David Matallanas

David Matallanas

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David Matallanas

David Matallanas

Publications by authors named "David Matallanas"

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Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles.

Cell Biol Toxicol 2019 Jul 27. Epub 2019 Jul 27.

Institut Jean Lamour, UMR 7198, CNRS-Université de Lorraine, 2 allée André Guinier, BP 50840, 54011, Nancy, France.

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http://dx.doi.org/10.1007/s10565-019-09484-6DOI Listing
July 2019

Quantifying the Kinase Activities of MST1/2.

Methods Mol Biol 2019 ;1893:289-304

Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland.

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http://link.springer.com/10.1007/978-1-4939-8910-2_22
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http://dx.doi.org/10.1007/978-1-4939-8910-2_22DOI Listing
June 2019

All over the place: deciphering HRAS signaling from different subcellular compartments.

Mol Cell Oncol 2019 20;6(5):e1605821. Epub 2019 May 20.

Systems Biology Ireland, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1080/23723556.2019.1605821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736159PMC
May 2019

An Integrated Global Analysis of Compartmentalized HRAS Signaling.

Cell Rep 2019 Mar;26(11):3100-3115.e7

Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland; Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Ireland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193020
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http://dx.doi.org/10.1016/j.celrep.2019.02.038DOI Listing
March 2019

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling.

Cell Syst 2018 08 11;7(2):161-179.e14. Epub 2018 Jul 11.

Systems Biology Ireland, University College Dublin, Dublin, Ireland; Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Ireland; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149545PMC
August 2018

A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.

Cell Syst 2017 10 11;5(4):399-409.e5. Epub 2017 Oct 11.

The Breast Cancer Now Toby Robins Breast Cancer Research Centre and CRUK Gene Function Laboratory, The Institute of Cancer Research, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.cels.2017.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660599PMC
October 2017

The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells.

Semin Cell Dev Biol 2016 10 24;58:96-107. Epub 2016 Jun 24.

Systems Biology Ireland, UCD School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland; Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2016.06.011DOI Listing
October 2016

Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.

Cell Stem Cell 2016 10 28;19(4):491-501. Epub 2016 Jul 28.

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; ICREA, Passeig de Lluís Companys 23, 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.06.020DOI Listing
October 2016

SARAH Domain-Mediated MST2-RASSF Dimeric Interactions.

PLoS Comput Biol 2016 Oct 7;12(10):e1005051. Epub 2016 Oct 7.

School of Physics & Institute for Discovery, University College Dublin, Belfield, Dublin, Ireland.

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http://dx.doi.org/10.1371/journal.pcbi.1005051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055338PMC
October 2016

The spatiotemporal regulation of RAS signalling.

Biochem Soc Trans 2016 10;44(5):1517-1522

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST20160127
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http://dx.doi.org/10.1042/BST20160127DOI Listing
October 2016

The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair.

Genes (Basel) 2016 Jun 17;7(6). Epub 2016 Jun 17.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.3390/genes7060028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929427PMC
June 2016

A microfluidic dual gradient generator for conducting cell-based drug combination assays.

Integr Biol (Camb) 2016 Jan 16;8(1):39-49. Epub 2015 Nov 16.

School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1039/c5ib00209eDOI Listing
January 2016

One Hippo and many masters: differential regulation of the Hippo pathway in cancer.

Biochem Soc Trans 2014 Aug;42(4):816-21

‡Division of Medical Oncology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, U.S.A.

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http://dx.doi.org/10.1042/BST20140030DOI Listing
August 2014

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling.

Nat Cell Biol 2014 Jul 15;16(7):673-84. Epub 2014 Jun 15.

1] Systems Biology Ireland, University College Dublin, Dublin 4, Ireland [2] Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin 4, Ireland [3] School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland [4].

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http://dx.doi.org/10.1038/ncb2986DOI Listing
July 2014

Signalling by protein phosphatases and drug development: a systems-centred view.

FEBS J 2013 Jan 14;280(2):751-65. Epub 2012 Mar 14.

Systems Biology Ireland, University College Dublin, Belfield, Ireland.

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http://dx.doi.org/10.1111/j.1742-4658.2012.08522.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368988PMC
January 2013

New druggable targets in the Ras pathway?

Curr Opin Mol Ther 2010 Dec;12(6):674-83

Universidad de Cantabria, Instituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas, IDICAN, Departamento de Biología Molecular, Facultad de Medicina, c/Cardenal Herrera Oria s/n, Santander, 39011 Cantabria, Spain.

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December 2010

Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.

Cancer Res 2010 Feb 19;70(3):1195-203. Epub 2010 Jan 19.

Proteomics and Signalling Networks Group, The Beatson Institute for Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880716PMC
February 2010

RAN GTPase is a RASSF1A effector involved in controlling microtubule organization.

Curr Biol 2009 Jul 25;19(14):1227-32. Epub 2009 Jun 25.

Section of Medical and Molecular Genetics, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1016/j.cub.2009.05.064DOI Listing
July 2009

Proteomics and phosphoproteomics for the mapping of cellular signalling networks.

Proteomics 2008 Nov;8(21):4402-15

The Beatson Institute for Cancer Research, Glasgow, UK.

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http://dx.doi.org/10.1002/pmic.200800136DOI Listing
November 2008

A Hippo in the ointment: MST signalling beyond the fly.

Cell Cycle 2008 Apr 22;7(7):879-84. Epub 2008 Jan 22.

Signalling and Proteomics Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom.

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http://dx.doi.org/10.4161/cc.7.7.5630DOI Listing
April 2008

Mammalian sterile 20-like kinases in tumor suppression: an emerging pathway.

Cancer Res 2005 Jul;65(13):5485-7

Beatson Insitute for Cancer Research, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1453DOI Listing
July 2005

Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway.

J Biol Chem 2005 Jan 4;280(2):1112-22. Epub 2004 Nov 4.

Grupo de Biología Molecular del Cáncer, Departamento de Biología Molecular, Unidad de Biomedicina del Consejo Superior de Investigaciones Cientiíficas, Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain.

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http://dx.doi.org/10.1074/jbc.M409503200DOI Listing
January 2005

Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.

J Biol Chem 2004 Jul 1;279(31):32813-23. Epub 2004 Jun 1.

Departamento de Biología Molecular, Unidad de Biomedicina de la Universidad de Cantabria-CSIC, Santander 39011, Spain.

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http://dx.doi.org/10.1074/jbc.M313656200DOI Listing
July 2004

Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.

Mol Cell Biol 2004 Feb;24(4):1516-30

Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas, Departamento de Biología Molecular, Unidad de Biomedicina de la Universidad de Cantabria-CSIC, Santander 39011, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC344182PMC
http://dx.doi.org/10.1128/mcb.24.4.1516-1530.2004DOI Listing
February 2004

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1.

EMBO J 2003 Jul;22(13):3326-36

Centro de Investigación del Cáncer, University of Salamanca-CSIC, Campus Unamuno, E-37007 Salamanca and Instituto de Investigaciones Biomédicas Alberto Sols, E-28929 Madrid, Spain.

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http://dx.doi.org/10.1093/emboj/cdg316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165641PMC
July 2003