David P Lane

David P Lane

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David P Lane

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Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly.

BMC Biol 2019 May 22;17(1):40. Epub 2019 May 22.

p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore, 138648, Singapore.

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http://dx.doi.org/10.1186/s12915-019-0658-0DOI Listing
May 2019

Radiation-induced astrocyte senescence is rescued by Δ133p53.

Neuro Oncol 2019 Mar;21(4):474-485

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1093/neuonc/noz001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422440PMC
March 2019

Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides.

Sci Rep 2019 Mar 20;9(1):4913. Epub 2019 Mar 20.

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8a Biomedical Grove, Singapore, 138648, Singapore.

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http://www.nature.com/articles/s41598-019-41211-3
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http://dx.doi.org/10.1038/s41598-019-41211-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426897PMC
March 2019

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket.

Nucleic Acids Res 2019 Feb;47(4):1637-1652

Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, Singapore 138671.

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http://dx.doi.org/10.1093/nar/gky1314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393305PMC
February 2019

Understanding p53 functions through p53 antibodies.

J Mol Cell Biol 2019 Feb 14. Epub 2019 Feb 14.

p53 Laboratory (p53Lab), Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1093/jmcb/mjz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487784PMC
February 2019

The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors.

Cancer Res 2018 Sep 19;78(17):5084-5093. Epub 2018 Jul 19.

Department of Immunology, Genetics & Pathology, Uppsala University, Uppsala, Sweden.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-0440DOI Listing
September 2018

Guardian of Genome Editing.

CRISPR J 2018 Aug;1:258-260

p53 Laboratory, Agency for Science, Technology and Research (A*STAR) , Singapore, Singapore .

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http://dx.doi.org/10.1089/crispr.2018.29021.dalDOI Listing
August 2018

Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone.

J Phys Chem Lett 2018 Jul 9;9(14):4082-4086. Epub 2018 Jul 9.

Science for Life Laboratory, Department of Microbiology, Tumor and Cell Biology , Karolinska Institutet , Tomtebodavägen 23A , 171 65 Stockholm , Sweden.

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http://dx.doi.org/10.1021/acs.jpclett.8b01817DOI Listing
July 2018

p53 isoforms regulate premature aging in human cells.

Oncogene 2018 05 12;37(18):2379-2393. Epub 2018 Feb 12.

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA.

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http://www.nature.com/articles/s41388-017-0101-3
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http://dx.doi.org/10.1038/s41388-017-0101-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954431PMC
May 2018

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase.

Cell Chem Biol 2018 03 18;25(3):309-317.e4. Epub 2018 Jan 18.

Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Nobels Väg 16, 171 77 Stockholm, Sweden; Science for Life Laboratory, Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Tomtebodavägen 23A, 171 65 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856493PMC
March 2018

Evidence for allosteric effects on p53 oligomerization induced by phosphorylation.

Protein Sci 2018 02 8;27(2):523-530. Epub 2017 Dec 8.

RECAMO, Masaryk Memorial Cancer Institute, Brno, 65653, Czech Republic.

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http://dx.doi.org/10.1002/pro.3344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775181PMC
February 2018

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others.

Nat Rev Clin Oncol 2018 Jan 26;15(1):13-30. Epub 2017 Sep 26.

p53 Laboratory (p53Lab), Agency for Science, Technology, and Research (A*STAR), Singapore 138648, Singapore.

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http://dx.doi.org/10.1038/nrclinonc.2017.151DOI Listing
January 2018

Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine.

Cell Rep 2018 01;22(1):299-312

Division of Cellular & Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore 169610, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Institute of Molecular & Cellular Biology, Singapore 138673, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.112DOI Listing
January 2018

Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53.

Oncotarget 2017 Dec 1;8(68):112825-112840. Epub 2017 Dec 1.

Bioinformatics Institute, Agency for Science, Technology and Research (ASTAR), Singapore.

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http://dx.doi.org/10.18632/oncotarget.22829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762554PMC
December 2017

Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations.

Sci Rep 2017 Nov 15;7(1):15600. Epub 2017 Nov 15.

Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Singapore.

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http://dx.doi.org/10.1038/s41598-017-15930-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688104PMC
November 2017

Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity.

Cancer Res 2017 08 27;77(16):4342-4354. Epub 2017 Jun 27.

p53 Laboratory, Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0424DOI Listing
August 2017

Anatomy of Mdm2 and Mdm4 in evolution.

J Mol Cell Biol 2017 02;9(1):3-15

p53 Laboratory, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #06-06, Singapore138648, Singapore.

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http://dx.doi.org/10.1093/jmcb/mjx002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372010PMC
February 2017

Water-Bridge Mediates Recognition of mRNA Cap in eIF4E.

Structure 2017 01 1;25(1):188-194. Epub 2016 Dec 1.

Bioinformatics Institute, A(∗)STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore; School of Biological Sciences, Nanyang Technological University, 50 Nanyang Drive, Singapore 637551, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.11.006DOI Listing
January 2017

Reactivation of mutant p53: Constraints on mechanism highlighted by principal component analysis of the DNA binding domain.

Proteins 2016 10 26;84(10):1443-61. Epub 2016 Jul 26.

Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore.

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http://dx.doi.org/10.1002/prot.25089DOI Listing
October 2016

Stapled peptide design: principles and roles of computation.

Drug Discov Today 2016 10 18;21(10):1642-1653. Epub 2016 Jun 18.

Bioinformatics Institute, A*STAR, 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13596446163023
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http://dx.doi.org/10.1016/j.drudis.2016.06.012DOI Listing
October 2016

Long range recognition and selection in IDPs: the interactions of the C-terminus of p53.

Sci Rep 2016 Mar 31;6:23750. Epub 2016 Mar 31.

Bioinformatics Institute (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671.

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http://dx.doi.org/10.1038/srep23750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814905PMC
March 2016

Wetting of nonconserved residue-backbones: A feature indicative of aggregation associated regions of proteins.

Proteins 2016 Feb 7;84(2):254-66. Epub 2016 Jan 7.

Biomolecular Modeling and Design Division, Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 138671, Singapore.

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http://dx.doi.org/10.1002/prot.24976DOI Listing
February 2016

Enhanced antigen detection in immunohistochemical staining using a 'digitized' chimeric antibody.

Protein Eng Des Sel 2016 Jan 27;29(1):11-21. Epub 2015 Oct 27.

p53 Laboratory, 8A Biomedical Grove, Immunos #06-06, Singapore 138648, Singapore

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http://dx.doi.org/10.1093/protein/gzv054DOI Listing
January 2016

Recognition Dynamics of p53 and MDM2: Implications for Peptide Design.

J Phys Chem B 2016 Jan 11;120(2):320-8. Epub 2016 Jan 11.

York Centre for Complex Systems Analysis (YCCSA), University of York , York, YO10 5GE, United Kingdom.

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http://dx.doi.org/10.1021/acs.jpcb.5b11162DOI Listing
January 2016

Isg15 controls p53 stability and functions.

Cell Cycle 2014 20;13(14):2200-10. Epub 2014 May 20.

Institute of Molecular and Cell Biology; A*STAR; Singapore; Institute for Research on Cancer and Ageing of Nice (IRCAN); INSERM; U1081-UMR CNRS 7284; University of Nice - Sophia Antipolis; Centre Antoine Lacassagne; Nice, France.

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http://dx.doi.org/10.4161/cc.29209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111675PMC
December 2015

R248Q mutation--Beyond p53-DNA binding.

Proteins 2015 Dec 27;83(12):2240-50. Epub 2015 Oct 27.

Bioinformatics Institute, Agency for Science, Technology, and Research, Singapore, Republic of Singapore.

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http://doi.wiley.com/10.1002/prot.24940
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http://dx.doi.org/10.1002/prot.24940DOI Listing
December 2015

Gating by tryptophan 73 exposes a cryptic pocket at the protein-binding interface of the oncogenic eIF4E protein.

Biochemistry 2015 Oct 9;54(42):6535-44. Epub 2015 Oct 9.

Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research) , 30 Biopolis Street, #07-01 Matrix, Singapore 138671.

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http://dx.doi.org/10.1021/acs.biochem.5b00812DOI Listing
October 2015

A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2.

Cell Cycle 2015 ;14(2):179-88

a York Center for Complex Systems Analysis (YCCSA); University of York ; York , UK.

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http://dx.doi.org/10.4161/15384101.2014.989043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353223PMC
September 2015

p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage.

Cell Res 2015 Mar 20;25(3):351-69. Epub 2015 Feb 20.

Key laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Signaling Network, College of Life Sciences.

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http://dx.doi.org/10.1038/cr.2015.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349251PMC
March 2015

mAb806 binding to epidermal growth factor receptor: a computational study.

Proteins 2015 Jan 18;83(1):153-68. Epub 2014 Nov 18.

Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Matrix, Singapore, 138671, Singapore.

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http://dx.doi.org/10.1002/prot.24714DOI Listing
January 2015

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence.

Nat Commun 2014 Aug 21;5:4706. Epub 2014 Aug 21.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892-4258, USA.

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http://dx.doi.org/10.1038/ncomms5706DOI Listing
August 2014

Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics.

PLoS One 2013 12;8(11):e80221. Epub 2013 Nov 12.

Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Republic of Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080221PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855832PMC
July 2014

Investigating peptide sequence variations for 'double-click' stapled p53 peptides.

Org Biomol Chem 2014 Jun;12(24):4074-7

University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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http://dx.doi.org/10.1039/c4ob00742eDOI Listing
June 2014

Mechanism of Stapled Peptide Binding to MDM2: Possible Consequences for Peptide Design.

J Chem Theory Comput 2014 Apr;10(4):1753-61

Bioinformatics Institute (A*STAR), 30 Biopolis Street #07-01, Matrix, Singapore 138671.

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http://dx.doi.org/10.1021/ct4009238DOI Listing
April 2014

Drugging the p53 pathway: understanding the route to clinical efficacy.

Nat Rev Drug Discov 2014 Mar;13(3):217-36

p53 Laboratory (p53Lab), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #06-06, Immunos, 138648 Singapore.

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http://www.nature.com/articles/nrd4236
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http://dx.doi.org/10.1038/nrd4236DOI Listing
March 2014

A comparison and optimization of methods and factors affecting the transformation of Escherichia coli.

Biosci Rep 2013 Dec 12;33(6). Epub 2013 Dec 12.

*Bioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore 138671.

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http://bioscirep.org/cgi/doi/10.1042/BSR20130098
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http://dx.doi.org/10.1042/BSR20130098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860579PMC
December 2013

On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein.

Cell Cycle 2013 Dec 21;12(24):3727-35. Epub 2013 Nov 21.

York Centre for Complex Systems Analysis (YCCSA); University of York; York, UK; Department of Biology; University of York; York, UK.

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http://dx.doi.org/10.4161/cc.27273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905064PMC
December 2013

Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces.

Sci Rep 2013 Dec 13;3:3451. Epub 2013 Dec 13.

p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore 138648.

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http://dx.doi.org/10.1038/srep03451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506440PMC
December 2013

How p53 wields the scales of fate: arrest or death?

Transcription 2012 Sep-Oct;3(5):240-4. Epub 2012 Sep 1.

p53 Laboratory, Agency for Science, Technology and Research, Singapore.

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http://dx.doi.org/10.4161/trns.21297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632620PMC
November 2013

A generic scaffold for conversion of peptide ligands into homogenous biosensors.

Biosens Bioelectron 2013 Sep 29;47:421-8. Epub 2013 Mar 29.

p53Lab (A(⁎)STAR), 8A Biomedical Grove, #06-04/05 Neuros, Singapore 138648, Singapore.

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http://dx.doi.org/10.1016/j.bios.2013.03.049DOI Listing
September 2013

Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth.

Oncotarget 2013 Jul;4(7):1019-36

p53 Laboratory, 8A Biomedical Grove, Immunos #06-06, Singapore, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759663PMC
http://dx.doi.org/10.18632/oncotarget.1075DOI Listing
July 2013

Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.

Cell Res 2013 May 29;23(5):620-34. Epub 2013 Jan 29.

Key Laboratory for Molecular Animal Nutrition, College of Animal Sciences, Ministry of Education, Zhejiang University, Hangzhou, Zhejiang 310058, China.

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http://dx.doi.org/10.1038/cr.2013.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641591PMC
May 2013

Detecting and quantifying p53 isoforms at mRNA level in cell lines and tissues.

Methods Mol Biol 2013 ;962:1-14

CR-UK Cell Transformation Research Group, Centre for Oncology and Molecular Medicine, Ninewells Hospital, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1007/978-1-62703-236-0_1DOI Listing
April 2013

Detecting p53 isoforms at protein level.

Methods Mol Biol 2013 ;962:15-29

CR-UK Cell Transformation Research Group, Centre for Oncology and Molecular Medicine, Ninewells Hospital, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1007/978-1-62703-236-0_2DOI Listing
April 2013

Stapled peptides with improved potency and specificity that activate p53.

ACS Chem Biol 2013 Mar 18;8(3):506-12. Epub 2012 Dec 18.

p53 Laboratory (p53Lab, A*STAR), 8A Biomedical Grove, #06-06, Immunos, Singapore 138648.

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http://pubs.acs.org/doi/10.1021/cb3005148
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http://dx.doi.org/10.1021/cb3005148DOI Listing
March 2013

Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations.

PLoS One 2012 31;7(8):e43985. Epub 2012 Aug 31.

Bioinformatics Institute, ASTAR (Agency for Science, Technology and Research), Biopolis, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043985PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432064PMC
February 2013

On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.

Cell Cycle 2013 Feb 16;12(3):394-404. Epub 2013 Jan 16.

York Centre for Complex Systems Analysis (YCCSA), University of York, York, UK.

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http://dx.doi.org/10.4161/cc.23511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587439PMC
February 2013

Seeking synergy in p53 transcriptional activation for cancer therapy.

Discov Med 2012 Oct;14(77):263-71

IFOM-p53Lab Joint Research Laboratory, A STAR, 138648, Singapore.

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October 2012

Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α.

J Virol 2012 Aug 30;86(16):8452-60. Epub 2012 May 30.

Division of Medical Science, Centre for Oncology and Molecular Medicine, University of Dundee, Ninewells Hospital, Dundee, Scotland, United Kingdom.

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http://jvi.asm.org/lookup/doi/10.1128/JVI.07143-11
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http://dx.doi.org/10.1128/JVI.07143-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421759PMC
August 2012

Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding.

Cell Cycle 2012 Jun 15;11(12):2239-47. Epub 2012 Jun 15.

Bioinformatics Centre, Bose Institute, Kolkata, India.

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http://dx.doi.org/10.4161/cc.20333DOI Listing
June 2012

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.

EMBO Rep 2012 Jun 29;13(7):638-44. Epub 2012 Jun 29.

Quantitative Proteomics Group, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.

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http://dx.doi.org/10.1038/embor.2012.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388785PMC
June 2012

The p53 isoforms are differentially modified by Mdm2.

Cell Cycle 2012 Apr 15;11(8):1646-55. Epub 2012 Apr 15.

Institute of Molecular and Cell Biology, Singapore.

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http://dx.doi.org/10.4161/cc.20119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341231PMC
April 2012

Mdm2 in evolution.

Genes Cancer 2012 Mar;3(3-4):320-4

p53Lab (ASTAR), Singapore.

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http://dx.doi.org/10.1177/1947601912458285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494368PMC
March 2012

Characterization of the Ligand Receptor Encounter Complex and Its Potential for in Silico Kinetics-Based Drug Development.

J Chem Theory Comput 2012 Jan 28;8(1):314-21. Epub 2011 Dec 28.

Bioinformatics Institute (A*STAR), 30 Biopolis Str., 07-01 Matrix , Singapore 138671.

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http://dx.doi.org/10.1021/ct200560wDOI Listing
January 2012

Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity.

Proc Natl Acad Sci U S A 2012 Jan 17;109(5):1685-90. Epub 2012 Jan 17.

p53 Laboratory, Agency for Science, Technology, Singapore 138648.

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http://dx.doi.org/10.1073/pnas.1114173109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277193PMC
January 2012

New insights into p53 based therapy.

Discov Med 2011 Aug;12(63):107-17

p53 Laboratory, A*STAR, and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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August 2011

NPMc(+) AML cell line shows differential protein expression and lower sensitivity to DNA-damaging and p53-inducing anticancer compounds.

Cell Cycle 2011 Jun 15;10(12):1978-87. Epub 2011 Jun 15.

Expression Engineering Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore.

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http://www.tandfonline.com/doi/abs/10.4161/cc.10.12.15859
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http://dx.doi.org/10.4161/cc.10.12.15859DOI Listing
June 2011

MDM4 downregulates p53 transcriptional activity and response to stress during differentiation.

Cell Cycle 2011 Apr 1;10(7):1100-8. Epub 2011 Apr 1.

Institute of Molecular and Cell Biology, Immunos, Singapore.

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http://dx.doi.org/10.4161/cc.10.7.15090DOI Listing
April 2011

Translating p53 into the clinic.

Nat Rev Clin Oncol 2011 Jan 26;8(1):25-37. Epub 2010 Oct 26.

p53 Laboratory, A*STAR, Singapore.

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http://dx.doi.org/10.1038/nrclinonc.2010.174DOI Listing
January 2011

The role of mutant p53 in human cancer.

J Pathol 2011 Jan 25;223(2):116-26. Epub 2010 Oct 25.

p53 Laboratory, A*Star, Singapore.

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http://dx.doi.org/10.1002/path.2784DOI Listing
January 2011

Reactivation of p53: from peptides to small molecules.

Trends Pharmacol Sci 2011 Jan 8;32(1):53-62. Epub 2010 Dec 8.

p53 Laboratory (p53Lab, A*STAR), 8A Biomedical Grove, #06-06, Immunos, 138648, Singapore.

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http://dx.doi.org/10.1016/j.tips.2010.11.004DOI Listing
January 2011

p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients.

Breast Cancer Res 2011 Jan 20;13(1):R7. Epub 2011 Jan 20.

Centre for Oncology and Molecular Medicine, Inserm-European Associated Laboratory, University of Dundee, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1186/bcr2811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109573PMC
January 2011

A novel unstructured scaffold based on 4EBP1 enables the functional display of a wide range of bioactive peptides.

J Mol Biol 2010 Dec 7;404(5):819-31. Epub 2010 Oct 7.

p53 Laboratory (A*STAR), 8A Biomedical Grove, #06-06 Immunos, Singapore 138648, Singapore.

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http://dx.doi.org/10.1016/j.jmb.2010.09.063DOI Listing
December 2010

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

Nat Cell Biol 2010 Dec 7;12(12):1205-12. Epub 2010 Nov 7.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-4258, USA.

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http://dx.doi.org/10.1038/ncb2123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470109PMC
December 2010

The p53 inducing drug dosage may determine quiescence or senescence.

Aging (Albany NY) 2010 Nov;2(11):748

p53 lab (A*STAR), #6-06 Immunos Singapore 138648.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006013PMC
http://dx.doi.org/10.18632/aging.100229DOI Listing
November 2010

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy.

Oncotarget 2010 Nov;1(7):639-50

Centre for Oncology and Molecular Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY Tayside, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248124PMC
http://dx.doi.org/10.18632/oncotarget.101015DOI Listing
November 2010

p53-based cancer therapy.

Cold Spring Harb Perspect Biol 2010 Sep 12;2(9):a001222. Epub 2010 May 12.

p53 Laboratory (A-Star) 8A Biomedical Grove Immunos Singapore 138648.

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http://dx.doi.org/10.1101/cshperspect.a001222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926755PMC
September 2010

SNPing Away at Cancer.

Cancer Cell 2010 Sep;18(3):201-2

p53 Laboratory, 8A Biomedical Grove, Immunos #06-06, Singapore 138648, Republic of Singapore.

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http://dx.doi.org/10.1016/j.ccr.2010.08.016DOI Listing
September 2010

International network of cancer genome projects.

Authors:
Thomas J Hudson Warwick Anderson Axel Artez Anna D Barker Cindy Bell Rosa R Bernabé M K Bhan Fabien Calvo Iiro Eerola Daniela S Gerhard Alan Guttmacher Mark Guyer Fiona M Hemsley Jennifer L Jennings David Kerr Peter Klatt Patrik Kolar Jun Kusada David P Lane Frank Laplace Lu Youyong Gerd Nettekoven Brad Ozenberger Jane Peterson T S Rao Jacques Remacle Alan J Schafer Tatsuhiro Shibata Michael R Stratton Joseph G Vockley Koichi Watanabe Huanming Yang Matthew M F Yuen Bartha M Knoppers Martin Bobrow Anne Cambon-Thomsen Lynn G Dressler Stephanie O M Dyke Yann Joly Kazuto Kato Karen L Kennedy Pilar Nicolás Michael J Parker Emmanuelle Rial-Sebbag Carlos M Romeo-Casabona Kenna M Shaw Susan Wallace Georgia L Wiesner Nikolajs Zeps Peter Lichter Andrew V Biankin Christian Chabannon Lynda Chin Bruno Clément Enrique de Alava Françoise Degos Martin L Ferguson Peter Geary D Neil Hayes Thomas J Hudson Amber L Johns Arek Kasprzyk Hidewaki Nakagawa Robert Penny Miguel A Piris Rajiv Sarin Aldo Scarpa Tatsuhiro Shibata Marc van de Vijver P Andrew Futreal Hiroyuki Aburatani Mónica Bayés David D L Botwell Peter J Campbell Xavier Estivill Daniela S Gerhard Sean M Grimmond Ivo Gut Martin Hirst Carlos López-Otín Partha Majumder Marco Marra John D McPherson Hidewaki Nakagawa Zemin Ning Xose S Puente Yijun Ruan Tatsuhiro Shibata Michael R Stratton Hendrik G Stunnenberg Harold Swerdlow Victor E Velculescu Richard K Wilson Hong H Xue Liu Yang Paul T Spellman Gary D Bader Paul C Boutros Peter J Campbell Paul Flicek Gad Getz Roderic Guigó Guangwu Guo David Haussler Simon Heath Tim J Hubbard Tao Jiang Steven M Jones Qibin Li Nuria López-Bigas Ruibang Luo Lakshmi Muthuswamy B F Francis Ouellette John V Pearson Xose S Puente Victor Quesada Benjamin J Raphael Chris Sander Tatsuhiro Shibata Terence P Speed Lincoln D Stein Joshua M Stuart Jon W Teague Yasushi Totoki Tatsuhiko Tsunoda Alfonso Valencia David A Wheeler Honglong Wu Shancen Zhao Guangyu Zhou Lincoln D Stein Roderic Guigó Tim J Hubbard Yann Joly Steven M Jones Arek Kasprzyk Mark Lathrop Nuria López-Bigas B F Francis Ouellette Paul T Spellman Jon W Teague Gilles Thomas Alfonso Valencia Teruhiko Yoshida Karen L Kennedy Myles Axton Stephanie O M Dyke P Andrew Futreal Daniela S Gerhard Chris Gunter Mark Guyer Thomas J Hudson John D McPherson Linda J Miller Brad Ozenberger Kenna M Shaw Arek Kasprzyk Lincoln D Stein Junjun Zhang Syed A Haider Jianxin Wang Christina K Yung Anthony Cros Anthony Cross Yong Liang Saravanamuttu Gnaneshan Jonathan Guberman Jack Hsu Martin Bobrow Don R C Chalmers Karl W Hasel Yann Joly Terry S H Kaan Karen L Kennedy Bartha M Knoppers William W Lowrance Tohru Masui Pilar Nicolás Emmanuelle Rial-Sebbag Laura Lyman Rodriguez Catherine Vergely Teruhiko Yoshida Sean M Grimmond Andrew V Biankin David D L Bowtell Nicole Cloonan Anna deFazio James R Eshleman Dariush Etemadmoghadam Brooke B Gardiner Brooke A Gardiner James G Kench Aldo Scarpa Robert L Sutherland Margaret A Tempero Nicola J Waddell Peter J Wilson John D McPherson Steve Gallinger Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Debabrata Mukhopadhyay Lynda Chin Ronald A DePinho Sarah Thayer Lakshmi Muthuswamy Kamran Shazand Timothy Beck Michelle Sam Lee Timms Vanessa Ballin Youyong Lu Jiafu Ji Xiuqing Zhang Feng Chen Xueda Hu Guangyu Zhou Qi Yang Geng Tian Lianhai Zhang Xiaofang Xing Xianghong Li Zhenggang Zhu Yingyan Yu Jun Yu Huanming Yang Mark Lathrop Jörg Tost Paul Brennan Ivana Holcatova David Zaridze Alvis Brazma Lars Egevard Egor Prokhortchouk Rosamonde Elizabeth Banks Mathias Uhlén Anne Cambon-Thomsen Juris Viksna Fredrik Ponten Konstantin Skryabin Michael R Stratton P Andrew Futreal Ewan Birney Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Sancha Martin Jorge S Reis-Filho Andrea L Richardson Christos Sotiriou Hendrik G Stunnenberg Giles Thoms Marc van de Vijver Laura van't Veer Fabien Calvo Daniel Birnbaum Hélène Blanche Pascal Boucher Sandrine Boyault Christian Chabannon Ivo Gut Jocelyne D Masson-Jacquemier Mark Lathrop Iris Pauporté Xavier Pivot Anne Vincent-Salomon Eric Tabone Charles Theillet Gilles Thomas Jörg Tost Isabelle Treilleux Fabien Calvo Paulette Bioulac-Sage Bruno Clément Thomas Decaens Françoise Degos Dominique Franco Ivo Gut Marta Gut Simon Heath Mark Lathrop Didier Samuel Gilles Thomas Jessica Zucman-Rossi Peter Lichter Roland Eils Benedikt Brors Jan O Korbel Andrey Korshunov Pablo Landgraf Hans Lehrach Stefan Pfister Bernhard Radlwimmer Guido Reifenberger Michael D Taylor Christof von Kalle Partha P Majumder Rajiv Sarin T S Rao M K Bhan Aldo Scarpa Paolo Pederzoli Rita A Lawlor Massimo Delledonne Alberto Bardelli Andrew V Biankin Sean M Grimmond Thomas Gress David Klimstra Giuseppe Zamboni Tatsuhiro Shibata Yusuke Nakamura Hidewaki Nakagawa Jun Kusada Tatsuhiko Tsunoda Satoru Miyano Hiroyuki Aburatani Kazuto Kato Akihiro Fujimoto Teruhiko Yoshida Elias Campo Carlos López-Otín Xavier Estivill Roderic Guigó Silvia de Sanjosé Miguel A Piris Emili Montserrat Marcos González-Díaz Xose S Puente Pedro Jares Alfonso Valencia Heinz Himmelbauer Heinz Himmelbaue Victor Quesada Silvia Bea Michael R Stratton P Andrew Futreal Peter J Campbell Anne Vincent-Salomon Andrea L Richardson Jorge S Reis-Filho Marc van de Vijver Gilles Thomas Jocelyne D Masson-Jacquemier Samuel Aparicio Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Hendrik G Stunnenberg Laura van't Veer Douglas F Easton Paul T Spellman Sancha Martin Anna D Barker Lynda Chin Francis S Collins Carolyn C Compton Martin L Ferguson Daniela S Gerhard Gad Getz Chris Gunter Alan Guttmacher Mark Guyer D Neil Hayes Eric S Lander Brad Ozenberger Robert Penny Jane Peterson Chris Sander Kenna M Shaw Terence P Speed Paul T Spellman Joseph G Vockley David A Wheeler Richard K Wilson Thomas J Hudson Lynda Chin Bartha M Knoppers Eric S Lander Peter Lichter Lincoln D Stein Michael R Stratton Warwick Anderson Anna D Barker Cindy Bell Martin Bobrow Wylie Burke Francis S Collins Carolyn C Compton Ronald A DePinho Douglas F Easton P Andrew Futreal Daniela S Gerhard Anthony R Green Mark Guyer Stanley R Hamilton Tim J Hubbard Olli P Kallioniemi Karen L Kennedy Timothy J Ley Edison T Liu Youyong Lu Partha Majumder Marco Marra Brad Ozenberger Jane Peterson Alan J Schafer Paul T Spellman Hendrik G Stunnenberg Brandon J Wainwright Richard K Wilson Huanming Yang

Nature 2010 Apr;464(7291):993-8

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http://dx.doi.org/10.1038/nature08987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902243PMC
April 2010

Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.

Cell Cycle 2010 Mar 15;9(6):1167-81. Epub 2010 Mar 15.

Bioinformatics Institute (A-STAR), Matrix, Singapore.

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http://dx.doi.org/10.4161/cc.9.6.11067DOI Listing
March 2010

Mdm2 and p53 are highly conserved from placozoans to man.

Cell Cycle 2010 Feb;9(3):540-7

p53 Laboratory (A*STAR), 8A Biomedical Grove, Immunos, Singapore.

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http://dx.doi.org/10.4161/cc.9.3.10516DOI Listing
February 2010

The Mdm2 and p53 genes are conserved in the Arachnids.

Cell Cycle 2010 Feb 12;9(4):748-54. Epub 2010 Feb 12.

p53 Laboratory, Immunos, Singapore.

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http://dx.doi.org/10.4161/cc.9.4.10616DOI Listing
February 2010

Modulating the p53 pathway.

Semin Cancer Biol 2010 Feb 1;20(1):3-9. Epub 2010 Mar 1.

p53 Laboratory (A*STAR), 8A Biomedical Drive, Immunos, Singapore 138648, Singapore.

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http://linkinghub.elsevier.com/retrieve/pii/S1044579X1000005
Publisher Site
http://dx.doi.org/10.1016/j.semcancer.2010.02.004DOI Listing
February 2010