Publications by authors named "David P Lane"

100Publications

Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks.

Nanomaterials (Basel) 2020 Apr 19;10(4). Epub 2020 Apr 19.

Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.

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http://dx.doi.org/10.3390/nano10040783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221704PMC
April 2020

Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2.

EJNMMI Res 2020 Apr 16;10(1):38. Epub 2020 Apr 16.

Department of Immunology, Genetics, and Pathology, The Rudbeck Laboratory, Uppsala University, SE-751 85, Uppsala, Sweden.

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http://dx.doi.org/10.1186/s13550-020-0613-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163001PMC
April 2020

Corrigendum to 'Understanding p53 functions through p53 antibodies'.

J Mol Cell Biol 2019 Dec;11(12):1105

p53 Laboratory (p53Lab), Agency for Science, Technology, and Research (A*STAR), Singapore 138648, Singapore.

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http://dx.doi.org/10.1093/jmcb/mjz110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934150PMC
December 2019

The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors.

Int J Mol Sci 2019 Nov 28;20(23). Epub 2019 Nov 28.

Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore.

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http://dx.doi.org/10.3390/ijms20235996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928821PMC
November 2019

Functionalized Resins for the Synthesis of Peptide Alcohols.

Chemistry 2020 Jan 19;26(2):379-383. Epub 2019 Nov 19.

p53 Laboratory, Agency for Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-04/05 Neuros/Immunos, Singapore, 138648, Singapore.

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http://dx.doi.org/10.1002/chem.201903965DOI Listing
January 2020

Therapeutic anti-cancer activity of antibodies targeting sulfhydryl bond constrained epitopes on unglycosylated RON receptor tyrosine kinase.

Oncogene 2019 11 15;38(48):7342-7356. Epub 2019 Aug 15.

P53 Laboratory, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1038/s41388-019-0946-8DOI Listing
November 2019

Intratumour heterogeneity of p53 expression; causes and consequences.

J Pathol 2019 11 27;249(3):274-285. Epub 2019 Aug 27.

p53 Laboratory, A*STAR, Singapore, Singapore.

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http://dx.doi.org/10.1002/path.5328DOI Listing
November 2019

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles.

Chem Sci 2019 Jul 30;10(26):6457-6466. Epub 2019 May 30.

Institute of Chemical and Engineering Sciences , Agency for Science , Technology and Research , 8 Biomedical Grove, Neuros, #07-01 , Singapore 138665 . Email:

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http://dx.doi.org/10.1039/c9sc01456jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610352PMC
July 2019

p53: updates on mechanisms, biology and therapy (I).

J Mol Cell Biol 2019 03;11(3):185-186

Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore.

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http://dx.doi.org/10.1093/jmcb/mjz017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734138PMC
March 2019

p53: updates on mechanisms, biology and therapy (II).

J Mol Cell Biol 2019 04;11(4):265-266

Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore.

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http://dx.doi.org/10.1093/jmcb/mjz018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734137PMC
April 2019

Characterization of Hydration Properties in Structural Ensembles of Biomolecules.

J Chem Inf Model 2019 07 17;59(7):3316-3329. Epub 2019 Jun 17.

Bioinformatics Institute , A*STAR (Agency for Science, Technology and Research) , 30 Biopolis Street, #07-01 Matrix , Singapore 138671.

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http://dx.doi.org/10.1021/acs.jcim.8b00453DOI Listing
July 2019

Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly.

BMC Biol 2019 05 22;17(1):40. Epub 2019 May 22.

p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore, 138648, Singapore.

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http://dx.doi.org/10.1186/s12915-019-0658-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530213PMC
May 2019

Guardian of Genome Editing.

CRISPR J 2018 08;1:258-260

p53 Laboratory, Agency for Science, Technology and Research (A*STAR) , Singapore, Singapore .

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http://dx.doi.org/10.1089/crispr.2018.29021.dalDOI Listing
August 2018

Understanding p53 functions through p53 antibodies.

J Mol Cell Biol 2019 04;11(4):317-329

p53 Laboratory (p53Lab), Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1093/jmcb/mjz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487784PMC
April 2019

Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides.

Sci Rep 2019 03 20;9(1):4913. Epub 2019 Mar 20.

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8a Biomedical Grove, Singapore, 138648, Singapore.

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http://www.nature.com/articles/s41598-019-41211-3
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http://dx.doi.org/10.1038/s41598-019-41211-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426897PMC
March 2019

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket.

Nucleic Acids Res 2019 02;47(4):1637-1652

Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, Singapore 138671.

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http://dx.doi.org/10.1093/nar/gky1314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393305PMC
February 2019

Radiation-induced astrocyte senescence is rescued by Δ133p53.

Neuro Oncol 2019 03;21(4):474-485

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1093/neuonc/noz001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422440PMC
March 2019

The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors.

Cancer Res 2018 09 19;78(17):5084-5093. Epub 2018 Jul 19.

Department of Immunology, Genetics & Pathology, Uppsala University, Uppsala, Sweden.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-0440DOI Listing
September 2018

Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone.

J Phys Chem Lett 2018 Jul 9;9(14):4082-4086. Epub 2018 Jul 9.

Science for Life Laboratory, Department of Microbiology, Tumor and Cell Biology , Karolinska Institutet , Tomtebodavägen 23A , 171 65 Stockholm , Sweden.

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http://dx.doi.org/10.1021/acs.jpclett.8b01817DOI Listing
July 2018

p53 isoforms regulate premature aging in human cells.

Oncogene 2018 05 12;37(18):2379-2393. Epub 2018 Feb 12.

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA.

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http://www.nature.com/articles/s41388-017-0101-3
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http://dx.doi.org/10.1038/s41388-017-0101-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954431PMC
May 2018

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase.

Cell Chem Biol 2018 03 18;25(3):309-317.e4. Epub 2018 Jan 18.

Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Nobels Väg 16, 171 77 Stockholm, Sweden; Science for Life Laboratory, Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Tomtebodavägen 23A, 171 65 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856493PMC
March 2018

Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53.

Oncotarget 2017 Dec 1;8(68):112825-112840. Epub 2017 Dec 1.

Bioinformatics Institute, Agency for Science, Technology and Research (ASTAR), Singapore.

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http://dx.doi.org/10.18632/oncotarget.22829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762554PMC
December 2017

Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine.

Cell Rep 2018 01;22(1):299-312

Division of Cellular & Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore 169610, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Institute of Molecular & Cellular Biology, Singapore 138673, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.112DOI Listing
January 2018

Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations.

Sci Rep 2017 Nov 15;7(1):15600. Epub 2017 Nov 15.

Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Singapore.

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http://dx.doi.org/10.1038/s41598-017-15930-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688104PMC
November 2017

Evidence for allosteric effects on p53 oligomerization induced by phosphorylation.

Protein Sci 2018 02 8;27(2):523-530. Epub 2017 Dec 8.

RECAMO, Masaryk Memorial Cancer Institute, Brno, 65653, Czech Republic.

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http://dx.doi.org/10.1002/pro.3344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775181PMC
February 2018

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others.

Nat Rev Clin Oncol 2018 Jan 26;15(1):13-30. Epub 2017 Sep 26.

p53 Laboratory (p53Lab), Agency for Science, Technology, and Research (A*STAR), Singapore 138648, Singapore.

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http://dx.doi.org/10.1038/nrclinonc.2017.151DOI Listing
January 2018

Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity.

Cancer Res 2017 08 27;77(16):4342-4354. Epub 2017 Jun 27.

p53 Laboratory, Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0424DOI Listing
August 2017

Anatomy of Mdm2 and Mdm4 in evolution.

J Mol Cell Biol 2017 02;9(1):3-15

p53 Laboratory, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #06-06, Singapore138648, Singapore.

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https://academic.oup.com/jmcb/article/9/1/3/2888568
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http://dx.doi.org/10.1093/jmcb/mjx002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372010PMC
February 2017

Water-Bridge Mediates Recognition of mRNA Cap in eIF4E.

Structure 2017 01 1;25(1):188-194. Epub 2016 Dec 1.

Bioinformatics Institute, A(∗)STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore; School of Biological Sciences, Nanyang Technological University, 50 Nanyang Drive, Singapore 637551, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.11.006DOI Listing
January 2017

Stapled peptide design: principles and roles of computation.

Drug Discov Today 2016 10 18;21(10):1642-1653. Epub 2016 Jun 18.

Bioinformatics Institute, A*STAR, 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13596446163023
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http://dx.doi.org/10.1016/j.drudis.2016.06.012DOI Listing
October 2016

Reactivation of mutant p53: Constraints on mechanism highlighted by principal component analysis of the DNA binding domain.

Proteins 2016 10 26;84(10):1443-61. Epub 2016 Jul 26.

Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore.

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http://dx.doi.org/10.1002/prot.25089DOI Listing
October 2016

Long range recognition and selection in IDPs: the interactions of the C-terminus of p53.

Sci Rep 2016 Mar 31;6:23750. Epub 2016 Mar 31.

Bioinformatics Institute (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671.

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http://dx.doi.org/10.1038/srep23750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814905PMC
March 2016

Recognition Dynamics of p53 and MDM2: Implications for Peptide Design.

J Phys Chem B 2016 Jan 11;120(2):320-8. Epub 2016 Jan 11.

York Centre for Complex Systems Analysis (YCCSA), University of York , York, YO10 5GE, United Kingdom.

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http://dx.doi.org/10.1021/acs.jpcb.5b11162DOI Listing
January 2016

Wetting of nonconserved residue-backbones: A feature indicative of aggregation associated regions of proteins.

Proteins 2016 Feb 7;84(2):254-66. Epub 2016 Jan 7.

Biomolecular Modeling and Design Division, Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 138671, Singapore.

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http://dx.doi.org/10.1002/prot.24976DOI Listing
February 2016

Enhanced antigen detection in immunohistochemical staining using a 'digitized' chimeric antibody.

Protein Eng Des Sel 2016 Jan 27;29(1):11-21. Epub 2015 Oct 27.

p53 Laboratory, 8A Biomedical Grove, Immunos #06-06, Singapore 138648, Singapore

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http://dx.doi.org/10.1093/protein/gzv054DOI Listing
January 2016

R248Q mutation--Beyond p53-DNA binding.

Proteins 2015 Dec 27;83(12):2240-50. Epub 2015 Oct 27.

Bioinformatics Institute, Agency for Science, Technology, and Research, Singapore, Republic of Singapore.

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http://doi.wiley.com/10.1002/prot.24940
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http://dx.doi.org/10.1002/prot.24940DOI Listing
December 2015

Gating by tryptophan 73 exposes a cryptic pocket at the protein-binding interface of the oncogenic eIF4E protein.

Biochemistry 2015 Oct 9;54(42):6535-44. Epub 2015 Oct 9.

Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research) , 30 Biopolis Street, #07-01 Matrix, Singapore 138671.

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http://dx.doi.org/10.1021/acs.biochem.5b00812DOI Listing
October 2015

A highly sensitive fluorescent light-up probe for real-time detection of the endogenous protein target and its antagonism in live cells.

J Mater Chem B 2015 Aug 3;3(29):5933-5937. Epub 2015 Jul 3.

Institute of Materials Research Engineering, A*STAR, 3 Research Link, Singapore 117602.

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http://dx.doi.org/10.1039/c5tb00819kDOI Listing
August 2015

p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage.

Cell Res 2015 Mar 20;25(3):351-69. Epub 2015 Feb 20.

Key laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Signaling Network, College of Life Sciences.

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http://dx.doi.org/10.1038/cr.2015.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349251PMC
March 2015

A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2.

Cell Cycle 2015 ;14(2):179-88

a York Center for Complex Systems Analysis (YCCSA); University of York ; York , UK.

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http://dx.doi.org/10.4161/15384101.2014.989043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353223PMC
September 2015

mAb806 binding to epidermal growth factor receptor: a computational study.

Proteins 2015 Jan 18;83(1):153-68. Epub 2014 Nov 18.

Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Matrix, Singapore, 138671, Singapore.

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http://dx.doi.org/10.1002/prot.24714DOI Listing
January 2015

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence.

Nat Commun 2014 Aug 21;5:4706. Epub 2014 Aug 21.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892-4258, USA.

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http://dx.doi.org/10.1038/ncomms5706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662595PMC
August 2014

Isg15 controls p53 stability and functions.

Cell Cycle 2014 20;13(14):2200-10. Epub 2014 May 20.

Institute of Molecular and Cell Biology; A*STAR; Singapore; Institute for Research on Cancer and Ageing of Nice (IRCAN); INSERM; U1081-UMR CNRS 7284; University of Nice - Sophia Antipolis; Centre Antoine Lacassagne; Nice, France.

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http://dx.doi.org/10.4161/cc.29209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111675PMC
December 2015

Investigating peptide sequence variations for 'double-click' stapled p53 peptides.

Org Biomol Chem 2014 Jun;12(24):4074-7

University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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http://dx.doi.org/10.1039/c4ob00742eDOI Listing
June 2014

Mechanism of Stapled Peptide Binding to MDM2: Possible Consequences for Peptide Design.

J Chem Theory Comput 2014 Apr;10(4):1753-61

Bioinformatics Institute (A*STAR), 30 Biopolis Street #07-01, Matrix, Singapore 138671.

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http://dx.doi.org/10.1021/ct4009238DOI Listing
April 2014

Drugging the p53 pathway: understanding the route to clinical efficacy.

Nat Rev Drug Discov 2014 Mar;13(3):217-36

p53 Laboratory (p53Lab), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #06-06, Immunos, 138648 Singapore.

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http://www.nature.com/articles/nrd4236
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http://dx.doi.org/10.1038/nrd4236DOI Listing
March 2014

Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces.

Sci Rep 2013 Dec 13;3:3451. Epub 2013 Dec 13.

p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore 138648.

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http://dx.doi.org/10.1038/srep03451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506440PMC
December 2013

Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics.

PLoS One 2013 12;8(11):e80221. Epub 2013 Nov 12.

Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Republic of Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080221PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855832PMC
July 2014

On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein.

Cell Cycle 2013 Dec 21;12(24):3727-35. Epub 2013 Nov 21.

York Centre for Complex Systems Analysis (YCCSA); University of York; York, UK; Department of Biology; University of York; York, UK.

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http://dx.doi.org/10.4161/cc.27273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905064PMC
December 2013

A comparison and optimization of methods and factors affecting the transformation of Escherichia coli.

Biosci Rep 2013 Dec 12;33(6). Epub 2013 Dec 12.

*Bioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore 138671.

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http://bioscirep.org/cgi/doi/10.1042/BSR20130098
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http://dx.doi.org/10.1042/BSR20130098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860579PMC
December 2013

Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth.

Oncotarget 2013 Jul;4(7):1019-36

p53 Laboratory, 8A Biomedical Grove, Immunos #06-06, Singapore, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759663PMC
http://dx.doi.org/10.18632/oncotarget.1075DOI Listing
July 2013

A generic scaffold for conversion of peptide ligands into homogenous biosensors.

Biosens Bioelectron 2013 Sep 29;47:421-8. Epub 2013 Mar 29.

p53Lab (A(⁎)STAR), 8A Biomedical Grove, #06-04/05 Neuros, Singapore 138648, Singapore.

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http://dx.doi.org/10.1016/j.bios.2013.03.049DOI Listing
September 2013

Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.

Cell Res 2013 May 29;23(5):620-34. Epub 2013 Jan 29.

Key Laboratory for Molecular Animal Nutrition, College of Animal Sciences, Ministry of Education, Zhejiang University, Hangzhou, Zhejiang 310058, China.

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http://dx.doi.org/10.1038/cr.2013.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641591PMC
May 2013

On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.

Cell Cycle 2013 Feb 16;12(3):394-404. Epub 2013 Jan 16.

York Centre for Complex Systems Analysis (YCCSA), University of York, York, UK.

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http://dx.doi.org/10.4161/cc.23511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587439PMC
February 2013

Stapled peptides with improved potency and specificity that activate p53.

ACS Chem Biol 2013 Mar 18;8(3):506-12. Epub 2012 Dec 18.

p53 Laboratory (p53Lab, A*STAR), 8A Biomedical Grove, #06-06, Immunos, Singapore 138648.

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http://pubs.acs.org/doi/10.1021/cb3005148
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http://dx.doi.org/10.1021/cb3005148DOI Listing
March 2013

Mdm2 in evolution.

Genes Cancer 2012 Mar;3(3-4):320-4

p53Lab (ASTAR), Singapore.

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http://dx.doi.org/10.1177/1947601912458285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494368PMC
March 2012

Detecting p53 isoforms at protein level.

Methods Mol Biol 2013 ;962:15-29

CR-UK Cell Transformation Research Group, Centre for Oncology and Molecular Medicine, Ninewells Hospital, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1007/978-1-62703-236-0_2DOI Listing
April 2013

Detecting and quantifying p53 isoforms at mRNA level in cell lines and tissues.

Methods Mol Biol 2013 ;962:1-14

CR-UK Cell Transformation Research Group, Centre for Oncology and Molecular Medicine, Ninewells Hospital, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1007/978-1-62703-236-0_1DOI Listing
April 2013

Seeking synergy in p53 transcriptional activation for cancer therapy.

Discov Med 2012 Oct;14(77):263-71

IFOM-p53Lab Joint Research Laboratory, A STAR, 138648, Singapore.

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October 2012

Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations.

PLoS One 2012 31;7(8):e43985. Epub 2012 Aug 31.

Bioinformatics Institute, ASTAR (Agency for Science, Technology and Research), Biopolis, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043985PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432064PMC
February 2013

How p53 wields the scales of fate: arrest or death?

Transcription 2012 Sep-Oct;3(5):240-4. Epub 2012 Sep 1.

p53 Laboratory, Agency for Science, Technology and Research, Singapore.

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http://dx.doi.org/10.4161/trns.21297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632620PMC
November 2013

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.

EMBO Rep 2012 Jun 29;13(7):638-44. Epub 2012 Jun 29.

Quantitative Proteomics Group, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.

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http://dx.doi.org/10.1038/embor.2012.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388785PMC
June 2012

Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α.

J Virol 2012 Aug 30;86(16):8452-60. Epub 2012 May 30.

Division of Medical Science, Centre for Oncology and Molecular Medicine, University of Dundee, Ninewells Hospital, Dundee, Scotland, United Kingdom.

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http://jvi.asm.org/lookup/doi/10.1128/JVI.07143-11
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http://dx.doi.org/10.1128/JVI.07143-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421759PMC
August 2012

Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding.

Cell Cycle 2012 Jun 15;11(12):2239-47. Epub 2012 Jun 15.

Bioinformatics Centre, Bose Institute, Kolkata, India.

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http://dx.doi.org/10.4161/cc.20333DOI Listing
June 2012

The p53 isoforms are differentially modified by Mdm2.

Cell Cycle 2012 Apr 15;11(8):1646-55. Epub 2012 Apr 15.

Institute of Molecular and Cell Biology, Singapore.

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http://dx.doi.org/10.4161/cc.20119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341231PMC
April 2012

Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity.

Proc Natl Acad Sci U S A 2012 Jan 17;109(5):1685-90. Epub 2012 Jan 17.

p53 Laboratory, Agency for Science, Technology, Singapore 138648.

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http://dx.doi.org/10.1073/pnas.1114173109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277193PMC
January 2012

Characterization of the Ligand Receptor Encounter Complex and Its Potential for in Silico Kinetics-Based Drug Development.

J Chem Theory Comput 2012 Jan 28;8(1):314-21. Epub 2011 Dec 28.

Bioinformatics Institute (A*STAR), 30 Biopolis Str., 07-01 Matrix , Singapore 138671.

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http://dx.doi.org/10.1021/ct200560wDOI Listing
January 2012