Publications




A matter of time: study of circadian clocks and their role in inflammation.
J Leukoc Biol 2016 Apr 8;99(4):549-60. Epub 2016 Feb 8.
*Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry, and Health, University of Sheffield, United Kingdom; Faculty of Medical and Human Sciences, Institute of Human Development, Manchester, United Kingdom; and Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus.
Sci Rep 2016 Mar 1;6:22341. Epub 2016 Mar 1.
Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.


Contrasting Patterns of Evolutionary Diversification in the Olfactory Repertoires of Reptile and Bird Genomes.
Genome Biol Evol 2016 Feb 9;8(3):470-80. Epub 2016 Feb 9.
Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University Institute for Genomics, Biocomputing and Biochemistry, Mississippi State University

Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells.
Respir Res 2016 Jan 25;17. Epub 2016 Jan 25.
Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester, NHS Foundation Trust Southmoor Road, Manchester, M23 9LT, UK.

Characterization of the molecular genetic pathology in patients with 11β-hydroxylase deficiency.
Clin Endocrinol (Oxf) 2015 Nov 14;83(5):629-35. Epub 2015 Jul 14.
Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.

Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.
Proc Natl Acad Sci U S A 2015 Apr 6;112(17):5479-84. Epub 2015 Apr 6.
Manchester Centre for Nuclear Hormone Research in Disease and Manchester Academic Health Sciences Centre, Institute of Human Development, Faculty of Medical and Human Sciences,

A 454 sequencing approach to dipteran mitochondrial genome research.
Genomics 2015 Jan 11;105(1):53-60. Epub 2014 Nov 11.
The Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Mississippi State, MS 39762, USA; Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Mississippi State, MS 39762, USA. Electronic address:



Comparative genomics reveals insights into avian genome evolution and adaptation.
Science 2014 Dec 11;346(6215):1311-20. Epub 2014 Dec 11.
China National GeneBank, Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, 518083, China. Macau University of Science and Technology, Avenida Wai long, Taipa, Macau 999078, China. Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark. Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Department of Medicine, University of Hong Kong, Hong Kong.

Whole-genome analyses resolve early branches in the tree of life of modern birds.
Science 2014 Dec;346(6215):1320-31
China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China. Centre for Social Evolution, Department of Biology, Universitetsparken 15, University of Copenhagen, DK-2100 Copenhagen, Denmark.


Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK.
J Endocrinol 2014 Nov 26;223(2):155-66. Epub 2014 Aug 26.
Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human DevelopmentFaculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UKInstitute of Cardiovascular SciencesFaculty of Medical and Human Sciences, University of Manchester, CTF Building, Grafton Street, Manchester, M13 9PT, UK

Large numbers of novel miRNAs originate from DNA transposons and are coincident with a large species radiation in bats.
Mol Biol Evol 2014 Jun 1;31(6):1536-45. Epub 2014 Apr 1.
Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State UniversityInstitute for Genomics, Biocomputing and Biotechnology, Mississippi State University

The effect of type 1 IFN on human aortic endothelial cell function in vitro: relevance to systemic lupus erythematosus.
J Interferon Cytokine Res 2014 May 20;34(5):404-12. Epub 2014 Jan 20.
1 Arthritis Research UK Epidemiology Unit, Institute of Inflammation and Repair, Manchester Academic Health Sciences Centre, The University of Manchester , Manchester, United Kingdom .

Corticosteroid effects on COPD alveolar macrophages: dependency on cell culture methodology.
J Immunol Methods 2014 Mar 12;405:144-53. Epub 2014 Feb 12.
The University of Manchester, Manchester Academic Health and Science Centre, University Hospital of South Manchester Foundation Trust, Respiratory and Allergy Centre, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester M23 9LT, UK.

CRAC channel inhibition produces greater anti-inflammatory effects than glucocorticoids in CD8 cells from COPD patients.
Clin Sci (Lond) 2014 Feb;126(3):223-32
*University of Manchester NIHR Translational Research Facility, Manchester Academic Health Science Centre, University Hospital of South Manchester Foundation Trust, Manchester M23 9LT, U.K.



Pin1 promotes GR transactivation by enhancing recruitment to target genes.
Nucleic Acids Res 2013 Oct 25;41(18):8515-25. Epub 2013 Jul 25.
Centre in Endocrinology and Diabetes, Institute of Human Development, University of Manchester, Manchester, M13 9PT, UK, Respiratory Therapy Area, GSK, Stevenage, SG1 2NY, UK, Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK and Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.

Optimized chemical probes for REV-ERBα.
J Med Chem 2013 Jun 23;56(11):4729-37. Epub 2013 May 23.
Molecular Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709-3398, USA.


Evaluation of glucocorticoid receptor function in COPD lung macrophages using beclomethasone-17-monopropionate.
PLoS One 2013 21;8(5):e64257. Epub 2013 May 21.
National Institute for Health Research Translational Research Facility, Manchester Academic Health Science Centre, University Hospital of South Manchester Foundation Trust, University of Manchester, Manchester, United Kingdom.

Immediate and delayed impact of oral glucocorticoid therapy on risk of serious infection in older patients with rheumatoid arthritis: a nested case-control analysis.
Ann Rheum Dis 2012 Jul 12;71(7):1128-33. Epub 2012 Jan 12.
Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, Stopford Building, Manchester M13 9PT, UK.

Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation.
PLoS One 2012 22;7(6):e38928. Epub 2012 Jun 22.
Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom.

The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.
Proc Natl Acad Sci U S A 2012 Jan 19;109(2):582-7. Epub 2011 Dec 19.
Faculty of Life Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PT, United Kingdom.




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