Dr. David Otaegui, PhD - Biodonostia Health Research Institute - Head of Multiple sclerosis group

Dr. David Otaegui

PhD

Biodonostia Health Research Institute

Head of Multiple sclerosis group

San Sebastián | Spain

ORCID logohttps://orcid.org/0000-0002-6625-5976

Dr. David Otaegui, PhD - Biodonostia Health Research Institute - Head of Multiple sclerosis group

Dr. David Otaegui

PhD

Introduction

Primary Affiliation: Biodonostia Health Research Institute - San Sebastián , Spain

Publications

44Publications

1075Reads

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372PubMed Central Citations

CircRNAs and cancer: Biomarkers and master regulators.

Semin Cancer Biol 2019 Oct 11;58:90-99. Epub 2018 Dec 11.

Molecular Oncology Group, Biodonostia Research Institute, Paseo Doctor Begiristain, s/n San Sebastián, 20014, Spain; Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom; IKERBASQUE, Basque Foundation for Science, María Díaz Haroko Kalea, 3, 48013, Bilbao, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1044579X183009
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http://dx.doi.org/10.1016/j.semcancer.2018.12.002DOI Listing
October 2019
12 Reads
9.330 Impact Factor

The circulating transcriptome as a source of cancer liquid biopsy biomarkers.

Semin Cancer Biol 2019 Oct 23;58:100-108. Epub 2019 Jan 23.

Molecular Oncology Group, Biodonostia Research Institute, Paseo Doctor Begiristain, s/n, San Sebastián, 20014, Spain; Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom; IKERBASQUE, Basque Foundation for Science, María Díaz Haroko Kalea, 3, 48013, Bilbao, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.01.003DOI Listing
October 2019
1 Read
9.330 Impact Factor

Therapeutic Potential of Extracellular Vesicles for Demyelinating Diseases; Challenges and Opportunities.

Front Mol Neurosci 2018 23;11:434. Epub 2018 Nov 23.

Multiple Sclerosis Unit, Biodonostia Health Research Institute, San Sebastian, Spain.

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http://dx.doi.org/10.3389/fnmol.2018.00434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265410PMC
November 2018

Transcriptomic integration of DR and MOR signaling in the rat caudate putamen.

Sci Rep 2018 05 9;8(1):7337. Epub 2018 May 9.

Universidad de Málaga, Instituto de Investigación Biomédica, Facultad de Ciencias, Málaga, Spain.

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http://dx.doi.org/10.1038/s41598-018-25604-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943359PMC
May 2018
2 Reads
5.080 Impact Factor

Expression Profiling Analysis Reveals Key MicroRNA-mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa.

Invest Ophthalmol Vis Sci 2018 05;59(6):2381-2392

Neuroscience Area, Sensorial Neurodegeneration Group, Biodonostia Health Research Institute, San Sebastian, Spain.

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http://dx.doi.org/10.1167/iovs.18-24091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939684PMC
May 2018
1 Read
3.404 Impact Factor

Yerba mate (Ilex paraguariensis) inhibits lymphocyte activation in vitro.

Food Funct 2016 Nov;7(11):4556-4563

Biodonostia Health Research Institute, Neuroscience Area, Multiple Sclerosis Group, San Sebastian, Spain. and Spanish Network on Multiple Sclerosis (Red Española de Esclerosis Múltiple - REEM), Spain.

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http://dx.doi.org/10.1039/c6fo01061jDOI Listing
November 2016
38 Reads
2.791 Impact Factor

Cancer risk in DM1 is sex-related and linked to miRNA-200/141 downregulation.

Neurology 2016 Sep 24;87(12):1250-7. Epub 2016 Aug 24.

From the Neuromuscular Unit, Neurology Department (R.F.-T., M.M., J.-J.P., J.-B.E., A.L.d.M.), and Department of Pathology (I.R.), Donostia Universitary Hospital, San Sebastian; Neurosciences Area (R.F.-T., M.Z., D.O., A.L.d.M.) and Oncology Area (M.G.-P., A.M.), Biodonostia Institute, San Sebastian; Center for Biomedical Research Network in Neurodegenerative Diseases (CIBERNED) (R.F.-T., A.L.d.M.), Institute Carlos III, Ministry of Economy and Competitiveness; Clinical Epidemiology Unit (J.-I.E.), Donostia Universitary Hospital, CIBER-ESP, San Sebastian, Spain; Neuromuscular Area (A.-M.C.), AP-HP Hôpital Marin de Hendaye, France; Molecular Genetics Section (L.M.), Hospital Sant Joan de Deu, Barcelona; and Department of Neurosciences (A.L.d.M.), University of the Basque Country, UPV/EHU, San Sebastian, Spain.

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http://dx.doi.org/10.1212/WNL.0000000000003124DOI Listing
September 2016
33 Reads
6 Citations
8.290 Impact Factor

Ferritin-mediated siRNA delivery and gene silencing in human tumor and primary cells.

Biomaterials 2016 08 5;98:143-51. Epub 2016 May 5.

CIC nanoGUNE, Tolosa Hiribidea 76, 20018 Donostia-San Sebastian, Spain; IKERBASQUE, Basque Foundation for Science, Maria Diaz de Haro 3, 48013 Bilbao, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.05.006DOI Listing
August 2016
65 Reads
4 Citations
8.560 Impact Factor

Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation.

Int J Mol Sci 2016 Jul 20;17(7). Epub 2016 Jul 20.

Multiple Sclerosis Unit, Biodonostia Health Research Institute-Donostia University Hospital, San Sebastian 20014, Spain.

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http://dx.doi.org/10.3390/ijms17071168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964539PMC
July 2016
9 Reads
2 Citations
2.862 Impact Factor

Age gene expression and coexpression progressive signatures in peripheral blood leukocytes.

Exp Gerontol 2015 Dec 8;72:50-6. Epub 2015 Sep 8.

Multiple Sclerosis and Neuromuscular Diseases Groups, Neurosciences Area, Biodonostia Health Research Institute, Donostia/San Sebastián, Spain; Neurology Department, Donostia University Hospital, Donostia/San Sebastián, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2015.09.003DOI Listing
December 2015
26 Reads
2 Citations
3.485 Impact Factor

Circulating microparticles reflect treatment effects and clinical status in multiple sclerosis.

Biomark Med 2014 ;8(5):653-61

Multiple Sclerosis Unit, Neuroscience Area, Biodonostia Health Research Institute, San Sebastián, Spain.

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http://dx.doi.org/10.2217/bmm.14.9DOI Listing
August 2015
24 Reads
21 Citations
2.860 Impact Factor

Editorial: Novel Clinical Applications of Extracellular Vesicles.

Front Immunol 2015 24;6:381. Epub 2015 Jul 24.

Multiple Sclerosis Unit, Biodonostia Health Research Institute , San Sebastián , Spain.

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http://dx.doi.org/10.3389/fimmu.2015.00381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513568PMC
August 2015
2 Reads
4 Citations

Transcriptomic profile reveals gender-specific molecular mechanisms driving multiple sclerosis progression.

PLoS One 2014 28;9(2):e90482. Epub 2014 Feb 28.

Multiple Sclerosis Unit, Neuroscience Area, Biodonostia Health Research Institute, Donostia-San Sebastian, Spain ; Spanish Multiple Sclerosis Net (REEM), Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090482PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938749PMC
June 2015
38 Reads
7 Citations
3.234 Impact Factor

Identification of ncRNAs as potential therapeutic targets in multiple sclerosis through differential ncRNA - mRNA network analysis.

BMC Genomics 2015 Mar 28;16:250. Epub 2015 Mar 28.

Multiple Sclerosis group, Biodonostia Health Research Institute, Paseo Dr. Begiristain s/n, San Sebastián, 20001, Spain.

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http://dx.doi.org/10.1186/s12864-015-1396-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391585PMC
March 2015
28 Reads
1 Citation
3.990 Impact Factor

Methods for extracellular vesicles isolation in a hospital setting.

Front Immunol 2015 13;6:50. Epub 2015 Feb 13.

Multiple Sclerosis Unit, Neuroscience Area, Biodonostia Health Research Institute , San Sebastián , Spain ; Spanish Network on Multiple Sclerosis , Madrid , Spain.

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http://dx.doi.org/10.3389/fimmu.2015.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327731PMC
March 2015
10 Reads
21 Citations

Neurogenetic disorders in the Basque population.

Ann Hum Genet 2015 Jan 1;79(1):57-75. Epub 2014 Dec 1.

Department of Neurology at Hospital Universitario Donostia (San Sebastián, Guipúzcoa), Basque Health Service (Osakidetza), Basque Country, Spain; Department of Neurosciences, University of Basque Country (UPV-EHU); Centre for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED); Carlos III Health Institute, Ministry of Economy and Competitiveness, Spain; BioDonostia Institute, San Sebastián, Guipúzcoa; JAKIUNDE, Academia de las Ciencias, de las Artes y de las Letras.

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http://dx.doi.org/10.1111/ahg.12088DOI Listing
January 2015
65 Reads
2 Citations
2.211 Impact Factor

Neural-competent cells of adult human dermis belong to the Schwann lineage.

Stem Cell Reports 2014 Nov 16;3(5):774-88. Epub 2014 Oct 16.

Tissue Engineering Laboratory, Bioengineering Area, Instituto Biodonostia, Hospital Universitario Donostia, Paseo Dr. Begiristain s/n, 20014 San Sebastián, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235233PMC
November 2014
65 Reads
10 Citations

Extracellular Vesicles in Multiple Sclerosis: What are They Telling Us?

Front Cell Neurosci 2014 28;8:100. Epub 2014 Mar 28.

Multiple Sclerosis Unit, Neuroscience Area, Biodonostia Health Research Institute , San Sebastián , Spain ; Spanish Network on Multiple Sclerosis , Madrid , Spain.

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http://dx.doi.org/10.3389/fncel.2014.00100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975116PMC
April 2014
7 Reads
22 Citations
4.290 Impact Factor

[Cognitive performance and quality of life in multiple sclerosis in Gipuzkoa].

Rev Neurol 2014 Apr;58(8):337-44

Universidad del Pais Vasco, Leioa, Espana.

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April 2014
7 Reads
0.930 Impact Factor

Longitudinal clinical follow-up of a large family with the R357P Twinkle mutation.

JAMA Neurol 2013 Nov;70(11):1425-8

Unidad de Enfermedades Neuromusculares, Servicio de Neurología, Hospital Universitario Virgen del Rocío/Instituto de Biomedicina de Sevilla/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Seville, Spain2Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Ministry of Economy and Competitiveness, Madrid, Spain3Department of Neurology, Columbia University Medical Center, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2013.3185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973017PMC
November 2013
50 Reads

The genetics of multiple sclerosis: review of current and emerging candidates.

Appl Clin Genet 2013 8;6:63-73. Epub 2013 Aug 8.

Multiple Sclerosis Unit, Instituto Biodonostia, San Sebastián, Spain ; Red Española de Esclerosis Múltiple (REEM), Barcelona, Spain.

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http://dx.doi.org/10.2147/TACG.S29107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760455PMC
September 2013
1 Read
11 Citations

HLA-DRB1*15:01 and multiple sclerosis: a female association?

Mult Scler 2012 May 29;18(5):569-77. Epub 2011 Nov 29.

Multiple Sclerosis Unit, Neuroscience Area, Biodonostia Health Research Institute, Donostia-San Sebastian, Spain.

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http://dx.doi.org/10.1177/1352458511426813DOI Listing
May 2012
14 Reads
12 Citations
4.822 Impact Factor

Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain).

Mov Disord 2010 Oct;25(14):2340-5

Servicio de Neurología, Hospital Donostia, San Sebastián, Gipuzkoa, Spain.

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http://dx.doi.org/10.1002/mds.23278DOI Listing
October 2010
13 Reads
9 Citations
5.680 Impact Factor

Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain.

J Neuroimmunol 2010 Jun 28;223(1-2):100-3. Epub 2010 Apr 28.

Neurogenomiks Laboratory, University of the Basque Country (UPV/EHU), Leioa, Spain.

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http://dx.doi.org/10.1016/j.jneuroim.2010.03.020DOI Listing
June 2010
12 Reads
12 Citations
2.470 Impact Factor

Phospholipase Cbeta4 isozyme is expressed in human, rat, and murine heart left ventricles and in HL-1 cardiomyocytes.

Mol Cell Biochem 2010 Apr 24;337(1-2):167-73. Epub 2009 Oct 24.

Experimental Unit, Hospital Donostia, San Sebastián, Spain.

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http://dx.doi.org/10.1007/s11010-009-0296-xDOI Listing
April 2010
6 Reads
2 Citations
2.393 Impact Factor

Increased transcriptional activity of milk-related genes following the active phase of experimental autoimmune encephalomyelitis and multiple sclerosis.

J Immunol 2007 Sep;179(6):4074-82

University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.4049/jimmunol.179.6.4074DOI Listing
September 2007
11 Reads
6 Citations
4.922 Impact Factor

Study of mitochondrial DNA mutations in patients with migraine with prolonged aura.

Headache 2004 Jul-Aug;44(7):674-7

Department of Neurology, Michigan Head-Pain and Neurological Institute, Ann Arbor 48104, USA.

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http://dx.doi.org/10.1111/j.1526-4610.2004.04126.xDOI Listing
December 2004
3 Reads
1 Citation
2.710 Impact Factor

Mitochondrial DNA depletion and dGK gene mutations.

Ann Neurol 2002 Sep;52(3):311-7

Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1002/ana.10284DOI Listing
September 2002
30 Reads
19 Citations
9.980 Impact Factor

Top co-authors

Javier Olascoaga
Javier Olascoaga

Biodonostia Health Research Institute

15
Matias Saenz-Cuesta
Matias Saenz-Cuesta

Biodonostia Health Research Institute

11
Haritz Irizar
Haritz Irizar

Biodonostia Health Research Institute

10
Tamara Castillo-Trivino
Tamara Castillo-Trivino

University of California San Francisco

9
Rafael Arroyo
Rafael Arroyo

Hospital Clínico San Carlos

6
Manuel Comabella
Manuel Comabella

Hospital Universitari Vall d'Hebron

6
Koen Vandenbroeck
Koen Vandenbroeck

School of Pharmacy

6