David R Kaplan

David R Kaplan

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David R Kaplan

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Translating neural stem cells to neurons in the mammalian brain.

Cell Death Differ 2019 Dec 24;26(12):2495-2512. Epub 2019 Sep 24.

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1038/s41418-019-0411-9DOI Listing
December 2019

Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration.

Cell Stem Cell 2019 02 29;24(2):240-256.e9. Epub 2018 Nov 29.

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.10.024DOI Listing
February 2019

Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development.

Stem Cell Reports 2018 05 5;10(5):1464-1480. Epub 2018 Apr 5.

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto M5G 1L7, Canada; Institute of Medical Science, University of Toronto, Toronto M5G 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5G 1A8, Canada; Department of Physiology, University of Toronto, Toronto M5G 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995693PMC
May 2018

A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification.

Neuron 2018 02 27;97(3):520-537.e6. Epub 2018 Jan 27.

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.12.045DOI Listing
February 2018

Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling.

Cell Rep 2017 12;21(13):3970-3986

Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; Institute of Medical Science , University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Molecular Genetics , University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1A8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173181
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http://dx.doi.org/10.1016/j.celrep.2017.12.017DOI Listing
December 2017

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.

J Cell Biol 2017 11 6;216(11):3655-3675. Epub 2017 Sep 6.

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada

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http://dx.doi.org/10.1083/jcb.201705085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674898PMC
November 2017

Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain.

Neuron 2017 May;94(3):500-516.e9

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.04.018DOI Listing
May 2017

A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.

Cancer Res 2017 02 29;77(3):696-706. Epub 2016 Nov 29.

Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1502DOI Listing
February 2017

Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma.

Mol Oncol 2016 11 18;10(9):1461-1472. Epub 2016 Aug 18.

Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada; James Birrell Laboratories, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.molonc.2016.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423212PMC
November 2016

Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip.

Cell Stem Cell 2016 10 1;19(4):433-448. Epub 2016 Jul 1.

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.06.002DOI Listing
October 2016

A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring.

Cell Rep 2016 10;17(4):1022-1036

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1A8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5G 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.067DOI Listing
October 2016

Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks.

Neuron 2016 Sep 18;91(5):988-1004. Epub 2016 Aug 18.

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5G 1A8, Canada; McEwen Centre for Regenerative Medicine, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1A8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273163042
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http://dx.doi.org/10.1016/j.neuron.2016.07.037DOI Listing
September 2016

Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system.

Cell Cycle 2015 ;14(20):3270-81

a Program in Neurosciences and Mental Health, Hospital for Sick Children ; Toronto , ON Canada.

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http://dx.doi.org/10.1080/15384101.2015.1087618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825551PMC
August 2016

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma.

Clin Cancer Res 2016 08 22;22(15):3860-75. Epub 2016 Mar 22.

Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada. Clark H. Smith Brain Tumour Centre, University of Calgary, Calgary, Alberta, Canada. Department of Oncology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1798DOI Listing
August 2016

Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.

Stem Cell Reports 2016 Jan 24;6(1):74-84. Epub 2015 Dec 24.

Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada. Electronic address:

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http://www.cell.com/cms/attachment/2042035152/2055345195/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221367111500367
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http://dx.doi.org/10.1016/j.stemcr.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719140PMC
January 2016

Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation.

Stem Cell Reports 2015 Dec 19;5(6):988-995. Epub 2015 Nov 19.

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada; Brain and Mind Research Institute, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682208PMC
December 2015

A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.

J Neurosci 2015 Nov;35(47):15666-81

Programs in Neurosciences and Mental Health and Departments of Molecular Genetics, Physiology, University of Toronto, Toronto, Ontario M5G 1X5, Canada

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http://dx.doi.org/10.1523/JNEUROSCI.2172-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705466PMC
November 2015

The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life.

PLoS One 2014 19;9(8):e104767. Epub 2014 Aug 19.

Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada; Institute for Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104767PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138084PMC
October 2015

Sox2-mediated regulation of adult neural crest precursors and skin repair.

Stem Cell Reports 2013 4;1(1):38-45. Epub 2013 Jun 4.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.stemcr.2013.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757738PMC
May 2015

Ankrd11 is a chromatin regulator involved in autism that is essential for neural development.

Dev Cell 2015 Jan 31;32(1):31-42. Epub 2014 Dec 31.

Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; McEwen Center for Regenerative Medicine, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X5, Canada. Electronic address:

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http://www.cell.com/developmental-cell/pdf/S1534-5807(14)007
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http://linkinghub.elsevier.com/retrieve/pii/S153458071400770
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http://dx.doi.org/10.1016/j.devcel.2014.11.031DOI Listing
January 2015

An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.

Neuron 2014 Nov 6;84(4):723-39. Epub 2014 Nov 6.

Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.10.022DOI Listing
November 2014

Direct genesis of functional rodent and human schwann cells from skin mesenchymal precursors.

Stem Cell Reports 2014 Jul 19;3(1):85-100. Epub 2014 Jun 19.

Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada ; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada ; Institute of Medical Science, University of Toronto, Toronto, ON M5G 0A4, Canada ; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 0A4, Canada ; Department of Physiology, University of Toronto, Toronto, ON M5G 0A4, Canada.

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http://dx.doi.org/10.1016/j.stemcr.2014.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110792PMC
July 2014

Strong performance on the Progressive Evaluation of Competency fellowship final examination predicts American Board of Pathology Certification.

J Am Soc Cytopathol 2014 Sep - Oct;3(5):269-273. Epub 2014 Jun 4.

Department of Pathology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jasc.2014.05.004DOI Listing
June 2014

Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development.

J Neurosci 2014 Apr;34(15):5164-75

Neuroscience and Mental Health Program, Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada, and Institute of Medical Science and Departments of Molecular Genetics and Physiology, University of Toronto, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.0370-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983799PMC
April 2014

CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development.

Dev Biol 2014 Jan 15;385(2):230-41. Epub 2013 Nov 15.

Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada M5G 1L7; Cell Biology, Hospital for Sick Children, Toronto, Canada M5G 1L7. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2013.11.005DOI Listing
January 2014

Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex.

J Neurosci 2014 Jan;34(2):539-53

Departments of Biochemistry and Molecular Biology and Medical Genetics, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Department of Pathology and Laboratory Medicine, Southern Alberta Cancer Research Institute, University of Calgary, Alberta T2N 4N1, Canada, Programs in Cell Biology, and Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto M5G 1L7, Canada, Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York 13210, Institute of Medical Science and Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada, and Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.0614-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608148PMC
January 2014

A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines.

Curr Drug Discov Technol 2013 Dec;10(4):283-304

Cell Biology Program, The Hospital for Sick Children, TMDT East Tower #12-314, 101 College St., Toronto, Ontario, M5G 1L7; Canada.

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http://dx.doi.org/10.2174/15701638113109990001DOI Listing
December 2013

Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway.

Cell Stem Cell 2013 Nov;13(5):564-76

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada; Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada; McEwen Center for Regenerative Medicine, University Health Network, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.stem.2013.10.002DOI Listing
November 2013

p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior.

J Neurosci 2013 Jul;33(31):12569-85

Programs in Cell Biology, Developmental and Stem Cell Biology, and Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.1251-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728680PMC
July 2013

Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes.

FEBS Lett 2013 May 10;587(10):1466-73. Epub 2013 Apr 10.

The Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada; Cell Biology Program, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1016/j.febslet.2013.03.035DOI Listing
May 2013

A novel neurofibromin (NF1) interaction with the leucine-rich pentatricopeptide repeat motif-containing protein links neurofibromatosis type 1 and the French Canadian variant of Leigh's syndrome in a common molecular complex.

J Neurosci Res 2013 Apr 30;91(4):494-505. Epub 2013 Jan 30.

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jnr.23189DOI Listing
April 2013

p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.

Neurobiol Aging 2013 Feb 15;34(2):387-99. Epub 2012 May 15.

Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.04.010DOI Listing
February 2013

FoxP2 regulates neurogenesis during embryonic cortical development.

J Neurosci 2013 Jan;33(1):244-58

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada M5G 1L7.

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http://dx.doi.org/10.1523/JNEUROSCI.1665-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618635PMC
January 2013

An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells.

Cell Stem Cell 2012 Oct 16;11(4):517-28. Epub 2012 Aug 16.

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada M5G 1L7.

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http://linkinghub.elsevier.com/retrieve/pii/S193459091200372
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http://dx.doi.org/10.1016/j.stem.2012.06.010DOI Listing
October 2012

Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.

Cell Stem Cell 2012 Jul;11(1):23-35

Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.

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http://dx.doi.org/10.1016/j.stem.2012.03.016DOI Listing
July 2012

Mobilizing endogenous stem cells for repair and regeneration: are we there yet?

Cell Stem Cell 2012 Jun;10(6):650-652

Cell Biology Program, Hospital for Sick Children, Toronto M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5G 1X5, Canada.

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http://dx.doi.org/10.1016/j.stem.2012.05.004DOI Listing
June 2012

Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins.

J Biol Chem 2011 Nov 29;286(47):40671-80. Epub 2011 Sep 29.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.271189
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http://dx.doi.org/10.1074/jbc.M111.271189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220488PMC
November 2011

Endogenous microglia regulate development of embryonic cortical precursor cells.

J Neurosci Res 2011 Mar 6;89(3):286-98. Epub 2011 Jan 6.

Developmental and Stem Cell Biology Program, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jnr.22533DOI Listing
March 2011

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells.

Cancer Res 2011 Feb 8;71(4):1385-95. Epub 2011 Feb 8.

Cell Biology Program and James Birrell Laboratories, The Hospital for Sick Children, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2484DOI Listing
February 2011

Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition.

Clin Cancer Res 2011 Jan;17(1):111-21

The Arthur and Sonia Labatt Brain Tumor Research Centre, Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2075DOI Listing
January 2011

Coffin-Lowry syndrome: a role for RSK2 in mammalian neurogenesis.

Dev Biol 2010 Nov 8;347(2):348-59. Epub 2010 Sep 8.

Developmental and Stem Cell Biology Program, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1L7.

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http://dx.doi.org/10.1016/j.ydbio.2010.08.035DOI Listing
November 2010

TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors.

Curr Biol 2010 Nov 11;20(22):2058-65. Epub 2010 Nov 11.

Cell Biology, Hospital for Sick Children, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.cub.2010.10.029DOI Listing
November 2010

p75NTR is an obligate signaling receptor required for cues that cause sympathetic neuron growth cone collapse.

Mol Cell Neurosci 2010 Oct 17;45(2):108-20. Epub 2010 Jun 17.

Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.mcn.2010.05.015DOI Listing
October 2010

SATB2 augments ΔNp63α in head and neck squamous cell carcinoma.

EMBO Rep 2010 Oct 10;11(10):777-83. Epub 2010 Sep 10.

Department of Molecular Genetics, University of Toronto, Cell Biology Program, Hospital for Sick Children Research Institute, Department of Paediatrics, 555 University Avenue, Toronto, Ontario, M5G 1L7, Canada.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2010.125
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http://dx.doi.org/10.1038/embor.2010.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948183PMC
October 2010

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.

Nat Neurosci 2010 May 28;13(5):559-66. Epub 2010 Mar 28.

Developmental and Stem Cell Biology, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nn.2513DOI Listing
May 2010

Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair.

Stem Cells Dev 2009 Jul-Aug;18(6):893-906

Department of Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/scd.2008.0260DOI Listing
September 2009

HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells.

Proc Natl Acad Sci U S A 2009 Sep 16;106(39):16805-10. Epub 2009 Sep 16.

Department of Laboratory Medicine, Center for Molecular Pathology, CREATE Health, University Hospital MAS, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1073/pnas.0904606106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745331PMC
September 2009

Costello syndrome H-Ras alleles regulate cortical development.

Dev Biol 2009 Jun 14;330(2):440-51. Epub 2009 Apr 14.

Stem Cell Biology Program, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ydbio.2009.04.010DOI Listing
June 2009

Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells.

Nat Neurosci 2009 Jun 17;12(6):735-44. Epub 2009 May 17.

Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nn.2339DOI Listing
June 2009

In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model.

Neoplasia 2009 May;11(5):426-35

New Agent and Innovative Therapy Program, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671855PMC
http://dx.doi.org/10.1593/neo.09166DOI Listing
May 2009

p63 antagonizes p53 to promote the survival of embryonic neural precursor cells.

J Neurosci 2009 May;29(20):6710-21

Developmental and Stem Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.5878-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665890PMC
May 2009

Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration.

Nat Neurosci 2008 Jun 1;11(6):649-58. Epub 2008 Apr 1.

Developmental and Stem Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Canada M5G 1X8.

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http://dx.doi.org/10.1038/nn.2114DOI Listing
June 2008

Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.

Cell Cycle 2008 Apr 11;7(7):909-16. Epub 2008 Jan 11.

Cancer Research Centre and Department of Medical Biology, Laval University, Québec, Québec, Canada.

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http://dx.doi.org/10.4161/cc.7.7.5610DOI Listing
April 2008

Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development.

Development 2007 Dec 14;134(24):4369-80. Epub 2007 Nov 14.

Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1242/dev.008227DOI Listing
December 2007

Developing with BDNF: a moving experience.

Neuron 2007 Jul;55(1):1-2

Cell Biology Program, Hospital for Sick Children, Toronto, M5G 1L7 ON, Canada.

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http://dx.doi.org/10.1016/j.neuron.2007.06.025DOI Listing
July 2007

Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome.

Neuron 2007 Apr;54(2):245-62

Developmental Biology Program, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

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http://dx.doi.org/10.1016/j.neuron.2007.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900070PMC
April 2007

To die or not to die: neurons and p63.

Cell Cycle 2007 Feb 3;6(3):312-7. Epub 2007 Feb 3.

Developmental Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4161/cc.6.3.3795DOI Listing
February 2007

AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans.

Curr Biol 2007 Feb;17(3):286-92

Cancer Research Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1016/j.cub.2006.12.038DOI Listing
February 2007

APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction.

Mol Cell Biol 2006 Dec 25;26(23):8928-41. Epub 2006 Sep 25.

Cancer Research Program, Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Ontario, Canada.

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http://dx.doi.org/10.1128/MCB.00228-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636815PMC
December 2006

Analysis of the neurogenic potential of multipotent skin-derived precursors.

Exp Neurol 2006 Sep 5;201(1):32-48. Epub 2006 May 5.

Program in Developmental Biology, University of Toronto, Toronto, Canada M5G 1X8; Program in Cancer Research, University of Toronto, Toronto, Canada M5G 1X8.

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http://dx.doi.org/10.1016/j.expneurol.2006.03.018DOI Listing
September 2006

The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons.

Mol Cell Neurosci 2006 Aug 14;32(4):387-402. Epub 2006 Jul 14.

Cancer Research and Developmental Biology Programs, Hospital for Sick Children, Toronto, Ontario, and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B4.

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http://dx.doi.org/10.1016/j.mcn.2006.06.001DOI Listing
August 2006

The p53 family in nervous system development and disease.

J Neurochem 2006 Jun;97(6):1571-84

Cancer Research, Hospital for Sick Children, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1111/j.1471-4159.2006.03980.xDOI Listing
June 2006

When a motor goes bad: a kinesin regulates neuronal survival.

Cell 2006 Apr;125(2):224-6

Cancer Research and Developmental Biology, Hospital for Sick Children Research Institute, Department of Molecular, University of Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1016/j.cell.2006.03.031DOI Listing
April 2006

p63 is an essential proapoptotic protein during neural development.

Neuron 2005 Dec;48(5):743-56

Cancer Research and Hospital for Sick Children, University of Toronto, Toronto ON, Canada M5G 1X8.

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http://dx.doi.org/10.1016/j.neuron.2005.10.027DOI Listing
December 2005

TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism.

J Biol Chem 2005 Aug 16;280(32):29199-207. Epub 2005 Jun 16.

Cancer Research Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1074/jbc.M502364200DOI Listing
August 2005

Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.

Mol Cancer Ther 2005 Jan;4(1):1-11

Cancer Research Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.

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January 2005

SRC regulates actin dynamics and invasion of malignant glial cells in three dimensions.

Mol Cancer Res 2004 Nov;2(11):595-605

Brain Tumor Research Center, Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, 3801 University Room BT-205, Montreal, Quebec, Canada H3A 2B4.

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November 2004

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms.

J Neurosci 2004 Oct;24(41):9174-84

Department of Developmental Biology, Hospital for Sick Children, Toronto, Ontario, M5G 1X8 Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.1588-04.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730077PMC
October 2004

The invulnerability of adult neurons: a critical role for p73.

J Neurosci 2004 Oct;24(43):9638-47

Developmental Biology and Cancer Research, Hospital for Sick Children, Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1523/JNEUROSCI.1299-04.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730156PMC
October 2004

ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3.

J Cell Biol 2004 May 3;165(3):357-69. Epub 2004 May 3.

Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, Im Neuenheimer Feld 307, 2. OG, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1083/jcb.200403028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172179PMC
May 2004

Neuronal MEK is important for normal fear conditioning in mice.

J Neurosci Res 2004 Mar;75(6):760-70

Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA. .

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http://dx.doi.org/10.1002/jnr.20052DOI Listing
March 2004

Neurobiology: a move to sort life from death.

Nature 2004 Feb;427(6977):798-9

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http://dx.doi.org/10.1038/427798aDOI Listing
February 2004

TrkB receptor signaling regulates developmental death dynamics, but not final number, of retinal ganglion cells.

J Neurosci 2003 Nov;23(31):10137-45

Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740848PMC
November 2003

Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse.

J Neurosci 2003 Aug;23(20):7602-9

The Hospital for Sick Children, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5G 1X8.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740747PMC
August 2003

Signaling mechanisms underlying dendrite formation.

Curr Opin Neurobiol 2003 Jun;13(3):391-8

Developmental Biology and Cancer Research Program, 555 University Avenue, Hospital for Sick Children, Toronto, M5G 1X8, Canada.

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http://dx.doi.org/10.1016/s0959-4388(03)00072-2DOI Listing
June 2003

Axon growth inhibition: signals from the p75 neurotrophin receptor.

Nat Neurosci 2003 May;6(5):435-6

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http://dx.doi.org/10.1038/nn0503-435DOI Listing
May 2003

Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1.

J Neurosci 2003 Mar;23(6):2131-40

Research Institute of the McGill University Health Center, Centre for Research in Neuroscience, Montreal, Quebec, Canada H3G 1A4.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741997PMC
March 2003

Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway.

Cancer Res 2002 Nov;62(22):6756-63

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

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November 2002