David P Nicolau

David P Nicolau

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Reply to Cheng and Chuang.

Clin Infect Dis 2019 Aug;69(5):903-904

Center for Anti-infective Research and Development, Hartford Hospital, Connecticut.

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http://dx.doi.org/10.1093/cid/ciz081DOI Listing
August 2019

In vitro activity of ampicillin and ceftriaxone against ampicillin-susceptible Enterococcus faecium.

J Antimicrob Chemother 2019 Aug;74(8):2269-2273

Western New England University College of Pharmacy and Health Sciences, Springfield, MA, USA.

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http://dx.doi.org/10.1093/jac/dkz173DOI Listing
August 2019

Carbapenem-Nonsusceptible Isolates from Intensive Care Units in the United States: a Potential Role for New β-Lactam Combination Agents.

J Clin Microbiol 2019 Aug 26;57(8). Epub 2019 Jul 26.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://jcm.asm.org/lookup/doi/10.1128/JCM.00535-19
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http://dx.doi.org/10.1128/JCM.00535-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663898PMC
August 2019

Pharmacokinetics-pharmacodynamics of β-lactamase inhibitors: are we missing the target?

Expert Rev Anti Infect Ther 2019 Aug 30;17(8):571-582. Epub 2019 Jul 30.

a Center for Anti-infective Research and Development, Hartford Hospital , Hartford , CT , USA.

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http://dx.doi.org/10.1080/14787210.2019.1647781DOI Listing
August 2019

Pharmacodynamics of a Novel Ceftibuten-Clavulanate Combination Antibiotic against Enterobacteriaceae.

Antimicrob Agents Chemother 2019 Jul 24;63(7). Epub 2019 Jun 24.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/AAC.00144-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591603PMC
July 2019

Pharmacodynamic Profile of Ceftibuten-Clavulanate Combination against Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in the Murine Thigh Infection Model.

Antimicrob Agents Chemother 2019 Jul 24;63(7). Epub 2019 Jun 24.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/AAC.00145-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591625PMC
July 2019

Efficacy of WCK 5222 (Cefepime-Zidebactam) against Multidrug-Resistant in the Neutropenic Murine Thigh Infection Model.

Antimicrob Agents Chemother 2019 Jul 24;63(7). Epub 2019 Jun 24.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/AAC.00233-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591597PMC
July 2019

Activity of Imipenem-Relebactam Alone or in Combination with Amikacin or Colistin against .

Antimicrob Agents Chemother 2019 Jul 1. Epub 2019 Jul 1.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT

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http://dx.doi.org/10.1128/AAC.00997-19DOI Listing
July 2019

Pharmacodynamics of daptomycin in combination with other antibiotics for the treatment of enterococcal bacteraemia.

Int J Antimicrob Agents 2019 Jul 5. Epub 2019 Jul 5.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA; Division of Infectious Diseases, Hartford Hospital, Hartford, Connecticut, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2019.07.002DOI Listing
July 2019

Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients.

Crit Care 2019 07 10;23(1):251. Epub 2019 Jul 10.

Cellex Laboratory, CibeRes ((Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, 06/06/0028), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), School of Medicine, University of Barcelona, C/ Casanova 143, 08036, Cellex laboratory, Barcelona, Spain.

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http://dx.doi.org/10.1186/s13054-019-2523-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617612PMC
July 2019

Recovery of Gram-Negative Bacteria from Aerobic Blood Culture Bottles Containing Antibiotic Binding Resins after Exposure to β-Lactam and Fluoroquinolone Concentrations.

J Clin Microbiol 2019 Jul 24. Epub 2019 Jul 24.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA

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http://dx.doi.org/10.1128/JCM.00849-19DOI Listing
July 2019

Application of the Hartford Hospital Nomogram for Plazomicin Dosing Interval Selection in Patients with Complicated Urinary Tract Infection.

Antimicrob Agents Chemother 2019 Jul 29. Epub 2019 Jul 29.

Center for Anti-infective Research and Development, Hartford Hospital, Hartford, CT

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http://dx.doi.org/10.1128/AAC.00148-19DOI Listing
July 2019

Prevalence of in vitro synergistic antibiotic interaction between fosfomycin and nonsusceptible antimicrobials in carbapenem-resistant Pseudomonas aeruginosa.

J Med Microbiol 2019 Jun 3;68(6):893-897. Epub 2019 May 3.

2 Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.1099/jmm.0.000984DOI Listing
June 2019

Ceftolozane/Tazobactam in the Treatment of Experimental Pneumonia in Persistently Neutropenic Rabbits: Impact on Strains with Genetically Defined Mechanisms of Resistance.

Antimicrob Agents Chemother 2019 Jun 24. Epub 2019 Jun 24.

Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1128/AAC.00344-19DOI Listing
June 2019

Where should antibiotic gradient diffusion strips be crossed to assess synergy? A comparison of the standard method with a novel method using steady-state antimicrobial concentrations.

Int J Antimicrob Agents 2019 May 14;53(5):698-702. Epub 2019 Mar 14.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2019.03.006DOI Listing
May 2019

Pharmacokinetics of Cefazolin and Vancomycin in Infants Undergoing Open-Heart Surgery With Cardiopulmonary Bypass.

Anesth Analg 2019 May;128(5):935-943

Department of Anesthesiology, Perioperative and Pain Medicine, Division of Pediatric Cardiac Anesthesia, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1213/ANE.0000000000003876DOI Listing
May 2019

In vitro investigation of synergy among fosfomycin and parenteral antimicrobials against carbapenemase-producing Enterobacteriaceae.

Diagn Microbiol Infect Dis 2019 May 25. Epub 2019 May 25.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.diagmicrobio.2019.05.014DOI Listing
May 2019

potency of antipseudomonal β-lactams against blood and respiratory isolates of collected from US hospitals.

J Thorac Dis 2019 May;11(5):1896-1902

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.21037/jtd.2019.05.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588753PMC
May 2019

Comparative efficacy of human-simulated epithelial lining fluid exposures of tedizolid, linezolid and vancomycin in neutropenic and immunocompetent murine models of staphylococcal pneumonia.

J Antimicrob Chemother 2019 Apr;74(4):970-977

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.1093/jac/dky513DOI Listing
April 2019

Use of continuous infusion ceftolozane-tazobactam with therapeutic drug monitoring in a patient with cystic fibrosis.

Am J Health Syst Pharm 2019 Apr;76(8):501-504

Department of Clinical Pharmacy and Outcomes Sciences, University of South Carolina College of Pharmacy, Columbia, SC.

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http://dx.doi.org/10.1093/ajhp/zxz011DOI Listing
April 2019

Is One Sample Enough? β-Lactam Target Attainment and Penetration into Epithelial Lining Fluid Based on Multiple Bronchoalveolar Lavage Sampling Time Points in a Swine Pneumonia Model.

Antimicrob Agents Chemother 2019 Feb 29;63(2). Epub 2019 Jan 29.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/AAC.01922-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355580PMC
February 2019

Pharmacokinetic and Pharmacodynamic Analysis of Ceftazidime/Avibactam in Critically Ill Patients.

Surg Infect (Larchmt) 2019 Jan 23;20(1):55-61. Epub 2018 Oct 23.

1 Department of Medicine, Michigan State University , East Lansing, Michigan.

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https://www.liebertpub.com/doi/10.1089/sur.2018.141
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http://dx.doi.org/10.1089/sur.2018.141DOI Listing
January 2019

Development of an HPLC-MS/MS method for the determination of ceftolozane/tazobactam in bronchoalveolar lavage fluid.

Future Sci OA 2019 Jan 15;5(1):FSO352. Epub 2018 Nov 15.

Center for Anti-Infective Research & Development Hartford Hospital, Hartford, CT, 06102 USA.

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https://www.future-science.com/doi/10.4155/fsoa-2018-0079
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http://dx.doi.org/10.4155/fsoa-2018-0079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331755PMC
January 2019

Optimizing Antibiotic Administration for Pneumonia.

Clin Chest Med 2018 12;39(4):837-852

Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA; Division of Infectious Diseases, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccm.2018.08.006DOI Listing
December 2018

Assessing the in vitro activity of ceftazidime/avibactam and aztreonam among carbapenemase-producing Enterobacteriaceae: Defining the zone of hope.

Int J Antimicrob Agents 2018 Nov 22;52(5):688-691. Epub 2018 Jul 22.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09248579183020
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http://dx.doi.org/10.1016/j.ijantimicag.2018.07.011DOI Listing
November 2018

Assessment of the Efficacy of WCK 5222 (Cefepime-Zidebactam) against Carbapenem-Resistant Acinetobacter baumannii in the Neutropenic Murine Lung Infection Model.

Antimicrob Agents Chemother 2018 11 24;62(11). Epub 2018 Oct 24.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.00948-18
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http://dx.doi.org/10.1128/AAC.00948-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201064PMC
November 2018

Management of Pediatric Acute Hematogenous Osteomyelitis, Part II: A Focus on Methicillin-Resistant Staphylococcus aureus, Current and Emerging Therapies.

Pharmacotherapy 2018 10 4;38(10):1021-1037. Epub 2018 Sep 4.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut.

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http://dx.doi.org/10.1002/phar.2164DOI Listing
October 2018

Pharmacodynamics of Daptomycin against Enterococcus faecium and Enterococcus faecalis in the Murine Thigh Infection Model.

Antimicrob Agents Chemother 2018 10 24;62(10). Epub 2018 Sep 24.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/AAC.00506-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153845PMC
October 2018

The defining a model for antimicrobial stewardship-results from an international cross-sectional survey.

Authors:
Massimo Sartelli Francesco M Labricciosa Pamela Barbadoro Leonardo Pagani Luca Ansaloni Adrian J Brink Jean Carlet Ashish Khanna Alain Chichom-Mefire Federico Coccolini Salomone Di Saverio Addison K May Pierluigi Viale Richard R Watkins Luigia Scudeller Lilian M Abbo Fikri M Abu-Zidan Abdulrashid K Adesunkanmi Sara Al-Dahir Majdi N Al-Hasan Halil Alis Carlos Alves André R Araujo da Silva Goran Augustin Miklosh Bala Philip S Barie Marcelo A Beltrán Aneel Bhangu Belefquih Bouchra Stephen M Brecher Miguel A Caínzos Adrian Camacho-Ortiz Marco Catani Sujith J Chandy Asri Che Jusoh Jill R Cherry-Bukowiec Osvaldo Chiara Elif Colak Oliver A Cornely Yunfeng Cui Zaza Demetrashvili Belinda De Simone Jan J De Waele Sameer Dhingra Francesco Di Marzo Agron Dogjani Gereltuya Dorj Laurent Dortet Therese M Duane Mutasim M Elmangory Mushira A Enani Paula Ferrada J Esteban Foianini Mahir Gachabayov Chinmay Gandhi Wagih Mommtaz Ghnnam Helen Giamarellou Georgios Gkiokas Harumi Gomi Tatjana Goranovic Ewen A Griffiths Rosio I Guerra Gronerth Julio C Haidamus Monteiro Timothy C Hardcastle Andreas Hecker Adrien M Hodonou Orestis Ioannidis Arda Isik Katia A Iskandar Hossein S Kafil Souha S Kanj Lewis J Kaplan Garima Kapoor Aleksandar R Karamarkovic Jakub Kenig Ivan Kerschaever Faryal Khamis Vladimir Khokha Ronald Kiguba Hong B Kim Wen-Chien Ko Kaoru Koike Iryna Kozlovska Anand Kumar Leonel Lagunes Rifat Latifi Jae G Lee Young R Lee Ari Leppäniemi Yousheng Li Stephen Y Liang Warren Lowman Gustavo M Machain Marc Maegele Piotr Major Sydney Malama Ramiro Manzano-Nunez Athanasios Marinis Isidro Martinez Casas Sanjay Marwah Emilio Maseda Michael E McFarlane Ziad Memish Dominik Mertz Cristian Mesina Shyam K Mishra Ernest E Moore Akutu Munyika Eleftherios Mylonakis Lena Napolitano Ionut Negoi Milica D Nestorovic David P Nicolau Abdelkarim H Omari Carlos A Ordonez José-Artur Paiva Narayan D Pant Jose G Parreira Michal Pędziwiatr Bruno M Pereira Alfredo Ponce-de-Leon Garyphallia Poulakou Jacobus Preller Céline Pulcini Guntars Pupelis Martha Quiodettis Timothy M Rawson Tarcisio Reis Miran Rems Sandro Rizoli Jason Roberts Nuno Rocha Pereira Jesús Rodríguez-Baño Boris Sakakushev James Sanders Natalia Santos Norio Sato Robert G Sawyer Sandro Scarpelini Loredana Scoccia Nusrat Shafiq Vishalkumar Shelat Costi D Sifri Boonying Siribumrungwong Kjetil Søreide Rodolfo Soto Hamilton P de Souza Peep Talving Ngo Tat Trung Jeffrey M Tessier Mario Tumbarello Jan Ulrych Selman Uranues Harry Van Goor Andras Vereczkei Florian Wagenlehner Yonghong Xiao Kuo-Ching Yuan Agnes Wechsler-Fördös Jean-Ralph Zahar Tanya L Zakrison Brian Zuckerbraun Wietse P Zuidema Fausto Catena

World J Emerg Surg 2017 1;12:34. Epub 2017 Aug 1.

Department of General Surgery, Maggiore Hospital, Parma, Italy.

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http://dx.doi.org/10.1186/s13017-017-0145-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540347PMC
September 2018

Humanized Exposures of Cefiderocol, a Siderophore Cephalosporin, Display Sustained in vivo Activity against Siderophore-Resistant Pseudomonas aeruginosa.

Pharmacology 2018 22;101(5-6):278-284. Epub 2018 Feb 22.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.

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http://dx.doi.org/10.1159/000487441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972512PMC
September 2018

Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Novel Therapy for Multidrug Resistant Gram Negative Infections in Children.

Curr Pediatr Rev 2018 ;14(2):97-109

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT 06102, United States.

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http://www.eurekaselect.com/160327/article
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http://dx.doi.org/10.2174/1573396314666180308150908DOI Listing
September 2018

In Vitro Activity of Newer and Conventional Antimicrobial Agents, Including Fosfomycin and Colistin, against Selected Gram-Negative Bacilli in Kuwait.

Pathogens 2018 Sep 17;7(3). Epub 2018 Sep 17.

Center of Anti-Infective Research, Hartford Hospital, Hartford, CT 06102, USA.

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http://dx.doi.org/10.3390/pathogens7030075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161270PMC
September 2018

Review of antimicrobial use and considerations in the elderly population.

Clin Interv Aging 2018 17;13:657-667. Epub 2018 Apr 17.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.2147/CIA.S133640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909780PMC
August 2018

Feasibility of routine synergy testing using antibiotic gradient diffusion strips in the clinical laboratory.

J Antimicrob Chemother 2018 Aug;73(8):2264-2265

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.1093/jac/dky165DOI Listing
August 2018

Meropenem time above the MIC exposure is predictive of response in cystic fibrosis children with acute pulmonary exacerbations.

Diagn Microbiol Infect Dis 2018 Jul 24;91(3):294-297. Epub 2018 Feb 24.

Center for Anti-Infective Research & Development, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.01.020DOI Listing
July 2018

Physical compatibility of plazomicin with select i.v. drugs during simulated Y-site administration.

Am J Health Syst Pharm 2018 Jul 12;75(14):1048-1056. Epub 2018 Jun 12.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT.

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http://dx.doi.org/10.2146/ajhp170839DOI Listing
July 2018

infection in the elderly: an update on management.

Clin Interv Aging 2017 24;12:1799-1809. Epub 2017 Oct 24.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

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https://www.dovepress.com/clostridium-difficile-infection-in
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http://dx.doi.org/10.2147/CIA.S149089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661493PMC
May 2018

Assessment of in vivo efficacy of eravacycline against Enterobacteriaceae exhibiting various resistance mechanisms: a dose-ranging study and pharmacokinetic/pharmacodynamic analysis.

Int J Antimicrob Agents 2018 May 8;51(5):727-732. Epub 2018 Jan 8.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2018.01.001DOI Listing
May 2018

Defining the potency of amikacin against , and derived from Chinese hospitals using CLSI and inhalation-based breakpoints.

Infect Drug Resist 2018 25;11:783-790. Epub 2018 May 25.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.2147/IDR.S161636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975598PMC
May 2018

Antibacterial activity of human simulated epithelial lining fluid concentrations of amikacin inhale alone and in combination with meropenem against Acinetobacter baumannii.

Infect Dis (Lond) 2017 Nov - Dec;49(11-12):831-839. Epub 2017 Jul 31.

a Center for Anti-Infective Research and Development , Hartford Hospital , Hartford , CT , USA.

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http://dx.doi.org/10.1080/23744235.2017.1356933DOI Listing
April 2018

Antibacterial activity of ceftolozane/tazobactam alone and in combination with other antimicrobial agents against MDR Pseudomonas aeruginosa.

J Antimicrob Chemother 2018 04;73(4):942-952

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.1093/jac/dkx483DOI Listing
April 2018

Subcutaneous cefazolin to reduce surgical site infections in a porcine model.

J Surg Res 2018 04 28;224:156-159. Epub 2017 Dec 28.

Division of Pediatric Surgery, Department of Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California; Division of Pediatric Surgery, Department of Surgery, Stanford University, Stanford, California. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2017.11.056DOI Listing
April 2018

Investigational drugs for the treatment of infections caused by multidrug-resistant Gram-negative bacteria.

Expert Opin Investig Drugs 2018 04 10;27(4):325-338. Epub 2018 Apr 10.

a Center for Anti-Infective Research and Development , Hartford Hospital , Hartford , CT , USA.

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https://www.tandfonline.com/doi/full/10.1080/13543784.2018.1
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http://dx.doi.org/10.1080/13543784.2018.1460354DOI Listing
April 2018

Novel pharmacotherapy for the treatment of hospital-acquired and ventilator-associated pneumonia caused by resistant gram-negative bacteria.

Expert Opin Pharmacother 2018 03 19;19(4):397-408. Epub 2018 Feb 19.

a Center for Anti-Infective Research and Development , Hartford Hospital , Hartford , CT , USA.

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http://dx.doi.org/10.1080/14656566.2018.1438408DOI Listing
March 2018

Pharmacodynamics of cefiderocol, a novel siderophore cephalosporin, in a Pseudomonas aeruginosa neutropenic murine thigh model.

Int J Antimicrob Agents 2018 Feb 27;51(2):206-212. Epub 2017 Oct 27.

Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2017.10.008DOI Listing
February 2018

Physical Compatibility of Meropenem and Vaborbactam With Select Intravenous Drugs During Simulated Y-site Administration.

Clin Ther 2018 02 28;40(2):261-269. Epub 2017 Dec 28.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut.

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http://dx.doi.org/10.1016/j.clinthera.2017.12.007DOI Listing
February 2018

Physical compatibility of fosfomycin for injection with select i.v. drugs during simulated Y-site administration.

Am J Health Syst Pharm 2018 Jan;75(1):e36-e44

Center for Anti-Infective Research and Development and Division of Infectious Diseases, Hartford Hospital, Hartford, CT

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http://dx.doi.org/10.2146/ajhp170123DOI Listing
January 2018

Management of Pneumonia in the Pediatric Critical Care Unit: An Area for Antimicrobial Stewardship.

Curr Pediatr Rev 2017 ;13(1):49-66

Department of Pharmacy Practice, University of Connecticut, School of Pharmacy, Storrs, CT. United States.

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http://dx.doi.org/10.2174/1573396312666161205102221DOI Listing
December 2017

Pharmacokinetics and Tissue Penetration of Ceftolozane-Tazobactam in Diabetic Patients with Lower Limb Infections and Healthy Adult Volunteers.

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/AAC.01449-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700352PMC
December 2017

Effects of Clinically Meaningful Concentrations of Antipseudomonal β-Lactams on Time to Detection and Organism Growth in Blood Culture Bottles.

J Clin Microbiol 2017 12 11;55(12):3502-3512. Epub 2017 Oct 11.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/JCM.01241-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703815PMC
December 2017

Simplifying Piperacillin/Tazobactam Dosing: Pharmacodynamics of Utilizing Only 4.5 or 3.375 g Doses for Patients With Normal and Impaired Renal Function.

J Pharm Pract 2017 Dec 21;30(6):593-599. Epub 2016 Dec 21.

1 Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.1177/0897190016684453DOI Listing
December 2017

Efficacy of Humanized Exposures of Cefiderocol (S-649266) against a Diverse Population of Gram-Negative Bacteria in a Murine Thigh Infection Model.

Antimicrob Agents Chemother 2017 11 24;61(11). Epub 2017 Oct 24.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/AAC.01022-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655050PMC
November 2017

Translational Efficacy of Humanized Exposures of Cefepime, Ertapenem, and Levofloxacin against Extended-Spectrum-β-Lactamase-Producing Escherichia coli in a Murine Model of Complicated Urinary Tract Infection.

Antimicrob Agents Chemother 2017 11 24;61(11). Epub 2017 Oct 24.

Center for Anti-infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/AAC.01329-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655047PMC
November 2017

Multicenter Evaluation of Ceftazidime-Avibactam and Ceftolozane-Tazobactam Inhibitory Activity against Meropenem-Nonsusceptible Pseudomonas aeruginosa from Blood, Respiratory Tract, and Wounds.

Antimicrob Agents Chemother 2017 10 22;61(10). Epub 2017 Sep 22.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/AAC.00875-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610483PMC
October 2017

The challenges of patient satisfaction: influencing factors and the patient - provider relationship in the United States.

Expert Rev Anti Infect Ther 2017 10 14;15(10):955-962. Epub 2017 Sep 14.

a Center for Anti-Infective Research and Development , Hartford , CT , USA ​​.

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https://www.tandfonline.com/doi/full/10.1080/14787210.2017.1
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http://dx.doi.org/10.1080/14787210.2017.1378097DOI Listing
October 2017

Use of ceftolozane-tazobactam in a cystic fibrosis patient with multidrug-resistant pseudomonas infection and renal insufficiency.

Respir Med Case Rep 2018 28;23:8-9. Epub 2017 Oct 28.

Maine Medical Center, Division of Pulmonary and Critical Care Medicine, Portland, ME 04102, USA.

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http://dx.doi.org/10.1016/j.rmcr.2017.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683800PMC
October 2017

Defining the impact of severity of illness on time above the MIC threshold for cefepime in Gram-negative bacteraemia: a 'Goldilocks' window.

Int J Antimicrob Agents 2017 Sep 28;50(3):487-490. Epub 2017 Jun 28.

Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, 555 31st Street, Downers Grove, IL 60515, USA; Department of Pharmacy, Northwestern Memorial Hospital, 251 E. Huron Street, Feinberg Pavilion, LC 700, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2017.04.023DOI Listing
September 2017

Inhaled Antimicrobials for Ventilator-Associated Pneumonia: Practical Aspects.

Drugs 2017 Sep;77(13):1399-1412

Department of Critical Care, University Hospital Attikon, Faculty of Medicine, National and Kapodistrian University of Athens, 1 Rimini St, Haidari, 12462, Athens, Greece.

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http://dx.doi.org/10.1007/s40265-017-0787-0DOI Listing
September 2017

Clinical and economic implications of urinary tract infections.

Expert Rev Pharmacoecon Outcomes Res 2017 Aug 26;17(4):377-383. Epub 2017 Jul 26.

b Center for Anti-Infective Research and Development , Hartford Hospital , Hartford , CT , USA.

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http://dx.doi.org/10.1080/14737167.2017.1358618DOI Listing
August 2017

Predicting and preventing antimicrobial resistance utilizing pharmacodynamics: part II Gram-negative bacteria.

Expert Opin Drug Metab Toxicol 2017 Jul 19;13(7):705-714. Epub 2017 May 19.

a Center for Anti-Infective Research and Development , Hartford Hospital , Hartford , CT , USA.

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https://www.tandfonline.com/doi/full/10.1080/17425255.2017.1
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http://dx.doi.org/10.1080/17425255.2017.1329417DOI Listing
July 2017

Cefazolin potency against methicillin-resistant : a microbiologic assessment in support of a novel drug delivery system for skin and skin structure infections.

Infect Drug Resist 2017 26;10:227-230. Epub 2017 Jul 26.

Department of Surgery, Sonoma West Medical Center, Sebastopol, CT, USA.

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http://dx.doi.org/10.2147/IDR.S134497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536227PMC
July 2017

Population Pharmacokinetics of Cefazolin in Serum and Adipose Tissue From Overweight and Obese Women Undergoing Cesarean Delivery.

J Clin Pharmacol 2017 06 7;57(6):712-719. Epub 2016 Dec 7.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.1002/jcph.851DOI Listing
June 2017

Obesity and skin and soft tissue infections: how to optimize antimicrobial usage for prevention and treatment?

Curr Opin Infect Dis 2017 Apr;30(2):180-191

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.

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http://dx.doi.org/10.1097/QCO.0000000000000356DOI Listing
April 2017

Clinical use comparison of a semiautomated PCR with fluorescent ribotyping for typing of Clostridium difficile.

Arch Microbiol 2017 Mar 11;199(2):317-323. Epub 2016 Oct 11.

Center for Anti-infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT, 06102, USA.

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http://dx.doi.org/10.1007/s00203-016-1305-6DOI Listing
March 2017

Detection of Piperacillin-Tazobactam-Resistant/Pan-β-Lactam-Susceptible Escherichia coli with Current Automated Susceptibility Test Systems.

Infect Control Hosp Epidemiol 2017 03 10;38(3):379-380. Epub 2017 Jan 10.

1Center for Anti-infective Research and Development,Hartford Hospital,Hartford,Connecticut.

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http://dx.doi.org/10.1017/ice.2016.325DOI Listing
March 2017

Epidemiology, treatment, and economics of patients presenting to the emergency department for skin and soft tissue infections.

Hosp Pract (1995) 2017 Feb 16;45(1):9-15. Epub 2017 Jan 16.

a Department of Pharmacy , Hartford Hospital , Hartford , CT , USA.

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https://www.tandfonline.com/doi/full/10.1080/21548331.2017.1
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http://dx.doi.org/10.1080/21548331.2017.1279519DOI Listing
February 2017

Comparative In Vivo Efficacies of Tedizolid in Neutropenic versus Immunocompetent Murine Streptococcus pneumoniae Lung Infection Models.

Antimicrob Agents Chemother 2017 01 27;61(1). Epub 2016 Dec 27.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

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http://dx.doi.org/10.1128/AAC.01957-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192146PMC
January 2017

Physical compatibility of ceftolozane-tazobactam with selected i.v. drugs during simulated Y-site administration.

Am J Health Syst Pharm 2017 Jan 22;74(1):e47-e54. Epub 2016 Dec 22.

Center for Anti-Infective Research and Development and Division of Infectious Diseases, Hartford Hospital, Hartford, CT.

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http://dx.doi.org/10.2146/ajhp150762DOI Listing
January 2017

Physical compatibility of isavuconazonium sulfate with select i.v. drugs during simulated Y-site administration.

Am J Health Syst Pharm 2017 Jan 22;74(1):e55-e63. Epub 2016 Dec 22.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT.

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http://dx.doi.org/10.2146/ajhp150733DOI Listing
January 2017

Anti-staphylococcal activity resulting from epithelial lining fluid (ELF) concentrations of amikacin inhale administered via the pulmonary drug delivery system.

Ann Clin Microbiol Antimicrob 2017 Jan 17;16(1). Epub 2017 Jan 17.

Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT, 06102, USA.

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http://dx.doi.org/10.1186/s12941-017-0178-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240302PMC
January 2017

Potency of parenteral antimicrobials including ceftolozane/tazobactam against nosocomial respiratory tract pathogens: considerations for empiric and directed therapy.

J Thorac Dis 2017 Jan;9(1):214-221

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA.

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http://dx.doi.org/10.21037/jtd.2017.01.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303068PMC
January 2017

Ceftolozane/tazobactam and ceftazidime/avibactam for the treatment of complicated intra-abdominal infections.

Ther Clin Risk Manag 2016 1;12:1811-1826. Epub 2016 Dec 1.

Department of Pharmacy Services, Hartford Hospital, Hartford, CT, USA; Department of Pharmacy Practice, School of Pharmacy, University of Connecticut, Storrs, CT, USA.

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http://dx.doi.org/10.2147/TCRM.S120811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140030PMC
December 2016

Physical compatibility of tedizolid phosphate with selected i.v. drugs during simulated Y-site administration.

Am J Health Syst Pharm 2016 Nov;73(21):1769-1776

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT.

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http://dx.doi.org/10.2146/ajhp150721DOI Listing
November 2016

Pharmacodynamic and pharmacokinetic profiling of delafloxacin in a murine lung model against community-acquired respiratory tract pathogens.

Int J Antimicrob Agents 2016 Nov 29;48(5):535-541. Epub 2016 Sep 29.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2016.08.012DOI Listing
November 2016

Multidrug-Resistant Pseudomonas aeruginosa Infection in a Child with Cystic Fibrosis.

Antimicrob Agents Chemother 2016 10 23;60(10):5627-30. Epub 2016 Sep 23.

Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/AAC.00705-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038228PMC
October 2016