000000000001789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648631PMC
November 2017

Joint FDA‐IXA Symposium, September 20, 2017.

Xenotransplantation 2017 11 28;24(6). Epub 2017 Nov 28.

Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Division of Medical Biotechnology, Langen, Germany.

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http://dx.doi.org/10.1111/xen.12365DOI Listing
November 2017

Methods for the detection and serum depletion of porcine galectin-3.

J Clin Apher 2017 Oct 13;32(5):335-341. Epub 2017 Jan 13.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jca.21521DOI Listing
October 2017

Ontak-like human IL-2 fusion toxin.

J Immunol Methods 2017 09 24;448:51-58. Epub 2017 May 24.

Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00221759173014
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http://dx.doi.org/10.1016/j.jim.2017.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576150PMC
September 2017

Immune Tolerance, Xenografts, and Large-Animal Studies in Transplantation.

Authors:
David H Sachs

Ann Am Thorac Soc 2017 Sep;14(Supplement_3):S220-S225

Department of Surgery, Columbia University Medical Center, New York, New York.

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http://dx.doi.org/10.1513/AnnalsATS.201607-534MGDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711340PMC
September 2017

Transposon Mutagenesis of the Zika Virus Genome Highlights Regions Essential for RNA Replication and Restricted for Immune Evasion.

J Virol 2017 08 12;91(15). Epub 2017 Jul 12.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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http://dx.doi.org/10.1128/JVI.00698-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512254PMC
August 2017

Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity.

Circ Res 2017 Aug 22;121(4):411-423. Epub 2017 Jun 22.

From the Cardiovascular Research Center (J.M., T.J.C., D.K.C., D.S., S.S., R.J.H., K.D.C.), Department of Developmental and Regenerative Biology (D.A.K.), and Department of Pharmacology and Systems Therapeutics (E.A.S.), Icahn School of Medicine at Mount Sinai, New York; Department of Medicine, University of Washington Seattle (B.V.J.); and The Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, FL (J.M.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899516PMC
August 2017

Regulation of Clinical Xenotransplantation-Time for a Reappraisal.

Transplantation 2017 08;101(8):1766-1769

1 Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA. 2 Division of Cardiac Surgery, Department of Surgery, University of Maryland, Baltimore VAMC, Baltimore, MD. 3 Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN. 4 National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. 5 MGH Transplantation Center and Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital/Harvard Medical School, Boston, MA. 6 Robert Koch Institute, Berlin, Germany. 7 Transplantation Research Institute, College of Medicine, Seoul National University, Seoul, South Korea. 8 Department of Surgery, University Hospital Geneva, Geneva, Switzerland. 9 Immunology Research Center, St Vincent's Hospital Melbourne, University of Melbourne, Melbourne, Victoria, Australia. 10 Department of Surgery, Westmead Clinical School, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia. 11 Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan. 12 Columbia University Medical Center, New York, NY.

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http://dx.doi.org/10.1097/TP.0000000000001683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702547PMC
August 2017

A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor.

Cell Rep 2017 08;20(7):1503-1512

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568676PMC
August 2017

RNase III nucleases from diverse kingdoms serve as antiviral effectors.

Nature 2017 07 28;547(7661):114-117. Epub 2017 Jun 28.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/nature22990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846625PMC
July 2017

Diphtheria toxin-based anti-human CD19 immunotoxin for targeting human CD19 tumors.

Mol Oncol 2017 05 4;11(5):584-594. Epub 2017 Apr 4.

Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/1878-0261.12056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527461PMC
May 2017

Factors associated with success of telaprevir- and boceprevir-based triple therapy for hepatitis C virus infection.

World J Hepatol 2017 Apr;9(11):551-561

Kian Bichoupan, Neeta Tandon, Valerie Martel-Laferriere, Neal M Patel, David Sachs, Michel Ng, Emily A Schonfeld, Alexis Pappas, James Crismale, Alicia Stivala, Viktoriya Khaitova, Donald Gardenier, Michael Linderman, William Olson, Ponni V Perumalswami, Thomas D Schiano, Joseph A Odin, Lawrence U Liu, Douglas T Dieterich, Andrea D Branch, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, Icahn Medical Instititute, New York, NY 10029, United States.

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http://www.wjgnet.com/1948-5182/full/v9/i11/551.htm
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http://dx.doi.org/10.4254/wjh.v9.i11.551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395804PMC
April 2017

Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47.

Transplantation 2017 02;101(2):316-321

1 Transplantation Biology Research Center, MGH, Boston, MA. 2 Harvard Medical School, Boston, MA. 3 Columbia Center for Translational Immunology, Columbia University, New York, NY. 4 Pathology Service, Massachusetts General Hospital (MGH), Boston, MA.

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http://dx.doi.org/10.1097/TP.0000000000001267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124423PMC
February 2017

Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin.

Vet Immunol Immunopathol 2016 Dec 29;182:150-158. Epub 2016 Oct 29.

Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vetimm.2016.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134928PMC
December 2016

Survival of Allogeneic Self-Assembled Cultured Skin.

Transplantation 2016 10;100(10):2071-8

1 Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2 Department of Pathology, Massachusetts General Hospital, Boston, MA. 3 Preclinical Research and Development Laboratory, Organogenesis Inc. Canton, MA. 4 Plastic Surgery Research Laboratory, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/TP.0000000000001353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030145PMC
October 2016

Postnatal xenogeneic B-cell tolerance in swine following in utero intraportal antigen exposure.

Xenotransplantation 2015 Sep-Oct;22(5):368-78. Epub 2015 Aug 28.

Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/xen.12186DOI Listing
June 2016

A Bridge to Somewhere: 25-day Survival After Pig-to-Baboon Liver Xenotransplantation.

Ann Surg 2016 06;263(6):1069-71

Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/SLA.0000000000001659DOI Listing
June 2016

Bioengineered Self-assembled Skin as an Alternative to Skin Grafts.

Plast Reconstr Surg Glob Open 2016 Jun 10;4(6):e731. Epub 2016 Jun 10.

Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.; Organogenesis Inc., Canton, Mass.; Department of Pathology, Massachusetts General Hospital, Boston, Mass.; and Plastic Surgery Research Laboratory, Massachusetts General Hospital, Boston, Mass.

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http://dx.doi.org/10.1097/GOX.0000000000000723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956843PMC
June 2016

Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity.

Proc Natl Acad Sci U S A 2016 Apr 21;113(14):3861-6. Epub 2016 Mar 21.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710

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http://dx.doi.org/10.1073/pnas.1522376113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833272PMC
April 2016

Integrating Tobacco Use Treatment Into Practice: Billing and Documentation.

Chest 2016 Feb 12;149(2):568-575. Epub 2016 Jan 12.

Palo Alto Center for Pulmonary Disease Prevention, Palo Alto, CA.

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http://dx.doi.org/10.1378/chest.15-0441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831568PMC
February 2016

Natural IgM Blockade Limits Infarct Expansion and Left Ventricular Dysfunction in a Swine Myocardial Infarct Model.

Circ Cardiovasc Interv 2016 Jan;9(1):e002547

From the Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown (S.S., J.D.G., J.C.M., D.H.S., J.S.A.); Cardiac Surgery Research Laboratory, Massachusetts General Hospital, Boston, (J.L.G., J.B., J.S.A.); DecImmune Therapeutics, Cambridge, MA (M.S.H., E.M.A., F.S., R.J.P., W.N.); Program in Cellular and Molecular Medicine, Boston Children's Hospital, MA (M.C.C.); Department of Pediatrics, Harvard Medical School, Boston, MA (M.C.C.); and Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia (K.M.K.).

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.115.002547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687758PMC
January 2016

Tolerance induction via mixed chimerism in vascularized composite allotransplantation: is it time for clinical application?

Curr Opin Organ Transplant 2015 Dec;20(6):602-7

aVascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, Massachusetts, USA bDivision of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA cTransplantation Biology Research Center Laboratories, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MOT.0000000000000248DOI Listing
December 2015

microRNA Function Is Limited to Cytokine Control in the Acute Response to Virus Infection.

Cell Host Microbe 2015 Dec;18(6):714-22

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683400PMC
December 2015

Progress towards inducing tolerance of pig-to-primate xenografts.

Int J Surg 2015 Nov 18;23(Pt B):291-295. Epub 2015 Aug 18.

Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2015.07.720DOI Listing
November 2015

Engineered Mammalian RNAi Can Elicit Antiviral Protection that Negates the Requirement for the Interferon Response.

Cell Rep 2015 Nov 5;13(7):1456-1466. Epub 2015 Nov 5.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654977PMC
November 2015

Effect of Irradiation on Incidence of Post-Transplant Lymphoproliferative Disorder after Hematopoietic Cell Transplantation in Miniature Swine.

Biol Blood Marrow Transplant 2015 Oct 22;21(10):1732-8. Epub 2015 Jul 22.

Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts; Columbia Center for Translational Immunology, Columbia University, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2015.07.017DOI Listing
October 2015

Miniature Swine as a Clinically Relevant Model of Graft-Versus-Host Disease.

Comp Med 2015 Oct;65(5):429-43

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617335PMC
October 2015

Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI.

Transplantation 2015 Aug;99(8):1574-81

1 Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA. 2 Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 3 Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA. 4 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA.

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http://pdfs.journals.lww.com/transplantjournal/9000/00000/Mo
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http://pdfs.journals.lww.com/transplantjournal/2015/08000/Mo
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http://dx.doi.org/10.1097/TP.0000000000000682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551574PMC
August 2015

Diphtheria-toxin based anti-human CCR4 immunotoxin for targeting human CCR4(+) cells in vivo.

Mol Oncol 2015 Aug 25;9(7):1458-70. Epub 2015 Apr 25.

Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528803PMC
August 2015

Retail Tobacco Sale in the Community. Should Pharmacies Sell Tobacco Products?

Ann Am Thorac Soc 2015 Aug;12(8):1116-7

4 Palo Alto Center for Pulmonary Disease Prevention, Palo Alto, California.

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http://dx.doi.org/10.1513/AnnalsATS.201504-229EDDOI Listing
August 2015

Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins.

Cell Rep 2015 Jun 21;11(9):1331-8. Epub 2015 May 21.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464907PMC
June 2015

Genetically modified porcine split-thickness skin grafts as an alternative to allograft for provision of temporary wound coverage: preliminary characterization.

Burns 2015 May 16;41(3):565-74. Epub 2014 Oct 16.

Transplant Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.burns.2014.09.003DOI Listing
May 2015

The Medawar Prize acceptance speech 2014.

Authors:
David H Sachs

Transplantation 2015 Feb;99(2):254-7

1 Massachusetts General Hospital, Boston MA.

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http://dx.doi.org/10.1097/TP.0000000000000627DOI Listing
February 2015

Stem cells: Immunology and immunomodulation.

Dev Ophthalmol 2014 10;53:122-32. Epub 2014 Apr 10.

Transplantation Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, Mass., USA.

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http://dx.doi.org/10.1159/000357360DOI Listing
January 2015

Influenza A virus transmission bottlenecks are defined by infection route and recipient host.

Cell Host Microbe 2014 Nov 23;16(5):691-700. Epub 2014 Oct 23.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128140035
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http://dx.doi.org/10.1016/j.chom.2014.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272616PMC
November 2014

Development of antidonor antibody directed toward non-major histocompatibility complex antigens in tolerant animals.

Transplantation 2014 Sep;98(5):514-9

1 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2 Catholic University of Louvain, Belgium. 3 Address correspondence to: David H. Sachs, M.D., Transplantation Biology Research Center, Massachusetts General Hospital, MGH-East, Bldg. 149-9019, 13th Street, Boston, MA, 02129.

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http://dx.doi.org/10.1097/TP.0000000000000249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149823PMC
September 2014

Diphtheria toxin-based recombinant murine IL-2 fusion toxin for depleting murine regulatory T cells in vivo.

Protein Eng Des Sel 2014 Sep;27(9):289-95

Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA MGH-DF/HCC Recombinant Protein Expression and Purification Core, Boston, MA, USA

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https://academic.oup.com/peds/article-lookup/doi/10.1093/pro
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http://dx.doi.org/10.1093/protein/gzu034DOI Listing
September 2014

The rejuvenating effects of leuprolide acetate on the aged baboon's thymus.

Transpl Immunol 2014 Sep 18;31(3):134-9. Epub 2014 Sep 18.

Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, United States; Harvard Medical School, Boston, MA 02129, United States.

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http://dx.doi.org/10.1016/j.trim.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188753PMC
September 2014

Increased levels of anti-non-Gal IgG following pig-to-baboon bone marrow transplantation correlate with failure of engraftment.

Xenotransplantation 2013 Nov-Dec;20(6):458-68. Epub 2013 Oct 29.

Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://doi.wiley.com/10.1111/xen.12065
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http://dx.doi.org/10.1111/xen.12065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848062PMC
August 2014

Long-term survival of influenza virus infected club cells drives immunopathology.

J Exp Med 2014 Aug 18;211(9):1707-14. Epub 2014 Aug 18.

Department of Microbiology, Global Health and Emerging Pathogens Institute, and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029 Department of Microbiology, Global Health and Emerging Pathogens Institute, and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029

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http://www.jem.org/lookup/doi/10.1084/jem.20140488
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http://dx.doi.org/10.1084/jem.20140488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144728PMC
August 2014

Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model.

Transplantation 2014 Aug;98(4):411-8

Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA. 1 Address correspondence to: Kazuhiko Yamada, M.D., Ph.D., Organ Transplantation Tolerance and Xenotransplantation Laboratory, Transplantation Biology Research Center, Massachusetts General Hospital, MGH-East, Bldg. 149-9019, 13th Street, Boston, MA, 02129.

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http://dx.doi.org/10.1097/TP.0000000000000232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176773PMC
August 2014

The Mammalian response to virus infection is independent of small RNA silencing.

Cell Rep 2014 Jul 19;8(1):114-25. Epub 2014 Jun 19.

Department of Microbiology, Icahn Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096324PMC
July 2014

Lack of cross-sensitization between α-1,3-galactosyltransferase knockout porcine and allogeneic skin grafts permits serial grafting.

Transplantation 2014 Jun;97(12):1209-15

Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA. 2 Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 3 Department of Biology, Emmanuel College, Boston, MA. 4 Address correspondence to Curtis L. Cetrulo, Jr, M.D., F.A.C.S., Transplantation Biology Research Center, Massachusetts General Hospital, MGH-East Building, 149-9019, 13th Street, Boston, MA.

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http://dx.doi.org/10.1097/TP.0000000000000093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407992PMC
June 2014

Drosha as an interferon-independent antiviral factor.

Proc Natl Acad Sci U S A 2014 May 28;111(19):7108-13. Epub 2014 Apr 28.

Department of Microbiology,Icahn Graduate School of Biomedical Sciences, and

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http://dx.doi.org/10.1073/pnas.1319635111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024876PMC
May 2014

Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25(+) cells.

J Immunol Methods 2014 Mar 24;405:57-66. Epub 2014 Jan 24.

Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; MGH-DF/HCC Recombinant Protein Expression and Purification Core, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2014.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120078PMC
March 2014

Induction of tolerance through mixed chimerism.

Cold Spring Harb Perspect Med 2014 Jan 1;4(1):a015529. Epub 2014 Jan 1.

Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129.

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http://dx.doi.org/10.1101/cshperspect.a015529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869282PMC
January 2014

Development of a diphtheria toxin-based recombinant porcine IL-2 fusion toxin for depleting porcine CD25+ cells.

J Immunol Methods 2013 Dec 18;398-399:33-43. Epub 2013 Sep 18.

Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; DF/HCC-MGH Recombinant Protein Expression and Purification Core, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jim.2013.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840057PMC
December 2013

Vascularized composite allograft transplant survival in miniature swine: is MHC tolerance sufficient for acceptance of epidermis?

Transplantation 2013 Dec;96(11):966-74

1 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2 Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 3 Address correspondence to: Kazuhiko Yamada, M.D., Ph.D., Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, MGH-East, Building 149-9014, 13th Street, Boston, MA 02129.

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http://dx.doi.org/10.1097/TP.0b013e3182a579d0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902136PMC
December 2013

Recombinant anti-monkey CD3 immunotoxin depletes peripheral lymph node T lymphocytes more effectively than rabbit anti-thymocyte globulin in naïve baboons.

Transpl Immunol 2013 Dec 22;29(1-4):60-3. Epub 2013 Oct 22.

Transplantation Biology Research Center, Massachusetts General Hospital, United States; Department of Surgery, Cleveland Clinic, United States.

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http://dx.doi.org/10.1016/j.trim.2013.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938119PMC
December 2013

Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins.

Proc Natl Acad Sci U S A 2013 Dec 25;110(50):20248-53. Epub 2013 Nov 25.

Departments of Microbiology, Genetics, and Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

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http://dx.doi.org/10.1073/pnas.1320524110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864309PMC
December 2013

An in vivo RNAi screening approach to identify host determinants of virus replication.

Cell Host Microbe 2013 Sep;14(3):346-56

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.chom.2013.08.007DOI Listing
September 2013