David S Lawrence

David S Lawrence

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Design, construction, and validation of optogenetic proteins.

Methods Enzymol 2019 12;621:171-190. Epub 2019 Mar 12.

Department of Chemistry, University of North Carolina, Chapel Hill, NC, United States; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2019.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003698PMC
February 2020

Selection and optimization of enzyme reporters for chemical cytometry.

Methods Enzymol 2019 23;622:221-248. Epub 2019 Mar 23.

Department of Chemistry, University of North Carolina, Chapel Hill, NC, United States; Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill; North Carolina State University, Raleigh, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2019.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905852PMC
February 2020

Optogenetic perturbation of the biochemical pathways that control cell behavior.

Methods Enzymol 2019 12;622:309-328. Epub 2019 Mar 12.

Department of Chemistry, East Carolina University, Greenville, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2019.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003693PMC
February 2020

Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems.

ACS Synth Biol 2020 01 17;9(1):1-9. Epub 2019 Dec 17.

Division of Chemical Biology and Medicinal Chemistry , UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

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http://dx.doi.org/10.1021/acssynbio.9b00277DOI Listing
January 2020

Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases.

Cell Chem Biol 2019 10 25;26(10):1393-1406.e7. Epub 2019 Jul 25.

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800631PMC
October 2019

Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease.

Curr Allergy Asthma Rep 2019 07 2;19(8):37. Epub 2019 Jul 2.

Duke School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1007/s11882-019-0869-zDOI Listing
July 2019

Emerging concepts in HIV-associated cryptococcal meningitis.

Curr Opin Infect Dis 2019 02;32(1):16-23

Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

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http://dx.doi.org/10.1097/QCO.0000000000000514DOI Listing
February 2019

Dasatinib Is Preferentially Active in the Activated B-Cell Subtype of Diffuse Large B-Cell Lymphoma.

J Proteome Res 2019 01 21;18(1):522-534. Epub 2018 Dec 21.

Department of Biomedical Sciences , College of Veterinary Medicine, Cornell University , T8 004b Veterinary Research Tower, Box 17 , Ithaca , New York 14853 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00841
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http://dx.doi.org/10.1021/acs.jproteome.8b00841DOI Listing
January 2019

Design and Application of Sensors for Chemical Cytometry.

ACS Chem Biol 2018 07 8;13(7):1741-1751. Epub 2018 Feb 8.

Department of Chemistry , The University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

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http://dx.doi.org/10.1021/acschembio.7b01009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061971PMC
July 2018

Cellular Cyborgs: On the Precipice of a Drug Delivery Revolution.

Cell Chem Biol 2018 06 5;25(6):648-658. Epub 2018 Apr 5.

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.03.003DOI Listing
June 2018

Optogenetics: A Primer for Chemists.

Chembiochem 2018 06 14;19(12):1201-1216. Epub 2018 May 14.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry and, Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1002/cbic.201800013DOI Listing
June 2018

Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase.

Cell Chem Biol 2018 01 5;25(1):100-109.e8. Epub 2017 Nov 5.

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777159PMC
January 2018

Red Blood Cells for Glucose-Responsive Insulin Delivery.

Adv Mater 2017 May 7;29(18). Epub 2017 Mar 7.

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.

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http://doi.wiley.com/10.1002/adma.201606617
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http://dx.doi.org/10.1002/adma.201606617DOI Listing
May 2017

Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents.

Angew Chem Int Ed Engl 2016 12 22;55(52):16080-16083. Epub 2016 Nov 22.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1002/anie.201609731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177521PMC
December 2016

An Integrated Chemical Cytometry Method: Shining a Light on Akt Activity in Single Cells.

Angew Chem Int Ed Engl 2016 10;55(42):13095-13098

Department of Chemistry and Pharmacology, University of North Carolina, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1002/anie.201606914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149395PMC
October 2016

Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells.

Analyst 2016 Oct;141(21):6008-6017

Department of Chemistry, University of North Carolina, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1039/c6an01378cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111365PMC
October 2016

Fluorophore Assisted Photolysis of Thiolato-Cob(III)alamins.

Inorg Chem 2016 Mar 5;55(5):1962-9. Epub 2016 Feb 5.

Department of Chemistry, ‡Division of Chemical Biology and Medicinal Chemistry, and §Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/acs.inorgchem.5b02036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238438PMC
March 2016

Rational Design of a Dephosphorylation-Resistant Reporter Enables Single-Cell Measurement of Tyrosine Kinase Activity.

ACS Chem Biol 2016 Feb 4;11(2):355-62. Epub 2015 Dec 4.

Joint Department of Biomedical Engineering, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599 and North Carolina State University, Raleigh, North Carolina 27695, United States.

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http://dx.doi.org/10.1021/acschembio.5b00667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024252PMC
February 2016

The Plasma Membrane as a Reservoir, Protective Shield, and Light-Triggered Launch Pad for Peptide Therapeutics.

Angew Chem Int Ed Engl 2016 Jan 4;55(3):950-4. Epub 2015 Dec 4.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1002/anie.201508767DOI Listing
January 2016

Vitamin B12: a tunable, long wavelength, light-responsive platform for launching therapeutic agents.

Acc Chem Res 2015 Nov 19;48(11):2866-74. Epub 2015 Oct 19.

Department of Chemistry, Division of Chemical Biology, and the Department of Pharmacology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/acs.accounts.5b00331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240631PMC
November 2015

Optogenetic apoptosis: light-triggered cell death.

Angew Chem Int Ed Engl 2015 Oct 25;54(41):12064-8. Epub 2015 Aug 25.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/anie.201506346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819321PMC
October 2015

B(12)-mediated, long wavelength photopolymerization of hydrogels.

J Am Chem Soc 2015 Mar 27;137(9):3372-8. Epub 2015 Feb 27.

Department of Chemistry, ‡Division of Chemical Biology and Medicinal Chemistry, and § Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

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http://pubs.acs.org/doi/10.1021/jacs.5b00182
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http://dx.doi.org/10.1021/jacs.5b00182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610811PMC
March 2015

Multicolor monitoring of the proteasome's catalytic signature.

ACS Chem Biol 2015 Feb 7;10(2):433-40. Epub 2014 Nov 7.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/cb5007322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340355PMC
February 2015

Cell-mediated assembly of phototherapeutics.

Angew Chem Int Ed Engl 2014 Oct 22;53(41):10945-8. Epub 2014 Aug 22.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/anie.201406216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209249PMC
October 2014

Optogenetic engineering: light-directed cell motility.

Angew Chem Int Ed Engl 2014 Oct 25;53(41):10904-7. Epub 2014 Aug 25.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/anie.201404198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196877PMC
October 2014

Measurement of protein kinase B activity in single primary human pancreatic cancer cells.

Anal Chem 2014 May 18;86(9):4573-80. Epub 2014 Apr 18.

Department of Chemistry, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/ac500616qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018172PMC
May 2014

Long-wavelength fluorescent reporters for monitoring protein kinase activity.

Angew Chem Int Ed Engl 2014 Apr 6;53(15):3975-8. Epub 2014 Mar 6.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/anie.201309691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036623PMC
April 2014

Tunable visible and near-IR photoactivation of light-responsive compounds by using fluorophores as light-capturing antennas.

Angew Chem Int Ed Engl 2014 Jan 27;53(3):875-8. Epub 2013 Nov 27.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina,Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/anie.201308816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036634PMC
January 2014

Lipid pools as photolabile "protecting groups": design of light-activatable bioagents.

Angew Chem Int Ed Engl 2013 Sep 31;52(38):9936-9. Epub 2013 Jul 31.

Department of Biomedical Engineering, Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/anie.201305510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840492PMC
September 2013

Direct observation of frequency modulated transcription in single cells using light activation.

Elife 2013 Sep 24;2:e00750. Epub 2013 Sep 24.

Laboratory of Receptor Biology and Gene Expression , Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , United States.

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http://dx.doi.org/10.7554/eLife.00750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780543PMC
September 2013

A broad spectrum dark quencher: construction of multiple colour protease and photolytic sensors.

Chem Commun (Camb) 2013 Aug;49(60):6728-30

Department of Chemistry, The University of North Carolina at Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1039/c3cc42628aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167382PMC
August 2013

Probes of the mitochondrial cAMP-dependent protein kinase.

Biochim Biophys Acta 2013 Jul 11;1834(7):1359-63. Epub 2013 Feb 11.

Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.bbapap.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665737PMC
July 2013

Measurement of protein tyrosine phosphatase activity in single cells by capillary electrophoresis.

Anal Chem 2013 Jun 30;85(12):6136-42. Epub 2013 May 30.

Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1021/ac401106eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704224PMC
June 2013

SRC kinase regulation in progressively invasive cancer.

PLoS One 2012 7;7(11):e48867. Epub 2012 Nov 7.

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048867PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492248PMC
May 2013

A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors.

Methods Mol Biol 2012 ;928:53-65

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://link.springer.com/10.1007/978-1-62703-008-3_5
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http://dx.doi.org/10.1007/978-1-62703-008-3_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231398PMC
February 2013

Monitoring of protein arginine deiminase activity by using fluorescence quenching: multicolor visualization of citrullination.

Angew Chem Int Ed Engl 2013 Feb 21;52(8):2323-5. Epub 2013 Jan 21.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1002/anie.201208464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752692PMC
February 2013

Development of a peptidase-resistant substrate for single-cell measurement of protein kinase B activation.

Anal Chem 2012 Aug 9;84(16):7195-202. Epub 2012 Aug 9.

Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1021/ac301489dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428732PMC
August 2012

Metabolism of peptide reporters in cell lysates and single cells.

Analyst 2012 Jul 7;137(13):3028-38. Epub 2012 Feb 7.

Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1039/c2an16162aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697743PMC
July 2012

Merging of confocal and caging technologies: selective three-color communication with profluorescent reporters.

Angew Chem Int Ed Engl 2012 Jul 27;51(31):7684-7. Epub 2012 Jun 27.

Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1002/anie.201202820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523745PMC
July 2012

Proteolytic regulation of the mitochondrial cAMP-dependent protein kinase.

Biochemistry 2012 Mar 8;51(11):2258-64. Epub 2012 Mar 8.

Departments of Chemistry, Chemical Biology and Medicinal Chemistry, and Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/bi201573kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309167PMC
March 2012

Dual wavelength photoactivation of cAMP- and cGMP-dependent protein kinase signaling pathways.

ACS Chem Biol 2011 Apr 26;6(4):377-84. Epub 2011 Jan 26.

Department of Chemistry, the Division of Medicinal Chemistry & Natural Products, School of Pharmacy, The University of North Carolina at Chapel Hill, United States.

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http://dx.doi.org/10.1021/cb100398eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078176PMC
April 2011

Construction of a photoactivatable profluorescent enzyme via propinquity labeling.

J Am Chem Soc 2011 Mar 8;133(8):2331-3. Epub 2011 Feb 8.

Department of Chemistry, Division of Medicinal Chemistry and Natural Products, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1021/ja108950qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045470PMC
March 2011

A new trick (hydroxyl radical generation) for an old vitamin (B12).

J Am Chem Soc 2011 Feb 28;133(7):2148-50. Epub 2011 Jan 28.

Department of Chemistry, Division of Medicinal Chemistry and Natural Products, University of North Carolina, Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/ja111585cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077068PMC
February 2011

Suborganelle sensing of mitochondrial cAMP-dependent protein kinase activity.

J Am Chem Soc 2010 May;132(17):6075-80

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1021/ja909652qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862470PMC
May 2010

Light-mediated remote control of signaling pathways.

Biochim Biophys Acta 2010 Mar 16;1804(3):547-58. Epub 2009 Sep 16.

Department of Chemistry, The University of North Carolina at Chapel Hill, Kenan Laboratories, Campus Box 3290, Chapel Hill, NC 27599-3290, USA.

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http://dx.doi.org/10.1016/j.bbapap.2009.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822126PMC
March 2010

Light-mediated spatial control via photolabile fluorescently quenched peptide cassettes.

J Am Chem Soc 2010 Feb;132(5):1446-7

Department of Chemistry, Division of Medicinal Chemistry and Natural Products, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1021/ja907427pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819137PMC
February 2010

Simultaneous fluorescent monitoring of proteasomal subunit catalysis.

J Am Chem Soc 2010 Feb;132(5):1578-82

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja907226n
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http://dx.doi.org/10.1021/ja907226nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820722PMC
February 2010

Uber-responsive peptide-based sensors of signaling proteins.

Angew Chem Int Ed Engl 2009 ;48(40):7290-2

Division of Medicinal Chemistry & Natural Products, School of Pharmacy, University of North Carolina, Campus Box 7363, Genetic Medicine Building, Chapel Hill, NC 27599-7363, USA.

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http://dx.doi.org/10.1002/anie.200903717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047891PMC
December 2009

Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy.

J Am Chem Soc 2009 Sep;131(36):13072-9

Department of Biochemistry and Molecular Biology, Chemical Genomics Core Facility, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1021/ja903733zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741613PMC
September 2009

Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds.

ACS Chem Biol 2009 Jun;4(6):409-27

Department of Chemistry, The University of North Carolina, Chapel Hill, North Carolina 27599-3290, USA.

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http://dx.doi.org/10.1021/cb900036sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700207PMC
June 2009

Light-mediated liberation of enzymatic activity: "small molecule" caged protein equivalents.

J Am Chem Soc 2008 Aug 19;130(32):10474-5. Epub 2008 Jul 19.

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1021/ja803395dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628309PMC
August 2008

Stepwise combinatorial evolution of Akt bisubstrate inhibitors.

Chembiochem 2008 Mar;9(4):507-9

Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1002/cbic.200700583DOI Listing
March 2008

Peptide-based fluorescent sensors of protein kinase activity: design and applications.

Biochim Biophys Acta 2008 Jan 15;1784(1):94-9. Epub 2007 Aug 15.

Department of Biochemistry, The Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.bbapap.2007.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684651PMC
January 2008

A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics.

Biochemistry 2008 Jan 23;47(3):986-96. Epub 2007 Dec 23.

Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi7021624
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http://dx.doi.org/10.1021/bi7021624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227476PMC
January 2008

Visual snapshots of intracellular kinase activity at the onset of mitosis.

Chem Biol 2007 Nov;14(11):1254-60

Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.chembiol.2007.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171364PMC
November 2007

An affinity-based fluorescence polarization assay for protein tyrosine phosphatases.

Methods 2007 Jul;42(3):261-7

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1016/j.ymeth.2007.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001261PMC
July 2007

Photochemically-activated probes of protein-protein interactions.

Org Lett 2007 Jun 17;9(12):2249-52. Epub 2007 May 17.

Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461-1602, USA.

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http://dx.doi.org/10.1021/ol070238tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057037PMC
June 2007

Seeing is believing: peptide-based fluorescent sensors of protein tyrosine kinase activity.

Chembiochem 2007 Mar;8(4):373-8

Department of Biochemistry, The Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1002/cbic.200600473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057110PMC
March 2007

Deep quench: an expanded dynamic range for protein kinase sensors.

J Am Chem Soc 2007 Mar 17;129(10):2742-3. Epub 2007 Feb 17.

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1021/ja068280rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517079PMC
March 2007

Light-regulated sampling of protein tyrosine kinase activity.

J Am Chem Soc 2006 Nov;128(43):14016-7

Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1021/ja065852zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660521PMC
November 2006

Acquisition of a "Group A"-selective Src kinase inhibitor via a global targeting strategy.

J Am Chem Soc 2006 May;128(18):5996-7

Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1021/ja060136iDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527056PMC
May 2006

Imaging of gene expression in living cells and tissues.

J Biomed Opt 2005 Sep-Oct;10(5):051406

Albert Einstein College of Medicine, Department of Anatomy and Structural Biology and Biochemistry, Biophotonics Center, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1117/1.2103032DOI Listing
April 2006

Self-reporting fluorescent substrates of protein tyrosine kinases.

J Am Chem Soc 2006 Feb;128(6):1808-9

Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1021/ja0577692DOI Listing
February 2006

Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate.

Biochemistry 2006 Jan;45(1):234-40

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi051560j
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January 2006

Signaling protein inhibitors via the combinatorial modification of peptide scaffolds.

Authors:
David S Lawrence

Biochim Biophys Acta 2005 Dec 12;1754(1-2):50-7. Epub 2005 Sep 12.

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.bbapap.2005.07.038DOI Listing
December 2005

The preparation and in vivo applications of caged peptides and proteins.

Authors:
David S Lawrence

Curr Opin Chem Biol 2005 Dec 22;9(6):570-5. Epub 2005 Sep 22.

Department of Biochemistry, The Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S136759310500132
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December 2005

Acquisition of Fyn-selective SH3 domain ligands via a combinatorial library strategy.

Chem Biol 2005 Aug;12(8):905-12

The Albert Einstein College of Medicine, Department of Biochemistry, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1016/j.chembiol.2005.06.007DOI Listing
August 2005

The role of protein-tyrosine phosphatase 1B in integrin signaling.

J Biol Chem 2005 Jul 2;280(26):24857-63. Epub 2005 May 2.

Departments of Molecular Pharmacology and Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M502780200
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July 2005

Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor.

Angew Chem Int Ed Engl 2005 Jul;44(27):4242-4

Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1002/anie.200462004DOI Listing
July 2005

Phosphorylation-driven protein-protein interactions: a protein kinase sensing system.

J Am Chem Soc 2005 Jun;127(21):7684-5

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1021/ja050789jDOI Listing
June 2005

Small molecule approach to studying protein tyrosine phosphatase.

Methods 2005 Jan;35(1):9-21

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.ymeth.2004.07.003DOI Listing
January 2005

Enhanced production of functional proteins from defective genes.

J Am Chem Soc 2004 May;126(18):5660-1

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja0318939
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May 2004

Cofilin promotes actin polymerization and defines the direction of cell motility.

Science 2004 Apr;304(5671):743-6

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1126/science.1094561DOI Listing
April 2004

Biosensors of protein kinase action: from in vitro assays to living cells.

Biochim Biophys Acta 2004 Mar;1697(1-2):39-51

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.bbapap.2003.11.012DOI Listing
March 2004

A highly potent and selective PKCalpha inhibitor generated via combinatorial modification of a peptide scaffold.

J Am Chem Soc 2004 Mar;126(11):3394-5

The Albert Einstein College of Medicine, Department of Biochemistry, 1300 Morris Park Ave., Bronx, New York 10461, USA.

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http://dx.doi.org/10.1021/ja037300bDOI Listing
March 2004

A light-activated probe of intracellular protein kinase activity.

J Am Chem Soc 2003 Nov;125(44):13358-9

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1021/ja037801xDOI Listing
November 2003

Cellular effects of small molecule PTP1B inhibitors on insulin signaling.

Biochemistry 2003 Nov;42(44):12792-804

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1021/bi035238pDOI Listing
November 2003

Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague.

J Biol Chem 2003 Oct 29;278(43):41734-41. Epub 2003 Jul 29.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1074/jbc.M307152200DOI Listing
October 2003

Chemical biology of signal transduction.

Authors:
David S Lawrence

Acc Chem Res 2003 Jun;36(6):353-4

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http://dx.doi.org/10.1021/ar0300672DOI Listing
June 2003

Chemical probes of signal-transducing proteins.

Authors:
David S Lawrence

Acc Chem Res 2003 Jun;36(6):401-9

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1021/ar020132sDOI Listing
June 2003

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor.

J Biol Chem 2003 Apr 23;278(14):12406-14. Epub 2003 Jan 23.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1074/jbc.M212491200DOI Listing
April 2003

Catalytic and regulatory domains of doublecortin kinase-1.

Biochemistry 2003 Feb;42(7):2185-94

Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, New York 14214, USA.

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http://dx.doi.org/10.1021/bi026913iDOI Listing
February 2003

From consensus sequence to high-affinity ligands: acquisition of signaling protein modulators.

Pharmacol Ther 2002 Feb-Mar;93(2-3):179-91

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/s0163-7258(02)00187-0DOI Listing
January 2003

Spatially discrete, light-driven protein expression.

Chem Biol 2002 Dec;9(12):1347-53

Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/s1074-5521(02)00288-0DOI Listing
December 2002

Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition.

J Biol Chem 2002 Oct 21;277(43):41014-22. Epub 2002 Aug 21.

Department of Molecular Pharmacology, Laboratory for Macromolecular Analysis and Proteomics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M207347200
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October 2002

Design and synthesis of a fluorescent reporter of protein kinase activity.

J Am Chem Soc 2002 Apr;124(15):3840-1

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1021/ja017530vDOI Listing
April 2002

A strategy for the construction of caged diols using a photolabile protecting group.

J Org Chem 2002 Apr;67(8):2723-6

Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1021/jo0163851DOI Listing
April 2002

Real time visualization of protein kinase activity in living cells.

J Biol Chem 2002 Mar 14;277(13):11527-32. Epub 2002 Jan 14.

Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461-1602, USA.

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http://dx.doi.org/10.1074/jbc.M111300200DOI Listing
March 2002

A new strategy for caging proteins regulated by kinases.

J Am Chem Soc 2002 Mar;124(11):2440-1

Department of Anatomy and Structural Biology, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1021/ja017592lDOI Listing
March 2002