David Maloney

David Maloney

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David Maloney

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Allogeneic Stem Cell Transplantation Provides Durable Remission in Patients with Primary Mediastinal Large B Cell Lymphoma.

Biol Blood Marrow Transplant 2019 Aug 5. Epub 2019 Aug 5.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Medical Oncology Division, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1016/j.bbmt.2019.07.041DOI Listing
August 2019

Late Events after Treatment with CD19-Targeted Chimeric Antigen Receptor Modified T Cells.

Biol Blood Marrow Transplant 2019 Aug 13. Epub 2019 Aug 13.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.08.003DOI Listing
August 2019

Second allogeneic hematopoietic cell transplantation for relapse after first allografts.

Leuk Lymphoma 2019 Jul 22;60(7):1758-1766. Epub 2019 Jan 22.

c Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.

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http://dx.doi.org/10.1080/10428194.2018.1542149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594865PMC
July 2019

Outcomes of Patients With Therapy-Related MDS After Chemoimmunotherapy for Chronic Lymphocytic Leukemia Compared With Patients With De Novo MDS: A Single-Institution Experience.

Clin Lymphoma Myeloma Leuk 2019 Jun 11;19(6):390-395. Epub 2019 Mar 11.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2019.03.003DOI Listing
June 2019

Anti-CD19 CAR T cell therapy for lymphoma - off to the races!

Authors:
David G Maloney

Nat Rev Clin Oncol 2019 05;16(5):279-280

Bezos Family Immunotherapy Clinic, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41571-019-0183-7DOI Listing
May 2019

Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.

Bioorg Med Chem Lett 2019 May 12;29(10):1220-1226. Epub 2019 Mar 12.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.03.014DOI Listing
May 2019

Not so crystal clear: observations from a case of crystalline arthritis with cytokine release syndrome (CRS) after chimeric antigen receptor (CAR)-T cell therapy.

Bone Marrow Transplant 2019 Apr 5;54(4):632-634. Epub 2018 Oct 5.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://www.nature.com/articles/s41409-018-0357-4
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http://dx.doi.org/10.1038/s41409-018-0357-4DOI Listing
April 2019

Management of cytokine release syndrome and neurotoxicity in chimeric antigen receptor (CAR) T cell therapy.

Expert Rev Hematol 2019 Mar 18;12(3):195-205. Epub 2019 Mar 18.

a Division of Medical Oncology, Department of Internal Medicine , University of Washington School of Medicine , Seattle , WA , USA.

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http://dx.doi.org/10.1080/17474086.2019.1585238DOI Listing
March 2019

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Cancer Cell 2018 12 21;34(6):939-953.e9. Epub 2018 Nov 21.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Ludwig Center at Harvard, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183048
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http://dx.doi.org/10.1016/j.ccell.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310147PMC
December 2018

Discovery and lead identification of quinazoline-based BRD4 inhibitors.

Bioorg Med Chem Lett 2018 11 31;28(21):3483-3488. Epub 2018 Aug 31.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.08.039DOI Listing
November 2018

Long-Term Follow-Up of Y-Ibritumomab Tiuxetan, Fludarabine, and Total Body Irradiation-Based Nonmyeloablative Allogeneic Transplant Conditioning for Persistent High-Risk B Cell Lymphoma.

Biol Blood Marrow Transplant 2018 11 3;24(11):2211-2215. Epub 2018 Jul 3.

Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10838791183038
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http://dx.doi.org/10.1016/j.bbmt.2018.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251312PMC
November 2018

Room-Temperature, Copper-Free Sonogashira Reactions Facilitated by Air-Stable, Monoligated Precatalyst [DTBNpP] Pd(crotyl)Cl.

ACS Omega 2018 Oct 10;3(10):12985-12998. Epub 2018 Oct 10.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/acsomega.8b01868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644404PMC
October 2018

Toxicity management after chimeric antigen receptor T cell therapy: one size does not fit 'ALL'.

Nat Rev Clin Oncol 2018 04 13;15(4):218. Epub 2018 Feb 13.

Department of Pediatrics and The Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/nrclinonc.2018.19DOI Listing
April 2018

Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016.

J Clin Oncol 2018 03 22;36(7):697-703. Epub 2018 Jan 22.

Mazyar Shadman, Ajay K. Gopal, David G. Maloney, and Oliver W. Press, University of Washington and Fred Hutchinson Cancer Research Center; Hongli Li and Michael LeBlanc, SWOG Statistical Center, Seattle, WA; Lisa Rimsza, Mayo Clinic Arizona, Scottsdale; Catherine M. Spier, University of Arizona, Tucson, AZ; John P. Leonard, Weill Cornell Medical College, New York; Jonathan W. Friedberg, Wilmot Cancer Institute, University of Rochester, Rochester, NY; Mark S. Kaminski, University of Michigan Health System, Ann Arbor, MI; Rita M. Braziel, Oregon Health & Science University, Portland, OR; Bruce D. Cheson, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC; Shaker Dakhil, University of Kansas School of Medicine-Wichita, Wichita, KS; Sonali M. Smith, University of Chicago Medicine, Chicago, IL; and Richard I. Fisher, Fox Chase Cancer Center and Temple University School of Medicine, Philadelphia, PA.

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http://ascopubs.org/doi/10.1200/JCO.2017.74.5083
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http://dx.doi.org/10.1200/JCO.2017.74.5083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553811PMC
March 2018

Reversal of Low Donor Chimerism after Hematopoietic Cell Transplantation Using Pentostatin and Donor Lymphocyte Infusion: A Prospective Phase II Multicenter Trial.

Biol Blood Marrow Transplant 2018 02 12;24(2):308-313. Epub 2017 Oct 12.

Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2017.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767527PMC
February 2018

Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products.

Mol Ther 2018 01 12;26(1):280-288. Epub 2017 Sep 12.

Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5156, USA.

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http://dx.doi.org/10.1016/j.ymthe.2017.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762981PMC
January 2018

First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.

Arterioscler Thromb Vasc Biol 2017 10 3;37(10):1828-1839. Epub 2017 Aug 3.

From the Department of Pharmacology (R.A., B.E.T., K.M., J.Y., M.H.) and Department of Internal Medicine, Division of Cardiovascular Medicine (M.H.), University of Michigan, Ann Arbor; Chemistry and Biochemistry, University of California Santa Cruz (J.C.F., A.G., T.R.H.); and National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, MD (D.K.L., A.J., A.S., D.J.M.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620123PMC
October 2017

Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold.

ACS Comb Sci 2017 10 5;19(10):646-656. Epub 2017 Sep 5.

Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin , Milwaukee, Wisconsin 53211, United States.

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http://dx.doi.org/10.1021/acscombsci.7b00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643073PMC
October 2017

Durable Molecular Remissions in Chronic Lymphocytic Leukemia Treated With CD19-Specific Chimeric Antigen Receptor-Modified T Cells After Failure of Ibrutinib.

J Clin Oncol 2017 Sep 17;35(26):3010-3020. Epub 2017 Jul 17.

Cameron J. Turtle, Kevin A. Hay, Laïla-Aïcha Hanafi, Shelly Heimfeld, Stanley R. Riddell, and David G. Maloney, Fred Hutchinson Cancer Research Center; Cameron J. Turtle, Sindhu Cherian, Xueyan Chen, Brent Wood, Stanley R. Riddell, and David G. Maloney, University of Washington; Daniel Li, Juno Therapeutics, Seattle, WA; and Arletta Lozanski and John C. Byrd, The Ohio State University, Columbus, OH.

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http://dx.doi.org/10.1200/JCO.2017.72.8519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590803PMC
September 2017

Immunotherapy in lymphoma.

Hematol Oncol 2017 Jun;35 Suppl 1:88-91

Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1002/hon.2408DOI Listing
June 2017

Beyond RCHOP: A Blueprint for Diffuse Large B Cell Lymphoma Research.

J Natl Cancer Inst 2016 12 16;108(12). Epub 2016 Dec 16.

Department of Medicine, Mayo Clinic, Rochester, MN (GSN); Department of Internal Medicine, Ohio State University, Columbus, OH (KAB); Department of Medicine, Oncology Division, Washington University, St. Louis, MO (BSK); Wilmot Cancer Center and Division of Hematology/Oncology, University of Rochester, Rochester, NY (JWF); Coordinating Center for Clinical Trials (LB), Division of Cancer Treatment and Diagnosis (RFL), and Center for Cancer Research (WHW), National Cancer Institute, National Institute of Health, Bethesda, MD; Division of Oncology, University of Washington, Seattle WA (DGM); British Colombia Cancer Agency, Vancouver, BC (LHS); Department of Medicine, University of Virginia, Charlottesville, VA (MEW); Department of Medicine, Weil Cornell University, New York, NY (JPL); Department of Medicine, University of Chicago, Chicago, IL (SMS).

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http://dx.doi.org/10.1093/jnci/djw257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080361PMC
December 2016

Comorbidities, Alcohol Use Disorder, and Age Predict Outcomes after Autologous Hematopoietic Cell Transplantation for Lymphoma.

Biol Blood Marrow Transplant 2016 09 14;22(9):1582-1587. Epub 2016 Jun 14.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2016.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981519PMC
September 2016

Clinical trials of CD19-targeted CAR-modified T cell therapy; a complex and varied landscape.

Expert Rev Hematol 2016 08 4;9(8):719-21. Epub 2016 Jul 4.

a Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.

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https://www.tandfonline.com/doi/full/10.1080/17474086.2016.1
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http://dx.doi.org/10.1080/17474086.2016.1203251DOI Listing
August 2016

A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies.

Cancer Res 2016 07 4;76(14):4183-91. Epub 2016 Jun 4.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland. Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea. Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033673PMC
July 2016

Preserved Activity of CD20-Specific Chimeric Antigen Receptor-Expressing T Cells in the Presence of Rituximab.

Cancer Immunol Res 2016 06 21;4(6):509-19. Epub 2016 Apr 21.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891234PMC
June 2016

Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase.

Biochemistry 2016 06 3;55(23):3329-40. Epub 2016 Jun 3.

Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00338DOI Listing
June 2016

Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy.

Blood 2016 05 23;127(20):2406-10. Epub 2016 Feb 23.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and Department of Medicine, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1182/blood-2015-08-665547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874221PMC
May 2016

A potent and selective inhibitor targeting human and murine 12/15-LOX.

Bioorg Med Chem 2016 Mar 21;24(6):1183-90. Epub 2016 Jan 21.

Chemistry and Biochemistry Department, University of California, Santa Cruz, CA 95060, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.01.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778748PMC
March 2016

Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants.

Retrovirology 2016 Feb 16;13:11. Epub 2016 Feb 16.

HIV Drug Resistance Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD, USA.

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http://dx.doi.org/10.1186/s12977-016-0244-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754833PMC
February 2016

The potential of 12/15-lipoxygenase inhibitors in stroke therapy.

Future Med Chem 2014 ;6(17):1853-5

Neuroprotection Research Laboratory, Dept. of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.4155/fmc.14.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280907PMC
August 2015

Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.

Mol Endocrinol 2015 Jun 24;29(6):791-800. Epub 2015 Mar 24.

Departments of Pediatrics and the Center for Diabetes and Metabolic Diseases (S.A.T., R.G.M.), Biochemistry and Molecular Biology (E.B., R.G.M.), Medicine (R.G.M.), and Cellular and Integrative Physiology (R.G.M.), Indiana University School of Medicine, Indianapolis, Indiana 46202; Department of Chemistry and Biochemistry (T.R.H.), University of California, Santa Cruz, Santa Cruz, California 95064; National Center for Advancing Translational Sciences (D.J.M.), National Institutes of Health, Rockville, Maryland 20850; and Department of Medicine and the Strelitz Diabetes Center (J.L.N.), Eastern Virginia Medical School, Norfolk, Virginia 23507.

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http://dx.doi.org/10.1210/me.2015-1041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447641PMC
June 2015

Low Serum Vitamin D Levels Are Associated With Inferior Survival in Follicular Lymphoma: A Prospective Evaluation in SWOG and LYSA Studies.

J Clin Oncol 2015 May 30;33(13):1482-90. Epub 2015 Mar 30.

Jennifer L. Kelly and Jonathan W. Friedberg, James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY; Gilles Salles, Hospices Civils de Lyon, Université Claude Bernard Lyon-1, Pierre Benite; Pauline Brice, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, Paris; Olivier Casasnovas, Centre Hospitalo-Universitaire de Dijon, Dijon; Pierre Soubeyran, Institut Bergonié and Université Victor Segalen Bordeaux 2, Bordeaux; Corinne Haioun, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil; Luc Xerri, Institut Paoli Calmettes, Marseille; Hervé Tilly, Centre Henri Becquerel, Rouen, France; Bryan Goldman, Oliver Press, and Michael LeBlanc, SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA; Richard I. Fisher, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA; and Lisa Rimsza, University of Arizona, Tucson, AZ.

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http://jco.ascopubs.org/content/early/2015/03/30/JCO.2014.57
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.57.5092
Publisher Site
http://dx.doi.org/10.1200/JCO.2014.57.5092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404425PMC
May 2015

Long-term outcomes of patients with persistent indolent B cell malignancies undergoing nonmyeloablative allogeneic transplantation.

Biol Blood Marrow Transplant 2015 Feb 1;21(2):281-7. Epub 2014 Nov 1.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408880PMC
February 2015

Discovery of a novel general anesthetic chemotype using high-throughput screening.

Anesthesiology 2015 Feb;122(2):325-33

From the Department of Anesthesiology and Critical Care (A.R.M.-W., W.B., R.G.E.) and Department of Pharmacology (B.P.W.), University of Pennsylvania, Philadelphia, Pennsylvania; National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland (G.R., W.A.L., A.S., A.J., D.J.M.); and College of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania (D.F.L.).

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http://dx.doi.org/10.1097/ALN.0000000000000505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300529PMC
February 2015

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.

Nat Commun 2014 Nov 12;5:5165. Epub 2014 Nov 12.

1] University Chemical Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK [2] Cancer Research UK, Li Ka Shing Centre, Cambridge Institute, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1038/ncomms6165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258842PMC
November 2014