David R Brigstock

David R Brigstock

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David R Brigstock

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Biological and Proteomic Characteristics of an Immortalized Human Pancreatic Stellate Cell Line.

Int J Med Sci 2020 1;17(1):137-144. Epub 2020 Jan 1.

Department of Hepatic Biliary Pancreatic Medicine, First Hospital of Jilin University, Changchun, 130021, China.

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http://dx.doi.org/10.7150/ijms.36337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945563PMC
January 2020

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018

Lipopolysaccharide enhances TGF-β1 signalling pathway and rat pancreatic fibrosis.

J Cell Mol Med 2018 04 9;22(4):2346-2356. Epub 2018 Feb 9.

Department of Hepatic Biliary Pancreatic Medicine, First Hospital of Jilin University, Changchun, China.

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http://dx.doi.org/10.1111/jcmm.13526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867168PMC
April 2018

CD4Foxp3CD25 Tregs characterize liver tissue specimens of patients suffering from drug-induced autoimmune hepatitis: A clinical-pathological study.

Hepatobiliary Pancreat Dis Int 2018 Apr 19;17(2):133-139. Epub 2018 Feb 19.

Department of Hepatic-Biliary-Pancreatic Medicine, First Hospital of Jilin University, Changchun 130021, China . Electronic address:

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http://dx.doi.org/10.1016/j.hbpd.2018.02.004DOI Listing
April 2018

Therapeutic effects of serum extracellular vesicles in liver fibrosis.

J Extracell Vesicles 2018 17;7(1):1461505. Epub 2018 Apr 17.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.

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http://dx.doi.org/10.1080/20013078.2018.1461505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912192PMC
April 2018

Pathways of production and delivery of hepatocyte exosomes.

J Cell Commun Signal 2018 Mar 23;12(1):343-357. Epub 2017 Oct 23.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.

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http://dx.doi.org/10.1007/s12079-017-0421-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842184PMC
March 2018

Role of Gut-Derived Endotoxin on Type I Collagen Production in the Rat Pancreas After Chronic Alcohol Exposure.

Alcohol Clin Exp Res 2018 Feb 18;42(2):306-314. Epub 2017 Dec 18.

Department of Hepatic, Biliary Pancreatic Medicine, First Hospital of Jilin University, Changchun, China.

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http://dx.doi.org/10.1111/acer.13550DOI Listing
February 2018

Analysis of Pathological Activities of CCN Proteins in Fibrotic Diseases: Liver Fibrosis.

Methods Mol Biol 2017 ;1489:445-463

The Research Institute at Nationwide Children's Hospital, Research Building 2, 700 Children's Drive, Columbus, OH, 43205, USA.

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http://dx.doi.org/10.1007/978-1-4939-6430-7_37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032510PMC
January 2018

Cellular or Exosomal microRNAs Associated with CCN Gene Expression in Liver Fibrosis.

Methods Mol Biol 2017 ;1489:465-480

The Research Institute at Nationwide Children's Hospital, Research Building 2, 700 Children's Drive, Columbus, OH, 43205, USA.

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http://dx.doi.org/10.1007/978-1-4939-6430-7_38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032513PMC
January 2018

IgG4-related sclerosing cholangitis and chronic sclerosing sialadenitis mimicking cholangiocarcinoma and neck malignancy.

Hepatobiliary Pancreat Dis Int 2017 Aug;16(4):443-445

Department of Hepatic-biliary-pancreatic Medicine, First Hospital of Jilin University, Changchun 130021, China. Electronic address:

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http://dx.doi.org/10.1016/S1499-3872(17)60042-0DOI Listing
August 2017

IgG4-related sclerosing cholangitis overlapping with autoimmune hepatitis: Report of a case.

Pathol Res Pract 2017 May 10;213(5):565-569. Epub 2017 Feb 10.

Department of Hepatic-Biliary-Pancreatic Medicine, First Hospital, Jilin University, Changchun 130021, Jilin Province, China. Electronic address:

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http://dx.doi.org/10.1016/j.prp.2017.01.024DOI Listing
May 2017

Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes.

FEBS Lett 2016 Dec 23;590(23):4263-4274. Epub 2016 Oct 23.

The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.

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http://dx.doi.org/10.1002/1873-3468.12448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154766PMC
December 2016

Fibrogenic Signaling Is Suppressed in Hepatic Stellate Cells through Targeting of Connective Tissue Growth Factor (CCN2) by Cellular or Exosomal MicroRNA-199a-5p.

Am J Pathol 2016 11 21;186(11):2921-2933. Epub 2016 Sep 21.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio; Department of Surgery, The Ohio State University, Columbus, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222964PMC
November 2016

An immortalized rat pancreatic stellate cell line RP-2 as a new cell model for evaluating pancreatic fibrosis, inflammation and immunity.

Hepatobiliary Pancreat Dis Int 2015 Dec;14(6):651-9

Department of Hepatic-biliary-pancreatic Medicine, the First Hospital of Jilin University, Changchun 130021, China.

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http://dx.doi.org/10.1016/s1499-3872(15)60415-5DOI Listing
December 2015

Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1.

Am J Physiol Gastrointest Liver Physiol 2015 Sep 30;309(6):G491-9. Epub 2015 Jul 30.

The Research Institute at Nationwide Children's Hospital, Columbus, Ohio; Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio; Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, Ohio

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http://dx.doi.org/10.1152/ajpgi.00140.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572411PMC
September 2015

Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice.

Diabetes 2015 Apr 12;64(4):1284-98. Epub 2014 Nov 12.

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN Department of Medicine, Vanderbilt University, Nashville, TN Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN

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http://dx.doi.org/10.2337/db14-1195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375083PMC
April 2015

Rare case of Helicobacter pylori-positive multiorgan IgG4-related disease and gastric cancer.

World J Gastroenterol 2015 Mar;21(11):3429-34

Min Li, Qiang Zhou, Kun Yang, Lu Zhang, Ming Xiu, Li Sun, Run-Ping Gao, Department of Hepatic-Biliary-Pancreatic Medicine, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

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http://dx.doi.org/10.3748/wjg.v21.i11.3429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363779PMC
March 2015

Focal autoimmune pancreatitis and chronic sclerosing sialadenitis mimicking pancreatic cancer and neck metastasis.

World J Gastroenterol 2014 Dec;20(46):17674-9

Li Sun, Qiang Zhou, Su Yan, Ming Xiu, Rong-Li Piao, Yan-Hang Gao, Run-Ping Gao, Department of Hepatic-Biliary-Pancreatic Medicine, First Hospital, Jilin University, Changchun 130021, Jilin Province, China.

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http://dx.doi.org/10.3748/wjg.v20.i46.17674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265632PMC
December 2014

Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver.

Surgery 2014 Sep 2;156(3):548-55. Epub 2014 Jun 2.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH; Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, OH; Department of Surgery, The Ohio State University, Columbus, OH. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2014.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150742PMC
September 2014

Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes.

J Cell Commun Signal 2014 Jun 26;8(2):147-56. Epub 2014 Jan 26.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.

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http://dx.doi.org/10.1007/s12079-014-0220-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063995PMC
June 2014

IgG4-related autoimmune pancreatitis overlapping with Mikulicz's disease and lymphadenitis: a case report.

World J Gastroenterol 2013 Dec;19(48):9490-4

Li-Mei Qu, Xiao-Yu Wen, Yong-Fang Liu, Ya-Jun Li, Run-Ping Gao, Department of Hepatic-Biliary-Pancreatic Medicine, First Hospital, Jilin University, Changchun 130021, Jilin Province, China.

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http://dx.doi.org/10.3748/wjg.v19.i48.9490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882427PMC
December 2013

Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2).

Cytokine Growth Factor Rev 2013 Feb 10;24(1):59-68. Epub 2012 Aug 10.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1016/j.cytogfr.2012.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508350PMC
February 2013

Connective tissue growth factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth.

World J Gastroenterol 2012 Dec;18(47):7070-8

Department of Hepatic-Biliary-Pancreatic Medicine, First Hospital, Jilin University, Changchun 130021, Jilin Province, China.

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http://dx.doi.org/10.3748/wjg.v18.i47.7070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531696PMC
December 2012

Regulation of hepatic stellate cells by connective tissue growth factor.

Front Biosci (Landmark Ed) 2012 Jun 1;17:2495-507. Epub 2012 Jun 1.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205, USA.

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http://dx.doi.org/10.2741/4067DOI Listing
June 2012

Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice.

Lab Invest 2012 May 13;92(5):703-12. Epub 2012 Feb 13.

The Research Institute at Nationwide Children's Hospital, Center for Clinical and Translational Research, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1038/labinvest.2012.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338873PMC
May 2012

Clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis.

World J Gastroenterol 2012 May;18(18):2280-6

Department of Hepatic-biliary-pancreatic Medicine, First Hospital, Jilin University, Changchun 130021, Jilin Province, China.

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http://dx.doi.org/10.3748/wjg.v18.i18.2280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351780PMC
May 2012

Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor.

J Hepatol 2011 Aug 13;55(2):399-406. Epub 2010 Dec 13.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, United States.

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http://dx.doi.org/10.1016/j.jhep.2010.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136646PMC
August 2011

Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2).

J Cell Mol Med 2011 May 19;15(5):1087-95. Epub 2010 Apr 19.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2010.01072.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912974PMC
May 2011

Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis.

Lab Invest 2010 Aug 5;90(8):1179-88. Epub 2010 Apr 5.

Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1038/labinvest.2010.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901405PMC
August 2010

Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes.

Hepatology 2009 Sep;50(3):939-47

Center for Cell and Developmental Biology, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1002/hep.23102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737071PMC
September 2009

Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function.

World J Gastroenterol 2009 Aug;15(30):3807-13

Research Institute of Liver Diseases, First Hospital, Jilin University, Changchun 130021, Jilin Province, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726461PMC
http://dx.doi.org/10.3748/wjg.15.3807DOI Listing
August 2009

Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells.

Growth Factors 2009 Apr;27(2):91-9

The Research Institute at Nationwide Children's Hospital, Center for Cell and Developmental Biology, Columbus, OH, USA.

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http://dx.doi.org/10.1080/08977190902786319DOI Listing
April 2009

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.

Mol Endocrinol 2009 Mar 8;23(3):324-36. Epub 2009 Jan 8.

Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, 2213 Garland Avenue, 7425C MRBIV, Nashville, Tennessee 37232-0475, USA.

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http://dx.doi.org/10.1210/me.2008-0045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654514PMC
March 2009

Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo.

J Cell Commun Signal 2009 Mar 18;3(1):5-18. Epub 2009 Mar 18.

The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA,

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http://dx.doi.org/10.1007/s12079-009-0043-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686750PMC
March 2009

Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells.

J Cell Commun Signal 2008 Jun 17;2(1-2):49-56. Epub 2008 Sep 17.

CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Dental Sciences Building, London, Ontario, N6A 5C1, Canada,

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http://dx.doi.org/10.1007/s12079-008-0029-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570012PMC
June 2008

High expression of connective tissue growth factor in pre-B acute lymphoblastic leukaemia.

Br J Haematol 2007 Sep;138(6):740-8

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, West Perth, WA, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06739.xDOI Listing
September 2007

Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis.

Am J Respir Crit Care Med 2007 Jul 12;176(1):78-89. Epub 2007 Apr 12.

Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, the Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1164/rccm.200609-1279OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2049062PMC
July 2007

Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor.

J Endocrinol 2006 Mar;188(3):R1-8

Center for Cell and Vascular Biology, Children's Research Institute, 700 Children's Drive, Columbus, Ohio 43205, USA.

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http://dx.doi.org/10.1677/joe.1.06719DOI Listing
March 2006

Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells.

Cell Commun Signal 2005 Nov 22;3:14. Epub 2005 Nov 22.

Center for Cell and Vascular Biology, Children's Research Institute, Columbus, Ohio 43205, USA.

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http://dx.doi.org/10.1186/1478-811X-3-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308830PMC
November 2005

Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor.

Gastroenterology 2005 Sep;129(3):1019-30

Center for Cell and Vascular Biology, Children's Research Institute, Columbus, Ohio 43205, USA.

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http://dx.doi.org/10.1053/j.gastro.2005.06.067DOI Listing
September 2005

Structural and functional properties of CCN proteins.

Vitam Horm 2005 ;70:69-103

Center for Cell and Vascular Biology, Children's Research Institute, Columbus, Ohio 43205, USA.

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http://dx.doi.org/10.1016/S0083-6729(05)70003-0DOI Listing
June 2005

Transforming growth factor-beta pathway is activated in cholecystolithiasis.

Langenbecks Arch Surg 2005 Feb 20;390(1):21-8. Epub 2004 Nov 20.

Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00423-004-0517-4DOI Listing
February 2005

Connective tissue growth factor siRNA modulates mRNA levels for a subset of molecules in normal and TGF-beta 1-stimulated porcine skin fibroblasts.

Wound Repair Regen 2004 Mar-Apr;12(2):205-16

McCaig Center for Joint Injury and Arthritis Research, Department of Microbiology and Infectious Disease, Faculty of Medicine, University of Calgary,Calgary, Alberta, Canada.

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http://dx.doi.org/10.1111/j.1067-1927.2004.012113.xDOI Listing
September 2004

Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan.

J Biol Chem 2004 Mar 17;279(10):8848-55. Epub 2003 Dec 17.

Departments of Surgery, The Ohio State University, Columbus, Ohio 43212, USA.

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http://dx.doi.org/10.1074/jbc.M313204200DOI Listing
March 2004

Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression.

Wound Repair Regen 2003 May-Jun;11(3):220-9

McCaig Center for Joint Injury and Arthritis Researcha, Department of Microbiology and Infectious Disease, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1046/j.1524-475x.2003.11311.xDOI Listing
December 2003

Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension.

Hypertension 2003 Dec 27;42(6):1164-70. Epub 2003 Oct 27.

Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202-2689, USA.

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http://dx.doi.org/10.1161/01.HYP.0000100423.24330.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824434PMC
December 2003

Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells.

Hepatol Res 2003 Nov;27(3):214-220

Department of Surgery, The Ohio State University, 700 Children's Drive, 43212, Columbus, OH, USA

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http://dx.doi.org/10.1016/s1386-6346(03)00241-9DOI Listing
November 2003

Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61).

Angiogenesis 2002 ;5(3):153-65

Department of Surgery, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1023/a:1023823803510DOI Listing
August 2003

Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis.

Hepatol Res 2003 May;26(1):1-9

Department of Surgery, The Ohio State University, 43212, Columbus, OH, USA

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http://dx.doi.org/10.1016/s1386-6346(03)00115-3DOI Listing
May 2003