David Pellman

David Pellman

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David Pellman

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Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.

RNA 2019 03 11;25(3):352-363. Epub 2018 Dec 11.

HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA

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http://dx.doi.org/10.1261/rna.069773.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380277PMC
March 2019

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements.

Mol Cell 2019 03;73(5):915-929.e6

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410736PMC
March 2019

Nuclear envelope assembly defects link mitotic errors to chromothripsis.

Nature 2018 09 19;561(7724):551-555. Epub 2018 Sep 19.

Howard Hughes Medical Institute, Chevy Chase, MD, USA.

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http://dx.doi.org/10.1038/s41586-018-0534-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599625PMC
September 2018

How the Genome Folds, Divides, Lives, and Dies.

Cold Spring Harb Symp Quant Biol 2017 25;82:349-360. Epub 2018 May 25.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/sqb.2017.82.035527DOI Listing
May 2018

From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes.

Cold Spring Harb Symp Quant Biol 2015 11;80:117-37. Epub 2016 Mar 11.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142 Howard Hughes Medical Institute, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1101/sqb.2015.80.027623DOI Listing
January 2018

Cell Biology: When Your Own Chromosomes Act like Foreign DNA.

Curr Biol 2017 11;27(22):R1228-R1231

Howard Hughes Medical Institute, Chevy Chase, MD, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2017.09.043DOI Listing
November 2017

Cancer biology: Genome jail-break triggers lockdown.

Nature 2017 10 4;550(7676):340-341. Epub 2017 Oct 4.

Howard Hughes Medical Institute and in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA, and the Department of Cell Biology, Harvard Medical School, Boston.

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http://dx.doi.org/10.1038/nature24146DOI Listing
October 2017

A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity.

Dev Cell 2017 07;42(1):37-51.e8

Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573156PMC
July 2017

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution.

Annu Rev Genet 2015 6;49:183-211. Epub 2015 Oct 6.

Department of Pediatric Oncology.

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http://dx.doi.org/10.1146/annurev-genet-120213-092228DOI Listing
September 2016

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Sci Data 2014 30;1:140035. Epub 2014 Sep 30.

Broad Institute of Harvard and MIT, 7 Cambridge Center , Cambridge, Massachusetts 02142, USA ; Department of Medical, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA ; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA ; Departments of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/sdata201435
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http://dx.doi.org/10.1038/sdata.2014.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432652PMC
February 2016

Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds.

Dev Cell 2015 Aug 30;34(3):323-37. Epub 2015 Jul 30.

Department of Pediatric Oncology, Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672950PMC
August 2015

Chromothripsis from DNA damage in micronuclei.

Nature 2015 Jun 27;522(7555):179-84. Epub 2015 May 27.

1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA [3] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA [4] Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.

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http://dx.doi.org/10.1038/nature14493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742237PMC
June 2015

Polyploidy can drive rapid adaptation in yeast.

Nature 2015 Mar 2;519(7543):349-52. Epub 2015 Mar 2.

1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA [2] Department of Cell Biology, Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02215, USA [3] Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815, USA [4] Department of Pediatric Hematology/Oncology, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature14187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497379PMC
March 2015

Aurea mediocritas: the importance of a balanced genome.

Cold Spring Harb Perspect Biol 2014 Sep 18;6(11):a015842. Epub 2014 Sep 18.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1101/cshperspect.a015842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413234PMC
September 2014

Cytokinesis failure triggers hippo tumor suppressor pathway activation.

Cell 2014 Aug;158(4):833-848

Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136486PMC
August 2014

Oncogene-like induction of cellular invasion from centrosome amplification.

Nature 2014 Jun 13;510(7503):167-71. Epub 2014 Apr 13.

1] Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana-Farber Cancer Institute and Pediatric Hematology/Oncology, Children's Hospital, Boston, Massachusetts 02115, USA [2] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061398PMC
June 2014

Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks.

Mol Cell 2014 May 3;54(3):512-25. Epub 2014 Apr 3.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030556PMC
May 2014

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements.

Genes Dev 2013 Dec;27(23):2513-30

Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA;

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http://dx.doi.org/10.1101/gad.229559.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861665PMC
December 2013

Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control.

Nat Cell Biol 2013 Aug 14;15(8):948-57. Epub 2013 Jul 14.

Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncb2801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767134PMC
August 2013

Inhibition of Cdc42 during mitotic exit is required for cytokinesis.

J Cell Biol 2013 Jul;202(2):231-40

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.201301090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718968PMC
July 2013

Linking abnormal mitosis to the acquisition of DNA damage.

J Cell Biol 2012 Dec;199(6):871-81

Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.201210040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518222PMC
December 2012

Move in for the kill: motile microtubule regulators.

Trends Cell Biol 2012 Nov 6;22(11):567-75. Epub 2012 Sep 6.

Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096289241200142
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http://dx.doi.org/10.1016/j.tcb.2012.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482944PMC
November 2012

Regulation of the formin Bnr1 by septins anda MARK/Par1-family septin-associated kinase.

Mol Biol Cell 2012 Oct 23;23(20):4041-53. Epub 2012 Aug 23.

Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1091/mbc.E12-05-0395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469519PMC
October 2012

Proteasomal degradation resolves competition between cell polarization and cellular wound healing.

Cell 2012 Jul 21;150(1):151-64. Epub 2012 Jun 21.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2012.05.030DOI Listing
July 2012

"Two" much of a good thing: telomere damage-induced genome doubling drives tumorigenesis.

Cancer Cell 2012 Jun;21(6):712-4

Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.05.033DOI Listing
June 2012

DNA breaks and chromosome pulverization from errors in mitosis.

Nature 2012 Jan 18;482(7383):53-8. Epub 2012 Jan 18.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature10802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271137PMC
January 2012

Causes and consequences of aneuploidy in cancer.

Nat Rev Genet 2012 Jan 24;13(3):189-203. Epub 2012 Jan 24.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrg3123DOI Listing
January 2012

Centrosomes and cilia in human disease.

Trends Genet 2011 Aug 15;27(8):307-15. Epub 2011 Jun 15.

Instituto Gulbenkian de Ciência, Oeiras, Portugal.

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http://linkinghub.elsevier.com/retrieve/pii/S016895251100065
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http://dx.doi.org/10.1016/j.tig.2011.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144269PMC
August 2011

Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast.

Mol Biol Cell 2011 May 9;22(9):1473-85. Epub 2011 Mar 9.

Department of Pediatric Oncology, Children's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1091/mbc.E10-08-0673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084670PMC
May 2011

Cancer genomes evolve by pulverizing single chromosomes.

Cell 2011 Jan;144(1):9-10

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2010.12.025DOI Listing
January 2011

HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells.

J Cell Biol 2010 Dec 20;191(7):1251-60. Epub 2010 Dec 20.

Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique/Université Pierre et Marie Curie, 75005 Paris, France.

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http://www.jcb.org/lookup/doi/10.1083/jcb.201005065
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http://dx.doi.org/10.1083/jcb.201005065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010075PMC
December 2010

Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells.

J Clin Invest 2010 Nov;120(11):3834-42

Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://www.jci.org/articles/view/43391
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http://dx.doi.org/10.1172/JCI43391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964984PMC
November 2010

A mechanism linking extra centrosomes to chromosomal instability.

Nature 2009 Jul 7;460(7252):278-82. Epub 2009 Jun 7.

Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature08136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743290PMC
July 2009

Centrosomes and cancer: how cancer cells divide with too many centrosomes.

Cancer Metastasis Rev 2009 Jun;28(1-2):85-98

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10555-008-9163-6DOI Listing
June 2009

Mechanisms for concentrating Rho1 during cytokinesis.

Genes Dev 2009 Apr;23(7):810-23

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.1785209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666341PMC
April 2009

A little CIN may cost a lot: revisiting aneuploidy and cancer.

Curr Opin Genet Dev 2009 Feb 3;19(1):74-81. Epub 2009 Feb 3.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0959437X0800190
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http://dx.doi.org/10.1016/j.gde.2008.12.004DOI Listing
February 2009

Symmetry breaking: scaffold plays matchmaker for polarity signaling proteins.

Curr Biol 2008 Dec;18(24):R1130-2

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cub.2008.11.005DOI Listing
December 2008

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

Genes Dev 2008 Aug 28;22(16):2189-203. Epub 2008 Jul 28.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1700908
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http://dx.doi.org/10.1101/gad.1700908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518815PMC
August 2008

G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae.

Mol Biol Cell 2008 Apr 6;19(4):1763-71. Epub 2008 Feb 6.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan.

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http://dx.doi.org/10.1091/mbc.e07-09-0950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291405PMC
April 2008

Plugging the GAP between cell polarity and cell cycle.

EMBO Rep 2008 Jan;9(1):39-41

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/sj.embor.7401142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246625PMC
January 2008

Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.

Mol Cell Biol 2007 Dec 24;27(23):8259-70. Epub 2007 Sep 24.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA..

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http://dx.doi.org/10.1128/MCB.00707-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169184PMC
December 2007

Limiting the proliferation of polyploid cells.

Cell 2007 Nov;131(3):437-40

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2007.10.024DOI Listing
November 2007

APC and colon cancer: two hits for one.

Nat Med 2007 Nov;13(11):1286-7

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http://dx.doi.org/10.1038/nm1107-1286DOI Listing
November 2007

Cell biology. Aneuploidy in the balance.

Science 2007 Aug;317(5840):904-5

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1126/science.1146857DOI Listing
August 2007

Yeast formins Bni1 and Bnr1 utilize different modes of cortical interaction during the assembly of actin cables.

Mol Biol Cell 2007 May 7;18(5):1826-38. Epub 2007 Mar 7.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1091/mbc.e06-09-0820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855024PMC
May 2007

Tetraploidy, aneuploidy and cancer.

Curr Opin Genet Dev 2007 Apr 26;17(2):157-62. Epub 2007 Feb 26.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X070003
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http://dx.doi.org/10.1016/j.gde.2007.02.011DOI Listing
April 2007

Cell biology: aneuploidy and cancer.

Authors:
David Pellman

Nature 2007 Mar;446(7131):38-9

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http://dx.doi.org/10.1038/446038aDOI Listing
March 2007

Genome-wide genetic analysis of polyploidy in yeast.

Nature 2006 Oct;443(7111):541-7

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature05178DOI Listing
October 2006

Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle.

Nat Cell Biol 2006 Sep 13;8(9):913-23. Epub 2006 Aug 13.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/ncb1457DOI Listing
September 2006

Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis.

Science 2006 Jul 8;313(5783):108-11. Epub 2006 Jun 8.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1126747DOI Listing
July 2006

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells.

Nature 2005 Oct;437(7061):1043-7

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature04217DOI Listing
October 2005

MEN signaling: daughter bound pole must escape her mother to be fully active.

Dev Cell 2005 Aug;9(2):168-70

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.devcel.2005.07.006DOI Listing
August 2005

Mitotic spindle: laser microsurgery in yeast cells.

Curr Biol 2004 Sep;14(18):R748-50

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cub.2004.09.010DOI Listing
September 2004

Defects arising from whole-genome duplications in Saccharomyces cerevisiae.

Genetics 2004 Jul;167(3):1109-21

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1534/genetics.104.029256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470947PMC
July 2004

Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation.

Dev Cell 2004 Jun;6(6):815-29

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153458070400162
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http://dx.doi.org/10.1016/j.devcel.2004.05.001DOI Listing
June 2004

The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit.

Mol Biol Cell 2004 Apr 12;15(4):1519-32. Epub 2004 Jan 12.

Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1091/mbc.e03-09-0708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC379252PMC
April 2004

Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture.

Cell 2004 Mar;116(5):711-23

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0092-8674(04)00210-7DOI Listing
March 2004

A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin.

Mol Biol Cell 2004 Feb 2;15(2):896-907. Epub 2003 Dec 2.

Department of Biology and The Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA.

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http://dx.doi.org/10.1091/mbc.e03-08-0621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC329402PMC
February 2004

From polyploidy to aneuploidy, genome instability and cancer.

Nat Rev Mol Cell Biol 2004 Jan;5(1):45-54

Department of Pediatric Oncology of The Dana-Farber Cancer Institute, Children's Hospital and Harvard Medical School, Room M621A, 44 Binney Street Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrm1276DOI Listing
January 2004

Surfing on microtubule ends.

Trends Cell Biol 2003 May;13(5):229-37

Departments of Pediatric Oncology, Dana-Farber Cancer Institute and Pediatric Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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May 2003

Processing, localization, and requirement of human separase for normal anaphase progression.

Proc Natl Acad Sci U S A 2003 Apr 2;100(8):4574-9. Epub 2003 Apr 2.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0730733100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153597PMC
April 2003

Determinants of S. cerevisiae dynein localization and activation: implications for the mechanism of spindle positioning.

Curr Biol 2003 Mar;13(5):364-72

Department of Pediatric Oncology, The Dana Farber Cancer Institute, The Children's Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0960-9822(03)00013-7DOI Listing
March 2003

The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.

J Cell Biol 2003 Feb;160(4):517-28

Department of Pediatric Oncology, The Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.200210021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173742PMC
February 2003

Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes.

Nat Cell Biol 2002 Dec;4(12):921-8

Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/ncb880DOI Listing
December 2002

An actin nucleation mechanism mediated by Bni1 and profilin.

Nat Cell Biol 2002 Aug;4(8):626-31

Department of Pediatric Oncology, The Dana-Farber Cancer Institute Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/ncb834DOI Listing
August 2002

Analysis of the size and shape of protein complexes from yeast.

Methods Enzymol 2002 ;351:150-68

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/s0076-6879(02)51845-0DOI Listing
July 2002

Yeast formins regulate cell polarity by controlling the assembly of actin cables.

Nat Cell Biol 2002 Jan;4(1):42-50

Department of Pediatric Hematology/Oncology, The Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncb719DOI Listing
January 2002