David Pisano

David Pisano

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David Pisano

David Pisano

Publications by authors named "David Pisano"

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CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation.

Epigenetics Chromatin 2018 06 8;11(1):30. Epub 2018 Jun 8.

CNIO-Lilly Epigenetics Laboratory, Spanish National Cancer Research Center (CNIO), Melchor Fernandez Almagro 3, 28029, Madrid, Spain.

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http://dx.doi.org/10.1186/s13072-018-0197-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992658PMC
June 2018

Prediction of miRNA-mRNA Interactions Using miRGate.

Methods Mol Biol 2017 ;1580:225-237

Bioinformatics Unit (UBio), Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1007/978-1-4939-6866-4_15DOI Listing
February 2018

Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer.

Gut 2017 08 6;66(8):1449-1462. Epub 2016 Apr 6.

Department of Cancer Biology, Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, IdiPAZ, Madrid, Spain.

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http://dx.doi.org/10.1136/gutjnl-2015-310977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530491PMC
August 2017

A Braf kinase-inactive mutant induces lung adenocarcinoma.

Nature 2017 08 2;548(7666):239-243. Epub 2017 Aug 2.

Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/nature23297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648056PMC
August 2017

Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells.

Mol Cancer Ther 2017 07 10;16(7):1366-1376. Epub 2017 Apr 10.

Genes and Cancer Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0104DOI Listing
July 2017

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance.

Aging Cell 2016 Dec 1;15(6):1113-1125. Epub 2016 Sep 1.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, Madrid, E-28029, Spain.

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http://dx.doi.org/10.1111/acel.12517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114719PMC
December 2016

NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.

Sci Rep 2016 09 8;6:32952. Epub 2016 Sep 8.

CNIO-Lilly Epigenetics Laboratory, Spanish National Cancer Research Center (CNIO), C/ Melchor Fernández Almagro, 3. 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/srep32952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015087PMC
September 2016

Somatic Embryonic FGFR2 Mutations in Keratinocytic Epidermal Nevi.

J Invest Dermatol 2016 08 19;136(8):1718-1721. Epub 2016 Apr 19.

Department of Dermatology, Parc de Salut Mar, Hospital del Mar, Barcelona, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.03.040DOI Listing
August 2016

miRGate: a curated database of human, mouse and rat miRNA-mRNA targets.

Database (Oxford) 2015 8;2015:bav035. Epub 2015 Apr 8.

Bioinformatics Unit (UBio), Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain and High Technical School of Computer Engineering, University of Vigo, Ourense, Spain.

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http://dx.doi.org/10.1093/database/bav035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390609PMC
December 2015

Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation.

Genom Data 2015 Dec 3;6:21-4. Epub 2015 Aug 3.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), C/ Melchor Fernández Almagro, 3, E-28029, Madrid, Spain.

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http://dx.doi.org/10.1016/j.gdata.2015.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664675PMC
December 2015

Genome-wide analysis of in vivo TRF1 binding to chromatin restricts its location exclusively to telomeric repeats.

Cell Cycle 2014 ;13(23):3742-9

a Telomeres and Telomerase Group; Molecular Oncology Program; Spanish National Cancer Research Center (CNIO) ; Madrid , Spain.

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http://dx.doi.org/10.4161/15384101.2014.965044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613987PMC
September 2015

iMSRC: converting a standard automated microscope into an intelligent screening platform.

Sci Rep 2015 May 27;5:10502. Epub 2015 May 27.

Confocal Microscopy Unit, Biotechnology programme, CNIO, Madrid, Spain.

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http://dx.doi.org/10.1038/srep10502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444834PMC
May 2015

The contribution of cohesin-SA1 to gene expression and chromatin architecture in two murine tissues.

Nucleic Acids Res 2015 Mar 3;43(6):3056-67. Epub 2015 Mar 3.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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http://dx.doi.org/10.1093/nar/gkv144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381060PMC
March 2015

miRNA expression profiling of formalin-fixed paraffin-embedded (FFPE) hereditary breast tumors.

Genom Data 2015 Mar 22;3:75-9. Epub 2014 Nov 22.

Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain ; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.

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http://dx.doi.org/10.1016/j.gdata.2014.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535901PMC
March 2015

Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.

Cancer Cell 2014 Dec 20;26(6):826-839. Epub 2014 Nov 20.

Growth Factors, Nutrients and Cancer Group, BBVA Foundation-Cancer Cell Biology Programme, Spanish National Cancer Research Centre, CNIO, 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.10.002DOI Listing
December 2014

Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes.

Nat Commun 2014 Sep 3;5:4723. Epub 2014 Sep 3.

Telomeres and Telomerase Group, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro, 3, 28029 Madrid, Spain.

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http://www.nature.com/articles/ncomms5723
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http://dx.doi.org/10.1038/ncomms5723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164772PMC
September 2014

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.

Nat Commun 2013 ;4:2697

1] Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, Oxford OX3 7DQ, UK [2] [3].

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http://dx.doi.org/10.1038/ncomms3697DOI Listing
July 2014

Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation.

Cell Rep 2014 Jul 17;8(2):487-500. Epub 2014 Jul 17.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905521PMC
July 2014

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.

Sci Rep 2011 12;1:189. Epub 2011 Dec 12.

Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), E-28029 Madrid, Spain.

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http://dx.doi.org/10.1038/srep00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240995PMC
September 2013

RUbioSeq: a suite of parallelized pipelines to automate exome variation and bisulfite-seq analyses.

Bioinformatics 2013 Jul 28;29(13):1687-9. Epub 2013 Apr 28.

Structural Computational Biology Group, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre, 28029 Madrid, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btt203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694642PMC
July 2013

INK4a/ARF limits the expansion of cells suffering from replication stress.

Cell Cycle 2013 Jun 15;12(12):1948-54. Epub 2013 May 15.

Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.4161/cc.25017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712892PMC
June 2013

The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer.

EMBO Mol Med 2012 Jul 11;4(7):603-16. Epub 2012 Apr 11.

Genes and Cancer Group, Cancer Epigenetics and Biology Program-PEBC, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/emmm.201200236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407948PMC
July 2012

UNG shapes the specificity of AID-induced somatic hypermutation.

J Exp Med 2012 Jul 4;209(7):1379-89. Epub 2012 Jun 4.

B Cell Biology Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.

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http://jem.rupress.org/content/209/7/1379.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20112253
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http://dx.doi.org/10.1084/jem.20112253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405504PMC
July 2012

The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development.

Cell Cycle 2012 Jun 15;11(12):2233-8. Epub 2012 Jun 15.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Madrid, Spain.

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http://www.tandfonline.com/doi/abs/10.4161/cc.20318
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http://dx.doi.org/10.4161/cc.20318DOI Listing
June 2012

Distinct DNA methylomes of newborns and centenarians.

Proc Natl Acad Sci U S A 2012 Jun 11;109(26):10522-7. Epub 2012 Jun 11.

Cancer Epigenetics and Biology Program, Spanish Biomedical Research Centre Network for Epidemiology and Public Health, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L’Hospitalet, Barcelona, Catalonia 08908, Spain.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1120658109
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http://dx.doi.org/10.1073/pnas.1120658109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387108PMC
June 2012

A unique role of cohesin-SA1 in gene regulation and development.

EMBO J 2012 May 13;31(9):2090-102. Epub 2012 Mar 13.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1038/emboj.2012.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343463PMC
May 2012

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.

EMBO J 2012 May 13;31(11):2498-510. Epub 2012 Apr 13.

Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1038/emboj.2012.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365431PMC
May 2012

Genome-wide analysis of Pax8 binding provides new insights into thyroid functions.

BMC Genomics 2012 Apr 24;13:147. Epub 2012 Apr 24.

Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas-CSIC y Universidad Autónoma de Madrid-UAM, C/Arturo Duperier 4, Madrid 28029, Spain.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2164-13-147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403905PMC
April 2012

Expression and functional validation of new p38α transcriptional targets in tumorigenesis.

Biochem J 2011 Mar;434(3):549-58

CNIO (Spanish National Cancer Centre), Melchor Fernandez Almagro 3, 28029 Madrid, Spain.

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http://biochemj.org/lookup/doi/10.1042/BJ20101410
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http://dx.doi.org/10.1042/BJ20101410DOI Listing
March 2011

Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1/SMARCA4 in lung primary tumors.

Hum Mutat 2011 Feb 7;32(2):E1999-2017. Epub 2010 Dec 7.

Genes and Cancer Group, Cancer Epigenetics and Biology Program-PEBC (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://doi.wiley.com/10.1002/humu.21415
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http://dx.doi.org/10.1002/humu.21415DOI Listing
February 2011

PileLine: a toolbox to handle genome position information in next-generation sequencing studies.

BMC Bioinformatics 2011 Jan 24;12:31. Epub 2011 Jan 24.

Higher Technical School of Computer Engineering, University of Vigo, Ourense, Spain.

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http://dx.doi.org/10.1186/1471-2105-12-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037855PMC
January 2011

PathJam: a new service for integrating biological pathway information.

J Integr Bioinform 2010 Oct 28;7(1). Epub 2010 Oct 28.

Escuela Superior de Ingeniería Informática University of Vigo, Edificio Politécnico, Campus Universitario As Lagoas s/n, 32004 Ourense, Spain.

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http://dx.doi.org/10.2390/biecoll-jib-2010-147DOI Listing
October 2010

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.

Nat Cell Biol 2010 Aug 11;12(8):768-80. Epub 2010 Jul 11.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid, E-28029, Spain.

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http://dx.doi.org/10.1038/ncb2081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792482PMC
August 2010

waviCGH: a web application for the analysis and visualization of genomic copy number alterations.

Nucleic Acids Res 2010 Jul 27;38(Web Server issue):W182-7. Epub 2010 May 27.

Bioinformatics Unit, Spanish National Cancer Research Centre.

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http://dx.doi.org/10.1093/nar/gkq441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896163PMC
July 2010

miR-181b negatively regulates activation-induced cytidine deaminase in B cells.

J Exp Med 2008 Sep 1;205(10):2199-206. Epub 2008 Sep 1.

DNA Hypermutation and Cancer Group, Spanish National Cancer Research Center, Madrid 28029, Spain.

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http://dx.doi.org/10.1084/jem.20080579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556787PMC
September 2008

Mechanistic principles of chromatin remodeling guided by siRNAs and miRNAs.

Cell Cycle 2008 Aug 3;7(16):2601-8. Epub 2008 Aug 3.

Spanish National Cancer Research Center, CNIO, Madrid, Spain.

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http://dx.doi.org/10.4161/cc.7.16.6541DOI Listing
August 2008

CARGO: a web portal to integrate customized biological information.

Nucleic Acids Res 2007 Jul 5;35(Web Server issue):W16-20. Epub 2007 May 5.

SCOMPBio Group, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1093/nar/gkm280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933121PMC
July 2007