David P Dearnaley

David P Dearnaley

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David P Dearnaley

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Microbiota- and Radiotherapy-Induced Gastrointestinal Side-Effects (MARS) Study: A Large Pilot Study of the Microbiome in Acute and Late-Radiation Enteropathy.

Authors:
Miguel Reis Ferreira H Jervoise N Andreyev Kabir Mohammed Lesley Truelove Sharon M Gowan Jia Li Sarah L Gulliford Julian R Marchesi David P Dearnaley

Clin Cancer Res 2019 Nov 25;25(21):6487-6500. Epub 2019 Jul 25.

The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0960DOI Listing
November 2019

Patterns of recurrence after prostate bed radiotherapy.

Authors:
Douglas H Brand Joanna I Parker David P Dearnaley Rosalind Eeles Robert Huddart Vincent Khoo Julia Murray Yae-Eun Suh Alison C Tree Nicholas van As Chris Parker

Radiother Oncol 2019 Sep 25. Epub 2019 Sep 25.

Urological Oncology Department, Royal Marsden Hospital, London & Sutton, UK; Radiotherapy and Imaging Division, Institute of Cancer Research, London & Sutton, UK. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2019.09.007DOI Listing
September 2019

Abiraterone in "High-" and "Low-risk" Metastatic Hormone-sensitive Prostate Cancer.

Authors:
Alex P Hoyle Adnan Ali Nicholas D James Adrian Cook Christopher C Parker Johann S de Bono Gerhardt Attard Simon Chowdhury William R Cross David P Dearnaley Christopher D Brawley Clare Gilson Fiona Ingleby Silke Gillessen Daniel M Aebersold Rob J Jones David Matheson Robin Millman Malcolm D Mason Alastair W S Ritchie Martin Russell Hassan Douis Mahesh K B Parmar Matthew R Sydes Noel W Clarke

Eur Urol 2019 Aug 22. Epub 2019 Aug 22.

The Christie and Royal Salford Hospitals, Manchester, UK; Genito Urinary Cancer Research Group and the FASTMAN Centre of Excellence, Division of Cancer Sciences, The University of Manchester, Manchester, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838193062
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http://dx.doi.org/10.1016/j.eururo.2019.08.006DOI Listing
August 2019

Radiogenomics Consortium Genome-Wide Association Study Meta-analysis of Late Toxicity after Prostate Cancer Radiotherapy.

Authors:
Sarah L Kerns Laura Fachal Leila Dorling Gillian C Barnett Andrea Baran Derick R Peterson Michelle Hollenberg Ke Hao Antonio Di Narzo Mehmet Eren Ahsen Gaurav Pandey Søren M Bentzen Michelle Janelsins Rebecca M Elliott Paul D P Pharoah Neil G Burnet David P Dearnaley Sarah L Gulliford Emma Hall Matthew R Sydes Miguel E Aguado-Barrera Antonio Gómez-Caamaño Ana M Carballo Paula Peleteiro Ramón Lobato-Busto Richard Stock Nelson N Stone Harry Ostrer Nawaid Usmani Sandeep Singhal Hiroshi Tsuji Takashi Imai Shiro Saito Rosalind Eeles Kim DeRuyck Matthew Parliament Alison M Dunning Ana Vega Barry S Rosenstein Catharine M L West

J Natl Cancer Inst 2019 May 16. Epub 2019 May 16.

Division of Cancer Sciences, the University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, UK.

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http://dx.doi.org/10.1093/jnci/djz075DOI Listing
May 2019

Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial.

Authors:
Christopher C Parker Nicholas D James Christopher D Brawley Noel W Clarke Alex P Hoyle Adnan Ali Alastair W S Ritchie Gerhardt Attard Simon Chowdhury William Cross David P Dearnaley Silke Gillessen Clare Gilson Robert J Jones Ruth E Langley Zafar I Malik Malcolm D Mason David Matheson Robin Millman J Martin Russell George N Thalmann Claire L Amos Roberto Alonzi Amit Bahl Alison Birtle Omar Din Hassan Douis Chinnamani Eswar Joanna Gale Melissa R Gannon Sai Jonnada Sara Khaksar Jason F Lester Joe M O'Sullivan Omi A Parikh Ian D Pedley Delia M Pudney Denise J Sheehan Narayanan Nair Srihari Anna T H Tran Mahesh K B Parmar Matthew R Sydes

Lancet 2018 12 21;392(10162):2353-2366. Epub 2018 Oct 21.

Medical Research Council (MRC) Clinical Trials Unit at University College London (UCL), London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183248
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http://dx.doi.org/10.1016/S0140-6736(18)32486-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269599PMC
December 2018

In Regard to Spratt.

Authors:
Anna C Wilkins Barry Gusterson David P Dearnaley Emma Hall Navita Somaiah

Int J Radiat Oncol Biol Phys 2018 12;102(5):1596-1597

Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom; The Royal Marsden, London, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2018.08.007DOI Listing
December 2018

Addition of Docetaxel to First-line Long-term Hormone Therapy in Prostate Cancer (STAMPEDE): Modelling to Estimate Long-term Survival, Quality-adjusted Survival, and Cost-effectiveness.

Authors:
Beth S Woods Eleftherios Sideris Matthew R Sydes Melissa R Gannon Mahesh K B Parmar Mymoona Alzouebi Gerhardt Attard Alison J Birtle Susannah Brock Richard Cathomas Prabir R Chakraborti Audrey Cook William R Cross David P Dearnaley Joanna Gale Stephanie Gibbs John D Graham Robert Hughes Rob J Jones Robert Laing Malcolm D Mason David Matheson Duncan B McLaren Robin Millman Joe M O'Sullivan Omi Parikh Christopher C Parker Clive Peedell Andrew Protheroe Alastair W S Ritchie Angus Robinson J Martin Russell Matthew S Simms Narayanan N Srihari Rajaguru Srinivasan John N Staffurth Santhanam Sundar George N Thalmann Shaun Tolan Anna T H Tran David Tsang John Wagstaff Nicholas D James Mark J Sculpher

Eur Urol Oncol 2018 12 14;1(6):449-458. Epub 2018 Sep 14.

Centre for Health Economics, University of York, York, UK.

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http://dx.doi.org/10.1016/j.euo.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692495PMC
December 2018

Ki67 Is an Independent Predictor of Recurrence in the Largest Randomized Trial of 3 Radiation Fractionation Schedules in Localized Prostate Cancer.

Authors:
Anna C Wilkins Barry Gusterson Zsolt Szijgyarto Joanne Haviland Clare Griffin Christine Stuttle Frances Daley Catherine M Corbishley David P Dearnaley Emma Hall Navita Somaiah

Int J Radiat Oncol Biol Phys 2018 06 3;101(2):309-315. Epub 2018 Feb 3.

Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom; The Royal Marsden, Sutton, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.01.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947826PMC
June 2018

Bone lesion absorbed dose profiles in patients with metastatic prostate cancer treated with molecular radiotherapy.

Authors:
Ana M Denis-Bacelar Sarah J Chittenden V Ralph McCready Antigoni Divoli David P Dearnaley Joe M O'Sullivan Bernadette Johnson Glenn D Flux

Br J Radiol 2018 Apr 5;91(1084):20170795. Epub 2018 Feb 5.

2 Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust , London , UK.

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http://dx.doi.org/10.1259/bjr.20170795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966004PMC
April 2018

The Efficacy and Safety of Conventional and Hypofractionated High-Dose Radiation Therapy for Prostate Cancer in an Elderly Population: A Subgroup Analysis of the CHHiP Trial.

Authors:
James M Wilson David P Dearnaley Isabel Syndikus Vincent Khoo Alison Birtle David Bloomfield Ananya Choudhury John Graham Catherine Ferguson Zafar Malik Julian Money-Kyrle Joe M O'Sullivan Miguel Panades Chris Parker Yvonne Rimmer Christopher Scrase John Staffurth Andrew Stockdale Clare Cruickshank Clare Griffin Emma Hall

Int J Radiat Oncol Biol Phys 2018 04 9;100(5):1179-1189. Epub 2018 Jan 9.

The Institute of Cancer Research, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183005
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http://dx.doi.org/10.1016/j.ijrobp.2018.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314452PMC
April 2018

Reply to 'Single high dose versus repeated bone-targeted radionuclide therapy'.

Authors:
Ana M Denis-Bacelar Sarah J Chittenden David P Dearnaley Antigoni Divoli Joe M O'Sullivan V Ralph McCready Bernadette Johnson Yong Du Glenn D Flux

Eur J Nucl Med Mol Imaging 2018 03;45(3):515-517

Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, London, SM2 5NG, UK.

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http://dx.doi.org/10.1007/s00259-017-3902-2DOI Listing
March 2018

Phase 1/2 Dose-Escalation Study of the Use of Intensity Modulated Radiation Therapy to Treat the Prostate and Pelvic Nodes in Patients With Prostate Cancer.

Authors:
Miguel Reis Ferreira Atia Khan Karen Thomas Lesley Truelove Helen McNair Annie Gao Chris C Parker Robert Huddart Margaret Bidmead Ros Eeles Vincent Khoo Nicholas J van As Vibeke N Hansen David P Dearnaley

Int J Radiat Oncol Biol Phys 2017 12 2;99(5):1234-1242. Epub 2017 Aug 2.

Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom; Urology Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697895PMC
December 2017

Symptom clusters for revising scale membership in the analysis of prostate cancer patient reported outcome measures: a secondary data analysis of the Medical Research Council RT01 trial (ISCRTN47772397).

Authors:
Agnieszka Lemanska Tao Chen David P Dearnaley Rajesh Jena Matthew R Sydes Sara Faithfull

Qual Life Res 2017 08 28;26(8):2103-2116. Epub 2017 Mar 28.

Faculty of Health and Medical Sciences, School of Health Sciences, University of Surrey, Guildford, UK.

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http://dx.doi.org/10.1007/s11136-017-1548-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509840PMC
August 2017

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy.

Authors:
Nicholas D James Johann S de Bono Melissa R Spears Noel W Clarke Malcolm D Mason David P Dearnaley Alastair W S Ritchie Claire L Amos Clare Gilson Rob J Jones David Matheson Robin Millman Gerhardt Attard Simon Chowdhury William R Cross Silke Gillessen Christopher C Parker J Martin Russell Dominik R Berthold Chris Brawley Fawzi Adab San Aung Alison J Birtle Jo Bowen Susannah Brock Prabir Chakraborti Catherine Ferguson Joanna Gale Emma Gray Mohan Hingorani Peter J Hoskin Jason F Lester Zafar I Malik Fiona McKinna Neil McPhail Julian Money-Kyrle Joe O'Sullivan Omi Parikh Andrew Protheroe Angus Robinson Narayanan N Srihari Carys Thomas John Wagstaff James Wylie Anjali Zarkar Mahesh K B Parmar Matthew R Sydes

N Engl J Med 2017 07 3;377(4):338-351. Epub 2017 Jun 3.

From the Institute of Cancer and Genomic Sciences, University of Birmingham (N.D.J.), and University Hospital Birmingham (A.Z.), Birmingham, the Institute of Cancer Research (J.S.B., D.P.D., G.A.), Medical Research Council Clinical Trials Unit at University College London (M.R. Spears, C.L.A., C.G., C.B., M.K.B.P., M.R. Sydes), King's College London and Guy's and St. Thomas' NHS Foundation Trust (S.C.), and Royal Marsden NHS Foundation Trust (C.C.P.), London, Salford Royal NHS Foundation Trust, Salford (N.W.C.), Cardiff University School of Medicine (M.D.M.) and Velindre Cancer Centre (J.F.L.), Cardiff, Gloucestershire Royal Hospital (A.W.S.R.) and Gloucestershire Hospitals NHS Foundation Trust (J.B.), Gloucester, University of Glasgow, Glasgow (R.J.J., J.M.R.), St. James's University Hospital, Leeds (W.R.C.), University Hospital of North-Midlands, Stoke-on-Trent (F.A.), Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter (S.A.), Rosemere Cancer Centre, Royal Preston Hospital, Preston (A.J.B.), Dorset Cancer Centre, Poole Hospital, Poole (S.B.), Royal Derby Hospital, Derby (P.C.), Weston Park Hospital, Sheffield (C.F.), Portsmouth Oncology Centre, Queen Alexandra Hospital, Portsmouth (J.G.), Musgrove Park Hospital, Taunton (E.G.), Hull and East Yorkshire Hospitals NHS Trust, Hull (M.H.), Mount Vernon Cancer Centre, Northwood (P.J.H.), Clatterbridge Cancer Centre, Wirral (Z.I.M.), Brighton and Sussex University Hospitals NHS Trust (F.M.) and Sussex Cancer Centre, Royal Sussex County Hospital (A.R.), Brighton, NHS Highland, Inverness (N.M.), Royal Surrey County Hospital, Guildford (J.M.-K.), Northern Ireland Cancer and Queens University, Belfast (J.O.), Lancashire Teaching Hospitals NHS Trust, Preston (O.P.), Churchill Hospital, Oxford (A.P.), Shrewsbury and Telford Hospitals NHS Trust, Shrewsbury (N.N.S.), East Kent Hospitals NHS Trust, Canterbury (C.T.), Swansea University College of Medicine, Swansea (J. Wagstaff), and Christie NHS Foundation Trust, Manchester (J. Wylie) - all in the United Kingdom; and the Department of Medical Oncology, Kantonsspital St. Gallen, St. Gallen (S.G.), and University Hospital of Lausanne, Lausanne (D.R.B.) - both in Switzerland. Two of the authors (D.M., R.M.) were unaffiliated lay members of the STAMPEDE investigators.

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http://dx.doi.org/10.1056/NEJMoa1702900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533216PMC
July 2017

Adding Celecoxib With or Without Zoledronic Acid for Hormone-Naïve Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial.

Authors:
Malcolm D Mason Noel W Clarke Nicholas D James David P Dearnaley Melissa R Spears Alastair W S Ritchie Gerhardt Attard William Cross Rob J Jones Christopher C Parker J Martin Russell George N Thalmann Francesca Schiavone Estelle Cassoly David Matheson Robin Millman Cyrill A Rentsch Jim Barber Clare Gilson Azman Ibrahim John Logue Anna Lydon Ashok D Nikapota Joe M O'Sullivan Emilio Porfiri Andrew Protheroe Narayanan Nair Srihari David Tsang John Wagstaff Jan Wallace Catherine Walmsley Mahesh K B Parmar Matthew R Sydes

J Clin Oncol 2017 May 13;35(14):1530-1541. Epub 2017 Mar 13.

Malcolm D. Mason, Cardiff University School of Medicine, Velindre Hospital; Jim Barber, Velindre Cancer Centre, Cardiff; Noel W. Clarke, The Christie and Salford Royal NHS Foundation Trusts; John Logue, Christie Hospital, Manchester; Nicholas D. James, Institute of Cancer and Genomic Sciences; Emilio Porfiri, The Medical School, University of Birmingham; Nicholas D. James, Queen Elizabeth Hospital; Emilio Porfiri, University Hospitals Birmingham NHS Foundation Trust, Birmingham; David P. Dearnaley, Gerhardt Attard, and Christopher C. Parker, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust; Melissa R. Spears, Alastair W.S. Ritchie, Francesca Schiavone, David Matheson, Robin Millman, Clare Gilson, Mahesh K.B. Parmar, and Matthew R. Sydes, MRC Clinical Trials Unit at UCL, London; William Cross, Leeds Teaching Hospitals NHS Trust, Leeds; Rob J. Jones and J. Martin Russell, University of Glasgow; Rob J. Jones and Jan Wallace, Beatson West of Scotland Cancer Centre, Glasgow; Azman Ibrahim, The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, Wirral; Anna Lydon, Torbay District Hospital, Torquay; Ashok D. Nikapota, Sussex Cancer Centre, Brighton; Ashok D. Nikapota, Worthing Hospital, Worthing; Joe M. O'Sullivan, Centre for Cancer Research and Cell Biology, Queen's University, Belfast; Andrew Protheroe, Churchill Hospital, Oxford; Narayanan Nair Srihari, Shrewsbury and Telford Hospitals NHS Trust, Shrewsbury; David Tsang, Southend Hospital, Southend-on-Sea; David Tsang, Basildon Hospital, Basildon; John Wagstaff, The South West Wales Cancer Institute; John Wagstaff, Swansea University College of Medicine, Swansea; Catherine Walmsley, Royal Preston Hospital, Preston, United Kingdom; George N. Thalmann, University Hospital; Estelle Cassoly, SAKK Coordinating Center, Berne; and Cyrill A. Rentsch, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1200/JCO.2016.69.0677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455701PMC
May 2017

Phase I/II trials of Re-HEDP in metastatic castration-resistant prostate cancer: post-hoc analysis of the impact of administered activity and dosimetry on survival.

Authors:
Ana M Denis-Bacelar Sarah J Chittenden David P Dearnaley Antigoni Divoli Joe M O'Sullivan V Ralph McCready Bernadette Johnson Yong Du Glenn D Flux

Eur J Nucl Med Mol Imaging 2017 Apr 21;44(4):620-629. Epub 2016 Oct 21.

Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1007/s00259-016-3543-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323472PMC
April 2017

A radiobiological model of metastatic burden reduction for molecular radiotherapy: application to patients with bone metastases.

Authors:
Ana M Denis-Bacelar Sarah J Chittenden Iain Murray Antigoni Divoli V Ralph McCready David P Dearnaley Joe M O'Sullivan Bernadette Johnson Glenn D Flux

Phys Med Biol 2017 04;62(7):2859-2870

Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1088/1361-6560/aa5e6fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953197PMC
April 2017

The Role of Hypofractionated Radiotherapy in Prostate Cancer.

Authors:
Linus C Benjamin Alison C Tree David P Dearnaley

Curr Oncol Rep 2017 Apr;19(4):30

Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, Downs Road, Sutton Surrey, SM2 5PT, London, UK.

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http://dx.doi.org/10.1007/s11912-017-0584-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366169PMC
April 2017

Prostate-specific Antigen Decline After 4 Weeks of Treatment with Abiraterone Acetate and Overall Survival in Patients with Metastatic Castration-resistant Prostate Cancer.

Authors:
Pasquale Rescigno David Lorente Diletta Bianchini Roberta Ferraldeschi Michael P Kolinsky Spyridon Sideris Zafeiris Zafeiriou Semini Sumanasuriya Alan D Smith Niven Mehra Anuradha Jayaram Raquel Perez-Lopez Joaquin Mateo Chris Parker David P Dearnaley Nina Tunariu Alison Reid Gerhardt Attard Johann S de Bono

Eur Urol 2016 11 7;70(5):724-731. Epub 2016 Mar 7.

The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, UK. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.02.055DOI Listing
November 2016

Quality of treatment plans and accuracy of in vivo portal dosimetry in hybrid intensity-modulated radiation therapy and volumetric modulated arc therapy for prostate cancer.

Authors:
James L Bedford Gregory Smyth Ian M Hanson Alison C Tree David P Dearnaley Vibeke N Hansen

Radiother Oncol 2016 08 25;120(2):320-6. Epub 2016 Jul 25.

The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/j.radonc.2016.07.004DOI Listing
August 2016

Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer.

Authors:
Sarah L Kerns Leila Dorling Laura Fachal Søren Bentzen Paul D P Pharoah Daniel R Barnes Antonio Gómez-Caamaño Ana M Carballo David P Dearnaley Paula Peleteiro Sarah L Gulliford Emma Hall Kyriaki Michailidou Ángel Carracedo Michael Sia Richard Stock Nelson N Stone Matthew R Sydes Jonathan P Tyrer Shahana Ahmed Matthew Parliament Harry Ostrer Barry S Rosenstein Ana Vega Neil G Burnet Alison M Dunning Gillian C Barnett Catharine M L West

EBioMedicine 2016 Aug 20;10:150-63. Epub 2016 Jul 20.

Institute of Cancer Sciences, The University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester M20 4BX, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036513PMC
http://dx.doi.org/10.1016/j.ebiom.2016.07.022DOI Listing
August 2016

Re: Christopher J.D. Wallis, Refik Saskin, Richard Choo, et al. Surgery Versus Radiotherapy for Clinically-localized Prostate Cancer: A Systematic Review and Meta-analysis. Eur Urol 2016;70:21-30.

Authors:
Alison C Tree Nicholas J van As David P Dearnaley

Eur Urol 2016 07 2;70(1):e10. Epub 2016 Mar 2.

Royal Marsden NHS Foundation Trust, London, UK; Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1016/j.eururo.2016.02.044DOI Listing
July 2016

Nine-year Follow-up for a Study of Diffusion-weighted Magnetic Resonance Imaging in a Prospective Prostate Cancer Active Surveillance Cohort.

Authors:
Daniel R Henderson Nandita M de Souza Karen Thomas Sophie F Riches Veronica A Morgan Syed A Sohaib David P Dearnaley Christopher C Parker Nicholas J van As

Eur Urol 2016 06 21;69(6):1028-33. Epub 2015 Oct 21.

Academic Urology Unit, Royal Marsden NHS Foundation Trust, London, UK; Institute of Cancer Research, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.10.010DOI Listing
June 2016

Common genetic variation associated with increased susceptibility to prostate cancer does not increase risk of radiotherapy toxicity.

Authors:
Mahbubl Ahmed Leila Dorling Sarah Kerns Laura Fachal Rebecca Elliott Matt Partliament Barry S Rosenstein Ana Vega Antonio Gómez-Caamaño Gill Barnett David P Dearnaley Emma Hall Matt Sydes Neil Burnet Paul D P Pharoah Ros Eeles Catharine M L West

Br J Cancer 2016 05 12;114(10):1165-74. Epub 2016 Apr 12.

Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital NHS Foundation Trust, Manchester M20 4BX, UK.

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https://repository.icr.ac.uk/bitstream/handle/internal/82/Co
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http://www.nature.com/doifinder/10.1038/bjc.2016.94
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http://dx.doi.org/10.1038/bjc.2016.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865979PMC
May 2016

Failure-Free Survival and Radiotherapy in Patients With Newly Diagnosed Nonmetastatic Prostate Cancer: Data From Patients in the Control Arm of the STAMPEDE Trial.

Authors:
Nicholas D James Melissa R Spears Noel W Clarke David P Dearnaley Malcolm D Mason Christopher C Parker Alastair W S Ritchie J Martin Russell Francesca Schiavone Gerhardt Attard Johann S de Bono Alison Birtle Daniel S Engeler Tony Elliott David Matheson Joe O'Sullivan Delia Pudney Narayanan Srihari Jan Wallace Jim Barber Isabel Syndikus Mahesh K B Parmar Matthew R Sydes

JAMA Oncol 2016 Mar;2(3):348-57

Medical Research Council Clinical Trials Unit, University College, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaoncol.2015.4350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789485PMC
March 2016

Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial.

Authors:
Nicholas D James Matthew R Sydes Noel W Clarke Malcolm D Mason David P Dearnaley Melissa R Spears Alastair W S Ritchie Christopher C Parker J Martin Russell Gerhardt Attard Johann de Bono William Cross Rob J Jones George Thalmann Claire Amos David Matheson Robin Millman Mymoona Alzouebi Sharon Beesley Alison J Birtle Susannah Brock Richard Cathomas Prabir Chakraborti Simon Chowdhury Audrey Cook Tony Elliott Joanna Gale Stephanie Gibbs John D Graham John Hetherington Robert Hughes Robert Laing Fiona McKinna Duncan B McLaren Joe M O'Sullivan Omi Parikh Clive Peedell Andrew Protheroe Angus J Robinson Narayanan Srihari Rajaguru Srinivasan John Staffurth Santhanam Sundar Shaun Tolan David Tsang John Wagstaff Mahesh K B Parmar

Lancet 2016 Mar 21;387(10024):1163-77. Epub 2015 Dec 21.

MRC Clinical Trials Unit at UCL, London, UK.

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http://dx.doi.org/10.1016/S0140-6736(15)01037-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800035PMC
March 2016

Rationale and development of image-guided intensity-modulated radiotherapy post-prostatectomy: the present standard of care?

Authors:
Julia R Murray Helen A McNair David P Dearnaley

Cancer Manag Res 2015 11;7:331-44. Epub 2015 Nov 11.

Academic Urology Unit, Institute of Cancer Research, London ; Department of Radiotherapy, The Royal Marsden NHS Foundation Trust, Sutton, UK.

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http://dx.doi.org/10.2147/CMAR.S51955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646477PMC
December 2015

Magnitude of observer error using cone beam CT for prostate interfraction motion estimation: effect of reducing scan length or increasing exposure.

Authors:
Helen A McNair Emma J Harris Vibeke N Hansen Karen Thomas Christopher South Shaista Hafeez Robert Huddart David P Dearnaley

Br J Radiol 2015 Oct 6;88(1054):20150208. Epub 2015 Aug 6.

1 Royal Marsden NHS Foundation Trust, Sutton, UK.

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http://dx.doi.org/10.1259/bjr.20150208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730970PMC
October 2015

The role of 18F-FDG PET/CT in the management of testicular cancers.

Authors:
Gary J Cook Aslam Sohaib Robert A Huddart David P Dearnaley Alan Horwich Sue Chua

Nucl Med Commun 2015 Jul;36(7):702-8

aKings College London bRoyal Marsden NHS Foundation Trust, London cInstitute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1097/MNM.0000000000000303DOI Listing
July 2015

Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019).

Authors:
Nicholas David James Melissa R Spears Noel W Clarke David P Dearnaley Johann S De Bono Joanna Gale John Hetherington Peter J Hoskin Robert J Jones Robert Laing Jason F Lester Duncan McLaren Christopher C Parker Mahesh K B Parmar Alastair W S Ritchie J Martin Russell Räto T Strebel George N Thalmann Malcolm D Mason Matthew R Sydes

Eur Urol 2015 Jun 6;67(6):1028-1038. Epub 2014 Oct 6.

Medical Research Council Clinical Trials Unit at University College London, London, UK.

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http://dx.doi.org/10.1016/j.eururo.2014.09.032DOI Listing
June 2015

Hypofractionated radiotherapy in prostate cancer.

Authors:
David P Dearnaley

Lancet Oncol 2015 Mar 3;16(3):237-8. Epub 2015 Feb 3.

Division of Radiotherapy and Imaging, The Institute of Cancer Research, London SM2 5NG, UK. Electronic address:

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March 2015

Combining enzalutamide with abiraterone, prednisone, and androgen deprivation therapy in the STAMPEDE trial.

Authors:
Gerhardt Attard Matthew R Sydes Malcolm D Mason Noel W Clarke Daniel Aebersold Johann S de Bono David P Dearnaley Chris C Parker Alastair W S Ritchie J Martin Russell George Thalmann Estelle Cassoly Robin Millman David Matheson Francesca Schiavone Melissa R Spears Mahesh K B Parmar Nicholas D James

Eur Urol 2014 Nov 27;66(5):799-802. Epub 2014 Jun 27.

University of Warwick, Warwick, UK.

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http://dx.doi.org/10.1016/j.eururo.2014.05.038DOI Listing
November 2014

A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1.

Authors:
Laura Fachal Antonio Gómez-Caamaño Gillian C Barnett Paula Peleteiro Ana M Carballo Patricia Calvo-Crespo Sarah L Kerns Manuel Sánchez-García Ramón Lobato-Busto Leila Dorling Rebecca M Elliott David P Dearnaley Matthew R Sydes Emma Hall Neil G Burnet Ángel Carracedo Barry S Rosenstein Catharine M L West Alison M Dunning Ana Vega

Nat Genet 2014 Aug 29;46(8):891-4. Epub 2014 Jun 29.

1] Fundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Santiago de Compostela, Spain. [2] Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.

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http://dx.doi.org/10.1038/ng.3020DOI Listing
August 2014

A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity.

Authors:
Gillian C Barnett Deborah Thompson Laura Fachal Sarah Kerns Chris Talbot Rebecca M Elliott Leila Dorling Charlotte E Coles David P Dearnaley Barry S Rosenstein Ana Vega Paul Symonds John Yarnold Caroline Baynes Kyriaki Michailidou Joe Dennis Jonathan P Tyrer Jennifer S Wilkinson Antonio Gómez-Caamaño George A Tanteles Radka Platte Rebecca Mayes Don Conroy Mel Maranian Craig Luccarini Sarah L Gulliford Matthew R Sydes Emma Hall Joanne Haviland Vivek Misra Jennifer Titley Søren M Bentzen Paul D P Pharoah Neil G Burnet Alison M Dunning Catharine M L West

Radiother Oncol 2014 May 28;111(2):178-85. Epub 2014 Apr 28.

Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, UK.

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http://dx.doi.org/10.1016/j.radonc.2014.02.012DOI Listing
May 2014

Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial.

Authors:
David P Dearnaley Gordana Jovic Isabel Syndikus Vincent Khoo Richard A Cowan John D Graham Edwin G Aird David Bottomley Robert A Huddart Chakiath C Jose John H L Matthews Jeremy L Millar Claire Murphy J Martin Russell Christopher D Scrase Mahesh K B Parmar Matthew R Sydes

Lancet Oncol 2014 Apr 26;15(4):464-73. Epub 2014 Feb 26.

Medical Research Council Clinical Trials Unit at University College London, London, UK. Electronic address:

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April 2014

Microbiota and radiation-induced bowel toxicity: lessons from inflammatory bowel disease for the radiation oncologist.

Authors:
Miguel R Ferreira Ann Muls David P Dearnaley H Jervoise N Andreyev

Lancet Oncol 2014 Mar;15(3):e139-47

Royal Marsden NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/S1470-2045(13)70504-7DOI Listing
March 2014

Coplanar intensity-modulated radiotherapy class solution for patients with prostate cancer with bilateral hip prostheses with and without nodal involvement.

Authors:
Young K Lee Gerard P McVey Chris P South David P Dearnaley

Med Dosim 2013 21;38(2):165-70. Epub 2012 Dec 21.

Joint Department of Physics, The Royal Marsden NHS Foundation Trust, Sutton, Surrey SM2 5PT, UK.

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December 2013

Medium-term outcomes of active surveillance for localised prostate cancer.

Authors:
Elizabeth D Selvadurai Mausam Singhera Karen Thomas Kabir Mohammed Ruth Woode-Amissah Alan Horwich Robert A Huddart David P Dearnaley Chris C Parker

Eur Urol 2013 Dec 18;64(6):981-7. Epub 2013 Feb 18.

The Royal Marsden Hospital, Sutton, Surrey, UK; The Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1016/j.eururo.2013.02.020DOI Listing
December 2013

Prostate radiotherapy for men with metastatic disease: a new comparison in the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) trial.

Authors:
Christopher C Parker Matthew R Sydes Malcolm D Mason Noel W Clarke Daniel Aebersold Johann S de Bono David P Dearnaley Alastair W S Ritchie J Martin Russell George Thalmann Mahesh K B Parmar Nicholas D James

BJU Int 2013 May;111(5):697-9

Institute of Cancer Research and Royal Marsden Hospitals Foundation Trust, Sutton, UK.

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http://dx.doi.org/10.1111/bju.12087DOI Listing
May 2013

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.

Authors:
Rosalind A Eeles Ali Amin Al Olama Sara Benlloch Edward J Saunders Daniel A Leongamornlert Malgorzata Tymrakiewicz Maya Ghoussaini Craig Luccarini Joe Dennis Sarah Jugurnauth-Little Tokhir Dadaev David E Neal Freddie C Hamdy Jenny L Donovan Ken Muir Graham G Giles Gianluca Severi Fredrik Wiklund Henrik Gronberg Christopher A Haiman Fredrick Schumacher Brian E Henderson Loic Le Marchand Sara Lindstrom Peter Kraft David J Hunter Susan Gapstur Stephen J Chanock Sonja I Berndt Demetrius Albanes Gerald Andriole Johanna Schleutker Maren Weischer Federico Canzian Elio Riboli Tim J Key Ruth C Travis Daniele Campa Sue A Ingles Esther M John Richard B Hayes Paul D P Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Elaine A Ostrander Lisa B Signorello Stephen N Thibodeau Dan Schaid Christiane Maier Walther Vogel Adam S Kibel Cezary Cybulski Jan Lubinski Lisa Cannon-Albright Hermann Brenner Jong Y Park Radka Kaneva Jyotsna Batra Amanda B Spurdle Judith A Clements Manuel R Teixeira Ed Dicks Andrew Lee Alison M Dunning Caroline Baynes Don Conroy Melanie J Maranian Shahana Ahmed Koveela Govindasami Michelle Guy Rosemary A Wilkinson Emma J Sawyer Angela Morgan David P Dearnaley Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Nicholas J Van As Christopher J Woodhouse Alan Thompson Tim Dudderidge Chris Ogden Colin S Cooper Artitaya Lophatananon Angela Cox Melissa C Southey John L Hopper Dallas R English Markus Aly Jan Adolfsson Jiangfeng Xu Siqun L Zheng Meredith Yeager Rudolf Kaaks W Ryan Diver Mia M Gaudet Mariana C Stern Roman Corral Amit D Joshi Ahva Shahabi Tiina Wahlfors Teuvo L J Tammela Anssi Auvinen Jarmo Virtamo Peter Klarskov Børge G Nordestgaard M Andreas Røder Sune F Nielsen Stig E Bojesen Afshan Siddiq Liesel M Fitzgerald Suzanne Kolb Erika M Kwon Danielle M Karyadi William J Blot Wei Zheng Qiuyin Cai Shannon K McDonnell Antje E Rinckleb Bettina Drake Graham Colditz Dominika Wokolorczyk Robert A Stephenson Craig Teerlink Heiko Muller Dietrich Rothenbacher Thomas A Sellers Hui-Yi Lin Chavdar Slavov Vanio Mitev Felicity Lose Srilakshmi Srinivasan Sofia Maia Paula Paulo Ethan Lange Kathleen A Cooney Antonis C Antoniou Daniel Vincent François Bacot Daniel C Tessier Zsofia Kote-Jarai Douglas F Easton

Nat Genet 2013 Apr;45(4):385-91, 391e1-2

The Institute of Cancer Research, Sutton, UK.

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http://dx.doi.org/10.1038/ng.2560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832790PMC
April 2013

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.

Authors:
Ali Amin Al Olama Zsofia Kote-Jarai Fredrick R Schumacher Fredrik Wiklund Sonja I Berndt Sara Benlloch Graham G Giles Gianluca Severi David E Neal Freddie C Hamdy Jenny L Donovan David J Hunter Brian E Henderson Michael J Thun Michael Gaziano Edward L Giovannucci Afshan Siddiq Ruth C Travis David G Cox Federico Canzian Elio Riboli Timothy J Key Gerald Andriole Demetrius Albanes Richard B Hayes Johanna Schleutker Anssi Auvinen Teuvo L J Tammela Maren Weischer Janet L Stanford Elaine A Ostrander Cezary Cybulski Jan Lubinski Stephen N Thibodeau Daniel J Schaid Karina D Sorensen Jyotsna Batra Judith A Clements Suzanne Chambers Joanne Aitken Robert A Gardiner Christiane Maier Walther Vogel Thilo Dörk Hermann Brenner Tomonori Habuchi Sue Ingles Esther M John Joanne L Dickinson Lisa Cannon-Albright Manuel R Teixeira Radka Kaneva Hong-Wei Zhang Yong-Jie Lu Jong Y Park Kathleen A Cooney Kenneth R Muir Daniel A Leongamornlert Edward Saunders Malgorzata Tymrakiewicz Nadiya Mahmud Michelle Guy Koveela Govindasami Lynne T O'Brien Rosemary A Wilkinson Amanda L Hall Emma J Sawyer Tokhir Dadaev Jonathan Morrison David P Dearnaley Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Nicholas Van As Christopher J Woodhouse Alan Thompson Tim Dudderidge Chris Ogden Colin S Cooper Artitaya Lophatonanon Melissa C Southey John L Hopper Dallas English Jarmo Virtamo Loic Le Marchand Daniele Campa Rudolf Kaaks Sara Lindstrom W Ryan Diver Susan Gapstur Meredith Yeager Angela Cox Mariana C Stern Roman Corral Markus Aly William Isaacs Jan Adolfsson Jianfeng Xu S Lilly Zheng Tiina Wahlfors Kimmo Taari Paula Kujala Peter Klarskov Børge G Nordestgaard M Andreas Røder Ruth Frikke-Schmidt Stig E Bojesen Liesel M FitzGerald Suzanne Kolb Erika M Kwon Danielle M Karyadi Torben Falck Orntoft Michael Borre Antje Rinckleb Manuel Luedeke Kathleen Herkommer Andreas Meyer Jürgen Serth James R Marthick Briony Patterson Dominika Wokolorczyk Amanda Spurdle Felicity Lose Shannon K McDonnell Amit D Joshi Ahva Shahabi Pedro Pinto Joana Santos Ana Ray Thomas A Sellers Hui-Yi Lin Robert A Stephenson Craig Teerlink Heiko Muller Dietrich Rothenbacher Norihiko Tsuchiya Shintaro Narita Guang-Wen Cao Chavdar Slavov Vanio Mitev Stephen Chanock Henrik Gronberg Christopher A Haiman Peter Kraft Douglas F Easton Rosalind A Eeles

Hum Mol Genet 2013 Jan 12;22(2):408-15. Epub 2012 Oct 12.

Strangeways Laboratory, Centre for Cancer Genetic Epidemiology, Worts Causeway, Cambridge CB1 8RN, UK.

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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/dds425
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526158PMC
January 2013

Stereotactic body radiotherapy for oligometastases.

Authors:
Alison C Tree Vincent S Khoo Rosalind A Eeles Merina Ahmed David P Dearnaley Maria A Hawkins Robert A Huddart Christopher M Nutting Peter J Ostler Nicholas J van As

Lancet Oncol 2013 Jan;14(1):e28-37

Royal Marsden NHS Foundation Trust, London, UK.

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January 2013

Evaluating the efficacy of statins and ACE-inhibitors in reducing gastrointestinal toxicity in patients receiving radiotherapy for pelvic malignancies.

Authors:
Linda J Wedlake Foteini Silia Barbara Benton Amyn Lalji Karen Thomas David P Dearnaley Peter Blake Diana Tait Vincent S Khoo H Jervoise N Andreyev

Eur J Cancer 2012 Sep 3;48(14):2117-24. Epub 2012 Mar 3.

Department of Nutrition and Dietetics, The Royal Marsden NHS Foundation Trust, London, UK.

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September 2012

Intermittent androgen suppression for rising PSA level after radiotherapy.

Authors:
Juanita M Crook Christopher J O'Callaghan Graeme Duncan David P Dearnaley Celestia S Higano Eric M Horwitz Eliot Frymire Shawn Malone Joseph Chin Abdenour Nabid Padraig Warde Thomas Corbett Steve Angyalfi S Larry Goldenberg Mary K Gospodarowicz Fred Saad John P Logue Emma Hall Paul F Schellhammer Keyue Ding Laurence Klotz

N Engl J Med 2012 Sep;367(10):895-903

British Columbia Cancer Agency, Cancer Centre for the Southern Interior, 399 Royal Ave., Kelowna, BC V1Y 5L3, Canada.

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http://dx.doi.org/10.1056/NEJMoa1201546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521033PMC
September 2012

Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial.

Authors:
Matthew R Sydes Mahesh K B Parmar Malcolm D Mason Noel W Clarke Claire Amos John Anderson Johann de Bono David P Dearnaley John Dwyer Charlene Green Gordana Jovic Alastair W S Ritchie J Martin Russell Karen Sanders George Thalmann Nicholas D James

Trials 2012 Sep 15;13:168. Epub 2012 Sep 15.

MRC Clinical Trials Unit, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466132PMC
September 2012

The dose-response of the anal sphincter region--an analysis of data from the MRC RT01 trial.

Authors:
Florian Buettner Sarah L Gulliford Steve Webb Matthew R Sydes David P Dearnaley Mike Partridge

Radiother Oncol 2012 Jun 18;103(3):347-52. Epub 2012 Apr 18.

Joint Department of Physics, Institute of Cancer Research, Surrey, UK.

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June 2012

Celecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer: first results from the STAMPEDE multiarm, multistage, randomised controlled trial.

Authors:
Nicholas D James Matthew R Sydes Malcolm D Mason Noel W Clarke John Anderson David P Dearnaley John Dwyer Gordana Jovic Alastair W S Ritchie J Martin Russell Karen Sanders George N Thalmann Gianfilippo Bertelli Alison J Birtle Joe M O'Sullivan Andrew Protheroe Denise Sheehan Narayanan Srihari Mahesh K B Parmar

Lancet Oncol 2012 May 26;13(5):549-58. Epub 2012 Mar 26.

School of Cancer Sciences, University of Birmingham, Birmingham, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398767PMC
May 2012

Parameters for the Lyman Kutcher Burman (LKB) model of Normal Tissue Complication Probability (NTCP) for specific rectal complications observed in clinical practise.

Authors:
Sarah L Gulliford Mike Partridge Matthew R Sydes Steve Webb Philip M Evans David P Dearnaley

Radiother Oncol 2012 Mar 25;102(3):347-51. Epub 2011 Nov 25.

Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK.

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http://dx.doi.org/10.1016/j.radonc.2011.10.022DOI Listing
March 2012

Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study.

Authors:
Gillian C Barnett Charlotte E Coles Rebecca M Elliott Caroline Baynes Craig Luccarini Don Conroy Jennifer S Wilkinson Jonathan Tyrer Vivek Misra Radka Platte Sarah L Gulliford Matthew R Sydes Emma Hall Søren M Bentzen David P Dearnaley Neil G Burnet Paul D P Pharoah Alison M Dunning Catharine M L West

Lancet Oncol 2012 Jan 12;13(1):65-77. Epub 2011 Dec 12.

University of Cambridge, Department of Oncology, Cambridge, UK.

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http://dx.doi.org/10.1016/S1470-2045(11)70302-3DOI Listing
January 2012

Can diet combined with treatment scheduling achieve consistency of rectal filling in patients receiving radiotherapy to the prostate?

Authors:
Helen A McNair Linda Wedlake Gerard P McVey Karen Thomas Jervoise Andreyev David P Dearnaley

Radiother Oncol 2011 Dec 6;101(3):471-8. Epub 2011 Sep 6.

Department of Radiotherapy, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, UK.

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http://dx.doi.org/10.1016/j.radonc.2011.08.003DOI Listing
December 2011

A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact.

Authors:
Robert J Macinnis Antonis C Antoniou Rosalind A Eeles Gianluca Severi Ali Amin Al Olama Lesley McGuffog Zsofia Kote-Jarai Michelle Guy Lynne T O'Brien Amanda L Hall Rosemary A Wilkinson Emma Sawyer Audrey T Ardern-Jones David P Dearnaley Alan Horwich Vincent S Khoo Christopher C Parker Robert A Huddart Nicholas Van As Margaret R McCredie Dallas R English Graham G Giles John L Hopper Douglas F Easton

Genet Epidemiol 2011 Sep 18;35(6):549-56. Epub 2011 Jul 18.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/gepi.20605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950816PMC
September 2011

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

Authors:
Zsofia Kote-Jarai Ali Amin Al Olama Graham G Giles Gianluca Severi Johanna Schleutker Maren Weischer Daniele Campa Elio Riboli Tim Key Henrik Gronberg David J Hunter Peter Kraft Michael J Thun Sue Ingles Stephen Chanock Demetrius Albanes Richard B Hayes David E Neal Freddie C Hamdy Jenny L Donovan Paul Pharoah Fredrick Schumacher Brian E Henderson Janet L Stanford Elaine A Ostrander Karina Dalsgaard Sorensen Thilo Dörk Gerald Andriole Joanne L Dickinson Cezary Cybulski Jan Lubinski Amanda Spurdle Judith A Clements Suzanne Chambers Joanne Aitken R A Frank Gardiner Stephen N Thibodeau Dan Schaid Esther M John Christiane Maier Walther Vogel Kathleen A Cooney Jong Y Park Lisa Cannon-Albright Hermann Brenner Tomonori Habuchi Hong-Wei Zhang Yong-Jie Lu Radka Kaneva Ken Muir Sara Benlloch Daniel A Leongamornlert Edward J Saunders Malgorzata Tymrakiewicz Nadiya Mahmud Michelle Guy Lynne T O'Brien Rosemary A Wilkinson Amanda L Hall Emma J Sawyer Tokhir Dadaev Jonathan Morrison David P Dearnaley Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Nicholas Van As Christopher J Woodhouse Alan Thompson Tim Christmas Chris Ogden Colin S Cooper Aritaya Lophatonanon Melissa C Southey John L Hopper Dallas R English Tiina Wahlfors Teuvo L J Tammela Peter Klarskov Børge G Nordestgaard M Andreas Røder Anne Tybjærg-Hansen Stig E Bojesen Ruth Travis Federico Canzian Rudolf Kaaks Fredrik Wiklund Markus Aly Sara Lindstrom W Ryan Diver Susan Gapstur Mariana C Stern Roman Corral Jarmo Virtamo Angela Cox Christopher A Haiman Loic Le Marchand Liesel Fitzgerald Suzanne Kolb Erika M Kwon Danielle M Karyadi Torben Falck Orntoft Michael Borre Andreas Meyer Jürgen Serth Meredith Yeager Sonja I Berndt James R Marthick Briony Patterson Dominika Wokolorczyk Jyotsna Batra Felicity Lose Shannon K McDonnell Amit D Joshi Ahva Shahabi Antje E Rinckleb Ana Ray Thomas A Sellers Hui-Yi Lin Robert A Stephenson James Farnham Heiko Muller Dietrich Rothenbacher Norihiko Tsuchiya Shintaro Narita Guang-Wen Cao Chavdar Slavov Vanio Mitev Douglas F Easton Rosalind A Eeles

Nat Genet 2011 Jul 10;43(8):785-91. Epub 2011 Jul 10.

The Institute of Cancer Research, Sutton, Surrey, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396006PMC
July 2011

Late gastrointestinal toxicity after dose-escalated conformal radiotherapy for early prostate cancer: results from the UK Medical Research Council RT01 trial (ISRCTN47772397).

Authors:
Isabel Syndikus Rachel C Morgan Matthew R Sydes John D Graham David P Dearnaley

Int J Radiat Oncol Biol Phys 2010 Jul 14;77(3):773-83. Epub 2009 Oct 14.

Clatterbridge Centre for Oncology, Bebington, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937212PMC
July 2010

Long-term neurologic and peripheral vascular toxicity after chemotherapy treatment of testicular cancer.

Authors:
Jennifer L Glendenning Yolanda Barbachano Andy R Norman David P Dearnaley Alan Horwich Robert A Huddart

Cancer 2010 May;116(10):2322-31

Urology Unit, The Royal Marsden National Health Service Foundation Trust, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1002/cncr.24981DOI Listing
May 2010

Serum micronutrient and antioxidant levels at baseline and the natural history of men with localised prostate cancer on active surveillance.

Authors:
Ramachandran Venkitaraman Karen Thomas Phillip Grace David P Dearnaley Alan Horwich Robert A Huddart Christopher C Parker

Tumour Biol 2010 Apr 16;31(2):97-102. Epub 2010 Feb 16.

Department of Clinical Oncology, Ipswich Hospital NHS Trust, Ipswich, Suffolk, UK.

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http://dx.doi.org/10.1007/s13277-009-0013-0DOI Listing
April 2010

Dose-volume constraints to reduce rectal side effects from prostate radiotherapy: evidence from MRC RT01 Trial ISRCTN 47772397.

Authors:
Sarah L Gulliford Kerwyn Foo Rachel C Morgan Edwin G Aird A Margaret Bidmead Helen Critchley Philip M Evans Stefano Gianolini W Philip Mayles A Rollo Moore Beatriz Sánchez-Nieto Mike Partridge Matthew R Sydes Steve Webb David P Dearnaley

Int J Radiat Oncol Biol Phys 2010 Mar 18;76(3):747-54. Epub 2009 Jun 18.

Joint Department of Physics, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2009.02.025DOI Listing
March 2010

A comparison of dose-volume constraints derived using peak and longitudinal definitions of late rectal toxicity.

Authors:
Sarah L Gulliford Mike Partridge Matthew R Sydes Jervoise Andreyev David P Dearnaley

Radiother Oncol 2010 Feb 22;94(2):241-7. Epub 2010 Jan 22.

Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK.

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http://dx.doi.org/10.1016/j.radonc.2009.12.019DOI Listing
February 2010

Prostate cancer segregation analyses using 4390 families from UK and Australian population-based studies.

Authors:
Robert J MacInnis Antonis C Antoniou Rosalind A Eeles Gianluca Severi Michelle Guy Lesley McGuffog Amanda L Hall Lynne T O'Brien Rosemary A Wilkinson David P Dearnaley Audrey T Ardern-Jones Alan Horwich Vincent S Khoo Christopher C Parker Robert A Huddart Margaret R McCredie Charmaine Smith Melissa C Southey Margaret P Staples Dallas R English John L Hopper Graham G Giles Douglas F Easton

Genet Epidemiol 2010 Jan;34(1):42-50

Cancer Research UK Genetic Epidemiology Unit, Strangeways Laboratory, University of Cambridge, Cambridge, UK.

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http://doi.wiley.com/10.1002/gepi.20433
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January 2010

A study of diffusion-weighted magnetic resonance imaging in men with untreated localised prostate cancer on active surveillance.

Authors:
Nicholas J van As Nandita M de Souza Sophie F Riches Veronica A Morgan Sayid A Sohaib David P Dearnaley Chris C Parker

Eur Urol 2009 Dec 6;56(6):981-7. Epub 2008 Dec 6.

Academic Unit of Radiotherapy and Oncology, Department of Radiology, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, Surrey, UK.

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December 2009

Assessing correlations between the spatial distribution of the dose to the rectal wall and late rectal toxicity after prostate radiotherapy: an analysis of data from the MRC RT01 trial (ISRCTN 47772397).

Authors:
Florian Buettner Sarah L Gulliford Steve Webb Matthew R Sydes David P Dearnaley Mike Partridge

Phys Med Biol 2009 Nov 14;54(21):6535-48. Epub 2009 Oct 14.

Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK.

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http://dx.doi.org/10.1088/0031-9155/54/21/006DOI Listing
November 2009

Multiple loci on 8q24 associated with prostate cancer susceptibility.

Authors:
Ali Amin Al Olama Zsofia Kote-Jarai Graham G Giles Michelle Guy Jonathan Morrison Gianluca Severi Daniel A Leongamornlert Malgorzata Tymrakiewicz Sameer Jhavar Ed Saunders John L Hopper Melissa C Southey Kenneth R Muir Dallas R English David P Dearnaley Audrey T Ardern-Jones Amanda L Hall Lynne T O'Brien Rosemary A Wilkinson Emma Sawyer Artitaya Lophatananon Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Christopher J Woodhouse Alan Thompson Tim Christmas Chris Ogden Colin Cooper Jenny L Donovan Freddie C Hamdy David E Neal Rosalind A Eeles Douglas F Easton

Nat Genet 2009 Oct 20;41(10):1058-60. Epub 2009 Sep 20.

Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.452DOI Listing
October 2009

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

Authors:
Rosalind A Eeles Zsofia Kote-Jarai Ali Amin Al Olama Graham G Giles Michelle Guy Gianluca Severi Kenneth Muir John L Hopper Brian E Henderson Christopher A Haiman Johanna Schleutker Freddie C Hamdy David E Neal Jenny L Donovan Janet L Stanford Elaine A Ostrander Sue A Ingles Esther M John Stephen N Thibodeau Daniel Schaid Jong Y Park Amanda Spurdle Judith Clements Joanne L Dickinson Christiane Maier Walther Vogel Thilo Dörk Timothy R Rebbeck Kathleen A Cooney Lisa Cannon-Albright Pierre O Chappuis Pierre Hutter Maurice Zeegers Radka Kaneva Hong-Wei Zhang Yong-Jie Lu William D Foulkes Dallas R English Daniel A Leongamornlert Malgorzata Tymrakiewicz Jonathan Morrison Audrey T Ardern-Jones Amanda L Hall Lynne T O'Brien Rosemary A Wilkinson Edward J Saunders Elizabeth C Page Emma J Sawyer Stephen M Edwards David P Dearnaley Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Nicholas Van As Christopher J Woodhouse Alan Thompson Tim Christmas Chris Ogden Colin S Cooper Melissa C Southey Artitaya Lophatananon Jo-Fen Liu Laurence N Kolonel Loic Le Marchand Tiina Wahlfors Teuvo L Tammela Anssi Auvinen Sarah J Lewis Angela Cox Liesel M FitzGerald Joseph S Koopmeiners Danielle M Karyadi Erika M Kwon Mariana C Stern Roman Corral Amit D Joshi Ahva Shahabi Shannon K McDonnell Thomas A Sellers Julio Pow-Sang Suzanne Chambers Joanne Aitken R A Frank Gardiner Jyotsna Batra Mary Anne Kedda Felicity Lose Andrea Polanowski Briony Patterson Jürgen Serth Andreas Meyer Manuel Luedeke Klara Stefflova Anna M Ray Ethan M Lange Jim Farnham Humera Khan Chavdar Slavov Atanaska Mitkova Guangwen Cao Douglas F Easton

Nat Genet 2009 Oct 20;41(10):1116-21. Epub 2009 Sep 20.

The Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1038/ng.450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846760PMC
October 2009

Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials.

Authors:
David P Dearnaley Malcolm D Mason Mahesh K B Parmar Karen Sanders Matthew R Sydes

Lancet Oncol 2009 Sep 10;10(9):872-6. Epub 2009 Aug 10.

Royal Marsden Foundation Trust and Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1016/S1470-2045(09)70201-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748902PMC
September 2009

Additional therapy for high-risk prostate cancer treated with surgery: what is the evidence?

Authors:
Scott C Morgan David P Dearnaley

Expert Rev Anticancer Ther 2009 Jul;9(7):939-51

Honorary Clinical Research Fellow, Academic Urology Unit, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK.

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http://dx.doi.org/10.1586/era.09.60DOI Listing
July 2009

Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial.

Authors:
Matthew R Sydes Mahesh K B Parmar Nicholas D James Noel W Clarke David P Dearnaley Malcolm D Mason Rachel C Morgan Karen Sanders Patrick Royston

Trials 2009 Jun 11;10:39. Epub 2009 Jun 11.

MRC Clinical Trials Unit, London, UK.

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http://dx.doi.org/10.1186/1745-6215-10-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704188PMC
June 2009

Prospective study of factors predicting adherence to medical advice in men with testicular cancer.

Authors:
Clare Moynihan Andy R Norman Yolanda Barbachano Louise Burchell Robert Huddart David P Dearnaley Alan Horwich

J Clin Oncol 2009 May 23;27(13):2144-50. Epub 2009 Mar 23.

Academic Radiotherapy Unit, The Institute of Cancer Research and Department of Clinical Research Development, Royal Marsden National Health Service Foundation Trust, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2008.16.1901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738633PMC
May 2009

Systemic therapy for advancing or metastatic prostate cancer (STAMPEDE): a multi-arm, multistage randomized controlled trial.

Authors:
Nicholas D James Matthew R Sydes Noel W Clarke Malcolm D Mason David P Dearnaley John Anderson Richard J Popert Karen Sanders Rachel C Morgan Jim Stansfeld John Dwyer John Masters Mahesh K B Parmar

BJU Int 2009 Feb 8;103(4):464-9. Epub 2008 Oct 8.

CRUK Institute for Cancer Studies, University of Birmingham, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2008.08034.xDOI Listing
February 2009

Clinical implications of introducing a new PSA assay.

Authors:
Ramachandran Venkitaraman Andrew R Norman Jhangir Iqbal David P Dearnaley Alan Horwich Robert A Huddart Chris C Parker

Int Urol Nephrol 2008 6;40(3):657-61. Epub 2008 Feb 6.

Academic Unit of Radiotherapy & Oncology, Institute of Cancer Research, Downs Road, Sutton, Surrey SM2 5PT, UK.

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http://dx.doi.org/10.1007/s11255-007-9330-7DOI Listing
January 2009

Identification of new genetic risk factors for prostate cancer.

Authors:
Michelle Guy Zsofia Kote-Jarai Graham G Giles Ali Amin Al Olama Sarah K Jugurnauth Shani Mulholland Daniel A Leongamornlert Stephen M Edwards Jonathan Morrison Helen I Field Melissa C Southey Gianluca Severi Jenny L Donovan Freddie C Hamdy David P Dearnaley Kenneth R Muir Charmaine Smith Melisa Bagnato Audrey T Ardern-Jones Amanda L Hall Lynne T O'Brien Beatrice N Gehr-Swain Rosemary A Wilkinson Angela Cox Sarah Lewis Paul M Brown Sameer G Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L Bryant Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Christopher J Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S Cooper Dallas R English John L Hopper David E Neal Douglas F Easton Rosalind A Eeles

Asian J Androl 2009 Jan 1;11(1):49-55. Epub 2008 Dec 1.

Section of Cancer Genetics, The Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1038/aja.2008.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735221PMC
January 2009

Identification of new genetic risk factors for prostate cancer.

Authors:
Michelle Guy Zsofia Kote-Jarai Graham G Giles Ali Amin Al Olama Sarah K Jugurnauth Shani Mulholland Daniel A Leongamornlert Stephen M Edwards Jonathan Morrison Helen I Field Melissa C Southey Gianluca Severi Jenny L Donovan Freddie C Hamdy David P Dearnaley Kenneth R Muir Charmaine Smith Melisa Bagnato Audrey T Ardern-Jones Amanda L Hall Lynne T O'Brien Beatrice N Gehr-Swain Rosemary A Wilkinson Angela Cox Sarah Lewis Paul M Brown Sameer G Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L Bryant Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Christopher J Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S Cooper Dallas R English John L Hopper David E Neal Douglas F Easton Rosalind A Eeles

Asian J Androl 2009 Jan 1;11(1):49-55. Epub 2008 Dec 1.

Section of Cancer Genetics, The Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1038/aja.2008.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735221PMC
January 2009

Predicting the probability of deferred radical treatment for localised prostate cancer managed by active surveillance.

Authors:
Nicholas J van As Andrew R Norman Karen Thomas Vincent S Khoo Alan Thompson Robert A Huddart Alan Horwich David P Dearnaley Christopher C Parker

Eur Urol 2008 Dec 7;54(6):1297-305. Epub 2008 Mar 7.

Academic Urology Unit, Institute of Cancer Research, Royal Marsden Hospital, Surrey, United Kingdom.

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http://dx.doi.org/10.1016/j.eururo.2008.02.039DOI Listing
December 2008

Multiple loci with different cancer specificities within the 8q24 gene desert.

Authors:
Maya Ghoussaini Honglin Song Thibaud Koessler Ali Amin Al Olama Zsofia Kote-Jarai Kristy E Driver Karen A Pooley Susan J Ramus Susanne Krüger Kjaer Estrid Hogdall Richard A DiCioccio Alice S Whittemore Simon A Gayther Graham G Giles Michelle Guy Stephen M Edwards Jonathan Morrison Jenny L Donovan Freddie C Hamdy David P Dearnaley Audrey T Ardern-Jones Amanda L Hall Lynne T O'Brien Beatrice N Gehr-Swain Rosemary A Wilkinson Paul M Brown John L Hopper David E Neal Paul D P Pharoah Bruce A J Ponder Rosalind A Eeles Douglas F Easton Alison M Dunning

J Natl Cancer Inst 2008 Jul 24;100(13):962-6. Epub 2008 Jun 24.

Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK.

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http://dx.doi.org/10.1093/jnci/djn190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902819PMC
July 2008

A comparison of the use of bony anatomy and internal markers for offline verification and an evaluation of the potential benefit of online and offline verification protocols for prostate radiotherapy.

Authors:
Helen A McNair Vibeke N Hansen Christopher C Parker Phil M Evans Andrew Norman Elizabeth Miles Emma J Harris Louise Del-Acroix Elizabeth Smith Richard Keane Vincent S Khoo Alan C Thompson David P Dearnaley

Int J Radiat Oncol Biol Phys 2008 May 8;71(1):41-50. Epub 2007 Nov 8.

Department of Radiotherapy, Royal Marsden NHS Trust and Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2007.09.002DOI Listing
May 2008

Multiple newly identified loci associated with prostate cancer susceptibility.

Authors:
Rosalind A Eeles Zsofia Kote-Jarai Graham G Giles Ali Amin Al Olama Michelle Guy Sarah K Jugurnauth Shani Mulholland Daniel A Leongamornlert Stephen M Edwards Jonathan Morrison Helen I Field Melissa C Southey Gianluca Severi Jenny L Donovan Freddie C Hamdy David P Dearnaley Kenneth R Muir Charmaine Smith Melisa Bagnato Audrey T Ardern-Jones Amanda L Hall Lynne T O'Brien Beatrice N Gehr-Swain Rosemary A Wilkinson Angie Cox Sarah Lewis Paul M Brown Sameer G Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L Bryant Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Christopher J Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jamieson Colin S Cooper Dallas R English John L Hopper David E Neal Douglas F Easton

Nat Genet 2008 Mar 10;40(3):316-21. Epub 2008 Feb 10.

The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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http://dx.doi.org/10.1038/ng.90DOI Listing
March 2008

Efficacy of low-dose dexamethasone in castration-refractory prostate cancer.

Authors:
Ramachandran Venkitaraman Karen Thomas Robert A Huddart Alan Horwich David P Dearnaley Chris C Parker

BJU Int 2008 Feb 17;101(4):440-3. Epub 2007 Oct 17.

Academic Urology Unit, Royal Marsden Hospital, Sutton, Surrey, UK.

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http://doi.wiley.com/10.1111/j.1464-410X.2007.07261.x
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http://dx.doi.org/10.1111/j.1464-410X.2007.07261.xDOI Listing
February 2008

Evaluation of margining algorithms in commercial treatment planning systems.

Authors:
Alistair M Pooler Helen M Mayles Olivia F Naismith John P Sage David P Dearnaley

Radiother Oncol 2008 Jan 3;86(1):43-7. Epub 2007 Dec 3.

Physics Department, Clatterbridge Centre for Oncology NHS Foundation Trust, Wirral, UK.

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http://dx.doi.org/10.1016/j.radonc.2007.11.006DOI Listing
January 2008

Outcome of early detection and radiotherapy for occult spinal cord compression.

Authors:
Ramachandran Venkitaraman Yolanda Barbachano David P Dearnaley Christopher C Parker Vincent Khoo Robert A Huddart Rosalind Eeles Alan Horwich S Aslam Sohaib

Radiother Oncol 2007 Dec 26;85(3):469-72. Epub 2007 Nov 26.

Academic Urology Unit, Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK.

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http://dx.doi.org/10.1016/j.radonc.2007.10.043DOI Listing
December 2007

Additional treatment for pT3 prostate cancer: now, later or never.

Authors:
David P Dearnaley

BJU Int 2007 Nov 10;100(5):977-9. Epub 2007 Sep 10.

Academic Radiotherapy, Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2007.07177.xDOI Listing
November 2007

A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer.

Authors:
Michael A Carducci Fred Saad Per-Anders Abrahamsson David P Dearnaley Claude C Schulman Scott A North Darryl J Sleep Jeffrey D Isaacson Joel B Nelson

Cancer 2007 Nov;110(9):1959-66

Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.

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http://doi.wiley.com/10.1002/cncr.22996
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http://dx.doi.org/10.1002/cncr.22996DOI Listing
November 2007

Assessing intra-fractional bladder motion using cine-MRI as initial methodology for Predictive Organ Localization (POLO) in radiotherapy for bladder cancer.

Authors:
Stephen A Mangar Erica Scurr Robert A Huddart S Aslam Sohaib Alan Horwich David P Dearnaley Vincent S Khoo

Radiother Oncol 2007 Nov 10;85(2):207-14. Epub 2007 Oct 10.

Department of Radiotherapy, Hammersmith Hospital NHS Trust, London, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016781400700428
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http://dx.doi.org/10.1016/j.radonc.2007.04.037DOI Listing
November 2007

A phase I study of dose-escalated chemoradiation with accelerated intensity modulated radiotherapy in locally advanced head and neck cancer.

Authors:
Teresa Guerrero Urbano Catharine H Clark Vibeke N Hansen Elizabeth J Adams Roger A'Hern Elizabeth A Miles Helen McNair Margaret Bidmead Alan P Warrington David P Dearnaley Kevin J Harrington Christopher M Nutting

Radiother Oncol 2007 Oct 20;85(1):36-41. Epub 2007 Aug 20.

Head and Neck Unit, Royal Marsden Hospital, Surrey, UK.

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http://dx.doi.org/10.1016/j.radonc.2007.07.011DOI Listing
October 2007

Intensity Modulated Radiotherapy (IMRT) in locally advanced thyroid cancer: acute toxicity results of a phase I study.

Authors:
Teresa Guerrero Urbano Catharine H Clark Vibeke N Hansen Elizabeth J Adams Elizabeth A Miles Helen Mc Nair A Margaret Bidmead Jim Warrington David P Dearnaley Clive Harmer Kevin J Harrington Christopher M Nutting

Radiother Oncol 2007 Oct 27;85(1):58-63. Epub 2007 Sep 27.

Head and Neck Unit, Royal Marsden Hospital, London, UK.

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http://dx.doi.org/10.1016/j.radonc.2007.07.020DOI Listing
October 2007

The utility of lactate dehydrogenase in the follow-up of testicular germ cell tumours.

Authors:
Ramachandran Venkitaraman Bernadette Johnson Robert A Huddart Chris C Parker Alan Horwich David P Dearnaley

BJU Int 2007 Jul;100(1):30-2

Academic Urology Unit, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2007.06905.xDOI Listing
July 2007

Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial.

Authors:
David P Dearnaley Matthew R Sydes John D Graham Edwin G Aird David Bottomley Richard A Cowan Robert A Huddart Chakiath C Jose John Hl Matthews Jeremy Millar A Rollo Moore Rachel C Morgan J Martin Russell Christopher D Scrase Richard J Stephens Isabel Syndikus Mahesh K B Parmar

Lancet Oncol 2007 Jun;8(6):475-87

Institute of Cancer Research and Royal Marsden Hospitals, Sutton and London, UK.

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http://dx.doi.org/10.1016/S1470-2045(07)70143-2DOI Listing
June 2007

Long-term effects of a short course of neoadjuvant luteinizing hormone-releasing hormone analogue and radical radiotherapy on the hormonal profile in patients with localized prostate cancer.

Authors:
Vedang Murthy Andrew R Norman Yolanda Barbachano Christopher C Parker David P Dearnaley

BJU Int 2007 Jun;99(6):1380-2

Academic Unit of Radiotherapy and Oncology, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2007.06843.xDOI Listing
June 2007

Oral sodium clodronate for nonmetastatic prostate cancer--results of a randomized double-blind placebo-controlled trial: Medical Research Council PR04 (ISRCTN61384873).

Authors:
Malcolm D Mason Matthew R Sydes John Glaholm Ruth E Langley Robert A Huddart Michael Sokal Mark Stott Anne C Robinson Nicholas D James Mahesh K B Parmar David P Dearnaley

J Natl Cancer Inst 2007 May;99(10):765-76

Velindre Hospital, Department of Oncology & Palliative Medicine, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1093/jnci/djk178DOI Listing
May 2007

The early toxicity of escalated versus standard dose conformal radiotherapy with neo-adjuvant androgen suppression for patients with localised prostate cancer: results from the MRC RT01 trial (ISRCTN47772397).

Authors:
David P Dearnaley Matthew R Sydes Ruth E Langley John D Graham Robert A Huddart Isabel Syndikus John H L Matthews Christopher D Scrase Chakiath C Jose John Logue Richard J Stephens

Radiother Oncol 2007 Apr 27;83(1):31-41. Epub 2007 Mar 27.

Institute of Cancer Research and Royal Marsden Hospitals, Sutton, UK.

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http://dx.doi.org/10.1016/j.radonc.2007.02.014DOI Listing
April 2007

The quality of life of men with locally advanced prostate cancer during neoadjuvant hormone therapy: data from the Medical Research Council RT01 trial (ISRCTN 47772397).

Authors:
Richard J Stephens David P Dearnaley Richard Cowan Matthew Sydes Sharon Naylor Lesley Fallowfield

BJU Int 2007 Feb 28;99(2):301-10. Epub 2006 Nov 28.

Cancer Group, MRC Clinical Trials Unit, London, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2006.06560.xDOI Listing
February 2007

Tumor dosimetry on SPECT (186)Re-HEDP scans: variations in the results from the reconstruction methods used.

Authors:
Antigoni Divoli Gemma Bloch Sarah Chittenden Alessandro Malaroda Joe M O'Sullivan David P Dearnaley Glenn D Flux

Cancer Biother Radiopharm 2007 Feb;22(1):121-4

Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sulton, Surrey, UK.

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http://dx.doi.org/10.1089/cbr.2007.303DOI Listing
February 2007

Evaluating the relationship between erectile dysfunction and dose received by the penile bulb: using data from a randomised controlled trial of conformal radiotherapy in prostate cancer (MRC RT01, ISRCTN47772397).

Authors:
Stephen A Mangar Matthew R Sydes Helen L Tucker Jerome Coffey Syed A Sohaib Stefano Gianolini Steve Webb Vincent S Khoo David P Dearnaley

Radiother Oncol 2006 Sep 1;80(3):355-62. Epub 2006 Sep 1.

Academic Department of Radiotherapy and Oncology, The Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1016/j.radonc.2006.07.037DOI Listing
September 2006

A comparison of CT- and ultrasound-based imaging to localize the prostate for external beam radiotherapy.

Authors:
Helen A McNair Stephen A Mangar Jerome Coffey Beverley Shoulders Vibeke N Hansen Andrew Norman John Staffurth S Aslam Sohaib Alan P Warrington David P Dearnaley

Int J Radiat Oncol Biol Phys 2006 Jul;65(3):678-87

Department of Radiotherapy, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2006.01.022DOI Listing
July 2006

Intensity-modulated radiotherapy in patients with locally advanced rectal cancer reduces volume of bowel treated to high dose levels.

Authors:
M Teresa Guerrero Urbano Anthony J Henrys Elisabeth J Adams Andrew R Norman James L Bedford Kevin J Harrington Christopher M Nutting David P Dearnaley Diana M Tait

Int J Radiat Oncol Biol Phys 2006 Jul;65(3):907-16

Department of Clinical Oncology, Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2005.12.056DOI Listing
July 2006

A versatile phantom for quality assurance in the UK Medical Research Council (MRC) RT01 trial (ISRCTN47772397) in conformal radiotherapy for prostate cancer.

Authors:
A Rollo Moore A P Jim Warrington Edwin G A Aird A Margaret Bidmead David P Dearnaley

Radiother Oncol 2006 Jul 7;80(1):82-5. Epub 2006 Jul 7.

Medical Physics, Royal Marsden NHS Foundation Trust, London, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016781400600244
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http://dx.doi.org/10.1016/j.radonc.2006.06.003DOI Listing
July 2006

Treating stage I nonseminomatous germ cell tumours with a single cycle of chemotherapy.

Authors:
Duncan C Gilbert Andrew R Norman Judith Nicholl David P Dearnaley Alan Horwich Robert A Huddart

BJU Int 2006 Jul;98(1):67-9

Academic Unit of Radiotherapy & Oncology, Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK.

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http://doi.wiley.com/10.1111/j.1464-410X.2006.06188.x
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http://dx.doi.org/10.1111/j.1464-410X.2006.06188.xDOI Listing
July 2006

Variability of bladder filling in patients receiving radical radiotherapy to the prostate.

Authors:
Una M O'Doherty Helen A McNair Andrew R Norman Elizabeth Miles Simon Hooper Mark Davies Naomi Lincoln Jan Balyckyi Peter Childs David P Dearnaley Robert A Huddart

Radiother Oncol 2006 Jun 16;79(3):335-40. Epub 2006 Jun 16.

Radiotherapy Department, Royal Marsden NHS Foundation Trust, Sutton, UK.

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http://dx.doi.org/10.1016/j.radonc.2006.05.007DOI Listing
June 2006

Recovery of serum testosterone after neoadjuvant androgen deprivation therapy and radical radiotherapy in localized prostate cancer.

Authors:
Vedang Murthy Andrew R Norman Mehdi Shahidi Christopher C Parker Alan Horwich Robert A Huddart Arsha Bange David P Dearnaley

BJU Int 2006 Mar;97(3):476-9

Academic Unit of Radiotherapy and Oncology, and Department of Computing and Information, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Surrey, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2006.06013.xDOI Listing
March 2006

The impact of introducing intensity modulated radiotherapy into routine clinical practice.

Authors:
Elizabeth A Miles Catharine H Clark M Teresa Guerrero Urbano Margaret Bidmead David P Dearnaley Kevin J Harrington Roger A'Hern Christopher M Nutting

Radiother Oncol 2005 Dec 17;77(3):241-6. Epub 2005 Nov 17.

Radiotherapy Department, Royal Marsden NHS Foundation Trust, London and Sutton, UK.

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http://dx.doi.org/10.1016/j.radonc.2005.10.011DOI Listing
December 2005

Treatment planning evaluation of non-coplanar techniques for conformal radiotherapy of the prostate.

Authors:
James L Bedford Anthony J Henrys David P Dearnaley Vincent S Khoo

Radiother Oncol 2005 Jun;75(3):287-92

Joint Department of Physics, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, UK.

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http://dx.doi.org/10.1016/j.radonc.2005.03.023DOI Listing
June 2005

Technological advances in radiotherapy for the treatment of localised prostate cancer.

Authors:
Stephen A Mangar Robert A Huddart Christopher C Parker David P Dearnaley Vincent S Khoo Alan Horwich

Eur J Cancer 2005 Apr;41(6):908-21

Academic Unit of Radiotherapy and Oncology, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Downs Road, Sutton SM2 5NG, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S095980490500051
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http://dx.doi.org/10.1016/j.ejca.2004.12.028DOI Listing
April 2005

Dose to bone marrow using IMRT techniques in prostate cancer patients.

Authors:
Eduard Gershkevitsh Catharine H Clark John Staffurth David P Dearnaley Klaus-Rüdiger Trott

Strahlenther Onkol 2005 Mar;181(3):172-8

Department of Radiotherapy, Cancer Center, North-Estonian Regional Hospital, Tallinn, Estonia.

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http://dx.doi.org/10.1007/s00066-005-1360-4DOI Listing
March 2005