David R Bauman

David R Bauman

UNVERIFIED PROFILE

Are you David R Bauman?   Register this Author

Register author
David R Bauman

David R Bauman

Publications by authors named "David R Bauman"

Are you David R Bauman?   Register this Author

14Publications

91Reads

20Profile Views

Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension.

Bioorg Med Chem Lett 2013 Jun 22;23(12):3650-3. Epub 2013 Mar 22.

Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2013.03.011DOI Listing
June 2013

CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions.

J Biol Chem 2009 Oct 16;284(42):28485-9. Epub 2009 Aug 16.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.R109.042168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781391PMC
October 2009

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production.

Proc Natl Acad Sci U S A 2009 Sep 15;106(39):16764-9. Epub 2009 Sep 15.

Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0909142106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757821PMC
September 2009

Pre-receptor regulation of the androgen receptor.

Mol Cell Endocrinol 2008 Jan 22;281(1-2):1-8. Epub 2007 Oct 22.

Center of Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104-6084, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2007.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225387PMC
January 2008

Identification of the molecular switch that regulates access of 5alpha-DHT to the androgen receptor.

Mol Cell Endocrinol 2007 Feb 16;265-266:77-82. Epub 2007 Jan 16.

Center of Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2006.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857325PMC
February 2007

Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer.

Endocrinology 2006 Dec 7;147(12):5806-16. Epub 2006 Sep 7.

Department of Pharmacology, Center of Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, 130C John Morgan Building, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104-6084, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2006-0627DOI Listing
December 2006

Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells.

Proc Natl Acad Sci U S A 2006 Sep 28;103(36):13304-9. Epub 2006 Aug 28.

Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0604672103
Publisher Site
http://dx.doi.org/10.1073/pnas.0604672103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569159PMC
September 2006

Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors.

Mol Cell Endocrinol 2006 Mar 18;248(1-2):182-91. Epub 2006 Jan 18.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104-6084, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2005.12.009DOI Listing
March 2006

Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease.

Mol Endocrinol 2006 Feb 22;20(2):444-58. Epub 2005 Sep 22.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2005-0287DOI Listing
February 2006

Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes.

Mol Pharmacol 2005 Jan 8;67(1):60-8. Epub 2004 Oct 8.

Department of Pharmacology, University of Pennsylvania School of Medicine, 130C John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

View Article

Download full-text PDF

Source
http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.104.00
Publisher Site
http://dx.doi.org/10.1124/mol.104.006569DOI Listing
January 2005

The roles of aldo-keto reductases in steroid hormone action.

Drug News Perspect 2004 Nov;17(9):563-78

Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, 135 John Morgan Building, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1358/dnp.2004.17.9.872570DOI Listing
November 2004

Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.

Endocrinology 2003 Jul;144(7):2922-32

Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
Publisher Site
http://dx.doi.org/10.1210/en.2002-0032DOI Listing
July 2003

The aldo-keto reductase superfamily homepage.

Chem Biol Interact 2003 Feb;143-144:621-31

Protein Function Discovery Facility, Queen's University, Ont., K7L 3N6, Kingston, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0009-2797(02)00193-xDOI Listing
February 2003