David O Bates

David O Bates

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David O Bates

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Vascular Endothelial Growth Factor-A165b Restores Normal Glomerular Water Permeability in a Diphtheria-Toxin Mouse Model of Glomerular Injury.

Nephron 2018 26;139(1):51-62. Epub 2018 Jan 26.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom.

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http://dx.doi.org/10.1159/000485664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969078PMC
September 2019

Enhanced notch signaling modulates unproductive revascularization in response to nitric oxide-angiopoietin signaling in a mouse model of peripheral ischemia.

Microcirculation 2019 Aug 19;26(6):e12549. Epub 2019 Jun 19.

Division of Cancer and Stem Cells, Tumour and Vascular Biology Laboratories, Cancer Biology, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1111/micc.12549DOI Listing
August 2019

Activation of Notch signaling by soluble Dll4 decreases vascular permeability via a cAMP/PKA-dependent pathway.

Am J Physiol Heart Circ Physiol 2019 May 25;316(5):H1065-H1075. Epub 2019 Jan 25.

Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, Queen's Medical Centre, University of Nottingham , Nottingham , United Kingdom.

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http://dx.doi.org/10.1152/ajpheart.00610.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580391PMC
May 2019

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

Oncogenesis 2019 Feb 19;8(3):13. Epub 2019 Feb 19.

Cancer Genetics and Stem Cell Group, Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1038/s41389-019-0125-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381143PMC
February 2019

Novel hemodynamic structures in the human glomerulus.

Am J Physiol Renal Physiol 2018 11 20;315(5):F1370-F1384. Epub 2018 Jun 20.

Bristol Renal and School of Physiology, Pharmacology and Neuroscience, University of Bristol , Bristol , United Kingdom.

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http://dx.doi.org/10.1152/ajprenal.00566.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293306PMC
November 2018

Consensus guidelines for the use and interpretation of angiogenesis assays.

Angiogenesis 2018 08;21(3):425-532

Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10456-018-9613-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237663PMC
August 2018

Sensory neuronal sensitisation occurs through HMGB-1-RAGE and TRPV1 in high-glucose conditions.

J Cell Sci 2018 07 26;131(14). Epub 2018 Jul 26.

School of Life Sciences, The Medical School QMC, University of Nottingham, Nottingham NG7 2UH, UK

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http://dx.doi.org/10.1242/jcs.215939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080605PMC
July 2018

Models of Oxygen Induced Retinopathy in Rodents.

Methods Mol Biol 2016 ;1430:317-32

Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Queen's Medical Centre, C Floor, Pope Building, University Park, Nottingham, NG2 7UH, UK.

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http://dx.doi.org/10.1007/978-1-4939-3628-1_22DOI Listing
December 2017

Measurement of Angiogenesis, Arteriolargenesis, and Lymphangiogenesis Phenotypes by Use of Two-Dimensional Mesenteric Angiogenesis Assay.

Methods Mol Biol 2016 ;1430:345-54

Cancer Biology Unit, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Queen's Medical Centre, West Block, D Floor, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1007/978-1-4939-3628-1_24DOI Listing
December 2017

Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-Aa, VEGF-Ab, PIGF and VE-cadherin.

Clin Sci (Lond) 2017 Dec 23;131(23):2763-2775. Epub 2017 Nov 23.

School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG2 7UH, U.K.

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http://clinsci.org/lookup/doi/10.1042/CS20171252
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http://dx.doi.org/10.1042/CS20171252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869853PMC
December 2017

Sulfated galactans from the red seaweed Gracilaria fisheri exerts anti-migration effect on cholangiocarcinoma cells.

Phytomedicine 2017 Dec 28;36:59-67. Epub 2017 Sep 28.

Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2017.09.014DOI Listing
December 2017

Sulfated Galactans from Red Seaweed Gracilaria fisheri Target EGFR and Inhibit Cholangiocarcinoma Cell Proliferation.

Am J Chin Med 2017 6;45(3):615-633. Epub 2017 Apr 6.

* Department of Anatomy, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1142/S0192415X17500367DOI Listing
September 2017

Sialic acids regulate microvessel permeability, revealed by novel in vivo studies of endothelial glycocalyx structure and function.

J Physiol 2017 08;595(15):5015-5035

Bristol Renal, Schools of Clinical Sciences and Physiology & Pharmacology, Dorothy Hodgkin Building, University of Bristol, Bristol, BS1 3NY, UK.

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http://dx.doi.org/10.1113/JP274167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538239PMC
August 2017

Can the co-dependence of the immune system and angiogenesis facilitate pharmacological targeting of tumours?

Curr Opin Pharmacol 2017 08 14;35:66-74. Epub 2017 Jun 14.

Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy; Scientific and Technology Pole, IRCCS MultiMedica, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2017.05.009DOI Listing
August 2017

Vascular endothelial growth factor-Ab ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina.

Clin Sci (Lond) 2017 Jun 24;131(12):1225-1243. Epub 2017 Mar 24.

Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham NG7 2UH, U.K.

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http://dx.doi.org/10.1042/CS20170102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450016PMC
June 2017

Differential regulation of blood flow-induced neovascularization and mural cell recruitment by vascular endothelial growth factor and angiopoietin signalling.

J Physiol 2017 03 2;595(5):1575-1591. Epub 2017 Feb 2.

Microvascular Research Laboratories, Bristol Heart Institute, School of Physiology and Pharmacology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1113/JP273430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330904PMC
March 2017

Mechanisms regulating angiogenesis underlie seasonal control of pituitary function.

Proc Natl Acad Sci U S A 2017 03 7;114(12):E2514-E2523. Epub 2017 Mar 7.

Centre for Comparative and Clinical Anatomy, Faculty of Health Sciences, University of Bristol, Bristol BS2 8EJ, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1618917114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373413PMC
March 2017

Pharmacology of Modulators of Alternative Splicing.

Pharmacol Rev 2017 Jan;69(1):63-79

Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom (D.O.B.); School of Chemistry, UNSW Australia, Sydney, Australia (J.C.M.); School of Physiology, Pharmacology and Neurosciences, School of Clinical Sciences/Bristol Renal, University of Bristol, Bristol, United Kingdom (S.O.); and School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom (L.F.D.).

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http://dx.doi.org/10.1124/pr.115.011239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226212PMC
January 2017

The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain.

Neurobiol Dis 2016 Dec 9;96:186-200. Epub 2016 Sep 9.

School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom; School of Life Sciences and Arthritis Research UK Pain Centre, University of Nottingham, Nottingham NG7 7UH, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113660PMC
December 2016

South African Herbal Extracts as Potential Chemopreventive Agents: Screening for Anticancer Splicing Activity.

Methods Mol Biol 2016 ;1379:201-11

Faculty of Medicine and Health Sciences, Division of Pre-clinical Oncology, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1007/978-1-4939-3191-0_18DOI Listing
September 2016

Erratum to: South African Herbal Extracts as Potential Chemopreventive Agents: Screening for Anticancer Splicing Activity.

Methods Mol Biol 2016 ;1379:E1

Faculty of Medicine and Health Sciences, Division of Pre-clinical Oncology, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1007/978-1-4939-3191-0_19DOI Listing
March 2016

Vascular endothelial growth factor-A165b prevents diabetic neuropathic pain and sensory neuronal degeneration.

Clin Sci (Lond) 2015 Oct;129(8):741-56

School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, U.K. Arthritis Research UK Pain Centre and School of Life Sciences, The Medical School QMC, University of Nottingham, Nottingham NG7 2UH, U.K.

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http://dx.doi.org/10.1042/CS20150124DOI Listing
October 2015

IL-4 regulates specific Arg-1(+) macrophage sFlt-1-mediated inhibition of angiogenesis.

Am J Pathol 2015 Aug 13;185(8):2324-35. Epub 2015 Jun 13.

School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom; Institute of Ophthalmology, University College London, London, United Kingdom; School of Clinical Sciences, University of Bristol, Bristol, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.04.013DOI Listing
August 2015

Circulating levels of anti-angiogenic VEGF-A isoform (VEGF-Axxxb) in colorectal cancer patients predicts tumour VEGF-A ratios.

Am J Cancer Res 2015 15;5(6):2083-9. Epub 2015 May 15.

Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Bristol, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529627PMC
August 2015

Regulation of vascular endothelial growth factor in prostate cancer.

Endocr Relat Cancer 2015 Jun 13;22(3):R107-23. Epub 2015 Apr 13.

Faculty of Medicine and Health SciencesSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UKDepartment of PharmacologySchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UKCancer BiologyDivision of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UKDepartment of International HealthImmunology and Microbiology, University of Copenhagen, Copenhagen, DenmarkClinical Research CenterLund University, Malmö, SwedenDepartment of PharmacologyWeill Cornell Medical College, New York, New York 10065, USA Faculty of Medicine and Health SciencesSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UKDepartment of PharmacologySchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UKCancer BiologyDivision of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UKDepartment of International HealthImmunology and Microbiology, University of Copenhagen, Copenhagen, DenmarkClinical Research CenterLund University, Malmö, SwedenDepartment of PharmacologyWeill Cornell Medical College, New York, New York 10065, USA

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http://dx.doi.org/10.1530/ERC-15-0123DOI Listing
June 2015

Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.

Mol Oncol 2015 Jan 20;9(1):167-78. Epub 2014 Aug 20.

Microvascular Research Laboratories, Veterinary Sciences Building, School of Physiology and Pharmacology, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Queen's Medical Centre, NG7 2UH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286123PMC
January 2015

The carboxyl terminus of VEGF-A is a potential target for anti-angiogenic therapy.

Angiogenesis 2015 Jan 2;18(1):23-30. Epub 2014 Oct 2.

Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Preclinical Veterinary Sciences Building, Southwell Street, Bristol, BS2 8EJ, UK.

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http://dx.doi.org/10.1007/s10456-014-9444-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280485PMC
January 2015

Novel mechanisms of resistance to vemurafenib in melanoma - V600E B-Raf reversion and switching VEGF-A splice isoform expression.

Am J Cancer Res 2015 15;5(1):433-41. Epub 2014 Dec 15.

Microvascular Research Laboratories, University of Bristol Bristol, UK, BS2 8EJ ; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Queen's Medical Centre Nottingham, UK, NG7 2UH.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300704PMC
January 2015

TNF-α-induced ICAM-1 expression and monocyte adhesion in human RPE cells is mediated in part through autocrine VEGF stimulation.

Mol Vis 2014 10;20:781-9. Epub 2014 Jun 10.

Microvascular Research Laboratories, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol, UK ; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057247PMC
September 2014

Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity.

Circulation 2014 Sep 12;130(13):1072-80. Epub 2014 Aug 12.

From the Evans Department of Medicine and Whitaker Cardiovascular Institute (D.T.M.N., M.G.F., R.K., S.K., S.T., S.J.B., N.M.H., J.A.V., K.W., N.G.) and Department of General Surgery (D.T.H.), Boston University School of Medicine, Boston, MA; Microvascular Research Laboratories, School of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Science, University of Bristol, Bristol, UK (D.O.B.); and Department of Biostatistics, Boston University School of Public Health, Boston, MA (M.P.L.).

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http://circ.ahajournals.org/content/130/13/1072.full.pdf
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http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAH
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.113.008171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175289PMC
September 2014

The role of VEGF-A165b in trophoblast survival.

BMC Pregnancy Childbirth 2014 Aug 15;14:278. Epub 2014 Aug 15.

Cancer Biology, Division of Oncology, University of Nottingham, Queen's Medical Centre, Nottingham NG2 7QT, UK.

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http://dx.doi.org/10.1186/1471-2393-14-278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143552PMC
August 2014

Detection of VEGF-A(xxx)b isoforms in human tissues.

PLoS One 2013 31;8(7):e68399. Epub 2013 Jul 31.

Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068399PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729684PMC
April 2014

SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity.

Invest Ophthalmol Vis Sci 2013 Aug 27;54(8):5797-806. Epub 2013 Aug 27.

Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1167/iovs.13-11634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485497PMC
August 2013

Association between VEGF splice isoforms and progression-free survival in metastatic colorectal cancer patients treated with bevacizumab.

Clin Cancer Res 2012 Nov 25;18(22):6384-91. Epub 2012 Oct 25.

Microvascular Research Laboratories, Department of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602975PMC
November 2012

Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction.

J Am Soc Nephrol 2012 Aug 12;23(8):1339-50. Epub 2012 Jul 12.

Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Southwell Street, Bristol, UK.

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http://dx.doi.org/10.1681/ASN.2012010017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402289PMC
August 2012

SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases.

Biochem Soc Trans 2012 Aug;40(4):831-5

Microvascular Research Laboratories, Bristol Heart Institute, School of Physiology and Pharmacology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1042/BST20120051DOI Listing
August 2012

An unexpected tail of VEGF and PlGF in pre-eclampsia.

Authors:
David O Bates

Biochem Soc Trans 2011 Dec;39(6):1576-82

Microvascular Research Laboratories, School of Physiology and Pharmacology, Preclinical Veterinary Sciences Building, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK.

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http://dx.doi.org/10.1042/BST20110671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399770PMC
December 2011

A human neutralizing antibody specific to Ang-2 inhibits ocular angiogenesis.

Microcirculation 2011 Oct;18(7):598-607

Microvascular Research Laboratories, Bristol Heart Institute, School of Physiology and Pharmacology, Veterinary Sciences Building, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/j.1549-8719.2011.00120.xDOI Listing
October 2011

Incorrect citation.

Authors:
David O Bates

Invest Ophthalmol Vis Sci 2011 Jun 21;52(7):4368; author response 4368. Epub 2011 Jun 21.

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http://dx.doi.org/10.1167/iovs.11-7310DOI Listing
June 2011

CCR7 mediates directed growth of melanomas towards lymphatics.

Microcirculation 2011 Apr;18(3):172-82

Microvascular Research Laboratories, Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/j.1549-8719.2010.00074.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287291PMC
April 2011

IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia.

Immunobiology 2010 Sep-Oct;215(9-10):796-803. Epub 2010 Jun 4.

Department of Clinical Sciences South Bristol, University of Bristol, University Walk, Bristol, UK.

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http://dx.doi.org/10.1016/j.imbio.2010.05.025DOI Listing
March 2011

Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms.

Chem Sci 2011 Feb;2011(2):273-278

Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street Bristol, BS2 8EJ, UK. ; Tel: +44 (0)117 9289818;

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http://dx.doi.org/10.1039/C0SC00297FDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399765PMC
February 2011

Glomerular filtration barrier and molecular segregation: guilty as charged?

J Am Soc Nephrol 2010 Dec 11;21(12):2009-11. Epub 2010 Nov 11.

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http://dx.doi.org/10.1681/ASN.2010101071DOI Listing
December 2010

Balance of pro- versus anti-angiogenic splice isoforms of vascular endothelial growth factor as a regulator of neuroblastoma growth.

J Pathol 2010 Oct;222(2):138-47

Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK.

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http://dx.doi.org/10.1002/path.2746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287290PMC
October 2010

Chemotrap-1: an engineered soluble receptor that blocks chemokine-induced migration of metastatic cancer cells in vivo.

Cancer Res 2010 Oct 24;70(20):8138-48. Epub 2010 Aug 24.

Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034641PMC
October 2010

An interstitial hypothesis for breast cancer related lymphoedema.

Authors:
David O Bates

Pathophysiology 2010 Sep 5;17(4):289-94. Epub 2009 Dec 5.

Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, United Kingdom.

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http://dx.doi.org/10.1016/j.pathophys.2009.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923079PMC
September 2010

VEGF-A165b is cytoprotective and antiangiogenic in the retina.

Invest Ophthalmol Vis Sci 2010 Aug 17;51(8):4273-81. Epub 2010 Mar 17.

Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1167/iovs.09-4296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910648PMC
August 2010

Recombinant human VEGF165b inhibits experimental choroidal neovascularization.

Invest Ophthalmol Vis Sci 2010 Aug 17;51(8):4282-8. Epub 2010 Mar 17.

Microvascular Research Laboratories, Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1167/iovs.09-4360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910649PMC
August 2010

Vascular endothelial growth factors and vascular permeability.

Authors:
David O Bates

Cardiovasc Res 2010 Jul 16;87(2):262-71. Epub 2010 Apr 16.

Microvascular Research Laboratories, Department of Physiology and Pharmacology, School of Veterinary Sciences, Bristol Heart Institute, University of Bristol, Southwell Street, Bristol, UK.

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http://dx.doi.org/10.1093/cvr/cvq105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895541PMC
July 2010

VEGF in the lung: a role for novel isoforms.

Am J Physiol Lung Cell Mol Physiol 2010 Jun 12;298(6):L768-74. Epub 2010 Mar 12.

Lung Research Group, Department of Clinical Science at North Bristol, University of Bristol Paul O'Gorman Lifeline Centre, Southmead Hospital, Westbury-on-Trym, United Kingdom.

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http://dx.doi.org/10.1152/ajplung.00353.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886605PMC
June 2010

Prediction of melanoma metastasis by the Shields index based on lymphatic vessel density.

BMC Cancer 2010 May 17;10:208. Epub 2010 May 17.

Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, University of Bristol, Bristol, UK.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-10-208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891632PMC
May 2010

Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis.

J Biol Chem 2010 Feb 11;285(8):5532-40. Epub 2009 Nov 11.

Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol BS2 8EJ, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.074930
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http://dx.doi.org/10.1074/jbc.M109.074930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820781PMC
February 2010

The anti-angiogenic isoforms of VEGF in health and disease.

Biochem Soc Trans 2009 Dec;37(Pt 6):1207-13

Department of Physiology and Pharmacology, Microvascular Research Laboratories, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK.

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http://dx.doi.org/10.1042/BST0371207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882696PMC
December 2009

Molecular diversity of VEGF-A as a regulator of its biological activity.

Microcirculation 2009 Oct 1;16(7):572-92. Epub 2009 Jun 1.

Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1080/10739680902997333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929464PMC
October 2009

Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx.

Cardiovasc Res 2009 Jul 18;83(1):24-33. Epub 2009 Mar 18.

Department of Physiology and Pharmacology, Preclinical Veterinary School, Microvascular Research Laboratories, Bristol Heart Institute, University of Bristol, Southwell Street, Bristol, UK.

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http://dx.doi.org/10.1093/cvr/cvp093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695703PMC
July 2009

Therapeutic potential of manipulating VEGF splice isoforms in oncology.

Future Oncol 2009 Jun;5(5):703-12

Microvascular Research Laboratories, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.2217/fon.09.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879319PMC
June 2009

Measurement of angiogenic phenotype by use of two-dimensional mesenteric angiogenesis assay.

Methods Mol Biol 2009 ;467:251-70

Division of Vascular Oncology and Metastasis, DKFZ, Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879323PMC
http://dx.doi.org/10.1007/978-1-59745-241-0_15DOI Listing
April 2009

Failure to up-regulate VEGF165b in maternal plasma is a first trimester predictive marker for pre-eclampsia.

Clin Sci (Lond) 2009 Feb;116(3):265-72

Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, University of Bristol, Bristol BS2 8EJ, U.K.

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http://dx.doi.org/10.1042/CS20080270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635543PMC
February 2009

VEGF-A splicing: the key to anti-angiogenic therapeutics?

Nat Rev Cancer 2008 Nov 16;8(11):880-7. Epub 2008 Oct 16.

Microvascular Research Laboratories, Department of Physiology & Pharmacology, Bristol Heart Institute, School of Veterinary Science, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK.

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http://dx.doi.org/10.1038/nrc2505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613352PMC
November 2008

VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6.

Microcirculation 2008 Oct;15(7):605-14

Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, United Kingdom.

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http://doi.wiley.com/10.1080/10739680802220323
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http://dx.doi.org/10.1080/10739680802220323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635545PMC
October 2008

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors.

J Cell Sci 2008 Oct;121(Pt 20):3487-95

Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK.

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http://dx.doi.org/10.1242/jcs.016410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613349PMC
October 2008

Recombinant human VEGF165b protein is an effective anti-cancer agent in mice.

Eur J Cancer 2008 Sep 24;44(13):1883-94. Epub 2008 Jul 24.

Microvascular Research Laboratories, Department of Physiology and Pharmacology, School of Veterinary Science, University of Bristol, Southwell Street, Bristol BS2 8EJ, United Kingdom.

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http://dx.doi.org/10.1016/j.ejca.2008.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565644PMC
September 2008

Arteriolar genesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature.

Arterioscler Thromb Vasc Biol 2008 Aug 22;28(8):1462-8. Epub 2008 May 22.

Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology, University of Bristol, Southwell Street, Bristol BS2 8EJ, United Kingdom.

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http://dx.doi.org/10.1161/ATVBAHA.108.169375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566940PMC
August 2008

VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis.

Cardiovasc Res 2008 May 7;78(2):315-23. Epub 2007 Dec 7.

Microvascular Research Laboratories, Department of Physiology, University of Bristol, BS2 8EJ Bristol, UK.

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http://dx.doi.org/10.1093/cvr/cvm094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613351PMC
May 2008

Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b.

FASEB J 2008 Apr 21;22(4):1104-12. Epub 2007 Nov 21.

Microvascular Research Laboratories, School of Veterinary Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1096/fj.07-9718comDOI Listing
April 2008

Glomerular filtration into the subpodocyte space is highly restricted under physiological perfusion conditions.

Am J Physiol Renal Physiol 2007 Dec 22;293(6):F1787-98. Epub 2007 Aug 22.

Dept. of Physiology, Univ. of Bristol, Southwell St., Bristol BS2 8EJ, UK.

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http://www.physiology.org/doi/10.1152/ajprenal.00157.2007
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http://dx.doi.org/10.1152/ajprenal.00157.2007DOI Listing
December 2007

Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space.

Am J Physiol Renal Physiol 2007 Dec 5;293(6):F1777-86. Epub 2007 Sep 5.

ZNI 335, Zilkha Neurogenetic Institute, 1501 San Pablo St., Keck School of Medicine, Univ. of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1152/ajprenal.00187.2007DOI Listing
December 2007

Hyperglycemia stimulates a sustained increase in hydraulic conductivity in vivo without any change in reflection coefficient.

Microcirculation 2007 Sep-Oct;14(7):683-96

Microvascular Research Laboratories, Department of Physiology, University of Bristol, Preclinical Veterinary School, Bristol, UK.

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http://doi.wiley.com/10.1080/10739680701436129
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http://dx.doi.org/10.1080/10739680701436129DOI Listing
December 2007

A role for the endothelial glycocalyx in regulating microvascular permeability in diabetes mellitus.

Cell Biochem Biophys 2007 ;49(2):65-72

Department of Surgery, University of California at Davis Medical Center, Sacramento, CA 95817, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613348PMC
November 2007

Alternative splicing in angiogenesis: the vascular endothelial growth factor paradigm.

Cancer Lett 2007 May 5;249(2):133-42. Epub 2006 Oct 5.

Centre for Research in Biomedicine, Bristol Genomics Research Institute, Faculty of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK.

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http://dx.doi.org/10.1016/j.canlet.2006.08.015DOI Listing
May 2007

VEGF and angiopoietin-1 stimulate different angiogenic phenotypes that combine to enhance functional neovascularization in adult tissue.

Microcirculation 2006 Sep;13(6):423-37

Microvascular Research Laboratories, Department of Physiology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1080/10739680600775940DOI Listing
September 2006

A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells.

Cell Calcium 2006 Jul 11;40(1):29-40. Epub 2006 May 11.

Cardiovascular and Microvascular Research Laboratories, Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S014341600600050
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http://dx.doi.org/10.1016/j.ceca.2006.03.007DOI Listing
July 2006

VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice.

Mol Vis 2006 May 26;12:626-32. Epub 2006 May 26.

Microvascular Research Laboratories, Preclinical Veterinary School, Department of Physiology, University of Bristol, Bristol, UK.

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May 2006

Therapeutic potential of inhibitory VEGF splice variants.

Future Oncol 2005 Aug;1(4):467-73

University of Bristol, Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, Southwell Street, Bristol, BS2 8EJ, UK.

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http://dx.doi.org/10.2217/14796694.1.4.467DOI Listing
August 2005