David Piwnica-Worms

David Piwnica-Worms

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David Piwnica-Worms

David Piwnica-Worms

Publications by authors named "David Piwnica-Worms"

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Novel derivatives of anaplastic lymphoma kinase inhibitors: Synthesis, radiolabeling, and preliminary biological studies of fluoroethyl analogues of crizotinib, alectinib, and ceritinib.

Eur J Med Chem 2019 Nov 9;182:111571. Epub 2019 Aug 9.

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234193070
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http://dx.doi.org/10.1016/j.ejmech.2019.111571DOI Listing
November 2019

Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study.

J Mater Chem B 2019 04 12;7(16):2678-2687. Epub 2019 Mar 12.

Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, 1881 East Road, 77054 Houston, TX, USA.

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http://dx.doi.org/10.1039/C8TB03299HDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501563PMC
April 2019

Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies.

Molecules 2019 Feb 12;24(3). Epub 2019 Feb 12.

Radiopharmaceutical Chemistry Unit, Oncologic and High Technologies Department, Azienda USL-IRCCS, via Amendola 2, 42122 Reggio Emilia, Italy.

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http://dx.doi.org/10.3390/molecules24030644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384893PMC
February 2019

Caspase-3 Substrates for Noninvasive Pharmacodynamic Imaging of Apoptosis by PET/CT.

Bioconjug Chem 2018 09 31;29(9):3180-3195. Epub 2018 Aug 31.

School of Biomedical Informatics , The University of Texas Health Science Center at Houston , Houston , Texas 77030 , United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.8b00514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467260PMC
September 2018

Nucleoside Diphosphate Kinase-3 () Enhances TLR5-Induced NFB Activation.

Mol Cancer Res 2018 06 9;16(6):986-999. Epub 2018 Mar 9.

Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0603DOI Listing
June 2018

Spatial and Temporal Confined Photothermolysis of Cancer Cells Mediated by Hollow Gold Nanospheres Targeted to Epidermal Growth Factor Receptors.

ACS Omega 2018 May;3(5):5888-5895

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1881 East Road, Houston, Texas 77054, United States.

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http://dx.doi.org/10.1021/acsomega.8b00712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981767PMC
May 2018

p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells.

J Biol Chem 2017 09 1;292(37):15266-15276. Epub 2017 Aug 1.

From the Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110 and

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http://dx.doi.org/10.1074/jbc.M117.787846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602387PMC
September 2017

Synthesis of a [(18)F]-labeled ceritinib analogue for positron emission tomography of anaplastic lymphoma kinase, a receptor tyrosine kinase, in lung cancer.

J Labelled Comp Radiopharm 2016 Mar 8;59(3):103-8. Epub 2016 Feb 8.

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1002/jlcr.3373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863448PMC
March 2016

From the Guest Editor: Illuminating Cancer In Vivo With Molecular Imaging.

Cancer J 2015 May-Jun;21(3):150-1

From the Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1097/PPO.0000000000000121DOI Listing
February 2016

Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival.

Proc Natl Acad Sci U S A 2015 Dec 7;112(51):E7148-54. Epub 2015 Dec 7.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1509249112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697381PMC
December 2015

A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion.

PLoS One 2014 29;9(10):e109361. Epub 2014 Oct 29.

BRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Departments of Cell Biology and Physiology and Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109361PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212944PMC
June 2015

From the Guest Editor: Illuminating Cancer In Vivo With Molecular Imaging.

Cancer J 2015 May-Jun;21(3):150-1

From the Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1097/PPO.0000000000000121DOI Listing
February 2016

PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.

PLoS One 2014 9;9(9):e107397. Epub 2014 Sep 9.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159344PMC
May 2015

DAPK3 suppresses acini morphogenesis and is required for mouse development.

Mol Cancer Res 2015 Feb 10;13(2):358-67. Epub 2014 Oct 10.

Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri. Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336824PMC
February 2015

A rapid bioluminescence assay for measuring myeloperoxidase activity in human plasma.

Nat Commun 2015 Feb 10;6:6271. Epub 2015 Feb 10.

1] Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA [2] Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1479, FCT16.6030, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncomms7271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347050PMC
February 2015

Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe.

PLoS One 2014 21;9(2):e88855. Epub 2014 Feb 21.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088855PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931650PMC
January 2015

Type I interferons link viral infection to enhanced epithelial turnover and repair.

Cell Host Microbe 2015 Jan 4;17(1):85-97. Epub 2014 Dec 4.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2014.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297260PMC
January 2015

Type I interferons link viral infection to enhanced epithelial turnover and repair.

Cell Host Microbe 2015 Jan 4;17(1):85-97. Epub 2014 Dec 4.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2014.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297260PMC
January 2015

A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer.

PLoS One 2014 13;9(2):e88667. Epub 2014 Feb 13.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America ; BRIGHT Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America ; Department of Cancer Systems Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088667PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923810PMC
October 2014

Intracellular calcium regulates nonsense-mediated mRNA decay.

Nat Med 2014 Aug 27;20(8):961-6. Epub 2014 Jul 27.

Department of Cell Biology &Physiology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/nm.3620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126864PMC
August 2014

A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.

Cancer Discov 2014 Jul 16;4(7):828-39. Epub 2014 Apr 16.

Authors' Affiliations:BRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas

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http://dx.doi.org/10.1158/2159-8290.CD-13-0572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197823PMC
July 2014

p38MAPK plays a crucial role in stromal-mediated tumorigenesis.

Cancer Discov 2014 Jun 26;4(6):716-29. Epub 2014 Mar 26.

Authors' Affiliations: Departments of Cell Biology and Physiology, Medicine, and Pathology and Immunology; BRIGHT Institute, Washington University School of Medicine; Departments of Biochemistry & Molecular Biology and Molecular Microbiology & Immunology, Saint Louis University School of Medicine; Confluence Life Sciences, Inc., St. Louis, Missouri; Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TexasAuthors' Affiliations: Departments of Cell Biology and Physiology, Medicine, and Pathology and Immunology; BRIGHT Institute, Washington University School of Medicine; Departments of Biochemistry & Molecular Biology and Molecular Microbiology & Immunology, Saint Louis University School of Medicine; Confluence Life Sciences, Inc., St. Louis, Missouri; Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TexasAuthors' Affiliations: Departments of Cell Biology and Physiology, Medicine, and Pathology and Immunology; BRIGHT Institute, Washington University School of Medicine; Departments of Biochemistry & Molecular Biology and Molecular Microbiology & Immunology, Saint Louis University School of Medicine; Confluence Life Sciences, Inc., St. Louis, Missouri; Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas sheila.stewart@wust

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http://dx.doi.org/10.1158/2159-8290.CD-13-0743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049323PMC
June 2014

Contribution of p53 to metastasis.

Cancer Discov 2014 Apr 21;4(4):405-14. Epub 2014 Mar 21.

Departments of 1Cancer Biology and 2Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063123PMC
April 2014

Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4.

Cancer Cell 2014 Apr;25(4):530-42

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097146PMC
April 2014

Illuminating cancer systems with genetically engineered mouse models and coupled luciferase reporters in vivo.

Cancer Discov 2013 Jun 12;3(6):616-29. Epub 2013 Apr 12.

Washington University School of Medicine, Campus Box 8225, 510 S. Kingshighway Boulevard, Box 8225, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679270PMC
June 2013

Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation.

Cancer Discov 2013 Feb 26;3(2):212-23. Epub 2012 Dec 26.

Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570610PMC
February 2013

Interrogation of inhibitor of nuclear factor κB α/nuclear factor κB (IκBα/NF-κB) negative feedback loop dynamics: from single cells to live animals in vivo.

J Biol Chem 2012 Sep 17;287(37):31359-70. Epub 2012 Jul 17.

Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Cell Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M112.364018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438965PMC
September 2012

Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization.

J Biol Chem 2012 Sep 20;287(37):31116-25. Epub 2012 Jul 20.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M112.373647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438943PMC
September 2012

Caspase-activated cell-penetrating peptides reveal temporal coupling between endosomal release and apoptosis in an RGC-5 cell model.

Bioconjug Chem 2012 Sep 30;23(9):1783-93. Epub 2012 Aug 30.

Molecular Imaging Center, Mallinckrodt Institute of Radiology, BRIGHT Institute, Department of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1021/bc300036zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447108PMC
September 2012

CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma.

PLoS One 2012 12;7(3):e33005. Epub 2012 Mar 12.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299723PMC
August 2012

Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest.

J Neurooncol 2012 May 1;108(1):59-67. Epub 2012 Mar 1.

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1007/s11060-012-0827-2DOI Listing
May 2012

Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression.

Cancer Res 2012 May 15;72(9):2251-61. Epub 2012 Mar 15.

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605047PMC
May 2012

On in vivo imaging in cancer.

Cold Spring Harb Perspect Biol 2012 Mar 1;4(3). Epub 2012 Mar 1.

BRIGHT Institute, Department of Cell Biology & Physiology, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1101/cshperspect.a013409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282407PMC
March 2012

SNM and AACR announce joint conference.

J Nucl Med 2012 Mar;53(3):18NA

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March 2012

An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors.

Hum Mol Genet 2012 Feb 3;21(3):664-80. Epub 2011 Nov 3.

Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1093/hmg/ddr500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259017PMC
February 2012

Imaging: strategies, controversies, and opportunities.

Clin Cancer Res 2012 Feb;18(3):631-7

Department of Neurology, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2020DOI Listing
February 2012

Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging.

Proc Natl Acad Sci U S A 2012 Jan 21;109(1):137-42. Epub 2011 Dec 21.

Department of Biochemistry, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.1111316109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252912PMC
January 2012

Bioluminescence imaging captures the expression and dynamics of endogenous p21 promoter activity in living mice and intact cells.

Mol Cell Biol 2011 Sep 26;31(18):3759-72. Epub 2011 Jul 26.

Department of Cell Biology and Physiology, Washington University, St. Louis, Missouri 63130, USA.

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http://dx.doi.org/10.1128/MCB.05243-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165732PMC
September 2011

Nano in cancer: linking chemistry, biology, and clinical applications in vivo.

Cancer Res 2011 Sep 23;71(17):5611-5. Epub 2011 Aug 23.

BRIGHT Institute, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0817DOI Listing
September 2011

CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.

Cancer Res 2011 Jul 20;71(14):4799-808. Epub 2011 May 20.

Department of Orthopedics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138866PMC
July 2011

In vivo cell death mediated by synthetic ion channels.

Chem Commun (Camb) 2011 Jul 17;47(28):7977-9. Epub 2011 Jun 17.

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.

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http://dx.doi.org/10.1039/c1cc12933cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608405PMC
July 2011

Real-time imaging of notch activation with a luciferase complementation-based reporter.

Sci Signal 2011 Jul 12;4(181):rs7. Epub 2011 Jul 12.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2001656
Publisher Site
http://dx.doi.org/10.1126/scisignal.2001656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387985PMC
July 2011

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.

J Clin Invest 2011 Feb 25;121(2):800-8. Epub 2011 Jan 25.

Department of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1172/JCI43114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026721PMC
February 2011

Probing multidrug resistance P-glycoprotein transporter activity with SPECT radiopharmaceuticals.

Curr Top Med Chem 2010 ;10(17):1834-45

Molecular Imaging Center, Washington University Medical School, St. Louis, MO, USA.

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http://dx.doi.org/10.2174/156802610792928086DOI Listing
January 2011

Monitoring molecular-specific pharmacodynamics of rapamycin in vivo with inducible Gal4->Fluc transgenic reporter mice.

Mol Cancer Ther 2010 Oct 21;9(10):2752-60. Epub 2010 Sep 21.

Molecular Imaging Center, Mallinckrodt Institute of Radiology, BRIGHT Institute, and Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-10
Publisher Site
http://dx.doi.org/10.1158/1535-7163.MCT-10-0265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953587PMC
October 2010

Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems.

PLoS One 2010 Oct 11;5(10):e13300. Epub 2010 Oct 11.

BRIGHT Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013300PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952622PMC
October 2010

Dual-color click beetle luciferase heteroprotein fragment complementation assays.

Chem Biol 2010 Sep;17(9):1018-29

Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Developmental Biology, Washington University, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.chembiol.2010.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943495PMC
September 2010

Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.

J Biol Chem 2010 Jul 27;285(31):24014-22. Epub 2010 May 27.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1074/jbc.M110.103317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911325PMC
July 2010

Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1.

Cancer Res 2010 Jul 15;70(14):5717-27. Epub 2010 Jun 15.

Department of Pediatrics, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Developmental Biology, and Anatomy and Neurobiology, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905483PMC
July 2010

CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice.

J Neuroimmunol 2010 Jul;224(1-2):108-13

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2010.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910179PMC
July 2010

Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice.

Cancer Res 2010 Jun 25;70(12):4859-67. Epub 2010 May 25.

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690845PMC
June 2010

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy.

Proc Natl Acad Sci U S A 2010 Mar 1;107(11):5136-41. Epub 2010 Mar 1.

Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.0911220107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841938PMC
March 2010

Measuring brain tumor growth: combined bioluminescence imaging-magnetic resonance imaging strategy.

Mol Imaging 2009 Sep-Oct;8(5):245-53

Department of Neurosurgery, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831362PMC
January 2010

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.

J Cell Biol 2009 Dec;187(6):875-88

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1083/jcb.200908115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806317PMC
December 2009

Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer.

Clin Cancer Res 2009 Dec;15(24):7529-7537

Authors' Affiliation: Molecular Imaging Center, Mallinckrodt Institute of Radiology, and Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797340PMC
December 2009

T-cell activation promotes tumorigenesis in inflammation-associated cancer.

Retrovirology 2009 Dec 17;6:116. Epub 2009 Dec 17.

Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1186/1742-4690-6-116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806367PMC
December 2009

Molecular imaging of pulmonary disease in vivo.

Proc Am Thorac Soc 2009 Aug;6(5):403-10

Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Developmental Biology, Washington University Medical School, 510 S. Kingshighway Blvd., Box 8225 St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1513/pats.200901-004AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266013PMC
August 2009