Publications



Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.
Cancer Cell 2017 Aug;32(2):238-252.e9
Department of Neurosurgery, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, 149 13(th) Street, Charlestown, MA 02129, USA. Electronic address:

Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models.
Mol Cancer Ther 2016 Sep 20;15(9):2166-74. Epub 2016 Jun 20.
Department of Pediatrics, Pediatric Hematology and Oncology, Cancer Center, Amsterdam, the Netherlands. Neuro-oncology Research Group Cancer Center, Amsterdam, the Netherlands.

Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model.
Mol Ther Oncolytics 2016 22;3:16017. Epub 2016 Jun 22.
Experimental Therapeutics and Molecular Imaging Laboratory, Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA; Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA.

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.
Cancer Cell 2015 Nov 29;28(5):666-676. Epub 2015 Oct 29.
Department of Neurosurgery, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA; thromboDx B.V., 1098 EA Amsterdam, the Netherlands. Electronic address:

Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria.
Neuro Oncol 2015 Jan 5;17(1):160-6. Epub 2014 Jun 5.
Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi

Convection enhanced delivery of carmustine to the murine brainstem: a feasibility study.
J Neurosci Methods 2014 Dec 27;238:88-94. Epub 2014 Sep 27.
Department of Pediatric Oncology, VU University Medical Center, Amsterdam, The Netherlands; Neuro-oncology Research Group, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis.
Sci Rep 2014 Jun 11;4:5260. Epub 2014 Jun 11.
1] Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands [2] Neuro-oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands [3] Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.




EZH2-regulated DAB2IP is a medulloblastoma tumor suppressor and a positive marker for survival.
Clin Cancer Res 2012 Aug 13;18(15):4048-58. Epub 2012 Jun 13.
Neuro-oncology Research Group, Department of Neurosurgery, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma.
FASEB J 2012 Jun 13;26(6):2639-47. Epub 2012 Mar 13.
Neuro-oncology Research Group, Department of Neurosurgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.
Oncotarget 2011 Dec;2(12):984-96
Department of Pediatric Oncology / Hematology, Neuro-oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.



miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis.
Oncotarget 2010 Dec;1(8):710-20
Neuro-oncology Research Group, Departments of Neurosurgery and Pediatric Oncology/Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.


Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma.
Oncotarget 2017 09 31;8(36):60447-60452. Epub 2017 Jul 31.
VU University Medical Center, Department of Paediatrics, Division of Oncology/Haematology, Amsterdam, The Netherlands.

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